WO2010077795A3 - Compositions and methods for improved oral health - Google Patents

Compositions and methods for improved oral health Download PDF

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Publication number
WO2010077795A3
WO2010077795A3 PCT/US2009/067809 US2009067809W WO2010077795A3 WO 2010077795 A3 WO2010077795 A3 WO 2010077795A3 US 2009067809 W US2009067809 W US 2009067809W WO 2010077795 A3 WO2010077795 A3 WO 2010077795A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
oral health
health
pneumonia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/067809
Other languages
French (fr)
Other versions
WO2010077795A2 (en
Inventor
Zamzam Kabiry Roughead
Kala Marie Kaspar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nestec SA
Original Assignee
Nestec SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to RU2011129693/15A priority Critical patent/RU2011129693A/en
Priority to CN2009801503950A priority patent/CN102245191A/en
Priority to US13/139,787 priority patent/US20120039860A1/en
Priority to SG2011040367A priority patent/SG171930A1/en
Priority to EP09793395A priority patent/EP2379091A2/en
Priority to AU2009333388A priority patent/AU2009333388A1/en
Priority to MX2011006488A priority patent/MX2011006488A/en
Priority to CA2747231A priority patent/CA2747231A1/en
Application filed by Nestec SA filed Critical Nestec SA
Priority to BRPI0922924A priority patent/BRPI0922924A2/en
Priority to JP2011540944A priority patent/JP2012512171A/en
Publication of WO2010077795A2 publication Critical patent/WO2010077795A2/en
Publication of WO2010077795A3 publication Critical patent/WO2010077795A3/en
Anticipated expiration legal-status Critical
Priority to ZA2011/05261A priority patent/ZA201105261B/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G3/366—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compositions and methods for preventing and treating illnesses associated with oral health are provided. In a general embodiment, the compositions and methods of the present disclosure can improve oral health by reducing the incidence of aspiration pneumonia, community-acquired pneumonia and nosocomial pneumonia, allowing for less gingivitis and plaque, and providing improved tongue flora. By utilizing probiotics naturally present in the oral cavity or gastrointestinal tract, the compositions and methods in embodiments of the present disclosure can reduce anaerobic gram-negative bacilli and increase the presence of the normal flora. By preventing and treating problems associated with oral health in a patient, subsequent health problems can be prevented or mitigated, which can result in reduced health care costs for the patient in the future.
PCT/US2009/067809 2008-04-10 2009-12-14 Compositions and methods for improved oral health Ceased WO2010077795A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
MX2011006488A MX2011006488A (en) 2008-12-16 2009-12-14 Compositions and methods for improved oral health.
US13/139,787 US20120039860A1 (en) 2008-04-10 2009-12-14 Compositions and methods for improved oral health
SG2011040367A SG171930A1 (en) 2008-12-16 2009-12-14 Compositions and methods for improved oral health
EP09793395A EP2379091A2 (en) 2008-12-16 2009-12-14 Compositions and methods for improved oral health
AU2009333388A AU2009333388A1 (en) 2008-12-16 2009-12-14 Compositions and methods for improved oral health
CA2747231A CA2747231A1 (en) 2008-12-16 2009-12-14 Compositions and methods for improved oral health
BRPI0922924A BRPI0922924A2 (en) 2008-12-16 2009-12-14 oral health improvement compositions, method of using a composition and use of at least one beneficial bacterium for the preparation of an oral health improvement composition
RU2011129693/15A RU2011129693A (en) 2008-12-16 2009-12-14 COMPOSITIONS AND METHODS FOR IMPROVING HEALTH OF THE ORAL CAVITY
CN2009801503950A CN102245191A (en) 2008-12-16 2009-12-14 Compositions and methods for improved oral health
JP2011540944A JP2012512171A (en) 2008-12-16 2009-12-14 Compositions and methods for improved oral health
ZA2011/05261A ZA201105261B (en) 2008-12-16 2011-07-15 Compositions and methods for improved oral health

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12290308P 2008-12-16 2008-12-16
US61/122,903 2008-12-16
US24082909P 2009-09-09 2009-09-09
US61/240,829 2009-09-09

Publications (2)

Publication Number Publication Date
WO2010077795A2 WO2010077795A2 (en) 2010-07-08
WO2010077795A3 true WO2010077795A3 (en) 2010-12-09

Family

ID=42236618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/067809 Ceased WO2010077795A2 (en) 2008-04-10 2009-12-14 Compositions and methods for improved oral health

Country Status (11)

Country Link
EP (1) EP2379091A2 (en)
JP (1) JP2012512171A (en)
CN (1) CN102245191A (en)
AU (1) AU2009333388A1 (en)
BR (1) BRPI0922924A2 (en)
CA (1) CA2747231A1 (en)
MX (1) MX2011006488A (en)
RU (1) RU2011129693A (en)
SG (1) SG171930A1 (en)
WO (1) WO2010077795A2 (en)
ZA (1) ZA201105261B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2420580A1 (en) * 2010-08-18 2012-02-22 AB-Biotics, S.A. Probiotic composition for oral health
KR101166798B1 (en) * 2011-12-19 2012-07-26 김대현 A pharmaceutical composition for the treatment or prevention of an allergic disease comprising dead bacteria of Lactobacillus asiophilus L.
CN102533790B (en) * 2011-12-23 2013-10-02 光明乳业股份有限公司 PCR detection method for detecting lactobacillus plantarum ST-III and primer and kit thereof
CA2783414A1 (en) 2012-07-22 2014-01-22 Integral Medical Inc. Probiotic composition
CN105007926A (en) 2013-03-14 2015-10-28 雀巢产品技术援助有限公司 Lactobacillus plantarum NCC 2936 preparations and oral health
CN104825380A (en) * 2015-04-21 2015-08-12 溧水区人民医院 Oral normal flora rapid recovery nursing liquid and preparation method thereof
CN105193859A (en) * 2015-09-25 2015-12-30 南昌大学 Application of natural oral bacterium transplanting in oral disease treatment
CN105193857A (en) * 2015-09-25 2015-12-30 南昌大学 Application of transplantation of artificially-cultured oral bacteria in treatment of oral diseases
EP3196318A1 (en) 2016-01-19 2017-07-26 Symrise AG Probiotics for altering the composition of oral biofilms
EP3405205B1 (en) 2016-01-19 2020-07-15 Symrise AG Probiotics for use as anti-inflammatory agents in the oral cavity
GB201600975D0 (en) 2016-01-19 2016-03-02 Probi Ab Novel strain of probiotic bacteria and compositions and uses thereof
CN106727819A (en) * 2016-12-09 2017-05-31 湖南文理学院 The preparation method of globe artichoke oral cleansing lotion
EP3351259A1 (en) 2017-01-18 2018-07-25 Symrise AG Probiotics for aggregation with disease-associated species in the oral cavity
CN107158040B (en) * 2017-04-12 2020-12-08 华南农业大学 A kind of oral microecological preparation and preparation method thereof
WO2020001747A1 (en) 2018-06-26 2020-01-02 Symrise Ag Lactobacillus plantarum for skin care
CN108553406B (en) * 2018-07-24 2020-12-01 北京斯利安药业有限公司 Composition, application thereof and oral preparation with function of improving oral health
KR102555748B1 (en) * 2023-03-23 2023-07-17 주식회사 그린스토어 Novel Streptococcus salivarius strain having antibacterial, antifungal, anti-inflammatory activity and inhibiting dental caries and oral composition comprising the same
CN118028182B (en) * 2024-04-12 2024-06-18 四川厌氧生物科技有限责任公司 Lactobacillus johnsonii for improving oral health and application thereof

Citations (5)

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WO2000009080A1 (en) * 1998-08-12 2000-02-24 Societe Des Produits Nestle S.A. Incorporation of exogenous lactic bacteria into the oral microflora
EP1159951A1 (en) * 2000-06-02 2001-12-05 Societe Des Produits Nestle S.A. Use of exogenous lactic bacteria strain against Actinomyces naeslundii-related diseases
US20040101495A1 (en) * 2002-11-27 2004-05-27 Leena Nase Method for improving dental health
WO2010008879A2 (en) * 2008-06-24 2010-01-21 Wm. Wrigley Jr. Company Probiotic chewing gum method of manufacture
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Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1260227A1 (en) * 2001-05-23 2002-11-27 Societe Des Produits Nestle S.A. Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative bacteria, potential pathogenic gram-positive bacteria

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000009080A1 (en) * 1998-08-12 2000-02-24 Societe Des Produits Nestle S.A. Incorporation of exogenous lactic bacteria into the oral microflora
EP1159951A1 (en) * 2000-06-02 2001-12-05 Societe Des Produits Nestle S.A. Use of exogenous lactic bacteria strain against Actinomyces naeslundii-related diseases
US20040101495A1 (en) * 2002-11-27 2004-05-27 Leena Nase Method for improving dental health
WO2010008879A2 (en) * 2008-06-24 2010-01-21 Wm. Wrigley Jr. Company Probiotic chewing gum method of manufacture
WO2010054439A1 (en) * 2008-11-14 2010-05-20 Unistraw Patent Holdings Limited Probiotic compositions, methods and apparatus for their administration

Non-Patent Citations (26)

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Title
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HATAKKA K ET AL: "Probiotics reduce the prevalence of oral Candida in the elderly - A randomized controlled trial", JOURNAL OF DENTAL RESEARCH, vol. 86, no. 2, February 2007 (2007-02-01), pages 125 - 130, XP002604328, ISSN: 0022-0345 *
HAUKIOJA A ET AL: "Oral adhesion and survival of probiotic and other lactobacilli and bifidobacteria in vitro", ORAL MICROBIOLOGY AND IMMUNOLOGY, vol. 21, no. 5, October 2006 (2006-10-01), pages 326 - 332, XP002604327, ISSN: 0902-0055 *
KLARIN B ET AL: "Use of the probiotic Lactobacillus plantarum 299 to reduce pathogenic bacteria in the oropharynx of intubated patients: A randomised controlled open pilot study", 6 November 2008, CRITICAL CARE 20081106 GB LNKD- DOI:10.1186/CC7109, VOL. 12, NR. 6, ISSN: 1364-8535 1466-609X, XP002594142 *
KOLL P ET AL: "Characterization of oral lactobacilli as potential probiotics for oral health", April 2008, ORAL MICROBIOLOGY AND IMMUNOLOGY, VOL. 23, NR. 2, PAGE(S) 139-147, ISSN: 0902-0055, XP002594151 *
KRASSE PER ET AL: "Decreased gum bleeding and reduced gingivitis by the probiotic Lactobacillus reuteri.", SWEDISH DENTAL JOURNAL 2006 LNKD- PUBMED:16878680, vol. 30, no. 2, 2006, pages 55 - 60, XP008127657, ISSN: 0347-9994 *
MAKRAS L ET AL: "Kinetic analysis of the antibacterial activity of probiotic lactobacilli towards Salmonella enterica serovar Typhimurium reveals a role for lactic acid and other inhibitory compounds", RESEARCH IN MICROBIOLOGY, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.RESMIC.2005.09.002, vol. 157, no. 3, 1 April 2006 (2006-04-01), pages 241 - 247, XP025101166, ISSN: 0923-2508, [retrieved on 20060401] *
MARIK PAUL E ET AL: "The role of anaerobes in patients with ventilator-associated pneumonia and aspiration pneumonia: A prospective study", January 1999, CHEST, VOL. 115, NR. 1, PAGE(S) 178-183, ISSN: 0012-3692, XP002594150 *
NIKAWA H ET AL: "Lactobacillus reuteri in bovine milk fermented decreases the oral carriage of mutans streptococci", INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, vol. 95, no. 2, 1 September 2004 (2004-09-01), pages 219 - 223, XP002604325, ISSN: 0168-1605 *
NIKAWA H ET AL: "The effect of saliva or serum on bacterial and Candida albicans colonization on type I collagen.", October 2006, JOURNAL OF ORAL REHABILITATION OCT 2006 LNKD- PUBMED:16938106, VOL. 33, NR. 10, PAGE(S) 767 - 774, ISSN: 0305-182X, XP002594152 *
NIV ET AL: "The efficacy of Lactobacillus reuteri ATCC 55730 in the treatment of patients with irritable bowel syndrome-a double blind, placebo-controlled, randomized study", CLINICAL NUTRITION, CHURCHILL LIVINGSTONE, LONDON, GB LNKD- DOI:10.1016/J.CLNU.2005.06.001, vol. 24, no. 6, 1 December 2005 (2005-12-01), pages 925 - 931, XP005177032, ISSN: 0261-5614 *
PHAM LIEN CHI ET AL: "Effects of probiotic Lactobacillus salivarius W24 on the compositional stability of oral microbial communities", 30 October 2008, ARCHIVES OF ORAL BIOLOGY, VOL. 54, NR. 2, PAGE(S) 132-137, ISSN: 0003-9969, XP002594145 *
PHILIP K ET AL: "Microbial Competition in Oral Health", INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, vol. 12, no. Suppl. 1, 22 June 2008 (2008-06-22), & 13TH INTERNATIONAL CONGRESS ON INFECTIOUS DISEASES; KUALA LUMPUR, MALAYSIA;, pages E216, XP002604326, ISSN: 1201-9712 *
POWER D A ET AL: "Preliminary investigations of the colonisation of upper respiratory tract tissues of infants using a paediatric formulation of the oral probiotic Streptococcus salivarius K12", 17 June 2008, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES 200812 DE LNKD- DOI:10.1007/S10096-008-0569-4, VOL. 27, NR. 12, PAGE(S) 1261 - 1263, ISSN: 0934-9723, XP002594148 *
SIMARK-MATTSSON CHARLOTTE ET AL: "Lactobacillus-mediated interference of mutans streptococci in caries-free vs. caries-active subjects", EUROPEAN JOURNAL OF ORAL SCIENCES, vol. 115, no. 4, August 2007 (2007-08-01), pages 308 - 314, XP002604332, ISSN: 0909-8836 *
TEUGHELS WIM ET AL: "Probiotics and oral healthcare.", PERIODONTOLOGY 2000 2008 LNKD- PUBMED:18715361, vol. 48, 7 August 2008 (2008-08-07), pages 111 - 147, XP002594143, ISSN: 1600-0757 *
YLI-KNUUTTILA H ET AL: "Colonization of Lactobacillus rhamnosus GG in the oral cavity", ORAL MICROBIOLOGY AND IMMUNOLOGY, vol. 21, no. 2, April 2006 (2006-04-01), pages 129 - 131, XP002604330, ISSN: 0902-0055 *

Also Published As

Publication number Publication date
JP2012512171A (en) 2012-05-31
CN102245191A (en) 2011-11-16
WO2010077795A2 (en) 2010-07-08
ZA201105261B (en) 2012-12-27
RU2011129693A (en) 2013-01-27
AU2009333388A1 (en) 2011-06-30
CA2747231A1 (en) 2010-07-08
EP2379091A2 (en) 2011-10-26
BRPI0922924A2 (en) 2017-06-06
MX2011006488A (en) 2011-07-13
SG171930A1 (en) 2011-07-28

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