WO2011068451A2 - Composant céramique utilisé pour la régénération osseuse - Google Patents

Composant céramique utilisé pour la régénération osseuse Download PDF

Info

Publication number
WO2011068451A2
WO2011068451A2 PCT/SE2010/000279 SE2010000279W WO2011068451A2 WO 2011068451 A2 WO2011068451 A2 WO 2011068451A2 SE 2010000279 W SE2010000279 W SE 2010000279W WO 2011068451 A2 WO2011068451 A2 WO 2011068451A2
Authority
WO
WIPO (PCT)
Prior art keywords
regeneration device
bone regeneration
bone
accordance
frame structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/SE2010/000279
Other languages
English (en)
Other versions
WO2011068451A3 (fr
Inventor
Erik Adolfsson
Lars-Åke JOHANSSON
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2011068451A2 publication Critical patent/WO2011068451A2/fr
Publication of WO2011068451A3 publication Critical patent/WO2011068451A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/10—Ceramics or glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2803—Bones for mandibular reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/842—Flexible wires, bands or straps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/302—Three-dimensional shapes toroidal, e.g. rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30224—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30242—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30242—Three-dimensional shapes spherical
    • A61F2002/30245—Partial spheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2002/30462—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30593—Special structural features of bone or joint prostheses not otherwise provided for hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30604—Special structural features of bone or joint prostheses not otherwise provided for modular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0065—Three-dimensional shapes toroidal, e.g. ring-shaped, doughnut-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0069—Three-dimensional shapes cylindrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0071—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
    • A61F2310/00239—Ceramics or ceramic-like structures based on metal oxides containing zirconia or zirconium oxide ZrO2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the present invention relates to a unique ceramic bone regeneration system of a certain shape.
  • the shape of the device contributes to the formation of a cavity which can be either within the device itself or when the device is attached to a bone surface.
  • the formation of a blood clot, with a shape that is controlled by the device, and subsequent guided bone regeneration will increase the bone volume and for example facilitate installation of dental implants when an insufficient bone volume is present.
  • the ceramic component can be used either in an augmentation procedure before dental implantation in order to enhance bone volume or in order to increase bone volume for other reasons.
  • Implants can now be used to replace missing teeth in all situations from a single tooth to the entire set of teeth in both jaws.
  • the vast majority of dental implants can be simply defined as a titanium screw that is placed within the jaw bone allowing a crown, bridge or denture to be attached to it.
  • the underlying bone volume is insufficient and has to be augmented to make an implant installation possible.
  • This can be achieved by using a patient's own bone (autogenous graft), bone from the animal kingdom (xenograft), or synthetic (alloplast) material or combinations of these grafts.
  • autogenous graft bone from the animal kingdom
  • alloplast alloplast
  • US Patent 20080319547 Al "Porous Material for Use as Implant, Bone Replacement and in General as Material.”
  • This invention concerns a method to produce scaffolds of various shapes with a defined and interconnected porosity. This was obtained by using a mold filled with expandable particles, which was further infiltrated with a ceramic suspension. When the pressure in the mold was reduced, the particles began to expand and came in contact with each other. Control of the initial particle size and amount of particles and the change in pressure allowed the pore size and the interconnectivity of the pores to be controlled by the shaping process that was patented.
  • WO2008104762 A2 Another example of a prior invention where the aim was to enhance the bone formation is WO2008104762 A2, "Bone -replacement materials, methods and devices.”
  • This invention concerns particles or granules to which a blood coagulating substance is added. These particles are small and not individually designed to create a larger homogeneous blood clot volume as the invention described herein.
  • the structure of the blood clot obtained by the invention WO2008104762 A2 would form a fine network, which consists of the volume in between the particles.
  • the ceramic is a bone regeneration device.
  • US Patent 5976140 “Foil for bone growth promotion” describes an invention related to the filed of the invention herein, but describes the use of a titanium membrane, rather than the ceramic structure of the invention herein. It is also a spherical form, rather than the invention herein, which can vary in shape, according to necessity.
  • US Patent 20010012607 Al “Guided tissue regeneration plate for use in a process for growing jaw bone in anticipation of performing dental implants,” describes a titanium plate, rather than a designed ceramic structure of the invention herein.
  • US Patent 20090004627 Al "Dental Material And Composite Dental Material Formed By Using Hydroxy Apatite” is also in a related field to the invention herein.
  • US Patent 20090004627 Al is aimed at dental bone regeneration, based on hydroxyapatite particles and a bioabsorbable film membrane, which is a flexible sheet used to cover a bone cavity filled with bone graft material. This is unlike the invention herein, in terms of structure and shape where the ceramic bone regeneration device have the structural strength to maintain the shape of the cavity in which a blood clot is formed instead of using a supporting bone graft material.
  • the present invention relates to a unique system where a ceramic bone regeneration device is used for bone regeneration.
  • the design of the ceramic bone regeneration device is such that it creates a cavity to facilitate blood clot formation and controlled bone regeneration.
  • the bone regeneration device can be used either as a pre-treatment for example before dental implantation in order to enhance bone volume, or as a strategy for reshaping the bone structure or in order to increase bone volume for other reasons. It can also be loaded with substances to enhance bone regeneration or blood coagulation in order to enhance the speed of bone reformation.
  • the component for building up bone achieves an osteoconductive mold for blood clot formation from where undifferentiated mesenchymal (multipotent) cells are recruited and stimulated to differentiate into osteoblasts and bone production.
  • the component does not need to be removed prior to installation of an implant.
  • the bone regeneration device comprises a three-dimensional frame structure formed from a biocompatible ceramic material where the frame structure have a defined shape with a dimension of at least 1 ,5 mm configured to create a macroscopic cavity.
  • the dimension of the frame structure is measured as the diameter of the smallest circular tube in which the bone regeneration device will fit.
  • the macroscopic cavity can be found within the frame structure that is created by the frame structure and will be completely or partially delimited by an inner or outer surface of the frame structure or by a combination of inner and outer surfaces.
  • An inner surface of the frame structure may be the walls of the macroscopic cavity while an outer surface is a surface that defines the outer shape of the frame structure.
  • the macroscopic cavity in the frame structure can be formed in a controlled way by the shaping process with the use of moulds or pressing tools as well as by machining. Since the macroscopic cavity is configured to collect blood, the volume of the macroscopic cavity penetrating the bone regeneration device is preferably designed to be as large as possible within the frame structure without reducing the strength of the bone regeneration device.
  • An additional type of macroscopic cavity can be found at the outer surface of the frame structure when the bone regeneration device is inserted between a hard surface and a flexible membrane, where the hard surface was enclosed by the flexible membrane before the frame structure was inserted.
  • the frame structure may have a "doughnut-shape" with a generally solid or porous structure and a through-going macroscopic hole, wherein a large proportion of the cavity space will be formed in the through-going hole.
  • the frame structure may have an irregular outer surface with one or more cavities where additional voids may be formed between the irregular outer surface and a bone surface or a membrane surface.
  • a macroscopic cavity can be found on the outside of the frame structure is for a cupola or a shell of a potion of a sphere, spheroid or ellipsoid.
  • the macroscopic cavity can then be found in between the outer surface of the frame structure and an enclosing surface having the minimal surface area for the frame structure to be enclosed.
  • the bone regeneration device can also be shaped as a sphere, a spheroid, an ellipsoid, a toroid, a dome, a shell, a cage or a cylinder.
  • the shape can further be as a portion of these shapes such as a half of an ellipsoid.
  • the internal macroscopic void is configured to have a fluid communication to the outer surface through one or more openings, pores or channels in said three-dimensional frame structure.
  • the bone regeneration device can further consist of an assembly of up to 100 parts of the same or different shape, preferably up to 25 parts are used. These parts can be joined with a metal or polymer thread, which also can be used to attach the assembled bone regeneration device to the bone tissue. With such assembled bone regeneration device an additional macroscopic cavity volume can be formed in between the individual parts.
  • the maximum dimension of said three-dimensional frame structure representing a part is in the range of from 1.5 to 60 mm and preferably in the range of from 5 to 30 mm.
  • the composition of the material used in the bone regeneration device can consist of various calcium phosphates, apatite, hydroxyapatite, tricalcium phosphate, calcium carbonate, calcium sulphate, zirconia or a mixture of two or more of these compounds.
  • frame structures with different compositions and microstructures can be combined to improve the performance.
  • the microstructure includes the size and distribution of particles and pores in the material and is determined by the powder, additives, process and sintering temperature used.
  • the material can thus contain both micro and macro porosity, configured to control the dissolution rate of the material, machinability of the material as well as controlled release of substances introduced in the pores.
  • These substances can comprise one or more additives, such as substances for promoting machinability, bone formation promoting agents, blood coagulation promoting agents or binders.
  • Figure 1 shows an illustration of a ceramic bone regeneration device with a spherical shape
  • Figure 2 shows an illustration of a ceramic bone regeneration device with a shape as a shell. There is a hole through the shell that can be used to fixate the bone regeneration device to the bone with a screw.
  • Figure 3 shows an example of a part that can be assembled with other parts to form space making device.
  • Figure 4 is an illustration, showing a ceramic space making devise, installed to increase the width of the bone structure.
  • the bone regeneration device was attached to the bone with a screw.
  • Figure 5 is an illustration, showing a ceramic bone regeneration device used to increase the height of the bone structure, which is a common situation when the bone volume is insufficient for implant installation due to pneumatization of sinus cavity and resorption of alveolar ridge.
  • Figure 6 is an illustration, showing the result when a ceramic space making devise was installed to increase the width of the bone structure.
  • Figure 7 shows an example where the bone level was not sufficient for a stable installation of an implant.
  • the bone level was increased by the use of a ceramic bone regeneration device. After healing, an implant was inserted through the bone regeneration device, the newly formed bone and the original bone.
  • FIG. 8 showing an illustration of a ceramic bone regeneration device that was made from several assembled parts used to cover a cranial bone defect. The different parts were joined with a thread and secured at the edge of the bone defect.
  • the present invention relates to a unique ceramic bone regeneration system where the micro and macro structural shape of the bone regeneration device are designed to enhance bone regeneration.
  • the invention herein is a ceramic bone regeneration device, preferably with openings or channels or designed as a cylinder, a cage, a dome, a sphere, spheroid, ellipsoid, toroid or as a shell of a portion of these shapes, preferably used to form a cavity and to allow for blood to be collected and to coagulate, acting as a bone regeneration device for guided bone regeneration.
  • the cavity can be present within the bone regeneration device, around the bone regeneration device as well as in between the bone regeneration device and the surrounding hard tissue, periosteum or sinus membrane.
  • the ceramic device can be used to enhance the height and/or the width of the bone in order to make installation of dental implants possible or to modify the bone volume for esthetical or other reasons.
  • the ceramic bone regeneration device can consist of calcium or calcium phosphates such as apatite, hydroxyapatite, tricalcium phosphate, calcium carbonate, calcium sulfate, zirconia or a mixture of these compounds.
  • the ceramic bone regeneration device can be formed by powder compaction, direct consolidation methods, injection moulding, machining or combinations of such methods. The material can be exposed to various heat treatment or sintering procedures to increase the material strength, to remove organic additives or for the raw materials to react and form the desired phase composition.
  • the ceramic bone regeneration device may further contain organic biocompatible materials such as polyethylene, polylactic acid or
  • the ceramic bone regeneration device may further be shaped by a hydratisation process with calcium or calcium phosphate based compounds.
  • the geometrical shape of the ceramic bone regeneration device can be shaped as a sphere, a spheroid, an ellipsoid, a toroid, a dome, a shell, a cage, a cylinder.
  • the shape can further be as a portion of these shapes such as a half of a sphere.
  • the dimension of the bone regeneration device can be in the range of 1.5 to 60 mm and preferably between 5 and 30 mm and can be standardized as well as individualized to a specific patient. The dimension is measured as the diameter of the smallest circular tube in which the bone regeneration device will fit.
  • One or several parts can be assembled in order to form a bone regeneration device where the cavity for blood clot formation also can be found in between the different parts. Additional additives can be used to promote coagulation or bone formation. Additives can be introduced in the porosity, which can be designed with respect to size, volume and interconnectivity in order to control the release rate of the substances.
  • the ceramic bone regeneration device of the invention (1) has an outer surface (2) at which a cavity can be formed in between a part of the device and the bone, the periostum, the sinus membrane or other parts of the device and an inner surface (3) that surrounds the cavity in the part or between the part and the bone.
  • the cavities formed facilitate the formation of a stable blood clot, from which controlled bone regeneration will occur.
  • the ceramic bone regeneration device can be used either as a pre-treatment in order to increase the bone volume before installation of various implants such as dental implants or as a strategy for reshaping the bone structure to increase bone volume for other reasons.
  • FIG 1 is a spherical device shown with internal cavities formed as channels through the device.
  • the surface surrounding the cavities represents the inner surface (3) and the surface of the sphere represents the outer surface (2).
  • Figure 2 shows a bone regeneration device shaped as a cupola or a shell of a half sphere.
  • the concave surface is thus the inner surface of the part since it was formed by removal of material from the half sphere.
  • the part has a design that can be used to form an assembled bone regeneration device.
  • the part has an internal cavity (14) for blood clot formation as well as smaller channels through the part (13) that can be used to connect different parts with threads as well as for blood clot formation.
  • SUBSTITUTE SHEET (RULE 36) area can fill the cavity (6) and be reorganized to bone involving the natural biological principals for bone healing.
  • a cavity is also formed when these devices are installed between the bone and a flexible membrane such as the sinus membrane or the periosteum covering the bone surfaces.
  • These ceramic bone regeneration devices consisting of one or several parts of the same or different materials can then be used to lift the flexible membrane to create a desired shape formed by the present bone structure, the bone regeneration device and the cavity.
  • Figure 4 shows an example where the device (1) was inserted in between the present bone (4) and a flexible membrane (5), to increase the width of the bone structure.
  • the shape of the bone structure after healing will be close to the shape of the flexible membrane (5) given by the bone regeneration device.
  • the cavity (6) formed within and at the surface of the bone regeneration device was filled with blood that formed a stable blood clot. To reduce the risk for the devise to move, it can be fixated to the bone structure with a screw (7).
  • a device (1) was used to increase the height of the present bone structure (4).
  • the inserted device has an internal cavity and creates an additional cavity at the surface of the part below the flexible membrane (5).
  • the entire cavity can then be filed with blood and form a stable clot (6) that will be transformed to new bone.
  • the width of the bone structure was increased as a pretreatment to facilitate implant installation.
  • the border of the former bone level (10) was expanded to the present bone level (9), following the outer surface of the former cavity formed by the flexible membrane in figure 4.
  • the installed part has also been partly dissolved (1), the fixation screw was removed and an implant (8) was installed through the bone and the remains of the device.
  • figure 7 has an implant (8) been installed through the bone and the bone regeneration device, previously installed in figure 5. Bone was found both within and around the installed device and the border of the previous bone level (10) was expanded to a new level (9), corresponding to the border of the cavity previously formed with the bone regeneration device.
  • figure 8 is an assembled structure of several parts (1) inserted in a bone defect (1 1).
  • the different parts in the assembly are connected with a thread (12) that can also be used to attach the bone regeneration device to the surrounding bone structure (4).
  • the cavity for blood to be collected (6) was found inside the parts, between the parts and between the parts and the bone.
  • the external shape of the periosteum, sinus membrane or the ceramic bone regeneration device will then correspond to the future shape of the bone structure, which can be well controlled in terms of both size and shape through the use of this invention.
  • the ceramic bone regeneration device which lift the membrane for guided bone regeneration can be used to enhance the bone volume as a pre-treatment before dental implants are installed or in order to increase or restore the bone volume for other reasons such as esthetical, trauma or diseases.
  • the ceramic bone regeneration device is preferably made of calcium or calcium phosphate based material, such as apatite, hydroxyapatite, tricalcium phosphate, calcium carbonate, calcium sulphate, or any combinations of these.
  • the ceramic raw materials can be used to prepare granules with binders such as polyvinyl alcohol, polyethylene glycol, cellulose, waxes, latex or a mixture of these to facilitate shaping by compaction.
  • These powder compacts often called green bodies can be produced by uniaxial pressing and/or cold isostatic pressing (CIP).
  • CIP cold isostatic pressing
  • the produced green compacts used with or without a presintering procedure can be used as blanks for machining of the desired shape.
  • colloidal methods is an alternative shaping method where the ceramic raw materials, liquid and dispersant are used to prepare a ceramic suspension.
  • An advantage with the colloidal methods is an increased freedom to design the micro porosity in the material used for the bone regeneration device.
  • gelforming agents such as agar, proteins, monomers for gel-casting like
  • methacrylamide MAM
  • MBAM methylene bisacrylamide
  • starch makes it possible to transform the suspension from a fluid to a solid green body through a consolidation process. This allows the suspension to be used to cast bone regeneration devices with desired shapes by using a mold. Additional features like internal cavities or pore channels that can be difficult to create by the mold can instead be obtained by organic materials that are removed after consolidation of the cast bone regeneration device by melting, dissolution or
  • the designed bone regeneration devices by a combination of casting and machining processes as known in the art.
  • the bone regeneration device are then sintered in order to increase the strength and to facilitate machining or to maintain the shape of the cavity for the blood clot formation while exposed to the surrounding mechanical forces; however some of the materials do not need to be sintered such as calcium sulfate containing materials or when addition of polymers like polylactic acid are used.
  • the fabrication procedures further allow additional organic and/or inorganic additives such as starch particles, graphite, polymer beads, wax structures and latex emulsions which can be used to produce different designed cavities, channels or porosities with one or several pore size distributions in the bone regeneration device.
  • the porosity and the microstructure in the frame structure of the bone regeneration device are used to control properties such as dissolution behavior which can be varied from a rather stable material to a material that can be dissolved within a certain time frame, strength, slow release of active substances and machinability.
  • the surface texture is also modified by the addition of the microporosity which also influences the cell attachment to the surface. All these pores can further be used for incorporation of substances that can promote coagulation and blood clot formation in the cavity or enhance the bone formation such as calcium chloride or bone morphogenetic proteins (BMP). The release rate of these substances can be controlled by the pore morphology.
  • the micro structure of the ceramic material is further designed in such a way that drilling can be performed through both bone and ceramic bone regeneration device material to facilitate implant installation with the same tools normally used when dental implants are installed.
  • One of the benefits of such a material design is that no further surgery is required in order to remove any parts of the bone regeneration device.
  • the shape of the ceramic bone regeneration device is designed to create a suitable cavity for blood clot formation and to stabilize the shape of the blood clot during bone formation. This can be done through either standardized shapes or individualized shapes. In certain situations where an individualized shape is desired, computer tomography data or other patient specific data can be used to determine a suitable shape of the ceramic bone regeneration device.
  • the shape of the ceramic bone regeneration device should create a cavity within itself or in combination with the surrounding bone in which the blood clot can be formed.
  • the bone regeneration device should also have the structural strength to maintain the shape of the blood clot.
  • the shape of the ceramic bone regeneration device can be designed to form a cavity when attached to the surrounding tissue, within the part, at the surface of the part or between different parts assembled to a bone regeneration device or another shape that in conjunction with the hard tissue can form a cavity where blood is allowed to coagulate.
  • the shape of the ceramic bone regeneration device can also be a shell, where a cavity between the shell and the bone tissue is formed. This cavity is in fluid communication with the outer surface of the bone regeneration device to allow for blood to fill the cavity.
  • Ceramic bone regeneration device with a spherical shape have successfully been used to increase bone volume in the lateral segments of the upper yaw where bone volume often is insufficient for implant installation due to atrophy. Ceramic bone regeneration device with a cupola shape have successfully been used to increase the width of the alveolar ridges to make implant installation possible or to improve esthetics before conventional tooth supported prosthetic treatment.
  • the ceramic frame structure of the bone regeneration device may consist of 1 or up to 100 parts or sub frame structures that can be assembled, preferably is 1 or up to 25 parts assembled into a coherent structure.
  • the maximum dimension of the parts or sub frame structures can be in the range from 1.5 to 60 mm, preferably in the range from 5 to 30 mm.
  • the overall design of the ceramic bone regeneration device allow for the blood to have access to the macroscopic void formed through openings, channels, voids or adjacent cavities.
  • the dimension of these openings can be from 0.3 to 40 mm, preferably from 1 to 20 mm.
  • the dimension is measured as the diameter of a circle that can be placed in the opening.
  • the combination of a suitable selection of materials and fabrication process parameters allow many important characteristics to be designed such as the dissolution rate of the bone regeneration device, the tissue response, the release rate of substances, and the blood clot formation as well as the machinability of the material during implant installation.
  • a fine grained raw powder of hydroxyapatite was further processed with an addition of water and dispersant (poly acrylic acid) to prepare a ceramic suspension by ball milling.
  • Starch particles were added to the suspension which was allowed to be stirred for one hour in order to obtain a homogeneous suspension before the suspension was poured into a mold with spherical cavities which had a diameter of 12 mm.
  • the addition of starch made it possible to transform the suspension from a fluid state to a green body by an increase of the temperature of the mold to around 70°C for one hour.
  • the cast spheres could then be removed from the mold, dried and presintered to burn out the organic additives and increase the strength of the material before channels with a diameter of 5 mm along three different and perpendicular directions were drilled through the centre of the sphere.
  • the ceramic bone regeneration device was finally sintered for 2 hours to increase the strength of the part.
  • the ceramic bone regeneration device consisted then of a hydroxyapatite sphere with a large internal volume for blood to coagulate and the
  • microstructure of the material contained a large volume fraction of a submicron sized porosity as well as pores of around 10-20 microns from the starch particles.
  • a fine grained raw material of hydroxyapatite was further processed with an addition of water and dispersant (poly acrylic acid) to prepare a ceramic suspension by ball milling with a high solids loading.
  • the green bodies were produced by gel casting where an addition of an organic monomer based binder was made to the suspension. A small temperature change could then be used to transform the fluid suspension in the mold to a solid green body
  • the bone regeneration device produced consisted of a thin ceramic shell of hydroxyapatite that can be attached to the bone by small fixation screws. The internal volume within the shell can then be filled with blood that forms a clot. The parts were finally sintered at a temperature above 600°C for 2 hours, to ensure that all organic additives were burnt away and to improve the strength of the ceramic structure.
  • the pore volume in the material consisted of a fine microporosity which was loaded with additional substances such as calcium chloride and bone morphogenic in order to promote the initial blood coagulation process as well as the following bone formation.
  • Hydroxyapatite and tricalcium phosphate powders were ball milled in order to obtain a homogenous ceramic suspension.
  • Binder for granulation such as polyethylene glycol, polyvinyl alcohol or latex was added to the suspension as well as organic particles with sizes corresponding to the additional porosities desired.
  • the homogenous suspension was freeze granulated and freeze dried.
  • the granules was used to produce green compacts by uniaxial pressing at 25 MPa to a given shape followed by cold isostatic pressing (CIP) at 300 MPa and presintering at 700°C.
  • CIP cold isostatic pressing
  • the geometrical shape of the bone structure of a patient was received from computer tomography data and a model of the desired future shape was drawn with a CAD program.
  • a model of an individualized bone regeneration device was produced with a CAD tool.
  • the model of the bone regeneration device was transferred to CAM program to prepare a suitable machining procedure of the component.
  • the individually designed shape of the bone regeneration device was obtained by CNC machining with hard metal cutting tools before sintering at a temperature of 900°C for 2 hours.
  • a bone regeneration device with a shell like structure was produced by a CNC machine.
  • the bone regeneration device was used as a master model from which a silicon rubber mould was produced.
  • a calcium sulphate powder was mixed with tricalcium phosphate and
  • the prepared suspension of water and powder was injected into the cavity of the silicon rubber mold in order to prepare ceramic bone regeneration devices.
  • the hydratisation process transformed the suspension from a fluid state to a solid material, the cast bone regeneration devices were removed from the mould to dry.
  • the posterior region of the edentulous maxilla often presents insufficient bone quantity and quality for prosthetic rehabilitation with endosseous implants.
  • the inadequate bone volume is a result of ongoing maxillary sinus pneumatization and remodelling of the alveolar crest.
  • the hollow, spherical and perforated ceramic bone regeneration device was evaluated in three patients where vertical bone height was insufficient for implant installation verified by radiographs.
  • the approach to the posterior maxilla was made using a crestal incision along the posterior alveolar process.
  • the alveolar crest and lateral aspect of the maxilla were subsequently exposed by raising a buccal mucoperiosteal flap and a bony window was established on the lateral aspect of the maxillary sinus.
  • the sinus membrane was carefully elevated.
  • the ceramic bone regeneration device was inserted under the sinus membrane.
  • the bony window was either replaced or particulated bone was harvested by a bone scraper to cover the opening in the lateral sinus wall.
  • Wound closure was made by absorbable sutures.
  • a trephine was used to get a specimen of bone and ceramic bone regeneration device at the site where an implant was inserted. This specimen was histologically processed and examined. After 8 weeks a crown was fabricated. Radiographs were taken before surgery, during healing and at one year follow up. In all three patients there was bone formation inside and around the ceramic component. This was also verified histologically and by radiographs in all patients. No complications were noted during one year follow up after crown was inserted.
  • a mixture of hydroxyapatite, tricalcium phosphate, binder and polymer particles with a size of 40 microns was used to prepare granules for compaction.
  • the mixture was cold

Landscapes

  • Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Ceramic Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

Cette invention concerne un système céramique unique de régénération osseuse, la forme de la partie ou des parties assemblées à un dispositif de régénération osseuse facilitant la formation d'un caillot sanguin et le contrôle de la régénération osseuse. Le dispositif céramique de régénération osseuse peut comporter des cavités internes ou former une cavité connectée avec l'os adjacent pour permettre la formation d'un caillot sanguin et le stabiliser. Le caillot sanguin permet de favoriser la formation d'os nouveau, ce qui peut faire office de traitement préalable, par exemple en implantation dentaire pour accroître le volume osseux, ou de stratégie de remodelage de la structure osseuse.
PCT/SE2010/000279 2009-12-01 2010-11-29 Composant céramique utilisé pour la régénération osseuse Ceased WO2011068451A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28321609P 2009-12-01 2009-12-01
US61/283,216 2009-12-01

Publications (2)

Publication Number Publication Date
WO2011068451A2 true WO2011068451A2 (fr) 2011-06-09
WO2011068451A3 WO2011068451A3 (fr) 2011-11-03

Family

ID=44115449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2010/000279 Ceased WO2011068451A2 (fr) 2009-12-01 2010-11-29 Composant céramique utilisé pour la régénération osseuse

Country Status (1)

Country Link
WO (1) WO2011068451A2 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2544627A1 (fr) 2010-03-10 2013-01-16 Oss-Q AB Implants et procédés pour la correction de défauts tissulaires
WO2014125381A3 (fr) * 2013-02-12 2015-01-08 Ossdsign Ab Implants en mosaïques, kits et procédés de correction de défauts osseux
US9220597B2 (en) 2013-02-12 2015-12-29 Ossdsign Ab Mosaic implants, kits and methods for correcting bone defects
WO2016024248A1 (fr) * 2014-08-14 2016-02-18 Ossdsign Ab Implants osseux et procédés de correction de défauts osseux
US9463046B2 (en) 2011-08-22 2016-10-11 Ossdsign Ab Implants and methods for using such implants to fill holes in bone tissue
WO2017089973A1 (fr) * 2015-11-24 2017-06-01 Ossdsign Ab Implants osseux et procédés de correction de défauts osseux
WO2021021246A1 (fr) * 2018-07-27 2021-02-04 Oregon Health & Science University Échafaudage de greffe de tissu synthétique
WO2025117313A1 (fr) * 2023-11-27 2025-06-05 KYOCERA Medical Technologies, Inc. Structures de granules biocompatibles
US12508054B2 (en) 2018-10-16 2025-12-30 Ossdsign Ab Implants for filling bore holes in bone and methods for filling bore holes in bone

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839215A (en) * 1986-06-09 1989-06-13 Ceramed Corporation Biocompatible particles and cloth-like article made therefrom
JP2706467B2 (ja) * 1988-05-27 1998-01-28 住友大阪セメント株式会社 骨移植用人工骨構造体
US6696073B2 (en) * 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
CN1426290A (zh) * 2000-03-03 2003-06-25 史密夫和内修有限公司 用于骨缺陷的定形颗粒和组合物以及该颗粒的制作方法
WO2002060504A1 (fr) * 2001-02-02 2002-08-08 Technology Finance Corporation (Proprietary) Limited Materiau de remplissage pour un os
WO2002083194A1 (fr) * 2001-04-12 2002-10-24 Therics, Inc. Procede et appareil destines a des biostructures de regeneration techniques
EP1359131A1 (fr) * 2002-04-26 2003-11-05 "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." Procédé de fabrication de produits metalliques et céramiques
WO2004098457A1 (fr) * 2003-04-30 2004-11-18 Therics, Inc. Elements de remplissage de cavites osseuses poreuses et procede de fabrication associe
US20050278023A1 (en) * 2004-06-10 2005-12-15 Zwirkoski Paul A Method and apparatus for filling a cavity
EP1623727A1 (fr) * 2004-07-14 2006-02-08 Bruno Sidler Moyen de remplissage et dispositif d'introduction pour établir une structure de soutien dans une cavite intraosseuse
US20100262259A1 (en) * 2006-02-14 2010-10-14 The University Of Tokyo Process for producing bone grafting material, bone grafting material, three-dimensional support for cell culture, and separation support for chromatography
WO2007124511A2 (fr) * 2006-04-25 2007-11-01 Washington State University Céramique résorbable avec taux de perte de résistance régulés

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795377B2 (en) 2010-03-10 2014-08-05 Ossdsign Ab Implants and methods for correcting tissue defects
EP2544627A4 (fr) * 2010-03-10 2014-08-13 Oss Q Ab Implants et procédés pour la correction de défauts tissulaires
AU2011224893B2 (en) * 2010-03-10 2015-01-22 Ossdsign Ab Implants and methods for correcting tissue defects
EP2544627A1 (fr) 2010-03-10 2013-01-16 Oss-Q AB Implants et procédés pour la correction de défauts tissulaires
US9445900B2 (en) 2010-03-10 2016-09-20 Ossdsign Ab Implants and methods for correcting tissue defects
US9463046B2 (en) 2011-08-22 2016-10-11 Ossdsign Ab Implants and methods for using such implants to fill holes in bone tissue
CN105120802B (zh) * 2013-02-12 2018-01-12 奥斯设计公司 镶嵌型植入物、试剂盒和用于矫正骨缺损的方法
WO2014125381A3 (fr) * 2013-02-12 2015-01-08 Ossdsign Ab Implants en mosaïques, kits et procédés de correction de défauts osseux
CN105120802A (zh) * 2013-02-12 2015-12-02 奥斯设计公司 镶嵌型植入物、试剂盒和用于矫正骨缺损的方法
US9220597B2 (en) 2013-02-12 2015-12-29 Ossdsign Ab Mosaic implants, kits and methods for correcting bone defects
US10076416B2 (en) 2013-02-12 2018-09-18 Ossdsign Ab Mosaic implants, kits and methods for correcting bone defects
US10881519B2 (en) 2014-08-14 2021-01-05 Ossdsign Ab Bone implants for correcting bone defects
CN106999214A (zh) * 2014-08-14 2017-08-01 奥斯设计公司 用于矫正骨缺陷的骨植入物
CN106999214B (zh) * 2014-08-14 2020-03-13 奥斯设计公司 镶嵌式植入物及其制造方法、支撑结构和植入物
WO2016024248A1 (fr) * 2014-08-14 2016-02-18 Ossdsign Ab Implants osseux et procédés de correction de défauts osseux
WO2017089973A1 (fr) * 2015-11-24 2017-06-01 Ossdsign Ab Implants osseux et procédés de correction de défauts osseux
US10898332B2 (en) 2015-11-24 2021-01-26 Ossdsign Ab Bone implants and methods for correcting bone defects
US11865005B2 (en) 2015-11-24 2024-01-09 Ossdsign Ab Bone implants and methods for correcting bone defects
WO2021021246A1 (fr) * 2018-07-27 2021-02-04 Oregon Health & Science University Échafaudage de greffe de tissu synthétique
US12508054B2 (en) 2018-10-16 2025-12-30 Ossdsign Ab Implants for filling bore holes in bone and methods for filling bore holes in bone
WO2025117313A1 (fr) * 2023-11-27 2025-06-05 KYOCERA Medical Technologies, Inc. Structures de granules biocompatibles

Also Published As

Publication number Publication date
WO2011068451A3 (fr) 2011-11-03

Similar Documents

Publication Publication Date Title
WO2011068451A2 (fr) Composant céramique utilisé pour la régénération osseuse
US8172907B2 (en) Method for the production of a biologically active prosthetic device for the reconstruction of bone tissue and the prosthetic device itself
US4199864A (en) Endosseous plastic implant method
US4244689A (en) Endosseous plastic implant
ES2431672T3 (es) Andamiajes de óxido metálico
JP4215595B2 (ja) インプラント固定部材およびインプラント複合材
CN103315829B (zh) 修复一侧下颌骨缺损超过4颗牙位个性化支架的制造方法
GB2078696A (en) Porous Calcium Phosphate Body
CA2882697A1 (fr) Echafaudage ayant une paroi corticale
CN103300946A (zh) 修复下颌骨缺损跨过中心平面的个性化支架的制造方法
Malmström et al. Bone ingrowth in zirconia and hydroxyapatite scaffolds with identical macroporosity
JP4802317B2 (ja) リン酸カルシウム系セラミックスビーズ集積体及びその構築方法
US8911762B2 (en) Polylactic acid/calcium sulfate scaffold
JPH0215221B2 (fr)
US20200390934A1 (en) Collagen matrix or granulate blend of bone substitute
US20140072747A1 (en) Biphasic Collagen Membrane or Capsule for Guided Tissue Regeneration
Chang Comparison of Clinical Parameters in Dental Implant Therapy between Implant Site Development Using Porcine-and Bovine-Derived Xenografts. Technologies. 2021; 9 (4): 72
JPS63294864A (ja) 人工骨材料の製造方法
JP2008200439A (ja) インプラント固定部材およびその製造方法
JP2004290418A (ja) 歯槽骨・顎骨用部材
TWI440486B (zh) 聚乳酸／硫酸鈣支架
JPH0252664A (ja) 複合インプラント材
JP3965204B1 (ja) 骨再生用治療キット
HK40061207B (en) Collagen matrix or granulate blend of bone substitute material
HK40061207A (en) Collagen matrix or granulate blend of bone substitute material

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10834828

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 10.09.2012.)

122 Ep: pct application non-entry in european phase

Ref document number: 10834828

Country of ref document: EP

Kind code of ref document: A2