ATE319856T1 - Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips - Google Patents

Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips

Info

Publication number
ATE319856T1
ATE319856T1 AT98930246T AT98930246T ATE319856T1 AT E319856 T1 ATE319856 T1 AT E319856T1 AT 98930246 T AT98930246 T AT 98930246T AT 98930246 T AT98930246 T AT 98930246T AT E319856 T1 ATE319856 T1 AT E319856T1
Authority
AT
Austria
Prior art keywords
gene
polymorphic forms
different
methods
detecting gene
Prior art date
Application number
AT98930246T
Other languages
English (en)
Inventor
Mark Chee
Original Assignee
Affymetrix Inc A Delaware Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc A Delaware Corp filed Critical Affymetrix Inc A Delaware Corp
Application granted granted Critical
Publication of ATE319856T1 publication Critical patent/ATE319856T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT98930246T 1997-06-13 1998-06-11 Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips ATE319856T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4961297P 1997-06-13 1997-06-13

Publications (1)

Publication Number Publication Date
ATE319856T1 true ATE319856T1 (de) 2006-03-15

Family

ID=21960749

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98930246T ATE319856T1 (de) 1997-06-13 1998-06-11 Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips

Country Status (6)

Country Link
US (1) US6368799B1 (de)
EP (1) EP1009857B1 (de)
JP (2) JP3693352B2 (de)
AT (1) ATE319856T1 (de)
DE (1) DE69833758T2 (de)
WO (1) WO1998056954A1 (de)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US6881571B1 (en) * 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6703228B1 (en) * 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1124990B1 (de) * 1998-10-27 2006-01-18 Affymetrix, Inc. Komplexitätsmanagement und analyse genomischer dna
US6670464B1 (en) 1998-11-17 2003-12-30 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US6245511B1 (en) * 1999-02-22 2001-06-12 Vialogy Corp Method and apparatus for exponentially convergent therapy effectiveness monitoring using DNA microarray based viral load measurements
US20040111219A1 (en) * 1999-02-22 2004-06-10 Sandeep Gulati Active interferometric signal analysis in software
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
US7008768B1 (en) 1999-02-26 2006-03-07 The United States Of America As Represented By The Department Of Health And Human Services Method for detecting radiation exposure
EP1196633A2 (de) * 1999-04-23 2002-04-17 Clontech Laboratories Inc. Verfahren und zusammensetzungen zur durchführung von hybridisierungstests, basierend auf arrays
US6638719B1 (en) * 1999-07-14 2003-10-28 Affymetrix, Inc. Genotyping biallelic markers
GB9917027D0 (en) * 1999-07-20 1999-09-22 Affibody Technology Sweeden Ab In vitro selection and optional identification of polypeptides using solid support carriers
US7179638B2 (en) 1999-07-30 2007-02-20 Large Scale Biology Corporation Microarrays and their manufacture by slicing
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
FR2798673B1 (fr) * 1999-09-16 2004-05-28 Exonhit Therapeutics Sa Methodes et compositions pour la detection d'evenements pathologiques
WO2001027327A2 (en) 1999-10-08 2001-04-19 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
US20060259251A1 (en) * 2000-09-08 2006-11-16 Affymetrix, Inc. Computer software products for associating gene expression with genetic variations
JP2002209584A (ja) * 2001-01-16 2002-07-30 Toyobo Co Ltd 塩基多型を検出する方法
AU785425B2 (en) 2001-03-30 2007-05-17 Genetic Technologies Limited Methods of genomic analysis
US7115726B2 (en) 2001-03-30 2006-10-03 Perlegen Sciences, Inc. Haplotype structures of chromosome 21
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
CA2497740C (en) 2001-10-15 2011-06-21 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
DE10158517A1 (de) * 2001-11-29 2003-06-12 Focusgenomics Gmbh Verfahren zur Analyse der translationskontrollierten Genexpression
US7223538B2 (en) 2001-12-14 2007-05-29 Ge Healthcare Bio-Sciences Ab Post-synthesis labeling of nucleic acids, assays using nucleic acids that are labeled post-synthetically, single nucleotide polymorphism detection, and associated compounds and microarrays
WO2003053586A1 (en) * 2001-12-19 2003-07-03 Affymetrix, Inc. Array plates and method for constructing array plates
US7006680B2 (en) * 2002-05-03 2006-02-28 Vialogy Corp. System and method for characterizing microarray output data
US7432342B2 (en) 2002-05-03 2008-10-07 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof and related documents
US20040072217A1 (en) * 2002-06-17 2004-04-15 Affymetrix, Inc. Methods of analysis of linkage disequilibrium
US7097976B2 (en) * 2002-06-17 2006-08-29 Affymetrix, Inc. Methods of analysis of allelic imbalance
US20060105337A1 (en) * 2002-08-30 2006-05-18 Brian Warner Solid phase based nucleic acid assays combining high affinity and high specificity
US7157228B2 (en) * 2002-09-09 2007-01-02 Bioarray Solutions Ltd. Genetic analysis and authentication
WO2004029586A1 (en) * 2002-09-27 2004-04-08 Nimblegen Systems, Inc. Microarray with hydrophobic barriers
JP4471927B2 (ja) 2002-09-30 2010-06-02 ニンブルゲン システムズ インコーポレイテッド アレイの並列装填方法
US20040110212A1 (en) * 2002-09-30 2004-06-10 Mccormick Mark Microarrays with visual alignment marks
CA2500783C (en) * 2002-10-01 2012-07-17 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
AU2003278309A1 (en) * 2002-10-18 2004-05-04 Isis Innovation Ltd Method of detecting polymorphisms affecting transcriptional activity
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
US20040229224A1 (en) * 2003-05-13 2004-11-18 Perlegen Sciences, Inc. Allele-specific expression patterns
EP1633892A4 (de) 2003-06-10 2007-10-24 Univ Boston Nachweismethoden für lungenerkrankungen
WO2005027719A2 (en) 2003-09-12 2005-03-31 Perlegen Sciences, Inc. Methods and systems for identifying predisposition to the placebo effect
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
JP4564959B2 (ja) 2003-09-22 2010-10-20 バイオアレイ ソリューションズ リミテッド 生体分子に共有結合できる、複数の官能基を持つ表面固定化高分子電解質
US20050136452A1 (en) * 2003-10-03 2005-06-23 Affymetrix, Inc. Methods for monitoring expression of polymorphic alleles
US7563569B2 (en) 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
CN1930306A (zh) * 2004-01-15 2007-03-14 美国政府健康及人类服务部 发展用于血栓形成倾向识别的方法(mert)
CA2497324A1 (en) 2004-02-17 2005-08-17 Affymetrix, Inc. Methods for fragmenting and labelling dna
CN1969044A (zh) * 2004-03-19 2007-05-23 东洋纺织株式会社 Dna阵列与单核苷酸多态性的检测方法
EP2290073A3 (de) 2004-05-28 2011-08-31 Asuragen, Inc. Verfahren und Zusammensetzungen mit MicroRNA
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
EP1792263A2 (de) * 2004-09-02 2007-06-06 Vialogy Corporation Erkennung von interessensereignissen unter verwendung von quantenresonanzinterferometrie
US20060073506A1 (en) 2004-09-17 2006-04-06 Affymetrix, Inc. Methods for identifying biological samples
EP1645640B1 (de) 2004-10-05 2013-08-21 Affymetrix, Inc. Verfahren zur Detektion von chromosomalen Translokationen
US20060078889A1 (en) * 2004-10-08 2006-04-13 Arindam Bhattacharjee Array-based methods for producing ribonucleic acids
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
CA2524964A1 (en) 2004-10-29 2006-04-29 Affymetrix, Inc. Automated method of manufacturing polymer arrays
CA2857878A1 (en) 2004-11-12 2006-12-28 Asuragen, Inc. Methods and compositions involving mirna and mirna inhibitor molecules
EP1829979B1 (de) * 2004-12-17 2012-11-14 The University of Tokyo Verfahren zur identifizierung eines gens mit variabler expression
US20060286571A1 (en) 2005-04-28 2006-12-21 Prometheus Laboratories, Inc. Methods of predicting methotrexate efficacy and toxicity
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US7634363B2 (en) * 2005-12-07 2009-12-15 Affymetrix, Inc. Methods for high throughput genotyping
JP5244103B2 (ja) 2006-08-09 2013-07-24 ホームステッド クリニカル コーポレイション 器官特異的蛋白質およびその使用方法
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
JP2010510964A (ja) 2006-09-19 2010-04-08 アシュラジェン インコーポレイテッド 治療的介入の標的としての、ｍｉＲ−１５、ｍｉＲ−２６、ｍｉＲ−３１、ｍｉＲ−１４５、ｍｉＲ−１４７、ｍｉＲ−１８８、ｍｉＲ−２１５、ｍｉＲ−２１６、ｍｉＲ−３３１、ｍｍｕ−ｍｉＲ−２９２−３ｐによって調節される遺伝子および経路
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US8685642B2 (en) * 2007-07-30 2014-04-01 Agilent Technologies, Inc. Allele-specific copy number measurement using single nucleotide polymorphism and DNA arrays
US20090062138A1 (en) * 2007-08-31 2009-03-05 Curry Bo U Array-based method for performing SNP analysis
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
CN101918597B (zh) 2008-03-11 2013-09-18 国立癌中心 应用snp阵列测量染色体、基因或特定核苷酸序列拷贝数的方法
US9074244B2 (en) 2008-03-11 2015-07-07 Affymetrix, Inc. Array-based translocation and rearrangement assays
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US20100056382A1 (en) * 2008-05-30 2010-03-04 Sussman Michael R Dna millichip
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
EP2408905B1 (de) 2009-03-16 2017-05-10 Pangu Biopharma Limited Zusammensetzungen und verfahren mit histidyl-trna-synthetase-spleissvarianten mit nicht-kanonischen biologischen aktivitäten
AU2010236913B2 (en) 2009-03-31 2016-03-24 Atyr Pharma, Inc. Compositions and methods comprising aspartyl-tRNA synthetases having non-canonical biological activities
EP3330385A1 (de) 2009-07-21 2018-06-06 Gen-Probe Incorporated Verfahren und zusammensetzungen für den quantitativen nachweis von nukleinsäuresequenzen in einem erweiterten dynamischen bereich
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
CN102713632B (zh) 2009-12-23 2015-10-07 希尔氏宠物营养品公司 用于诊断和治疗犬肾脏病症的组合物和方法
EP3214174B1 (de) 2010-03-04 2019-10-16 InteRNA Technologies B.V. Mirna-molekül, das über seine quelle definiert ist, und seine diagnostischen und therapeutischen verwendungen bei mit emt assoziierten krankheiten
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ， インコーポレイテッド イソロイシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103097524B (zh) 2010-04-28 2016-08-03 Atyr医药公司 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2011150279A2 (en) 2010-05-27 2011-12-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
CA2797977C (en) 2010-05-03 2019-08-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
WO2011140135A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
WO2011139986A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
CN103200953B (zh) 2010-05-14 2017-02-15 Atyr 医药公司 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
US8530157B2 (en) 2010-07-01 2013-09-10 Agilent Technologies, Inc. SNP-dependent end labeling method
NZ605420A (en) 2010-07-06 2015-02-27 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2817882C (en) 2010-11-17 2022-08-23 Asuragen, Inc. Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
EP2678687B1 (de) 2011-02-24 2015-09-02 Hill's Pet Nutrition, Inc. Zusammensetzungen und verfahren zur diagnostizierung und behandlung von nierenerkrankungen bei katzen
MX2013009863A (es) 2011-02-28 2013-12-06 Univ Iowa Res Found Cambios de la hormona anti-mulleriana en el embarazo y prediccion de sexo y de resultados adversos en el embarazo.
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
CA2839207A1 (en) 2011-06-15 2012-12-20 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
US20130157884A1 (en) 2011-10-26 2013-06-20 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
EP2771487A1 (de) 2011-10-27 2014-09-03 Asuragen, INC. Mirnas als diagnostische biomarker zur unterscheidung gutartiger von bösartigen tumoren in der schilddrüse
RU2612901C2 (ru) 2011-12-19 2017-03-13 Хилл'С Пет Ньютришн, Инк. Композиции и способы диагностики и лечения гипертиреоза у животных-компаньонов
IN2014MN01642A (de) 2012-02-16 2015-07-03 Atyr Pharma Inc
CA2865575C (en) 2012-02-27 2024-01-16 Cellular Research, Inc. Compositions and kits for molecular counting
US11177020B2 (en) 2012-02-27 2021-11-16 The University Of North Carolina At Chapel Hill Methods and uses for molecular tags
US20150152499A1 (en) 2012-07-03 2015-06-04 Interna Technologies B.V. Diagnostic portfolio and its uses
US20140100124A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
MX367366B (es) 2012-11-27 2019-08-16 Univ Pontificia Catolica Chile Composiciones y metodos para diagnosticar tumores de tiroides.
US9758835B2 (en) 2013-03-15 2017-09-12 Baylor Research Institute Ulcerative colitis (UC)-associated colorectal neoplasia markers
US9944992B2 (en) 2013-03-15 2018-04-17 The University Of Chicago Methods and compositions related to T-cell activity
US9868992B2 (en) 2013-03-15 2018-01-16 Baylor Research Institute Tissue and blood-based miRNA biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
RU2706203C1 (ru) 2015-10-18 2019-11-14 Эффиметрикс, Инк. Мультиаллельное генотипирование однонуклеотидных полиморфизмов и индел-мутаций
EP3704250A1 (de) 2017-11-03 2020-09-09 InteRNA Technologies B.V. Mirna-molekül, äquivalent, antagomir oder quelle davon zur behandlung und/oder diagnose eines zustands und/oder einer erkrankung im zusammenhang mit neuronaler defizienz oder neuronaler (re)generation
EP3714053B1 (de) 2017-11-22 2025-12-31 The University of Chicago Von chemischer sonde abhängige bewertung der proteinaktivität und verwendung davon
US20190366292A1 (en) 2018-05-29 2019-12-05 Centrillion Technologies, Inc. Increasing Efficiency Of Photochemical Reactions On Substrates
US20220205035A1 (en) 2019-04-05 2022-06-30 Board Of Regents, The University Of Texas System Methods and applications for cell barcoding
WO2020210521A2 (en) 2019-04-12 2020-10-15 The Regents Of The University Of California Compositions and methods for increasing muscle mass and oxidative metabolism
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders
WO2025248505A1 (en) 2024-05-31 2025-12-04 Wayne State University Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567809A (en) * 1986-03-13 1996-10-22 Hoffmann-La Roche Inc. Methods and reagents for HLA DRbeta DNA typing
WO1992007095A1 (en) * 1990-10-15 1992-04-30 Stratagene Arbitrarily primed polymerase chain reaction method for fingerprinting genomes
US5503980A (en) * 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5858659A (en) * 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5610287A (en) * 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5709998A (en) * 1993-12-15 1998-01-20 The Johns Hopkins University Molecular diagnosis of familial adenomatous polyposis
US6048689A (en) * 1997-03-28 2000-04-11 Gene Logic, Inc. Method for identifying variations in polynucleotide sequences

Also Published As

Publication number Publication date
JP2004166716A (ja) 2004-06-17
US6368799B1 (en) 2002-04-09
EP1009857A1 (de) 2000-06-21
DE69833758T2 (de) 2006-08-31
JP3693352B2 (ja) 2005-09-07
EP1009857A4 (de) 2004-04-14
EP1009857B1 (de) 2006-03-08
HK1028983A1 (en) 2001-03-16
JP2002514091A (ja) 2002-05-14
DE69833758D1 (de) 2006-05-04
WO1998056954A1 (en) 1998-12-17

Similar Documents

Publication Publication Date Title
DE69833758D1 (de) Verfahren zur erkennung von genpolymorphismen und allelexpression unter verwendung von sondenchips
US7303880B2 (en) Microdissection-based methods for determining genomic features of single chromosomes
Liljedahl et al. Detecting imbalanced expression of SNP alleles by minisequencing on microarrays
ATE328115T1 (de) Multiplex genotypisierung unter verwendung von fluoreszenzmarkierten hybridisierungssonden
WO2002099126A1 (en) Method for detecting single nucleotide polymorphisms (snp's) and point mutations
EP0785280A3 (de) Nachweis von Polymorphismus
AU2008229669A1 (en) Methods and compositions for determining methylation profiles
Tost et al. DNA analysis by mass spectrometry—past, present and future
Hayashi Recent enhancements in SSCP
Genissel et al. No evidence for an association between common nonsynonymous polymorphisms in Delta and bristle number variation in natural and laboratory populations of Drosophila melanogaster
DE60121219D1 (de) Verfahren zum Nachweis von Homo- oder Heterozygotie eines Organismus unter Verwendung markerter Primer und RFLP
Wang et al. Rapid identification of heterozygous mutations in Drosophila melanogaster using genomic capture sequencing
KR101735075B1 (ko) Dmr를 이용한 돼지의 산자수 예측용 조성물 및 예측방법
JP2009516516A (ja) ヌクレオチド配列を同定するための方法及びプローブ
CN117089634B (zh) 分析山羊奶用性能的分子标记组合及应用
US6762018B1 (en) Analysis of nucleotide polymorphisms at a site
KR101683086B1 (ko) 유전자의 발현량 및 메틸화 프로필을 활용한 돼지의 산자수 예측방법
Ye et al. Rapid identification of single nucleotide polymorphisms and estimation of allele frequencies using sequence traces from DNA pools
ATE315103T1 (de) Verfahren zur typisierung des ha-1 nebenhistokompatibilitätsantigens
US7794982B2 (en) Method for identifying gene with varying expression levels
Shen et al. Experimental tools for the identification of specific genes in autism spectrum disorders and intellectual disability
US20070231803A1 (en) Multiplex pcr mixtures and kits containing the same
KR20210066620A (ko) 우리흑돈의 전신 흑모색 식별용 snp 마커 및 이를 이용한 전신 흑모색 식별 방법
US20080044916A1 (en) Computational selection of probes for localizing chromosome breakpoints
Simsek et al. A PCR-RFLP test for simultaneous detection of two single-nucleotide insertions in the Connexin-26 gene promoter

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties