WO2012000608A3 - Nouveaux dérivés bêta-aminoaldéhyde, procédé de préparation de ces dérivés et leur utilisation en chimie comme intermédiaires réactifs - Google Patents

Nouveaux dérivés bêta-aminoaldéhyde, procédé de préparation de ces dérivés et leur utilisation en chimie comme intermédiaires réactifs Download PDF

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WO2012000608A3
WO2012000608A3 PCT/EP2011/002923 EP2011002923W WO2012000608A3 WO 2012000608 A3 WO2012000608 A3 WO 2012000608A3 EP 2011002923 W EP2011002923 W EP 2011002923W WO 2012000608 A3 WO2012000608 A3 WO 2012000608A3
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preparation
novel beta
reactive intermediates
chemical use
aminoaldehyde derivatives
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WO2012000608A2 (fr
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Karl-Heinz GLÜSENKAMP
Christian Mengede
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    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
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    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

L'invention concerne de nouveaux dérivés bêta-aminoaldéhyde représentés par les formules (I), (II) et (III) dans lesquelles les substituants R1 à R5 et A ont les significations données dans le descriptif, un nouveau procédé de préparation de ces dérivés, leurs produits intermédiaires et des utilisations de ces nouveaux dérivés bêta-aminoaldéhyde par exemple pour l'utilisation (en chimie) comme intermédiaires réactifs, et pour l'utilisation en médecine, par exemple comme peptidomimétiques, comme agents de couplage etc.
PCT/EP2011/002923 2010-06-30 2011-06-14 Nouveaux dérivés bêta-aminoaldéhyde, procédé de préparation de ces dérivés et leur utilisation en chimie comme intermédiaires réactifs Ceased WO2012000608A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010025663.3 2010-06-30
DE102010025663A DE102010025663A1 (de) 2010-06-30 2010-06-30 Neue beta-Aminoaldehyd-Derivate, Verfahren zu ihrer Herstellung und ihre chemische Verwendung als reaktive Intermediate

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WO2012000608A2 WO2012000608A2 (fr) 2012-01-05
WO2012000608A3 true WO2012000608A3 (fr) 2012-03-08

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1203092A1 (ru) * 1984-06-07 1986-01-07 Московский Ордена Трудового Красного Знамени Институт Тонкой Химической Технологии Им.М.В.Ломоносова Способ получени алкилзамещенных тетрагидро-1,3,-оксазин-2-онов
WO2003106399A2 (fr) * 2002-06-17 2003-12-24 Theravance, Inc. Procede de preparation de composes aldehydes $g(b)-amino <i>n</i>-proteges
US20040014763A1 (en) * 2002-02-14 2004-01-22 Myriad Pharmaceuticals, Inc. beta-sheet mimetics and composition and methods relating thereto
WO2004043958A1 (fr) * 2002-11-06 2004-05-27 Amgen Inc. Composes heterocycliques condenses
WO2005049033A1 (fr) * 2003-11-17 2005-06-02 Astrazeneca Ab Derives de pyrazole en tant qu'inhibiteurs de recepteur tyrosine kinases
WO2005121145A2 (fr) * 2004-06-09 2005-12-22 F. Hoffmann-La Roche Ag Composes antiviraux heterocycliques
US20070191335A1 (en) * 2006-02-15 2007-08-16 Remy Lemoine Heterocylic antiviral compounds
US20070259888A1 (en) * 2006-05-02 2007-11-08 Astrazeneca Ab Novel Compounds
WO2008006039A1 (fr) * 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrothiéno pyrimidines comme inhibiteurs de la protéine kinase akt
WO2008043798A1 (fr) * 2006-10-10 2008-04-17 Organoclick Ab PROCÉDÉ DE PRÉPARATION DE β-AMINO-ALDÉHYDES ET DE DÉRIVÉS DE CES DERNIERS
US20090275627A1 (en) * 2008-05-05 2009-11-05 Allergan, Inc. Alpha2b and alpha2c agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9797998A (en) 1997-10-10 1999-05-03 Trustees Of The University Of Pennsylvania, The Compositions and methods for inhibiting arginase activity
ATE394361T1 (de) * 2003-12-19 2008-05-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von chiralen oder enantiomerenangereicherten beta-aminosaeuren, - aldehyden, - ketonen und gamma-aminoalkoholen
BRPI0510929A (pt) 2004-06-18 2007-07-17 Chiron Corp derivados de n-(1-(1-benzil-4-fenil-1h-imidazol-2-il)-2,2-dimetilpropil) benzamida e compostos relacionados como inibidores de proteìna de eixo de kinesin (ksp) para o tratamento de cáncer
WO2006064340A2 (fr) * 2004-12-13 2006-06-22 Pfizer Limited Elaboration de n-acyl beta-aminoaldehydes
DE102006033362A1 (de) 2006-07-19 2008-01-24 Studiengesellschaft Kohle Mbh Verfahren zur Herstellung von chiralen Aminocarbonylverbindungen

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1203092A1 (ru) * 1984-06-07 1986-01-07 Московский Ордена Трудового Красного Знамени Институт Тонкой Химической Технологии Им.М.В.Ломоносова Способ получени алкилзамещенных тетрагидро-1,3,-оксазин-2-онов
US20040014763A1 (en) * 2002-02-14 2004-01-22 Myriad Pharmaceuticals, Inc. beta-sheet mimetics and composition and methods relating thereto
WO2003106399A2 (fr) * 2002-06-17 2003-12-24 Theravance, Inc. Procede de preparation de composes aldehydes $g(b)-amino <i>n</i>-proteges
WO2004043958A1 (fr) * 2002-11-06 2004-05-27 Amgen Inc. Composes heterocycliques condenses
WO2005049033A1 (fr) * 2003-11-17 2005-06-02 Astrazeneca Ab Derives de pyrazole en tant qu'inhibiteurs de recepteur tyrosine kinases
WO2005121145A2 (fr) * 2004-06-09 2005-12-22 F. Hoffmann-La Roche Ag Composes antiviraux heterocycliques
US20070191335A1 (en) * 2006-02-15 2007-08-16 Remy Lemoine Heterocylic antiviral compounds
US20070259888A1 (en) * 2006-05-02 2007-11-08 Astrazeneca Ab Novel Compounds
WO2008006039A1 (fr) * 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrothiéno pyrimidines comme inhibiteurs de la protéine kinase akt
WO2008043798A1 (fr) * 2006-10-10 2008-04-17 Organoclick Ab PROCÉDÉ DE PRÉPARATION DE β-AMINO-ALDÉHYDES ET DE DÉRIVÉS DE CES DERNIERS
US20090275627A1 (en) * 2008-05-05 2009-11-05 Allergan, Inc. Alpha2b and alpha2c agonists

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
FRANKLIN A. DAVIS ET AL: "Asymmetric Synthesis of cis -5- tert -Butylproline with Metal Carbenoid NH Insertion", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 13, 1 June 2003 (2003-06-01), pages 5147 - 5152, XP055015228, ISSN: 0022-3263, DOI: 10.1021/jo030081s *
HIROAKI OHNO ET AL: "Stereoselective Synthesis of 2-Alkenylaziridines and 2-Alkenylazetidines by Palladium-Catalyzed Intramolecular Amination of [alpha]- and [beta]-Amino Allenes", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 14, 1 July 2001 (2001-07-01), pages 4904 - 4914, XP055015220, ISSN: 0022-3263, DOI: 10.1021/jo015683v *
LEE H K ET AL: "Facile conversion of 2-azetidinones to 2-piperidones: application to a formal synthesis of Prosopis and Cassia alkaloids", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 59, no. 34, 18 August 2003 (2003-08-18), pages 6445 - 6454, XP004444220, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(03)01063-9 *
M. RODRIGUEZ ET AL.: ""CARBA" PEPTIDE BOND SURROGATES: SYNTHESIS OF BOC-L-LEU-psi(CH2-CH2)-L-PHE-OH AND BOC-L-LEU-psi(CH2-CH2)-D-PHE-OH THROUGH A HORNER-EMMONS REACTION", TETRAHEDRON LETTERS, vol. 31, no. 50, 1 January 1990 (1990-01-01), Great Britain, pages 7319 - 7322, XP055015226 *
MENDRE C ET AL: "PEPTIDE AND PSEUDOPEPTIDE ANALOGUES OF CHOLECYSTOKININ. CHEMICAL MODIFICATION OF THE MET28-GLY29 REGION", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 44, no. 14, 1 January 1988 (1988-01-01), pages 4415 - 4430, XP001153467, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(01)86144-5 *
PESCHKE B ET AL: "Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 34, no. 5, 1 May 1999 (1999-05-01), pages 363 - 380, XP004180344, ISSN: 0223-5234, DOI: 10.1016/S0223-5234(99)80086-5 *
SZAKONYI Z ET AL: "Regio- and stereoselective synthesis of constrained enantiomeric beta-amino acid derivatives", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 19, no. 19, 6 October 2008 (2008-10-06), pages 2296 - 2303, XP025609005, ISSN: 0957-4166, [retrieved on 20081022], DOI: 10.1016/J.TETASY.2008.09.026 *
YOSHIZAWA HIDENORI ET AL: "S-3578, a new broad psectrum parenteral cephalosporin exhibiting potent activity against both methicillin-resistant staphylococcus aureus (MRSA) and pseudomonas aeruginosa. Synthesis and structure-activity relationships", THE JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, TOKYO, JP, vol. 55, no. 11, 1 January 2002 (2002-01-01), pages 975 - 992, XP002973822, ISSN: 0021-8820 *

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