WO2012167893A1 - Pulvérisateur de liquide - Google Patents

Pulvérisateur de liquide Download PDF

Info

Publication number
WO2012167893A1
WO2012167893A1 PCT/EP2012/002337 EP2012002337W WO2012167893A1 WO 2012167893 A1 WO2012167893 A1 WO 2012167893A1 EP 2012002337 W EP2012002337 W EP 2012002337W WO 2012167893 A1 WO2012167893 A1 WO 2012167893A1
Authority
WO
WIPO (PCT)
Prior art keywords
suction tube
container
metering
suction
spraying device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/002337
Other languages
German (de)
English (en)
Inventor
Jörn-Ole HANSEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
G Pohl Boskamp GmbH and Co KG
Original Assignee
G Pohl Boskamp GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G Pohl Boskamp GmbH and Co KG filed Critical G Pohl Boskamp GmbH and Co KG
Publication of WO2012167893A1 publication Critical patent/WO2012167893A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
    • B05B15/30—Dip tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
    • B05B11/1001—Piston pumps
    • B05B11/1023—Piston pumps having an outlet valve opened by deformation or displacement of the piston relative to its actuating stem
    • B05B11/1025—Piston pumps having an outlet valve opened by deformation or displacement of the piston relative to its actuating stem a spring urging the outlet valve in its closed position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

Definitions

  • the invention relates to a nebulizer for a liquid according to the preamble of claim 1.
  • the invention relates in particular to a nebulizer for a therapeutic
  • the container has the form of a small glass or plastic bottle, the opening of which is closed by a dosing and spraying device mounted on the neck of the bottle.
  • the metering and spraying device comprises an integrated piston pump, which allows sucking the suction stroke of the pump nitroglycerin solution from the container into a metering chamber and deliver a precisely metered amount of nitroglycerin solution in the discharge stroke, which displaced by the volume of the metering chamber
  • Nitroglycerin solution is set.
  • the nitroglycerin solution is aspirated through the flexible suction or riser and dispensed through a spray nozzle of the metering and spraying device in the form of an aerosol spray, which is directed for administration to the underside of the patient's tongue.
  • pocket sprayers of these type are produced in large quantities since pocket sprayers of this type are used not only for the acute treatment of angina pectoris but for many other uses, such as for administering other drugs or for spraying perfume. In particular, in the latter case, it is desirable to empty the container as completely as possible.
  • small glass or plastic bottles of Bottom of the bottle is often curved slightly convex upward, with the apex of the vault is located near the longitudinal central axis of the bottle, collects at largely deflated
  • the suction pipe of metering and spraying devices known atomizer often made of a flexible plastic, usually high density polyethylene (HDPE) and is supplied to the manufacturer of dosing and spraying equipment as a roll.
  • HDPE high density polyethylene
  • This roll product takes over a certain storage period to a curvature, which is still maintained after the separation and assembly of the suction pipes in the metering and spraying, so that the suction pipes have an inherent curvature.
  • the curvature causes the suction pipes after assembly of the metering and spraying on a container not just along the container central axis extend downwards, but are deflected to one side in the direction of the container wall.
  • suction pipes from the inner circumference of the roll goods usually have a smaller radius of curvature than suction pipes which are separated from the outer periphery of the roll goods.
  • the lower end of the suction tube will not or only slightly deflected away from the container longitudinal axis if the suction tube has a relatively large radius of curvature.
  • Curvature may occur for placing the lower end on a convexly upwardly curved container bottom, for example, when the metering and spraying not on the
  • Container neck unscrewed, but by latching or
  • Crimping is attached to the edge of the container opening, as is the case with some machines, which are used by the applicant in the manufacture of pocket atomizers for the acute treatment of angina pectoris.
  • the metering and spraying device is released after insertion of the suction tube into the container opening and falls down to the stop against the edge of the container opening down, where it usually tilts to one side to rest. If the lower end of the suction pipe is seated in this tilted state of the metering and spraying on the convexly upwardly curved container bottom, it may happen that it remains in this position and blocking the suction against the container bottom is pressed, as shown in Fig.
  • Acute treatment of diseases such as the aforementioned Taschenzerstäubern for the acute treatment of angina pectoris with a nitroglycerin solution, however, can already have a partial blockage of the intake serious consequences, since during the suction stroke an insufficient amount of nitroglycerin solution is sucked. Therefore, in these atomizers, even a partial blockage of the suction port must be precluded with a 100% certainty, i. she may even at 1
  • Suction tube guide extends, which bends and deflects the suction pipe to one side. Aside from being one
  • WO2005 / 113385 A2 discloses an atomizer in the form of a spray can with a suction tube immersed in the liquid, in which a pipe bend rotatably mounted within a container on a metering and spraying device bends the suction pipe depending on the orientation of the spray can so that it always immersed in the liquid.
  • the pipe bend is provided with a weight so that it rotates in dependence on the orientation of the spray can around its longitudinal central axis and deforms the intake pipe firmly connected to the metering and spraying by changing directions of force changing the bending direction.
  • the present invention seeks to improve a nebulizer of the type mentioned in that a placement of the lower end of the suction pipe can always be prevented with certainty on a convexly upwardly curved container bottom and thereby caused blocking a suction port of the suction pipe.
  • a "force in a constant direction” is understood to mean a force whose force application point and force direction on
  • Suction tube remains the same, so that the suction tube is exposed to a change in the orientation of the atomizer no changed bending forces or deformation forces.
  • the invention is based on the idea that by such a forced bending and deflection of the suction tube in a defined direction and by a defined amount for a lateral minimum distance between the longitudinal central axis of the container and the lower end of the suction tube can be taken care of placing the lower End of the suction tube on a convexly upwardly curved container bottom and thereby causing blockage of the suction in each position of the container impossible.
  • Invention is attached frictionally, so that it through
  • Sprayer is held, beyond such a deflector without any structural change to the metering and spraying or disassembly of parts of the metering and spraying after their preparation and before mounting on a container in a simple manner
  • the deflecting element acts on an upper half of the suction pipe facing the metering and spraying device, preferably close to the upper end of the suction pipe, whereby the extent of bending of the suction pipe can be reduced with a corresponding lateral deflection of the lower end.
  • a preferred embodiment of the invention provides that the deflecting deflects the suction tube by a predetermined minimum of the longitudinal center axis of the container and / or the metering and spraying away. This minimum can be for
  • Example may be defined as a deflection angle between the longitudinal center axis of the suction tube above the baffle and the longitudinal center axis of the suction tube below the baffle which should be at least 10 degrees, preferably at least 15 and most preferably about 20 degrees.
  • the predetermined minimum amount of deflection of the suction pipe away from the longitudinal central axis of the container and / or the metering and spraying device may also be referred to as a radial distance between the center of the suction opening at the lower end of
  • Suction tube and the longitudinal center axis of the container and / or the metering and spraying be defined.
  • This radial Spacing is desirably greater than 20%, preferably greater than 30% and most preferably greater than 40% of the inner diameter of the container.
  • the lower end of the suction tube is deflected far enough away from the center of a curved container bottom, so that it can no longer sit on the container bottom even with large manufacturing tolerances. To ensure that the lower end of the suction tube enters the container opening and does not abut against its boundary edge when it is during assembly of the dosing and
  • the deflection of the suction pipe should not exceed a predetermined maximum. If the maximum deflection is stated as the deflection angle, it should be expediently less than 30 degrees, and preferably less than 25 degrees. If the maximum deflection is stated as the radial distance between the center of the suction opening at the lower end of the suction pipe and the longitudinal central axis of the container and / or the metering and spraying device, this should not exceed 50% and preferably not more than 40% of the inner diameter the container opening through which the suction pipe is inserted into the container.
  • a further preferred embodiment of the invention provides that the deflecting element is a pushed onto the suction pipe curved or kinked pipe or hose piece, which is advantageously made by injection molding of plastic.
  • the pipe or hose piece is made of the same material as the suction pipe, preferably high density polyethylene (HDPE).
  • HDPE high density polyethylene
  • the pipe or hose piece is preferably not bent but bent, wherein it consists of two integrally connected rectilinear
  • sections so that they can be deducted in the direction of their respective longitudinal central axis of the associated mandrel.
  • the two sections are advantageously connected to each other along a flat buckling surface and expediently have approximately the same length.
  • the pipe or hose piece is preferably pushed with loose sliding or clearance fit on the suction tube, which expediently after pushing on the flexible elastic suction tube by the restoring forces or by the contact pressure of the outer circumference of the bent suction tube on both sides of the
  • a further advantageous embodiment of the invention provides that the pipe or hose piece is pushed from the free end of the suction pipe mounted on the metering and spraying device forth on the suction pipe and moved along the suction pipe upwards in the direction of the metering and spraying until it abuts against an end face of the metering and spraying device.
  • the atomizer according to the invention is with particular advantage as a pocket atomizer for the acute treatment of angina pectoris with a nitroglycerin solution of a Container in the form of a small glass or plastic bottle (vial) with a convexly upwardly curved bottom suitable.
  • Fig. 1 is a sectional view of an inventive
  • Taschenumstäubers with a suction tube and a tubular deflecting element for deflecting the suction tube;
  • Taschenzerstäubers with a sleeve-shaped deflector for deflecting the suction tube;
  • Fig. 7 is a bottom view of the deflector of Figs. 5 and 6;
  • Fig. 8 is a sectional view of a non-inventive
  • Pocket atomizers 10 are for nebulizing a therapeutic Fluid (not shown), which is a nitroglycerin solution for the acute treatment of angina
  • the pocket atomizers 10 consist essentially of a small bottle (vial) 12 made of glass or plastic, as well as a mounted on a neck 14 of the bottle 12 metering and spray head 16, which has a filling opening at the top of the
  • Bottle neck 14 closes liquid-tight.
  • the bottle 12 has a rotationally symmetrical, to a longitudinal central axis 18 of the bottle 12 and the metering and
  • Spray head 16 coaxial shape with a convex upwardly into the interior of the bottle 12 curved bottom 20, whose apex lies on the longitudinal central axis 18.
  • the metering and spraying head 16 essentially comprises a holder 22 which is sealingly but rotatably connected to the bottle neck 14 and made by injection molding of plastic, likewise an actuating member 24 which is produced by injection molding from plastic and provided with a spray nozzle 26, counter to the force of a spring 28 in the interior of the holder 22 displaceable piston 30, and a suction pipe 32 for sucking liquid from the bottle 12 into the metering and spray head sixteenth
  • the holder 22 has a downwardly projecting into the interior of the bottle 12 hollow tubular extension 34 which, like the rest of the holder 22 is coaxial with the longitudinal center axis 18 and tapers down to stepwise.
  • a middle part 36 of the extension 34 surrounds a metering chamber 38.
  • the metering chamber 38 contains a ball 40, which in the upright position of the atomizer 10 shown in FIG. 1 against a conically downwardly tapered valve seat 42 at the bottom End of the metering chamber 38 is applied and the metering chamber 38 closes there liquid-tight.
  • the extension 34 has a tubular cylindrical end portion 44.
  • the actuator 24 is rigid with the upper end of the
  • Piston 30 is connected so that it moves together with the actuator 24, but with respect to
  • Bracket 22 about the longitudinal central axis 18 rotatable.
  • Actuator 24 surrounds a downwardly open recess 46 into which the upper end of the piston 30 projects. Above the upper end of the piston 30, a plug 48 is slidably inserted into the recess 46, which is pressed by a helical compression spring 50 sealingly against the upper end of the piston 30. The plug 48 is surrounded by an annular gap 52, which is recessed by a recessed within the actuator 24 outlet channel 54 with the side of the actuator 24th
  • Spray nozzle 26 communicates.
  • the extended lower part of the piston 30 projects from above into the metering chamber 38, in which it is displaceable while sealing against the cylindrical peripheral wall of the metering chamber 38.
  • the arranged in the metering chamber 38 spring 28 is a helical compression spring, which is supported against the valve seat 42 and up against the piston 30 and the downward movement of the piston 30 during depression of the
  • Actuator 24 counteracts.
  • the downward movement of the piston 30 is limited by a stop surface 60 of the holder 22, against which the actuating member 24 abuts in the lower end position of the piston 30.
  • the piston 30 surrounds a central fluid channel 58 which passes through the piston 30 along the longitudinal central axis 18 over its entire length.
  • the high-density polyethylene suction pipe 32 is press-fitted into the tubular lower end portion 44 of the bracket 22 at its upper end and provided with a suction port 62 at its lower end.
  • the lower end of the suction tube 32 may be limited instead of a flat sectional surface of a concave curved sectional surface which curves down on both sides of a lying on the longitudinal central axis of the suction tube 32 apex.
  • the dosing and spray head 16 is provided after its manufacture and prior to its mounting on the bottle 12 with a deflector 64 to bend the suction tube 32 below the tubular lower end portion of the holder 22 and thereby deflecting by a defined amount to one side from the longitudinal central axis 18 of the bottle 12 and the metering and spraying head 16, as shown in Fig. 1 and 5.
  • the bent pipe piece 66 produced by injection molding of high-density polyethylene (HDPE) consists of two
  • the inner diameter of the two pipe sections 70, 72 is slightly larger than the outer diameter of the suction pipe 32, so that the lower end of the suction pipe 32 with play in the end portion 70 can be inserted.
  • the suction tube 32 passes the kinked plane 74, however, the suction tube 32 is slightly bent at this point and elastically deformed, whereby it on both sides of the kinking plane 74 due to a resulting from the deformation elastic restoring force with its outer periphery something against the inner circumference of Pipe piece 66 is pressed. This has the consequence that the completely pushed onto the suction pipe 32 pipe piece 66 is held by the frictional force between its inner periphery and the outer circumference of the suction pipe 32 thereon.
  • the two pipe sections 70, 72 each have a longitudinal central axis 76, 78 and a flat end face 80, 82 perpendicular to this longitudinal central axis 76, 78.
  • the kink plane 74 is related to each of the two pipe sections 70, 72
  • End faces 80, 82 at an angle of about 10 degrees
  • Pipe sections 70, 72 are inclined at an acute deflection angle of about 20 degrees to each other and, accordingly, the suction pipe 32 within the pipe section 66 by about 20 degrees from the
  • Bottle 12 is deflected away. By this deflection, the lower end of the suction tube 32 always has a certain minimum radial distance from the longitudinal central axis 18, the one Placement of the lower end of the suction tube 32 on the curved bottle bottom 20 prevents.
  • the deflector 64 shown in Figs. 5-7 is a hollow cylindrical sleeve 84 which is also made by high density polyethylene injection molding having an open top end and a partially closed bottom end provided with an eccentric circular aperture 86.
  • the open end is press-fitted onto the tubular lower end portion 44 of the extension 34 of the bracket 22, which receives the upper end of the suction tube 32.
  • the lower end of the suction tube 32 is passed through the eccentric opening 86.
  • the edge of the opening 86 externally exerts a lateral force on the suction tube 32, so that it is deflected in the direction of the offset of the opening 86, as shown in Fig. 5.
  • the degree of deflection corresponds to that in FIG. 1.
  • the operation of the nebulizer 10 is as follows: When the actuator 24 is depressed in the upright position of the nebulizer 10 shown in Figures 1 and 5 by a downward force and thereby the piston 30th
  • Liquid is immersed when the container 12 is brought into a slight tilt during the discharge of the liquid.
  • the actuator 24 is rotated with the spray nozzle 26 shown in FIG. 1 position in which the suction tube 32 relative to the longitudinal center axis 18 in a direction opposite to the spray nozzle 26 direction is distracted.
  • the actuator 24 is rotated with the spray nozzle 26 in a position in which the suction pipe 32 is deflected relative to the longitudinal center axis 18 in the same direction as the spray nozzle 26 when the spray nozzle 26 at the delivery of the
  • Liquid should be directed slightly downwards. As the actuator 24 and spray nozzle 26 rotate, the remainder of the metering and spray head 16, as well as the suction tube, remain stationary with respect to the container 12.

Landscapes

  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un pulvérisateur de liquide, en particulier un pulvérisateur de poche (10) pour le traitement en phase aigüe de l'angine de poitrine à l'aide d'une solution de nitroglycérine. Ledit pulvérisateur comprend un récipient (12) contenant le liquide et un dispositif de dosage et de pulvérisation (16) comprenant un tube d'aspiration (32) flexible immergé dans le liquide. L'invention vise à empêcher de manière sûre que l'extrémité inférieure du tube d'aspiration (32) ne se positionne sur le fond du récipient (20) et ne bloque ainsi un orifice d'aspiration (62) du tube d'aspiration (32), en particulier lorsque le récipient (12) présente un fond (20) courbé de manière convexe vers le haut. A cet effet, le pulvérisateur (10) comprend un élément de déviation (64) fixé au tube d'aspiration (32) ou à une autre partie du dispositif de dosage et de pulvérisation (16), qui, indépendamment de l'orientation respective du pulvérisateur (10), exerce une force sur le tube d'aspiration (32) dans une direction constante et tord ledit tube vers un côté.
PCT/EP2012/002337 2011-06-10 2012-06-01 Pulvérisateur de liquide Ceased WO2012167893A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011106138A DE102011106138A1 (de) 2011-06-10 2011-06-10 Zerstäuber für eine Flüssigkeit
DE102011106138.3 2011-06-10

Publications (1)

Publication Number Publication Date
WO2012167893A1 true WO2012167893A1 (fr) 2012-12-13

Family

ID=46207972

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/002337 Ceased WO2012167893A1 (fr) 2011-06-10 2012-06-01 Pulvérisateur de liquide

Country Status (2)

Country Link
DE (1) DE102011106138A1 (fr)
WO (1) WO2012167893A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108380256A (zh) * 2018-05-12 2018-08-10 吴群欣 一种石英吸管

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202015000670U1 (de) 2015-01-29 2016-02-01 Eberhard Frick Saugrohr für Dosier- oder Sprühvorrichtung
TWI719873B (zh) 2020-03-31 2021-02-21 競聯企業有限公司 高壓噴罐

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647119A (en) * 1970-05-26 1972-03-07 S C John & Son Inc Pressurized package
US4273272A (en) 1979-11-13 1981-06-16 William B. Anderson Liquid dispenser
US5464129A (en) * 1994-05-27 1995-11-07 Ho; Richard K. Pump spray bottle
US5611467A (en) * 1996-05-07 1997-03-18 Peng; Karl K. Invertible pressurized fluid dispenser with guided fluid inlet member
US5875940A (en) 1997-06-10 1999-03-02 Mayfield; Todd A Container with integral straw guide
WO2005113385A2 (fr) 2004-04-14 2005-12-01 Carlos Alberto Ruiz Flores Dispositif pour la decharge controlee de produits contenus sous pression

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004062711A2 (fr) * 2003-01-06 2004-07-29 Glaxo Group Limited Atomiseur nasal à pompe

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3647119A (en) * 1970-05-26 1972-03-07 S C John & Son Inc Pressurized package
US4273272A (en) 1979-11-13 1981-06-16 William B. Anderson Liquid dispenser
US5464129A (en) * 1994-05-27 1995-11-07 Ho; Richard K. Pump spray bottle
US5611467A (en) * 1996-05-07 1997-03-18 Peng; Karl K. Invertible pressurized fluid dispenser with guided fluid inlet member
US5875940A (en) 1997-06-10 1999-03-02 Mayfield; Todd A Container with integral straw guide
WO2005113385A2 (fr) 2004-04-14 2005-12-01 Carlos Alberto Ruiz Flores Dispositif pour la decharge controlee de produits contenus sous pression

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108380256A (zh) * 2018-05-12 2018-08-10 吴群欣 一种石英吸管

Also Published As

Publication number Publication date
DE102011106138A1 (de) 2012-12-13

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