WO2012134231A3 - Dérivé de benzamide utilisable en tant qu'antagoniste du récepteur des cannabinoïdes (cb1) - Google Patents

Dérivé de benzamide utilisable en tant qu'antagoniste du récepteur des cannabinoïdes (cb1) Download PDF

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Publication number
WO2012134231A3
WO2012134231A3 PCT/KR2012/002405 KR2012002405W WO2012134231A3 WO 2012134231 A3 WO2012134231 A3 WO 2012134231A3 KR 2012002405 W KR2012002405 W KR 2012002405W WO 2012134231 A3 WO2012134231 A3 WO 2012134231A3
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Prior art keywords
obesity
antagonist
cannabinoid receptor
benzamide derivative
prevention
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PCT/KR2012/002405
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Korean (ko)
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WO2012134231A9 (fr
WO2012134231A2 (fr
Inventor
이현규
최은복
양희철
김광록
장택수
오정택
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Korea Research Institute of Chemical Technology KRICT
Chong Kun Dang Corp
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Korea Research Institute of Chemical Technology KRICT
Chong Kun Dang Corp
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Publication of WO2012134231A2 publication Critical patent/WO2012134231A2/fr
Publication of WO2012134231A9 publication Critical patent/WO2012134231A9/fr
Publication of WO2012134231A3 publication Critical patent/WO2012134231A3/fr
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne un composé benzamide inédit agissant en tant qu'agoniste inverse ou antagoniste d'un récepteur des cannabinoïdes (CB1), ou des sels pharmaceutiquement acceptables de celui-ci. Le composé selon la présente invention peut être utilisé en vue de la prévention ou du traitement de l'obésité et des maladies métaboliques liées à l'obésité. De plus, l'invention concerne un procédé de préparation du composé benzamide, un composé pharmaceutique comprenant celui-ci et une méthode de prévention ou de traitement de l'obésité et des maladies métaboliques liées à l'obésité.
PCT/KR2012/002405 2011-03-31 2012-03-30 Dérivé de benzamide utilisable en tant qu'antagoniste du récepteur des cannabinoïdes (cb1) Ceased WO2012134231A2 (fr)

Applications Claiming Priority (2)

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KR10-2011-0029928 2011-03-31
KR1020110029928A KR101326557B1 (ko) 2011-03-31 2011-03-31 카나비노이드 수용체〔ｃｂｉ〕길항제로서의 벤즈아미드 유도체

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WO2012134231A2 WO2012134231A2 (fr) 2012-10-04
WO2012134231A9 WO2012134231A9 (fr) 2013-01-03
WO2012134231A3 true WO2012134231A3 (fr) 2013-02-21

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Publication number Priority date Publication date Assignee Title
KR101447510B1 (ko) * 2013-02-07 2014-10-08 한국화학연구원 카나비노이드 수용체（ｃｂ１） 길항제로서의 헤테로고리 벤즈아미드 유도체
KR101432012B1 (ko) * 2013-02-19 2014-08-21 한국식품연구원 항비만용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047516A2 (fr) * 2004-10-26 2006-05-04 Irm Llc Composes et compositions servant d'inhibiteurs d'activite de recepteur cannabinoide de type 1
WO2007058960A1 (fr) * 2005-11-10 2007-05-24 Adolor Corporation Sulfamoyle benzamides et procedes d’utilisation
WO2007096764A2 (fr) * 2006-02-27 2007-08-30 Glenmark Pharmaceuticals S.A. Dérivés d'hétéroaryles bicycliques en tant que modulateurs des récepteurs cannabinoïdes
WO2008094476A1 (fr) * 2007-01-31 2008-08-07 Merck & Co., Inc. Dérivés de pyrano[2,3-b]pyridine substituée en tant que modulateurs du récepteur du cannabinoïde 1

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047516A2 (fr) * 2004-10-26 2006-05-04 Irm Llc Composes et compositions servant d'inhibiteurs d'activite de recepteur cannabinoide de type 1
WO2007058960A1 (fr) * 2005-11-10 2007-05-24 Adolor Corporation Sulfamoyle benzamides et procedes d’utilisation
WO2007096764A2 (fr) * 2006-02-27 2007-08-30 Glenmark Pharmaceuticals S.A. Dérivés d'hétéroaryles bicycliques en tant que modulateurs des récepteurs cannabinoïdes
WO2008094476A1 (fr) * 2007-01-31 2008-08-07 Merck & Co., Inc. Dérivés de pyrano[2,3-b]pyridine substituée en tant que modulateurs du récepteur du cannabinoïde 1

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WO2012134231A9 (fr) 2013-01-03
KR101326557B1 (ko) 2013-11-08
KR20120111454A (ko) 2012-10-10
WO2012134231A2 (fr) 2012-10-04

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