WO2011128209A3 - Vorrichtung und verfahren zum bestimmen eines biologischen, chemischen und/oder physikalischen parameters in lebendem biologischem gewebe - Google Patents

Vorrichtung und verfahren zum bestimmen eines biologischen, chemischen und/oder physikalischen parameters in lebendem biologischem gewebe Download PDF

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Publication number
WO2011128209A3
WO2011128209A3 PCT/EP2011/054977 EP2011054977W WO2011128209A3 WO 2011128209 A3 WO2011128209 A3 WO 2011128209A3 EP 2011054977 W EP2011054977 W EP 2011054977W WO 2011128209 A3 WO2011128209 A3 WO 2011128209A3
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WO
WIPO (PCT)
Prior art keywords
biological tissue
biological
ascertaining
interpolation
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/EP2011/054977
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English (en)
French (fr)
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WO2011128209A2 (de
Inventor
Arno Müller
Heinz-Peter Utz
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Vivantum GmbH
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Vivantum GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vivantum GmbH filed Critical Vivantum GmbH
Priority to JP2013504195A priority Critical patent/JP2013523362A/ja
Priority to CA2795171A priority patent/CA2795171A1/en
Priority to US13/639,574 priority patent/US20130237797A1/en
Priority to CN2011800186062A priority patent/CN102858243A/zh
Priority to EP11712536A priority patent/EP2557991A2/de
Publication of WO2011128209A2 publication Critical patent/WO2011128209A2/de
Publication of WO2011128209A3 publication Critical patent/WO2011128209A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14558—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters by polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4711—Multiangle measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/12—Circuits of general importance; Signal processing
    • G01N2201/128—Alternating sample and standard or reference part in one path
    • G01N2201/1281—Reflecting part, i.e. for autocollimation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Die Erfindung betrifft eine Vorrichtung zum Bestimmen biologischer, chemischer und/oder physikalischer Parameter in lebendem biologischem Gewebe mit einer Energieversorgungseinheit, einer Laser-Betriebseinheit mit mindestens einer auf das biologische Gewebe gerichteten Laserquelle, mindestens einer Sensoreinheit zum Detektieren des von dem biologischen Gewebe rückgestreuten und/oder absorbierten Lichtes, einer Steuereinheit, einer Speicher- und Verarbeitungseinheit und einer Schnittstelle für eine externe Datenverarbeitungseinheit. Das erfindungsgemäße Verfahren enthält ein Ausführen einer Kalibrierungsphase zur Ermittlung einer Referenzmenge (R) aus Referenzvektoren (Ri), bestehend jeweils aus einer unabhängigen Ermittlung eines Parameters (BZi), einem Einstrahlen unpolarisierten Laserlichtes auf das biologische Gewebe und einem Registrieren eines Messwertvektors (Mi) aus einer Reihe von optischen Messgrößen und ein Ausführen einer Interpolationsphase zum Ermitteln einer Interpolationsmenge (I) aus Interpolationsvektoren (Ik), bestehend jeweils aus einem Einstrahlen unpolarisierten Laserlichtes auf das biologische Gewebe und einem Registrieren eines Messwertvektors (Mk) aus einer rückgestreuten Lichtintensität mit einer nachfolgenden Bestimmung eines interpolierten Parameters (BKk) aus der Referenzmenge (R).
PCT/EP2011/054977 2010-04-13 2011-03-31 Vorrichtung und verfahren zum bestimmen eines biologischen, chemischen und/oder physikalischen parameters in lebendem biologischem gewebe Ceased WO2011128209A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2013504195A JP2013523362A (ja) 2010-04-13 2011-03-31 生体組織における生物学的、化学的、及び／又は生理学的パラメータを決定するための装置及び方法
CA2795171A CA2795171A1 (en) 2010-04-13 2011-03-31 Device and method for determining a biological, chemical and/or physical parameter in a living biological tissue
US13/639,574 US20130237797A1 (en) 2010-04-13 2011-03-31 Device and method for determining a biological, chemical and/or physical parameter in a living biological tissue
CN2011800186062A CN102858243A (zh) 2010-04-13 2011-03-31 用于确定活着的生物组织中的生物学、化学和/或物理学参数的装置和方法
EP11712536A EP2557991A2 (de) 2010-04-13 2011-03-31 Vorrichtung und verfahren zum bestimmen eines biologischen, chemischen und/oder physikalischen parameters in lebendem biologischem gewebe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010014775.3 2010-04-13
DE102010014775A DE102010014775A1 (de) 2010-04-13 2010-04-13 Vorrichtung und Verfahren zur Bestimmen eines biologischen, chemischen und/oder physikalischen Parameters in lebendem biologischem Gewebe

Publications (2)

Publication Number Publication Date
WO2011128209A2 WO2011128209A2 (de) 2011-10-20
WO2011128209A3 true WO2011128209A3 (de) 2011-12-08

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PCT/EP2011/054977 Ceased WO2011128209A2 (de) 2010-04-13 2011-03-31 Vorrichtung und verfahren zum bestimmen eines biologischen, chemischen und/oder physikalischen parameters in lebendem biologischem gewebe

Country Status (7)

Country Link
US (1) US20130237797A1 (de)
EP (1) EP2557991A2 (de)
JP (1) JP2013523362A (de)
CN (1) CN102858243A (de)
CA (1) CA2795171A1 (de)
DE (1) DE102010014775A1 (de)
WO (1) WO2011128209A2 (de)

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WO2014173558A1 (en) 2013-04-24 2014-10-30 Fresenius Kabi Deutschland Gmbh Method of operating a control device for controlling an infusion device
DE102013010611A1 (de) * 2013-06-25 2015-01-08 Sms Swiss Medical Sensor Ag Messvorrichtung und Messverfahren zum Messen von Rohdaten zur Bestimmung eines Blutparameters, insbesondere zur nichtinvasiven Bestimmung der D-Glucose-Konzentration
KR102126378B1 (ko) * 2013-08-07 2020-06-25 삼성디스플레이 주식회사 위치 제어 장치, 위치 제어 방법 및 이를 포함한 장치
WO2015106220A1 (en) * 2014-01-10 2015-07-16 Glucovista, Inc. Non-invasive system and method for measuring a substance concentration
JP2015198689A (ja) * 2014-04-04 2015-11-12 セイコーエプソン株式会社 生体計測装置および生体計測方法
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JP6616069B2 (ja) * 2014-10-30 2019-12-04 ローム株式会社 バイタルセンサモジュール
JP6706465B2 (ja) * 2015-05-25 2020-06-10 ローム株式会社 バイタルセンサモジュール
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KR102658241B1 (ko) * 2016-11-03 2024-04-16 삼성전자주식회사 생체 성분 측정 장치 및 방법
KR102487058B1 (ko) * 2017-11-17 2023-01-09 삼성전자주식회사 생체정보 측정 장치 및 방법
CN114569102B (zh) * 2020-11-30 2025-07-25 华为技术有限公司 生物特征参数的测量方法和装置
US12359554B2 (en) * 2021-03-15 2025-07-15 Saudi Arabian Oil Company Real-time multimodal radiometry for subsurface characterization during high-power laser operations
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US4449535A (en) * 1981-03-25 1984-05-22 Compagnie Industrielle Des Lasers Cilas Alcatel Apparatus for measuring in situ the state of oxidation-reduction of a living organ
EP0074428A1 (de) * 1981-09-15 1983-03-23 Arno Dr. Dipl.-Phys. Müller Verfahren und Vorrichtung zur quantitativen Bestimmung gelöster Substanzen in Ein- und Mehrkomponentensystemen durch Laser-Lichtstreuung
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US5383452A (en) * 1993-07-01 1995-01-24 Buchert; Janusz Method, apparatus and procedure for non-invasive monitoring blood glucose by measuring the polarization ratio of blood luminescence
WO1996041566A2 (en) * 1995-06-09 1996-12-27 Cybro Medical Ltd. Sensor, method and device for optical blood oximetry
US5896198A (en) * 1996-11-11 1999-04-20 Chien Chou Optical heterodyne-based method and apparatus for determining the concentration of optically active substances
US6370407B1 (en) * 1999-07-27 2002-04-09 Tecmed, Incorporated System for improving the sensitivity and stability of optical polarimetric measurements
EP1738689A2 (de) * 2005-06-30 2007-01-03 General Electronic Company System und Verfahren für Monitoring von nichtinvasiver Glucose

Also Published As

Publication number Publication date
US20130237797A1 (en) 2013-09-12
WO2011128209A2 (de) 2011-10-20
EP2557991A2 (de) 2013-02-20
CA2795171A1 (en) 2011-10-20
CN102858243A (zh) 2013-01-02
DE102010014775A1 (de) 2011-10-13
JP2013523362A (ja) 2013-06-17

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