WO2012107765A3 - Formulation de particules - Google Patents

Formulation de particules Download PDF

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Publication number
WO2012107765A3
WO2012107765A3 PCT/GB2012/050283 GB2012050283W WO2012107765A3 WO 2012107765 A3 WO2012107765 A3 WO 2012107765A3 GB 2012050283 W GB2012050283 W GB 2012050283W WO 2012107765 A3 WO2012107765 A3 WO 2012107765A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmacologically active
active ingredients
particle
particle formulations
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2012/050283
Other languages
English (en)
Other versions
WO2012107765A2 (fr
Inventor
Mark Henry SAUNDERS
Marcel De Matas
Jason Robert Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LENA NANOCEUTICS Ltd
Kuecept Ltd
Original Assignee
LENA NANOCEUTICS Ltd
Kuecept Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LENA NANOCEUTICS Ltd, Kuecept Ltd filed Critical LENA NANOCEUTICS Ltd
Publication of WO2012107765A2 publication Critical patent/WO2012107765A2/fr
Publication of WO2012107765A3 publication Critical patent/WO2012107765A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention porte sur des formulations de particules combinées, appropriées pour être utilisées dans une formulation d'inhalateur comprenant plusieurs ingrédients pharmacologiquement actifs caractérisés en ce que les ingrédients pharmacologiquement actifs sont cristallins. La présente invention comprend en outre une formulation de particules appropriée pour être utilisée dans une formulation d'inhalation comprenant plusieurs ingrédients pharmacologiquement actifs, par exemple des ingrédients pharmacologiquement actifs cristallins caractérisés en ce que le rapport des substances pharmacologiquement actives présente une distribution de moins de ±5 % du rapport cible tel que mesuré par un test d'impacteur. En particulier, la présente invention porte sur des formulations de particules préparées à partir de nanoparticules, par exemple par séchage par pulvérisation d'une suspension aqueuse de nanoparticules. L'invention comprend en outre des procédés de fabrication desdites formulations de particules et un procédé d'utilisation desdites formulations de particules dans des traitements thérapeutiques pour parvenir à une co-localisation d'agents dans le corps, en particulier lorsqu'elles sont administrées sous la forme de formulations inhalées aux voies aériennes et aux poumons d'êtres humains.
PCT/GB2012/050283 2011-02-09 2012-02-09 Formulation de particules Ceased WO2012107765A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1102237.3A GB201102237D0 (en) 2011-02-09 2011-02-09 Particle formulation
GB1102237.3 2011-02-09

Publications (2)

Publication Number Publication Date
WO2012107765A2 WO2012107765A2 (fr) 2012-08-16
WO2012107765A3 true WO2012107765A3 (fr) 2012-11-15

Family

ID=43836446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2012/050283 Ceased WO2012107765A2 (fr) 2011-02-09 2012-02-09 Formulation de particules

Country Status (2)

Country Link
GB (1) GB201102237D0 (fr)
WO (1) WO2012107765A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
CN107880091B (zh) 2012-05-08 2020-12-18 尼科斯眼药公司 疏水性治疗剂的制剂、其制备方法及应用
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
CN105473133A (zh) 2013-04-30 2016-04-06 欧缇托匹克公司 干粉制剂及使用方法
CN112656780A (zh) 2014-02-20 2021-04-16 奥迪托皮克股份有限公司 用于吸入的干粉制剂
PL3179986T3 (pl) 2014-07-31 2023-06-26 Vectura Inc. Suche formulacje w proszku do inhalacji
WO2016055544A1 (fr) * 2014-10-08 2016-04-14 Eratech S.R.L. Composition comprenant au moins une poudre sèche obtenue par séchage par pulvérisation pour augmenter la stabilité de la formulation
DE102016218604A1 (de) 2016-09-27 2018-03-29 Constantin Adams Partikuläres Stoffgemisch, vorzugsweise zur Verwendung bei der Prophylaxe und/oder Behandlung einer Atemwegsstörung
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
EP3684338A4 (fr) 2017-09-22 2021-06-23 Otitopic Inc. Compositions de poudre sèche contenant du stéarate de magnésium
WO2021216710A1 (fr) * 2020-04-24 2021-10-28 The Medical College Of Wisconsin, Inc. Utilisation du salmétérol en tant qu'agent antiviral

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080254127A1 (en) * 2000-10-06 2008-10-16 Orion Corporation Inhalation particles incorporating a combination of two or more active ingredients
US7521068B2 (en) * 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
EP2050437A1 (fr) * 2007-10-15 2009-04-22 Laboratoires SMB Compositions de poudre sèche pharmaceutiquement améliorées pour l'inhalation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK283569B6 (sk) 1993-10-01 2003-09-11 Astra Aktiebolag Spôsob spracovania jemne deleného práškového liečiva, zariadenie na vykonávanie tohto spôsobu a aglomeráty vyrobené týmto spôsobom
US7572430B2 (en) 2000-11-09 2009-08-11 Cyprus Amax Minerals Company Method for producing nano-particles
GB0516549D0 (en) 2005-08-12 2005-09-21 Sulaiman Brian Milling system
EP2083944A4 (fr) 2006-10-24 2013-07-24 Beneq Oy Dispositif de production de nanoparticules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521068B2 (en) * 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US20080254127A1 (en) * 2000-10-06 2008-10-16 Orion Corporation Inhalation particles incorporating a combination of two or more active ingredients
EP2050437A1 (fr) * 2007-10-15 2009-04-22 Laboratoires SMB Compositions de poudre sèche pharmaceutiquement améliorées pour l'inhalation

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MICHIKO KUMON ET AL: "Can low-dose combination products for inhalation be formulated in single crystalline particles?", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 40, no. 1, 1 April 2010 (2010-04-01), pages 16 - 24, XP055036842, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2010.02.004 *
REINHARD VEHRING: "Pharmaceutical Particle Engineering via Spray Drying", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 25, no. 5, 28 November 2007 (2007-11-28), pages 999 - 1022, XP019613056, ISSN: 1573-904X *

Also Published As

Publication number Publication date
GB201102237D0 (en) 2011-03-23
WO2012107765A2 (fr) 2012-08-16

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