WO2009113962A2 - Composition et procédé de production d’une composition - Google Patents

Composition et procédé de production d’une composition Download PDF

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Publication number
WO2009113962A2
WO2009113962A2 PCT/SG2008/000078 SG2008000078W WO2009113962A2 WO 2009113962 A2 WO2009113962 A2 WO 2009113962A2 SG 2008000078 W SG2008000078 W SG 2008000078W WO 2009113962 A2 WO2009113962 A2 WO 2009113962A2
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WO
WIPO (PCT)
Prior art keywords
composition
body mass
mass index
excess body
brassica
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/SG2008/000078
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English (en)
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WO2009113962A3 (fr
Inventor
Yek Cheng Ong
Chiang Ming Tan
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EMBRYO Pte Ltd
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EMBRYO Pte Ltd
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Priority to PCT/SG2008/000078 priority Critical patent/WO2009113962A2/fr
Priority to TW097126751A priority patent/TW200938099A/zh
Publication of WO2009113962A2 publication Critical patent/WO2009113962A2/fr
Publication of WO2009113962A3 publication Critical patent/WO2009113962A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/22—Comminuted fibrous parts of plants, e.g. bagasse or pulp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates generally to a composition and a method for producing a composition.
  • the present invention relates to a composition comprising an isolated ground fibrous preparation of an extract of Brassica, Apium and/or lpomoea genera and a method of producing that composition.
  • the composition is useful in the preparation of a food product and/or in the preparation of a medicinal product.
  • the pandemic of obesity poses a global health and medical threat to the latter day populace.
  • Pharmacological efforts to induce body weight loss include reducing lipid absorption by the human gastrointestinal (Gl) tract through pancreatic lipase inhibitory compounds such as orlistat and catechins, at the enzyme level (Dunican, 2007; Koo, 2007).
  • the underlying basis for observed weight reduction is the shifting of the body's energy flux into a deficit state, by reducing the energy inflow (measured as calorie units, in energy macromolecules such as fats, proteins and carbohydrates) versus the body's energy outflow
  • Energy inflow and/or outflow can also be simultaneously reduced through less food intake and/or calorie burning by the use of pharmacological agents such as sibutramine, rimonabant and medium chain triglycerides (MCT) (Bray, 2007; Krotkiewski, 2001).
  • pharmacological agents such as sibutramine, rimonabant and medium chain triglycerides (MCT) (Bray, 2007; Krotkiewski, 2001).
  • Lignins, hemicellulose and cellulose are major water-insoluble fiber constituents.
  • Lignins form part of the xylem.
  • Xylem and phloem are vascular bundles of higher plants that conduct water, soil and photosynthetic nutrients. Lignins are covalently linked to hemicellulose and thereby crosslinks different plant polysaccharides, conferring mechanical strength to the cell wall.
  • lignins, cellulose and hemicellulose are termed as water-insoluble plant fibers. These water-insoluble plant fibers confer mechanical strength to vascular plants; the former trio group together with resins and are commonly termed as wood, in trees and other woody plants.
  • wood is indigestible by mammalian and human gastrointestinal digestive enzymes. However, wood is mostly unpalatable to humans.
  • non-fiber components of wood sourced from different families of angiosperms, can be acutely or chronically toxic to the human body.
  • lignins found in water-insoluble fibrous tissues have been reported to confer therapeutic benefits, when liberated by the microbial flora residing in the human and mammalian gastrointestinal tract, notably in the colon.
  • lignins are precursors of mammalian lignans in vivo, and contribute to the prevention of breast cancer and cardiovascular disorders (Begum et al, 2004).
  • Suberin is a plant polymer containing aromatics and polyesters, forming part of the plant periderms.
  • Periderms are the outer tissue layers of woody roots and stems.
  • Cutin is a polymer formed from hydoxy and epoxy fatty acids that forms the surface hydrophobic barrier of leaf cuticles (Li et al, 2007).
  • Brassica genus belongs to the mustard family (Brassicaceae) and is native in the wild in western Europe, the Mediterranean and temperate regions of
  • BG is commonly known as cruciferous vegetables, eaten by humans for dietary or culinary reasons. For instance - broccoli, brussel sprouts, cabbage, cauliflower, chye sim, kale and mustard.
  • Cruciferous vegetables, such as broccoli, cabbage and kale are also rich sources of sulfur-containing compounds called glucosinolates.
  • lsothiocyanates are biologically active hydrolysis (breakdown) products of glucosinolates, with anti-neoplastic (anti-cancer) activities.
  • Cooked cabbages can still deliver isothiocyanates, albeit to a lesser degree than raw cabbages, lsothiocyanate release from raw BG vegetables is catalysed by the plant's native myrosinase, from the glucosinolate sinigrin, in the upper intestinal tract, while isothiocyanate release from cooked BG vegetables, occurs in the lower intestinal tract through hydrolysis by colonic microflora (Rouauzd, 2004).
  • the present invention is broadly directed to providing a composition that comprises an isolated ground fibrous preparation of an extract of Brassica,
  • the composition may have a low calorie content and/or chemopreventative effect.
  • the invention resides in a composition comprising an isolated ground fibrous preparation of an extract of Brassica, Apium and/or lpomoea genera.
  • the invention resides in a food product comprising an isolated ground fibrous preparation of an extract of Brassica, Apium and/or lpomoea genera.
  • the food product may comprise half or less than half an energy yield of a conventional edible chip.
  • the food product may comprise half or less than half an energy yield of a conventional edible cookie.
  • the invention resides in a method of producing a composition including the steps of: soaking isolated Brassica, Apium and/or lpomoea genera plant material; separating a solid phase from the soaked plant material; and grinding the separated solid phase to thereby produce the composition.
  • the method of the third aspect may further include the step of washing the isolated Brassica, Apium and/or lpomoea genera plant material.
  • the method of the third aspect may further include the step of adding one or more food additive to the ground separated solid phase.
  • the method of the third aspect may further include the step of heating the ground separated solid phase.
  • the method of the third aspect may further include the step of purifying the ground separated solid phase.
  • the invention resides in a food product produced according to the third aspect.
  • the invention resides in a composition comprising an extract of Brassica, Apium and/or lpomoea genera prepared by water purification thereof and grinding in a wet state, recovered as solid phase for the formation of a low and/or non-energy yielding food.
  • the composition of the first and fifth aspects may be heated and or cooked.
  • composition of the first and fifth aspects may further comprise one or more food additive.
  • the one or more food additive may be a water-soluble fiber.
  • the water-soluble fiber may be acacia gum and or konjac gum.
  • the one or more food additive may be erythritol.
  • the one or more food additive may be erythritol, curry spice and salt.
  • the one or more food additive may be acacia gum, konjac gum, erythritol, an intense sweetener, cocoa powder and vanillin.
  • the extract of the first and fifth aspects may be of a Brassica genus.
  • composition of the first and fifth aspects may further comprise a carrier, diluent and/or excipient.
  • composition of the first and fifth aspect may comprise at least one insoluble fibrous compound.
  • composition of the first and fifth aspect may comprise at least one cellulosic structure.
  • composition of the first and fifth aspect may comprise at least one lignin structure.
  • composition of the first and fifth aspect may comprise at least one suberin structure.
  • composition of the first and fifth aspect may comprise at least one cutin structure.
  • the composition of the first and fifth aspect may comprise at least one cellulosic structure and at least one soluble fiber.
  • composition of the first and fifth aspect may comprise at least one food-grade additive.
  • the invention resides in a method of modulating an excess body mass index condition in a subject, said method comprising administering to said subject the composition of the first and/or fifth aspect to thereby modulate the excess body mass index.
  • the invention resides in a method of modulating a cancer risk in a subject, said method comprising administering to said subject the composition of the first and/or fifth aspect to thereby lower the cancer risk in the subject.
  • the administration may be ad libitum.
  • the composition may be administered to a human.
  • the excess body mass index may be due to hyperphagia.
  • the excess body mass index may be due to hypercalorification.
  • the excess body mass index may be due to behavior.
  • the excess body mass index may be due to behavioriet.
  • the excess body mass index may be due to diet.
  • the invention resides in an article of manufacture or kit comprising the composition according to claim 1 and written material that may provide instructions and/or urge the use of the composition to modulate, a body mass index condition, a body weight-related condition or chemoprevention mediated by the behavior, behavioriet and/or diet.
  • the invention resides in a method of purifying edible, water-insoluble fibrous isolates from Brassica, Apium and/or lpomoea genera plants.
  • the steps may comprise purging water-soluble sugars and starches from the tissues of the Brassica, Apium and/or lpomoea genera plants with a heated aqueous system, separating the liquid from the solid phase, recovering the solid phase in a hydrated state, wet-grinding the solid phase, applying vented dry heat to this solid phase and exposing the solid phase to heat such as, microwave energy, to obtain the dried fibrous isolate.
  • tissues of the Brassica, Apium and/or lpomoea genera plants all tissues can be used; the aerial parts are preferred, and leaves and stems are most preferred.
  • the invention resides in a composition comprising of low and/or non-energy yielding, water-insoluble hydrated solid phase forming a matrix with the water-soluble gum fibers, in the presence of added water, applying vented dry heat to this heterogenous matrix, to obtain a porous composite fibrous mass.
  • the invention resides in an article of manufacture that comprises a composite material of the invention, that has low and/or non- energy yielding, water-insoluble hydrated solid phase in a matrix of water-soluble gum fibers and trapped water, together with flavouring agents, condiments and low and/or non-energy yielding sweeteners (especially with a polyol or glycoside compound).
  • the invention resides in use of Brassica, Apium and/or lpomoea genus plant material, or a botanical or horticultural equivalent thereof, which is capable of providing an edible, water-insoluble, fibrous isolate, after subjection of the aerial plant tissues to the method described herein.
  • the invention resides in a purified, biosynthetic or chemical synthetic molecule form of Brassica, Apium and/or lpomoea genera plant material, or a botanical or horticultural equivalent thereof, or an extract thereof which molecule is capable of forming a composite material with water- soluble gum fibers of microbial, botanical, biosynthetic or wholly synthetic origins.
  • the invention resides in use of Brassica, Apium and/or lpomoea genera plant material or botanical or horticultural equivalent thereof or an isolate thereof or an extract thereof or a chemical or functional equivalent of the purified water-insoluble fibrous isolate or biosynthetic form or chemical synthetic form of one or more components of the water-insoluble fibrous isolate in the manufacture of a therapeutic or medicament for the treatment of an overweight or obese condition.
  • the genus may be a Brassica genus.
  • the Brassica genus may be Brassica oleracea.
  • Suitable Brassica genus include a cruciferous vegetable such as a broccoli, a brussel sprout, a cabbage, a cauliflower, a chye sim, a kale, a mustard and/or any combination thereof.
  • FIG. 1 is a flowchart illustrating one embodiment of the method of the invention.
  • FIG. 2 is a flowchart illustrating a second embodiment of the method of the invention.
  • FIG. 3 is a flowchart illustrating a third embodiment of the method of the invention.
  • FIG. 4 is a flowchart illustrating a fourth embodiment of the method of the invention.
  • FIGS. 5A and 5B are illustrations showing the effects of the processing method: (A) Purification and isolation of homogenous BG fibrous isolate
  • FIG. 6 shows the formation of behaviorietary chips with vented dry- heating. The final characteristics of the BG fibrous isolate alone, after undergoing the treatment processes and final baking formulation.
  • FIGS. 7A and 7B are illustrations showing the effects of the combination between the BG fibrous isolate and water-soluble fibers acacia gum and konjac gum:
  • A The composition at 4OX magnification.
  • B Macroscopic view of the composition.
  • FIG. 8 shows the formation of behaviorietary cookies with vented dry- heating. The final characteristics of the BG fibrous isolate in combination with soluble fibers and final baking formulation.
  • the inventors have discovered a novel isolated ground fibrous preparation of an extract of Brassica, Apium and/or lpomoea genus that has a low energy yield.
  • the composition can be combined with a common vegetable gum to form an edible food product such as, a chip, a cookie and a biscuit.
  • the inventors have provided a novel and inventive product and method which may overcome or reduce the economic and health costs of obesity and related disease and disorders. Additionally the inventors have provided a novel and inventive product which may have a chemopreventive effect.
  • the food product of the invention may have a texture and consistency the same as or similar to conventional food products such as, a chip a cookie and a biscuit.
  • conventional food products such as, a chip a cookie and a biscuit.
  • a composition "consisting essentially of recited ingredients will produce edible behaviorietary foods with textures and consistencies that are palatable to humans and yet, yields no or a low physiological sources of food energy, vitamins and minerals in the gastrointestinal tract (GIT), compared to the foods obtained using baking flours or bulking food agents or wood or cellulose alone as the base compound.
  • GIT gastrointestinal tract
  • a 1g cooked food using baking flours and the like, or wood will have four (4) Calories, or approximately zero (0) Calories respectively.
  • Insoluble fibers are also potential sources of lifelong anti-cancer chemopreventive foods, but eating a lot of vegetables daily, for an entire lifetime may not be palatable for many people.
  • behaviorietary food with extremely low biological- usable energy, vitamins and minerals, but with palatable consistency and texture is obtained, when the composition of the invention and suitable flavourings or condiments, are applied together to produce the final cooked behaviorietary food.
  • the water-insoluble fibrous isolates also provide a daily, lifelong, source of anti-cancer lignins and other chemopreventive compounds.
  • the present invention is predicated in part on the production of a purified fibrous isolate with food product-like properties such as, cookie-like and chips-like behaviorietary properties, in a formulation comprising parts of a plant and water-soluble gums or equivalents thereof.
  • Suitable plants include Brassica, Apium and/or lpomoea genera. In one embodiment the plant or plants are one or more member of the Brassica genus.
  • Any plant material and/or tissue may be used.
  • the aerial parts are preferred, and leaves and stems are most preferred.
  • Aerial parts as used herein means those parts of a plant that are above the ground and/or exposed to air during normal plant growth and normal plant life. Aerial parts include the stem and leaves.
  • raW means isolated and not treated or processed in any way.
  • purify, refined, treated and separated are relative terms and any step that increases purity by any amount is considered a purification, refinement, treatment and/or separation.
  • the plant material may be washed for example, to remove soil and/or other surface contaminant.
  • the washed plant material may then be soaked in a solvent.
  • Suitable solvents include water and other aqueous solvents. The soaking is performed to extract unwanted compounds from the aerial parts into the solvent.
  • a soaking method is one of the several methods of extracting and removing unwanted compounds, such as sugars and starches, from the plant material.
  • the intact aerial part of the plant is soaked with an aqueous system and left for a period of time to allow the active compounds to dissolve into the aqueous system.
  • the mixture can be mechanically agitated and/or heated to a pre-determined temperature.
  • the mechanical agitation methods include but are not limited to the following: shaking, vortexing, swirling, stirring and ultrasonicating.
  • one (1 ) kg of plant material is soaked in five (5) litres of 100% water at 100 0 C for 30 minutes.
  • a person of skill in the art is readily able to select an appropriate plant material : solvent ratio as well as appropriate temperature and time period for soaking.
  • the aqueous system can comprise any of the well-known systems such as potable water or a combination of potable water and organic solvents.
  • the organic solvent is alcohol and more preferably, ethanol.
  • Other organic solvents such as hexane, dichloromethane, ethyl acetate will also be effective.
  • the percentage of water can range from 100% to 50%. The percentage of water may be 100%, 95%, 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55% or 50%. If the organic solvent is not part of the initial aqueous system, it can be added to the liquid phase during the soaking period, at least 1 hour before heat is applied to the aqueous system.
  • Organic solvent can be added up to 300% by volume. A person of skill in the art is readily able to select other suitable solvents.
  • the liquid may then be separated from the solid by any one of the well-known techniques such as filtration and centrifugation. Any suitable separation process may used. A person of skill in the art is readily able to select a suitable mechanical, chemical and/or physical separation process.
  • the separation is mechanical separation such as, sieving.
  • the sieving may be conducted with a fine wire mesh.
  • the solid phase may then be ground into a slurry.
  • the grinding is a wet-grinding.
  • the grinding may be performed with a grinding machine.
  • the grinding machine is a wet-grinding machine.
  • Grinding means to reduce to fine particles, and may be performed by pounding or crushing to reduce to fine particles.
  • the grinding preferably produces a homogenous, purified, fibrous isolate that may be manipulated into a food product, such as a chip and/or a biscuit.
  • An optional additional stage may be introduced to further purify the ground fibrous isolate of unwanted compounds.
  • the fibrous isolate may be percolated with a continuously refluxed solvent system such as the soxhlet-type method for extraction.
  • the highly purified solid isolate may then be separated from the liquid containing the unwanted compounds, by using any one of the well known separation methods such as filtration and/or centrifugation.
  • the food product may be a behaviorietary food.
  • "Behavio ⁇ etary food' as used herein includes an edible solid, a potable liquid and/or other edibles and potables in varying degree of physical state, which is taken for recreational and lifestyle purposes.
  • the behaviorietary food has a low biologically- usable food energy, negligible vitamin and/or mineral content to the human user (Ong, 2007).
  • the "physical state” referred to herein includes but is not limited to, solid, semi-solid, semi-liquid, viscous liquid, gel solid and forms thereof.
  • Behavioriet is behaviorietary foods and/or the consumption, taking and/or use of "behaviorietary food'.
  • a food product according to the invention may comprise half or less than half an energy yield of a convention food product of comparable weight.
  • the food product of the invention may comprise 50%, 45%, 40%, 35%, 30%, 25%, 20%,
  • the food may have a chemopreventive property.
  • the chemopreventive property may include an anti-cancer effect, but is not limited thereto.
  • the food may include one or more water-soluble fiber. Suitable water- soluble fibers include acacia gum and konjac gum.
  • the food may also include one or more food additive.
  • the food additive may be a flavouring and/or a sweetener.
  • Suitable food additives include a sugar, a sugar substitute, a flavouring and or a colouring.
  • Suitable sugar substitutes include natural and artificial sugar substitutes including both natural and artificial intense sweeteners.
  • the sugar substitute is a zero or low calorie sugar substitute.
  • Suitable natural sugar substitutes include erythritol.
  • Suitable flavourings include curry spice, salt, cocoa powder and vanillin.
  • FIG. 1 illustrates one embodiment of a method 100 of the invention.
  • plant material is soaked.
  • step 30 the soaked plant material is separated.
  • step 40 the separated solid phase is ground.
  • FIG. 2 illustrates method 200 which includes optional step 10 washing the plant material.
  • FIG. 3 illustrates method 300 which includes optional step 50 adding one or more food additive.
  • FIG. 4 illustrates method 400 which includes optional step 60 heating.
  • the heating may be dry heating, microwave radiation or any suitable heating. A person of skill in the art is readily able to select a suitable heating method. The heating may result in cooking.
  • the invention is directed to a composition
  • a composition comprising one or more edible non-starch polysaccharide agent useful for bulking the aforesaid processed food product, without the concomitant liberation of energy-yielding, glycemic polysaccharides, disaccharides and monosaccharides in the stomach and small intestine of humans through physiological enzymatic digestion by eukaryotic (human) gastric and intestinal amylases and the like, but act as a source of lignins, cutins and anti-cancer chemopreventive phytocompounds.
  • composition of the present invention preferably comprises water-insoluble fibrous isolates of botanicals or vegetative or horticultural equivalents of the botanicals or chemical or functional equivalents of one or more components of the botanical isolates; in combination with water-soluble, gum fibres of botanical or microbial origins, or vegetative or horticultural equivalents of the botanicals or chemical or functional equivalents of one or more components of the botanicals or microbials.
  • one aspect of the present invention is a method of purifiying fibrous isolates from a Brassica, Apium and/or lpomoea genera plant. Fresh
  • Brassica, Apium and/or lpomoea genera plant parts are rinsed with water and the purging process (Stage 1 ) initiated.
  • Purified fibrous isolate can be obtained from different parts of the plants, the preferred part of the plant for isolation is the aerial part, comprising of leaves and stems tissue.
  • Another aspect of the present invention contemplates a method of modulating hyperphagia and hypercalorification in a subject with weight-related condition, said method comprising administering to said subject an effective amount of a formulation comprising a purified fibrous Brassica, Apium and/or lpomoea genera plant isolate or botanical or horticultural equivalents of these plants or chemical or microbial or functional equivalents of the fibrous isolate or a purified or chemical synthetic form of one or more components of the fibrous isolate.
  • a "weight-related condition” includes excess body mass index, normal body mass index with excess body fat, type 2 diabetes mellitus, dyslipidaemia, hypertension, metabolic syndrome and/or other pathophysiological condition associated with obesity.
  • Anti-hyperphagia agents are useful in behavior modification therapy in orexigenic conditions such as but not limited to obsessive- compulsive eating, snacking, over-sized meal consumption.
  • Anti- hypercalorification agents are useful in abnormal body weight states such as but not limited to obesity and adiposity.
  • Yet another aspect of the present invention is directed to the use of a Brassica, Apium and/or lpomoea genera plant or a botanical or horticultural equivalent thereof or a purified isolate thereof or a chemical or a microbial or functional equivalent of the purified fibrous isolate or an extract or chemical synthetic form of one or more components of the purified fibrous isolate in the manufacture of a medicament for the treatment of weight-related conditions.
  • Still yet another aspect of the present invention provides a method for anticancer therapy in a subject, said method comprising administering to said subject an effective amount of a purified fibrous isolate of Brassica, Apium and/or lpomoea genera or botanical or horticultural equivalents of Brassica, Apium and/or lpomoea genera under conditions to produce anti-cancer activity.
  • the administration may be for an extended period of weeks, months or years or for a life-time.
  • compositions or pharmaceutical compositions for treatment or prophylaxis of obesity comprising an effective amount of the composition of the invention.
  • Dosage forms include tablets, dispersions, suspensions, injections, solutions, syrups, troches, capsules, suppositories, aerosols, transdermal patches and the like. These dosage forms may also include injecting or implanting devices designed specifically for, or modified to, control release of the pharmaceutical composition. Controlled release of the therapeutic agent may be affected by coating, for example, with hydrophobic polymers including acrylic resins, waxes, higher aliphatic alcohols, polyactic and polyglycolic acids and certain cellulose derivates such as hydroxypropylmethyl cellulose. In addition, the controlled release may be effected or affected by using other polymer matrices, liposomes and/or microspheres. Pharmaceutically acceptable carriers for systemic administration may also be incorporated into the compositions of this invention.
  • the composition or pharmaceutical composition comprises an excipient or pharmaceutically-acceptable excipient.
  • excipient or “pharmaceutically-acceptable excipient” is meant a solid or liquid filler, diluent or encapsulating substance that may be safely used in systemic administration.
  • a variety of carriers well known in the art may be used.
  • These carriers or excipients may be selected from a group including sugars, starches, cellulose and its derivates, malt, gelatine, talc, calcium sulphate, vegetable oils, synthetic oils, polyols, alginic acid, phosphate buffered solutions, emulsifiers, isotonic saline, and pyrogen-free water.
  • any suitable route of administration may be employed for providing a patient with the composition or pharmaceutical composition of the invention.
  • oral, rectal, parenteral, sublingual, buccal, intravenous, intraarticular, intra-muscular, intra-dermal, subcutaneous, inhalational, intraocular, intraperitoneal, intracerebroventricular, transdermal and the like may be employed.
  • compositions of the present invention suitable for administration may be presented in discrete units such as vials, capsules, sachets or tablets each containing a predetermined amount of one or more behaviorietary or pharmaceutically active compounds of the invention, as a powder or granules or as a solution or a suspension in an aqueous liquid, a non- aqueous liquid, an oil-in-water emulsion or a water-in-oil emulsion.
  • Such compositions may be prepared by any of the method of pharmacy but all methods include the step of bringing into association one or more behaviorietary and/or pharmaceutically active compounds of the invention with the carrier which constitutes one or more necessary ingredients.
  • the compositions are prepared by uniformly and intimately admixing the agents of the invention with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product into the desired presentation.
  • FIG. 5A shows the microscopic changes of the three treatment stages:
  • FIG. 5Ai-raw BG aerial parts FIG. 5Aii-purged, recovered BG aerial parts after Stage 1
  • FIG. 5B shows the macroscopic changes of the three treatment stages:
  • FIG. 5Bii-purged, recovered BG aerial parts after Stage 1 FIG. 5Biii-purified, wet-grinded BG fibrous isolate after Stage 2
  • a composition of the invention is preferably one with water-insoluble fibrous BG isolate with water- soluble fibers of acacia and konjac gums.
  • a composition of the invention preferably one with water-insoluble fibrous BG isolate with water- soluble fibers of acacia and konjac gums.
  • 2.2g of the acacia gum with 1.4g of the konjac gum, together with suitable quantity of flavourings and sweeteners, are added to 7.5g of the fibrous BG isolate (FIG. 6).
  • FIG. 6 shows the microscropic, macroscopic and gross physical characteristics of behaviorietary chips formed through subjecting the purified fibrous BG isolate, with spices and other suitable additives, to 9O 0 C dry heat for 300 mins.
  • Table 1a shows one such exemplary formulation involving curry powder, erythritol and salt. More strikingly, the purified fibrous BG isolate, in combination with acacia and konjac gums, produced porous dried bulk, with the consistency and friability of cookies (FIG. 8). Additives such as flavourings, salt and zero calorie sweeteners were added to enhance taste. Table 1b shows an example of such flavoured cookie formulations.
  • Behaviorietary chips thus formed were subjected to energy yield calculations, to determine their caloric content, post-formation. As shown in Table 2a, behaviorietary chips thus formed has approximately 10 times fewer calories than typical chips made from potato or corn.
  • behaviorietary cookies produced from a composition of purified BG fibrous isolate and water-soluble fibers maintained the drastic reduction in calorie count relative to ordinary cookies, with a 10:1 ratio (Table 2b).
  • Heinonen SM Heinonen SM, Adlercreutz H, Remesy C, Scalbert A. Dietary lignins are precursors of mammalian lignans in rats. J Nutr. 2004 Jan;134(1 ): 120-7.
  • Harris PJ Ferguson LR. Dietary fibre: its composition and role in protection against colorectal cancer. Mutat Res. 1993 Nov;290(1 ):97-110.

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Abstract

La présente invention concerne, d’une manière générale, une composition comprenant une préparation fibreuse broyée isolée d’un extrait de Brassica, d’Apium et/ou d’Ipomoea genera. L’invention concerne également un procédé de production d’une composition qui inclut les étapes suivantes : trempage de matériel végétal isolé de Brassica, d’Apium et/ou d’Ipomoea genera ; séparation d’une phase solide à partir du matériel végétal trempé ; et broyage de la phase solide séparée en vue de produire ainsi la composition.
PCT/SG2008/000078 2008-03-12 2008-03-12 Composition et procédé de production d’une composition Ceased WO2009113962A2 (fr)

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TW097126751A TW200938099A (en) 2008-03-12 2008-07-15 Composition and method for producing composition

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JPS6140764A (ja) * 1984-07-31 1986-02-27 Tatsuo Emura 変異原吸着性のあるアスパラ繊維を主体とした野菜繊維食品
US7182968B2 (en) * 2001-01-11 2007-02-27 Fran Gare Composition containing xylitol and fiber
KR20030005086A (ko) * 2002-11-08 2003-01-15 주식회사 이롬라이프 생식 및 식이섬유를 함유하는 다이어트 조성물
KR101106509B1 (ko) * 2003-03-10 2012-01-20 다니스코 유에스 인크. 선생물적 이소말토-올리고사카라이드를 함유하는 곡물조성물 및 이의 제조 및 이용 방법

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