WO2009113779A3 - Ｓｎｐ 어레이를 이용한 염색체, 유전자, 또는 특정 뉴클레오티드 서열의 카피 수 측정방법 - Google Patents

Ｓｎｐ 어레이를 이용한 염색체, 유전자, 또는 특정 뉴클레오티드 서열의 카피 수 측정방법 Download PDF

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WO2009113779A3
WO2009113779A3 PCT/KR2009/001111 KR2009001111W WO2009113779A3 WO 2009113779 A3 WO2009113779 A3 WO 2009113779A3 KR 2009001111 W KR2009001111 W KR 2009001111W WO 2009113779 A3 WO2009113779 A3 WO 2009113779A3
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gene
nucleotide sequence
specific nucleotide
copy numbers
sequence copy
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Ceased
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French (fr)
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WO2009113779A2 (ko
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홍경만
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National Cancer Center Japan
National Cancer Center Korea
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National Cancer Center Japan
National Cancer Center Korea
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Priority to CA2710807A priority Critical patent/CA2710807C/en
Priority to US12/810,229 priority patent/US9012370B2/en
Priority to AU2009224170A priority patent/AU2009224170B2/en
Priority to JP2010544244A priority patent/JP5683964B2/ja
Priority to EP09718746.2A priority patent/EP2253713B1/en
Priority to CN200980101478.0A priority patent/CN101918597B/zh
Publication of WO2009113779A2 publication Critical patent/WO2009113779A2/ko
Publication of WO2009113779A3 publication Critical patent/WO2009113779A3/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plant Pathology (AREA)

Abstract

본 발명은 (a) 동형접합체 (homozygote) DNA를 검체시료 DNA 와 혼합하는 단계; (b) 상기 혼합한 DNA 를 SNP 어레이(array)로 분석하는 단계; 및 (c) 동형접합체 (homozygote) DNA 및 검체시료 DNA 에서 나온 신호의 차이를 측정하여 염색체, 유전자 또는 특정 뉴클레오티드 서열의 카피 수를 결정하는 단계를 포함하는, 염색체, 유전자 또는 특정 뉴클레오티드 서열의 카피 수 측정 방법에 관한 것이다.
PCT/KR2009/001111 2008-03-11 2009-03-05 Ｓｎｐ 어레이를 이용한 염색체, 유전자, 또는 특정 뉴클레오티드 서열의 카피 수 측정방법 Ceased WO2009113779A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2710807A CA2710807C (en) 2008-03-11 2009-03-05 Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using snp array
US12/810,229 US9012370B2 (en) 2008-03-11 2009-03-05 Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using SNP array
AU2009224170A AU2009224170B2 (en) 2008-03-11 2009-03-05 Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using SNP array
JP2010544244A JP5683964B2 (ja) 2008-03-11 2009-03-05 Ｓｎｐアレイを用いた染色体、遺伝子または特定ヌクレオチド配列のコピー数測定方法
EP09718746.2A EP2253713B1 (en) 2008-03-11 2009-03-05 Method for measuring chromosome, gene or specific nucleotide sequence copy numbers using snp array
CN200980101478.0A CN101918597B (zh) 2008-03-11 2009-03-05 应用snp阵列测量染色体、基因或特定核苷酸序列拷贝数的方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080022500 2008-03-11
KR10-2008-0022500 2008-03-11

Publications (2)

Publication Number Publication Date
WO2009113779A2 WO2009113779A2 (ko) 2009-09-17
WO2009113779A3 true WO2009113779A3 (ko) 2009-12-10

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PCT/KR2009/001111 Ceased WO2009113779A2 (ko) 2008-03-11 2009-03-05 Ｓｎｐ 어레이를 이용한 염색체, 유전자, 또는 특정 뉴클레오티드 서열의 카피 수 측정방법

Country Status (8)

Country Link
US (1) US9012370B2 (ko)
EP (1) EP2253713B1 (ko)
JP (1) JP5683964B2 (ko)
KR (1) KR101030476B1 (ko)
CN (1) CN101918597B (ko)
AU (1) AU2009224170B2 (ko)
CA (1) CA2710807C (ko)
WO (1) WO2009113779A2 (ko)

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EP2253713A2 (en) 2010-11-24
JP2011510626A (ja) 2011-04-07
EP2253713A4 (en) 2012-03-21
CA2710807C (en) 2015-09-08
JP5683964B2 (ja) 2015-03-11
US20110105352A1 (en) 2011-05-05
AU2009224170B2 (en) 2012-03-29
KR101030476B1 (ko) 2011-04-25
AU2009224170A1 (en) 2009-09-17
CA2710807A1 (en) 2009-09-17
WO2009113779A2 (ko) 2009-09-17
EP2253713B1 (en) 2015-02-25
CN101918597B (zh) 2013-09-18
CN101918597A (zh) 2010-12-15
KR20090097792A (ko) 2009-09-16
US9012370B2 (en) 2015-04-21

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