WO2012172122A3 - Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal - Google Patents

Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal Download PDF

Info

Publication number
WO2012172122A3
WO2012172122A3 PCT/EP2012/070879 EP2012070879W WO2012172122A3 WO 2012172122 A3 WO2012172122 A3 WO 2012172122A3 EP 2012070879 W EP2012070879 W EP 2012070879W WO 2012172122 A3 WO2012172122 A3 WO 2012172122A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
dimethylphenyl
propanal
medetomidine
chloroacetone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2012/070879
Other languages
English (en)
Other versions
WO2012172122A2 (fr
Inventor
Florencio Zaragoza Doerwald
Anna KULESZA
Stephan Elzner
Robert BUJOK
Zbigniew WROBEL
Krzysztof Wojciechowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Priority to KR1020147029606A priority Critical patent/KR101537203B1/ko
Priority to ES12784615.2T priority patent/ES2565065T3/es
Priority to EA201400938A priority patent/EA024425B1/ru
Priority to PL12784615T priority patent/PL2867195T3/pl
Priority to SG11201405608QA priority patent/SG11201405608QA/en
Priority to HUE12784615A priority patent/HUE027383T2/en
Priority to NZ700643A priority patent/NZ700643B2/en
Priority to BR112014022268A priority patent/BR112014022268A8/pt
Priority to MYPI2014002562A priority patent/MY165118A/en
Priority to HRP20160250TT priority patent/HRP20160250T1/hr
Priority to JP2015510663A priority patent/JP5779298B2/ja
Priority to DK12784615.2T priority patent/DK2867195T3/en
Priority to EP12784615.2A priority patent/EP2867195B1/fr
Priority to PCT/EP2012/072799 priority patent/WO2013011158A2/fr
Priority to CA2866441A priority patent/CA2866441C/fr
Priority to US14/385,789 priority patent/US9126914B1/en
Priority to CN201280072221.9A priority patent/CN104220408B/zh
Priority to AU2012285678A priority patent/AU2012285678B2/en
Priority to HK15101494.2A priority patent/HK1200810B/xx
Priority to IN8121DEN2014 priority patent/IN2014DN08121A/en
Publication of WO2012172122A2 publication Critical patent/WO2012172122A2/fr
Publication of WO2012172122A3 publication Critical patent/WO2012172122A3/fr
Priority to TW102122677A priority patent/TWI535692B/zh
Priority to CL2014002906A priority patent/CL2014002906A1/es
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/58—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in three-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal à partir de 1-bromo 2,3-diméthylbenzène et de chloro-acétone, son utilisation en parfumerie et pour la préparation de médétodimine.
PCT/EP2012/070879 2012-06-28 2012-10-22 Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal Ceased WO2012172122A2 (fr)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DK12784615.2T DK2867195T3 (en) 2012-06-28 2012-11-15 PROCESS FOR THE PREPARATION OF 2- (2,3-dimethylphenyl) -1-propanal WITH chloroacetone
EP12784615.2A EP2867195B1 (fr) 2012-06-28 2012-11-15 Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal avec du chloro-acétone
EA201400938A EA024425B1 (ru) 2012-06-28 2012-11-15 Способ получения 2-(2,3-диметилфенил)-1-пропаналя с использованием хлорацетона
PL12784615T PL2867195T3 (pl) 2012-06-28 2012-11-15 Sposób wytwarzania 2-(2,3-dimetylofenylo)-1-propanalu przy pomocy chloroacetonu
SG11201405608QA SG11201405608QA (en) 2012-06-28 2012-11-15 Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
HUE12784615A HUE027383T2 (en) 2012-06-28 2012-11-15 Process for the preparation of 2- (2,3-dimethylphenyl) -1-propanal with chloroacetone
NZ700643A NZ700643B2 (en) 2012-06-28 2012-11-15 Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
BR112014022268A BR112014022268A8 (pt) 2012-06-28 2012-11-15 método para preparação de 2-(2,3-dimetilfenil)-1-propanal com cloroacetona
MYPI2014002562A MY165118A (en) 2012-06-28 2012-11-15 Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
HRP20160250TT HRP20160250T1 (hr) 2012-06-28 2012-11-15 Postupak za pripravu 2-(2,3-dimetilfenil)-1-propanala s kloracetonom
JP2015510663A JP5779298B2 (ja) 2012-06-28 2012-11-15 クロロアセトンを用いて２−（２，３−ジメチルフェニル）−１−プロパナールを調製するための方法
KR1020147029606A KR101537203B1 (ko) 2012-06-28 2012-11-15 2-(2,3-디메틸페닐)-1-프로파날의 클로로아세톤으로의 제조 방법
IN8121DEN2014 IN2014DN08121A (fr) 2012-06-28 2012-11-15
PCT/EP2012/072799 WO2013011158A2 (fr) 2012-06-28 2012-11-15 Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal avec du chloro-acétone
HK15101494.2A HK1200810B (en) 2012-06-28 2012-11-15 Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
US14/385,789 US9126914B1 (en) 2012-06-28 2012-11-15 Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
CN201280072221.9A CN104220408B (zh) 2012-06-28 2012-11-15 用氯丙酮制备2-(2,3-二甲基苯基)-1-丙醛的方法
AU2012285678A AU2012285678B2 (en) 2012-06-28 2012-11-15 Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone
CA2866441A CA2866441C (fr) 2012-06-28 2012-11-15 Procede de preparation de 2-(2,3-dimethylphenyl)-1-propanal avec du chloro-acetone
ES12784615.2T ES2565065T3 (es) 2012-06-28 2012-11-15 Método para la preparación de 2-(2,3-dimetilfenil)-1-propanal con cloroacetona
TW102122677A TWI535692B (zh) 2012-06-28 2013-06-26 藉氯丙酮製備２－（２,３－二甲基苯基）－１－丙醛之方法
CL2014002906A CL2014002906A1 (es) 2012-06-28 2014-10-27 Un metodo para la preparacion de 2-(2,3-dimetilfenil)-1-propanal a partir de 1-bromo-2,3-dimetilbenceno y cloroacetona, util en perfumes y en la preparacion de medetomidina.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261665528P 2012-06-28 2012-06-28
EP12174104.5 2012-06-28
EP12174104 2012-06-28
US61/665,528 2012-06-28
EP12189239 2012-10-19
EP12189239.2 2012-10-19

Publications (2)

Publication Number Publication Date
WO2012172122A2 WO2012172122A2 (fr) 2012-12-20
WO2012172122A3 true WO2012172122A3 (fr) 2013-05-10

Family

ID=47357539

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2012/070879 Ceased WO2012172122A2 (fr) 2012-06-28 2012-10-22 Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal

Country Status (1)

Country Link
WO (1) WO2012172122A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2557638T3 (es) * 2012-05-08 2016-01-27 Lonza Ltd Método para la preparación de 2-(2,3-dimetilfenil)-1-propanal
IN2014DN07983A (fr) * 2012-05-08 2015-05-01 Lonza Ag
JP5777841B2 (ja) * 2012-06-28 2015-09-09 ロンザ・リミテッド クロロアセトンを用いてメデトミジンを調製するための方法
IN2014DN08121A (fr) * 2012-06-28 2015-05-01 Lonza Ag
GB201308236D0 (en) 2013-05-08 2013-06-12 Givaudan Sa Improvements in or relating to organic compounds
WO2014205782A1 (fr) 2013-06-28 2014-12-31 Givaudan Sa Composés organiques
WO2016074698A1 (fr) 2014-11-10 2016-05-19 Givaudan Sa Perfectionnements apportés à des composés organiques ou en relation avec ces derniers
CN106518812A (zh) * 2016-10-25 2017-03-22 湖南大学 一种美托咪定及其中间体的制备方法
CN110550669A (zh) * 2018-05-30 2019-12-10 贵州水投水务集团锦屏有限公司 一种自来水处理剂及制作方法
EP4506340A1 (fr) 2022-03-22 2025-02-12 Obshestvo s Ogranichennoj Otvetstvennostju "Vikzdorove Zhivotnyh" Procédé de production de médétomidine et de ses dérivés

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51100042A (en) * 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100041A (en) * 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
EP0153692A2 (fr) * 1984-02-24 1985-09-04 Sagami Chemical Research Center Métode pour l'isomérisation d'un glycidate
US6313354B1 (en) * 1997-04-05 2001-11-06 Henkel Kommanditgesellschaft Auf Aktien Method for producing aromatic aldehydes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE513474C2 (sv) 1999-01-25 2000-09-18 Hans Elwing Instutionen Foer C Metod för att förhindra kräftdjurs, särskilt havstulpaners, etablering på fasta ytor med hjälp av en substans som stör nervsignaler, varvid substansen är medetomidin, dvs (+)-4-/1- (2,3-dimetylfenyl)-etyl/-IH-imidazol
EP1918282A1 (fr) 2006-11-06 2008-05-07 "Joint Stock Company Grindeks" Procédé pour la préparation de medetomidine et ses sels

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51100042A (en) * 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
JPS51100041A (en) * 1975-02-26 1976-09-03 Kanebo Ltd 22 * 44 isobuchirufueniru * puropionsanno seizoho
EP0153692A2 (fr) * 1984-02-24 1985-09-04 Sagami Chemical Research Center Métode pour l'isomérisation d'un glycidate
US6313354B1 (en) * 1997-04-05 2001-11-06 Henkel Kommanditgesellschaft Auf Aktien Method for producing aromatic aldehydes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 197642, Derwent World Patents Index; AN 1976-78501X, XP002692703 *
DATABASE WPI Week 197642, Derwent World Patents Index; AN 1976-78502X, XP002692704 *
MUKHERJEE-MÜLLER, G. ET AL: "176. Säurekatalysierte Umlagerungen von 1,5.Dimethyl-6-methyliden-tricyclo[3.2.1.0 2,7]oct-3-en-8endo-olen", HELVETICA CHIMICA ACTA, vol. 60, no. 5, 31 December 1977 (1977-12-31), pages 1758 - 1780, XP002683671 *

Also Published As

Publication number Publication date
WO2012172122A2 (fr) 2012-12-20

Similar Documents

Publication Publication Date Title
WO2013011158A3 (fr) Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal avec du chloro-acétone
WO2012172122A3 (fr) Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal
WO2012172120A3 (fr) 2-(2,3-diméthylphényl)-1-propanal et son utilisation comme parfum
WO2013046060A9 (fr) Papier et procédés de fabrication du papier
HK1202549A1 (en) Donepezil pamoate, preparation method and its use
IL227963A0 (en) History History of cytotoxic benzodiazepines, preparations containing them and their uses
SMT201900118T1 (it) Lisato piastrinico, usi di esso e metodo per la sua preparazione
WO2014091167A3 (fr) Composes cyclopropylboroniques, leur procede de preparation et leur utilisation
WO2013011156A3 (fr) Procédé de préparation de 2-(2,3-diméthylphényl)-1-propanal
IN2014DN07984A (fr)
WO2013011155A3 (fr) Procédé de préparation de médétomidine
WO2012172119A3 (fr) Procédé de préparation de médétomidine
WO2013123046A3 (fr) Matériaux tampons de cathode et dispositifs et procédés associés
EP3199526A4 (fr) Intermédiaire utile dans la synthèse de la paroxétine, procédé de préparation de l'intermédiaire et utilisations associées
WO2014105777A8 (fr) Sel de dichlohydrate de cobicistat
EP2634182B8 (fr) Procédé de préparation de 1,3,5-trioxane
EP2634183B8 (fr) Procédé de préparation de 1,3,5-trioxane
GB201012359D0 (en) Invention 6.5.10
EP3164389A4 (fr) Composés intermédiaires de l'ibrutinib, procédés de préparation et utilisations de ceux-ci
UA111528C2 (uk) Спосіб одержання 2-(2,3-диметилфеніл)-1-пропаналю з використанням хлорацетону
WO2013095994A3 (fr) Micro-émulsions de parfum aqueuses transparentes
PH12014500565A1 (en) Cycloalkane aldehydes, method for preparing same, and use thereof in the perfume industry
IL212235A (en) Component of inspiration
EP2576910A4 (fr) Procédé, élément et forme
GB201015621D0 (en) Invention 30.08.10

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12773346

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12773346

Country of ref document: EP

Kind code of ref document: A2