WO2010146420A3 - Oligopeptidos sinteticos diseñados a partir de cisteinproteasas de acaros y metodos para la produccion de anticuerpos policlonales igy para la deteccion de acaros intradomiciliarios - Google Patents

Oligopeptidos sinteticos diseñados a partir de cisteinproteasas de acaros y metodos para la produccion de anticuerpos policlonales igy para la deteccion de acaros intradomiciliarios Download PDF

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Publication number
WO2010146420A3
WO2010146420A3 PCT/IB2010/000554 IB2010000554W WO2010146420A3 WO 2010146420 A3 WO2010146420 A3 WO 2010146420A3 IB 2010000554 W IB2010000554 W IB 2010000554W WO 2010146420 A3 WO2010146420 A3 WO 2010146420A3
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WO
WIPO (PCT)
Prior art keywords
polyclonal antibodies
detection
production
igy
igy polyclonal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2010/000554
Other languages
English (en)
French (fr)
Other versions
WO2010146420A8 (es
WO2010146420A2 (es
Inventor
Eduardo Egea
Luis Alejandro Barrera
Leonardo Lareo
Johana Espejo
Catalina Sosa
Elkin Navarro
Gloria Garavito
Dary Luz Mendoza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pontificia Universidad Javeriana
Fundacion Universidad del Norte Co
Original Assignee
Pontificia Universidad Javeriana
Fundacion Universidad del Norte Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CO09027540A external-priority patent/CO6200105A1/es
Application filed by Pontificia Universidad Javeriana, Fundacion Universidad del Norte Co filed Critical Pontificia Universidad Javeriana
Priority to MX2011009862A priority Critical patent/MX345018B/es
Priority to ES10789072.5T priority patent/ES2618898T3/es
Priority to US13/256,918 priority patent/US9416163B2/en
Priority to EP10789072.5A priority patent/EP2431381B1/en
Publication of WO2010146420A2 publication Critical patent/WO2010146420A2/es
Publication of WO2010146420A3 publication Critical patent/WO2010146420A3/es
Anticipated expiration legal-status Critical
Publication of WO2010146420A8 publication Critical patent/WO2010146420A8/es
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Insects & Arthropods (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere al diseño, síntesis y evaluación de 6 oligopéptidos sintéticos, no descritos previamente diseñados a partir de los epítopes T y B de alérgenos del grupo I de los ácaros intradomiciliarios de las especies Dermatophagoides pteronyssinus, Dermatophagoides farinae y Blomia tropicales los cuales pueden ser empleados en inmunomodulación en sujetos con sistemas inmunocompetentes y en la producción de anticuerpos policlonales IgY. Asimismo la presente invención corresponde a un primer método para la obtención de una composición de anticuerpos policlonales IgY útil como reactivo de diagnóstico de bajo costo y alta reactividad frente a ácaros intradomiciliarios, y a un segundo método para la detección de alérgenos de ácaros que emplea la composición de anticuerpos IgY desarrollada en el primer método. La presente invención también comprende la composición como tal de los anticuerpos policlonales IgY.
PCT/IB2010/000554 2009-03-17 2010-03-17 Oligopeptidos sinteticos diseñados a partir de cisteinproteasas de acaros y metodos para la produccion de anticuerpos policlonales igy para la deteccion de acaros intradomiciliarios Ceased WO2010146420A2 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
MX2011009862A MX345018B (es) 2009-03-17 2010-03-17 Oligopeptidos sintéticos diseñados a partir de cisteinproteasas de ácaros y métodos para la producción de anticuerpos policlonales igy para la detección de ácaros intradomiciliarios.
ES10789072.5T ES2618898T3 (es) 2009-03-17 2010-03-17 Oligopéptidos sintéticos diseñados de cistein proteasas de ácaros y métodos para la producción de anticuerpos policlonales IgY para la detección de ácaros intradomiciliares
US13/256,918 US9416163B2 (en) 2009-03-17 2010-03-17 Synthetic oligopeptides designed from mite cysteine proteases and methods for the production of polyclonal IgY antibodies for the detection of intradomiciliary mites
EP10789072.5A EP2431381B1 (en) 2009-03-17 2010-03-17 Synthetic oligopeptides designed from mite cysteine proteases and methods for the production of igy polyclonal antibodies for the detection of intradomiciliary mites

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CO09027540 2009-03-17
CO09027540A CO6200105A1 (es) 2009-03-17 2009-03-17 Ologoppeptidos sinteticos lineales diseñados a partir de secuencias de los alergenos del grupo i de acaros intradomiciliarios y sus aplicaciones potenciales
CO10024590 2010-03-02
CO10024590A CO6260019A1 (es) 2009-01-30 2010-03-02 Metodo y composicion inmunoquimica para la deteccion de alergenos de acaros usando anticuerpos policlonales igy

Publications (3)

Publication Number Publication Date
WO2010146420A2 WO2010146420A2 (es) 2010-12-23
WO2010146420A3 true WO2010146420A3 (es) 2011-05-12
WO2010146420A8 WO2010146420A8 (es) 2012-01-05

Family

ID=43356819

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/000554 Ceased WO2010146420A2 (es) 2009-03-17 2010-03-17 Oligopeptidos sinteticos diseñados a partir de cisteinproteasas de acaros y metodos para la produccion de anticuerpos policlonales igy para la deteccion de acaros intradomiciliarios

Country Status (6)

Country Link
US (1) US9416163B2 (es)
EP (1) EP2431381B1 (es)
CO (1) CO6260019A1 (es)
ES (1) ES2618898T3 (es)
MX (1) MX345018B (es)
WO (1) WO2010146420A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112336856B (zh) * 2020-09-16 2021-09-17 湖南大学 一种有机nir-ⅱ光热转换膜及其制备方法和应用
CN117362453B (zh) * 2023-12-08 2024-02-27 山东硕景生物科技有限公司 一种Derf1重组抗原、其制备方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820862A (en) * 1994-04-14 1998-10-13 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
WO2007140505A2 (en) * 2006-06-09 2007-12-13 Biomay Ag Vaccine carrier

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288256B1 (en) * 1991-10-16 2007-10-30 Merck Patent Gmbh T cell epitopes of the major allergens from dermatophagoides (house dust mite)
AT503530A1 (de) * 2006-04-28 2007-11-15 Biomay Ag Polypeptid mit allergenen eigenschaften

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820862A (en) * 1994-04-14 1998-10-13 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
WO2007140505A2 (en) * 2006-06-09 2007-12-13 Biomay Ag Vaccine carrier

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GARAVITO G. ET AL: "Generation and purification of polyclonal chicken IgY antibodies induced by synthetic oligopeptides against allergens of the group 1 dust mites", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 123, no. 2, 1 February 2009 (2009-02-01), pages S223, XP027569942 *
GARCIA D.A. ET AL: "Obtention, purification and characterization of IgY polyclonal antibodies, developed in hens, directed against Colombian isolates of Giardia duodenalis", BIOMEDICA, vol. 25, no. 4, December 2005 (2005-12-01), pages 451 - 463, XP055102525 *
MORA C. ET AL: "Cloning and expression of Blo t 1, a novel allergen from the dust mite Blomia tropicalis, homologous to cysteine proteases", CLINICAL AND EXPERIMENTAL ALLERGY, vol. 33, no. 1, January 2003 (2003-01-01), pages 28 - 34, XP055102540 *
POUR-AMIR M. ET AL: "A simple and economical procedure for the purification of immunoglobulin Y from egg yolk by T-gel chromatography", IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY, vol. 1, no. 2, April 2000 (2000-04-01), pages 53 - 57, XP008167488 *
See also references of EP2431381A4 *

Also Published As

Publication number Publication date
CO6260019A1 (es) 2011-03-22
US9416163B2 (en) 2016-08-16
WO2010146420A8 (es) 2012-01-05
ES2618898T3 (es) 2017-06-22
EP2431381A2 (en) 2012-03-21
US20120107335A1 (en) 2012-05-03
WO2010146420A2 (es) 2010-12-23
EP2431381A4 (en) 2013-02-20
MX2011009862A (es) 2015-08-05
MX345018B (es) 2017-01-13
EP2431381B1 (en) 2016-10-12

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