WO2012134231A3 - 카나비노이드 수용체（ｃｂ１） 길항제로서의 벤즈아미드 유도체 - Google Patents

카나비노이드 수용체（ｃｂ１） 길항제로서의 벤즈아미드 유도체 Download PDF

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WO2012134231A3
WO2012134231A3 PCT/KR2012/002405 KR2012002405W WO2012134231A3 WO 2012134231 A3 WO2012134231 A3 WO 2012134231A3 KR 2012002405 W KR2012002405 W KR 2012002405W WO 2012134231 A3 WO2012134231 A3 WO 2012134231A3
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obesity
antagonist
cannabinoid receptor
benzamide derivative
prevention
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PCT/KR2012/002405
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English (en)
French (fr)
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WO2012134231A9 (ko
WO2012134231A2 (ko
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이현규
최은복
양희철
김광록
장택수
오정택
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Korea Research Institute of Chemical Technology KRICT
Chong Kun Dang Corp
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Korea Research Institute of Chemical Technology KRICT
Chong Kun Dang Corp
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Publication of WO2012134231A2 publication Critical patent/WO2012134231A2/ko
Publication of WO2012134231A9 publication Critical patent/WO2012134231A9/ko
Publication of WO2012134231A3 publication Critical patent/WO2012134231A3/ko
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    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 칸나비노이드 CB1 수용체의 역효능제 또는 길항제로서 작용하는 신규한 벤즈아미드 화합물 또는 이의 약학적으로 허용가능한 염에 관한 것으로, 본 발명에 따른 화합물은 비만 및 비만-관련 대사질환의 예방 또는 치료에 유용하게 사용될 수 있다. 또한, 본 발명은 상기 벤즈아미드 화합물을 제조하는 방법, 이를 함유하는 약학 조성물, 및 비만 및 비만관련 대사질환의 예방 또는 치료 방법을 제공한다.
PCT/KR2012/002405 2011-03-31 2012-03-30 카나비노이드 수용체（ｃｂ１） 길항제로서의 벤즈아미드 유도체 Ceased WO2012134231A2 (ko)

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KR10-2011-0029928 2011-03-31
KR1020110029928A KR101326557B1 (ko) 2011-03-31 2011-03-31 카나비노이드 수용체〔ｃｂｉ〕길항제로서의 벤즈아미드 유도체

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KR101447510B1 (ko) * 2013-02-07 2014-10-08 한국화학연구원 카나비노이드 수용체（ｃｂ１） 길항제로서의 헤테로고리 벤즈아미드 유도체
KR101432012B1 (ko) * 2013-02-19 2014-08-21 한국식품연구원 항비만용 조성물

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WO2006047516A2 (en) * 2004-10-26 2006-05-04 Irm Llc Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
WO2007058960A1 (en) * 2005-11-10 2007-05-24 Adolor Corporation Sulfamoyl benzamides as cannabinoid receptor modulators
WO2007096764A2 (en) * 2006-02-27 2007-08-30 Glenmark Pharmaceuticals S.A. Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
WO2008094476A1 (en) * 2007-01-31 2008-08-07 Merck & Co., Inc. Substituted pyrano [2, 3 - b] pyridine derivatives as cannabinoid -1 receptor modulators

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
WO2006047516A2 (en) * 2004-10-26 2006-05-04 Irm Llc Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
WO2007058960A1 (en) * 2005-11-10 2007-05-24 Adolor Corporation Sulfamoyl benzamides as cannabinoid receptor modulators
WO2007096764A2 (en) * 2006-02-27 2007-08-30 Glenmark Pharmaceuticals S.A. Bicyclic heteroaryl derivatives as cannabinoid receptor modulators
WO2008094476A1 (en) * 2007-01-31 2008-08-07 Merck & Co., Inc. Substituted pyrano [2, 3 - b] pyridine derivatives as cannabinoid -1 receptor modulators

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