WO2009071065A3 - Vorrichtung zur messung von transportsystemen in membranen - Google Patents

Vorrichtung zur messung von transportsystemen in membranen Download PDF

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Publication number
WO2009071065A3
WO2009071065A3 PCT/DE2008/002010 DE2008002010W WO2009071065A3 WO 2009071065 A3 WO2009071065 A3 WO 2009071065A3 DE 2008002010 W DE2008002010 W DE 2008002010W WO 2009071065 A3 WO2009071065 A3 WO 2009071065A3
Authority
WO
WIPO (PCT)
Prior art keywords
membranes
transport systems
measuring transport
properties
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE2008/002010
Other languages
English (en)
French (fr)
Other versions
WO2009071065A2 (de
Inventor
Stefan Hummel
Matthias Pirsch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SYNENTEC GmbH
Original Assignee
SYNENTEC GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SYNENTEC GmbH filed Critical SYNENTEC GmbH
Priority to EP08856201A priority Critical patent/EP2257788A2/de
Priority to JP2010538323A priority patent/JP2011519017A/ja
Priority to US12/734,944 priority patent/US20100274496A1/en
Publication of WO2009071065A2 publication Critical patent/WO2009071065A2/de
Anticipated expiration legal-status Critical
Publication of WO2009071065A3 publication Critical patent/WO2009071065A3/de
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Die Erfindung betrifft eine Vorrichtung (1) zur optischen Messung von Eigenschaften von Transportsystemen (50) in Membranen (40), insbesondere von Carrier- oder Kanalproteinen. Um die Eigenschaften von biologischen Transportermolekülen (50) mit hohem Durchsatz messen zu können, wird vorgeschlagen, dass die Vorrichtung (1) eine optische Messeinrichtung (2) und eine Datenverarbeitungseinheit (6) mit einer Prozesssteuerung (7) und einer Datenerfassung aufweist.
PCT/DE2008/002010 2007-12-06 2008-12-05 Vorrichtung zur messung von transportsystemen Ceased WO2009071065A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08856201A EP2257788A2 (de) 2007-12-06 2008-12-05 Vorrichtung zur messung von transportsystemen
JP2010538323A JP2011519017A (ja) 2007-12-06 2008-12-05 輸送システムの測定装置
US12/734,944 US20100274496A1 (en) 2007-12-06 2008-12-05 Device for measurement of transport systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007059166A DE102007059166A1 (de) 2007-12-06 2007-12-06 Vorrichtung zur Messung von Transportsystemen
DE102007059166.9 2007-12-06

Publications (2)

Publication Number Publication Date
WO2009071065A2 WO2009071065A2 (de) 2009-06-11
WO2009071065A3 true WO2009071065A3 (de) 2013-03-21

Family

ID=40621249

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2008/002010 Ceased WO2009071065A2 (de) 2007-12-06 2008-12-05 Vorrichtung zur messung von transportsystemen

Country Status (5)

Country Link
US (1) US20100274496A1 (de)
EP (1) EP2257788A2 (de)
JP (1) JP2011519017A (de)
DE (1) DE102007059166A1 (de)
WO (1) WO2009071065A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010035003B4 (de) * 2010-08-20 2015-08-06 PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung Räumlich und zeitlich hochauflösende Mikroskopie
CA2865922A1 (en) * 2012-03-02 2013-09-06 Huron Technologies International Inc. Scanner with increased dynamic range
CA3046284A1 (en) * 2016-12-09 2018-06-14 Perfusion Tech IVS System and method for assessing perfusion in an anatomical structure

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000073799A1 (en) * 1999-06-01 2000-12-07 Caliper Technologies Corp. Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
WO2004059299A1 (en) * 2002-12-16 2004-07-15 Cytodiscovery, Inc. Microfluidic system with integrated permeable membrane
DE102007016699A1 (de) * 2007-04-04 2008-10-09 Synentec Gmbh Biochip für die Fluoreszenzanalyse von einzelnen Transportern

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US5111221A (en) * 1988-05-13 1992-05-05 United States Of America As Represented By The Secretary Of The Navy Receptor-based sensor
IL93020A (en) * 1990-01-09 1995-06-29 Yeda Res & Dev Biosensors comprising a lipid bilayer doped with ion channels anchored to a recording electrode by bridging molecules
ATE265676T1 (de) * 1996-05-29 2004-05-15 Walter Dr Schubert Automatisierte vorrichtung und verfahren zum messen und bestimmen von molekülen oder teilen davon
US6103479A (en) * 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US6228326B1 (en) * 1996-11-29 2001-05-08 The Board Of Trustees Of The Leland Stanford Junior University Arrays of independently-addressable supported fluid bilayer membranes
US7144486B1 (en) * 1997-04-30 2006-12-05 Board Of Trustees Of The University Of Arkansas Multilayer microcavity devices and methods
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6323039B1 (en) * 1999-06-22 2001-11-27 Mitokor Compositions and methods for assaying subcellular conditions and processes using energy transfer
AU6075100A (en) * 1999-07-07 2001-01-30 Ljl Biosystems, Inc. Light detection device
US6917726B2 (en) * 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6977155B2 (en) * 2000-08-10 2005-12-20 Corning Incorporated Arrays of biological membranes and methods and use thereof
US6913697B2 (en) * 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
WO2002101364A1 (en) * 2001-06-09 2002-12-19 Glsynthesis Inc. Lipid structures and uses thereof
US20050230272A1 (en) * 2001-10-03 2005-10-20 Lee Gil U Porous biosensing device
AU2002365079A1 (en) * 2001-10-03 2003-06-30 Osman A. Basaran Device and bioanalytical method utilizing asymmetric biofunction alized membrane
US20040121377A1 (en) * 2002-10-05 2004-06-24 Chiaki Ishii Spatially encoded and mobile arrays of tethered lipids
US20040096914A1 (en) * 2002-11-20 2004-05-20 Ye Fang Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof
GB2403951A (en) * 2003-07-08 2005-01-19 Medical Res Council Assay method for endocytosis or exocytosis
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000073799A1 (en) * 1999-06-01 2000-12-07 Caliper Technologies Corp. Microscale assays and microfluidic devices for transporter, gradient induced, and binding activities
WO2004059299A1 (en) * 2002-12-16 2004-07-15 Cytodiscovery, Inc. Microfluidic system with integrated permeable membrane
DE102007016699A1 (de) * 2007-04-04 2008-10-09 Synentec Gmbh Biochip für die Fluoreszenzanalyse von einzelnen Transportern

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUZUKI H ET AL: "Lipid Bilayer Microchambers: An Optical Detection System for Membrane Transport", MICRO ELECTRO MECHANICAL SYSTEMS, 2006. MEMS 2006 ISTANBUL. 19TH IEEE INTERNATIONAL CONFERENCE ON ISTANBUL, TURKEY 22-26 JAN. 2006, IEEE, PISCATAWAY, NJ, USA, 22 January 2006 (2006-01-22), pages 482 - 485, XP010914287, ISBN: 978-0-7803-9475-9, DOI: 10.1109/MEMSYS.2006.1627841 *

Also Published As

Publication number Publication date
DE102007059166A1 (de) 2009-06-10
US20100274496A1 (en) 2010-10-28
JP2011519017A (ja) 2011-06-30
EP2257788A2 (de) 2010-12-08
WO2009071065A2 (de) 2009-06-11

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