Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
  • A61K36/282—Artemisia, e.g. wormwood or sagebrush
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/185—Magnoliopsida (dicotyledons)
  • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
  • A61K36/534—Mentha (mint)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
  • A61K36/18—Magnoliophyta (angiosperms)
  • A61K36/88—Liliopsida (monocotyledons)
  • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Definitions

• This invention relates to the design and development of improved traditional phytomedicine based on five medicinal plants from South-East Morocco, selected from ethnopharmacological surveys.
• anti-inflammatory steroids also called AIS
• NSAIDs nonsteroidal anti-inflammatory drugs
• AIS are derivatives of natural corticosteroid hormones manufactured by the
• corticosteroids have an anti-oedematous action, and most importantly, a general anti-inflammatory action by preventing the release from the vessels of cells responsible for triggering inflammation and to reduce the influx. They are very powerful, widely used in stomatology, ENT and rheumatology. They have the disadvantages of corticosteroids (aggressiveness vis-à-vis the stomach, thinning
• the present invention relates to the field of health and particularly to that of the improved traditional phthalomedicine or dietary supplement. This invention brings an originality to the existing in terms of inflammation by the development of a phthtomedicine with a non-steroidal anti-inflammatory profile 100% natural.
• Herbal medicine offers many plants with anti-inflammatory properties, whose safety is recognized for the most part, and to use in their natural state in the form of infusion or decoction for some. For others, laboratories offer them in different forms: powder, extracts, mother tinctures (Cassis, Queen of the Near, Willow, Turmeric ).
• Rosmarinus officinalis is known as an antioxidant and hepatoprotective in rats [3].
• the hydroalcoholic extract of this species has an anti-ulcerogenic capacity by decreasing the index of indomethacin-induced ulcer [4].
• Other studies have shown that the methanolic extract of R. officinalis is known for its antioxidant and antibacterial effect [6].
• the essential oil of the species Artemisia herba-alba has been studied phytochemically and biologically. It has been shown that the essential oil of white wormwood is endowed with a set of activities such as anti-oxidant, anti-venous, antifungal, anti-bacterial, anti-spasmodic and hypoglycemic activities [7].
• the essential oil of Mentha pulegium has also been studied phytochemically, and 28 chemical compounds have been identified by GC-FID and GC-MS [8].
• the essential oil of Mentha suaveolens has also been shown to be more than 50% inhibitory of acetylcholinesterase [9]. - Detailed description of the invention
• This syrup is the result of a synergy of effects of five plant species (Rosmarinus officinalis L., Phoenix dactylifera L., Artemisict herba-alba Asso, Menthq pulegium L. and Mentha suaveolens Ehrh.), Selected for their inflammatory diseases in the traditional therapeutic arsenal of the Rissani-Errachidia area (South-East Morocco).
• the five species were harvested in October 2010 in the region of Rissani-ER-Rachidia, identified and herborized at the herbarium of the National Institute of Medicinal and Aromatic Plants (INPMA) of Taounate: exsiccata No. INP216 ( R. officinalis), ⁇ 215 (P. dactylifera), ⁇ ⁇ 218 (A. herba-alba), ⁇ 221 (M. pulegium) and ⁇ 220 (M. suaveolens).
• INP216 R. officinalis
• ⁇ 215 P. dactylifera
• ⁇ ⁇ 218 A. herba-alba
• ⁇ 221 M. pulegium
• ⁇ 220 M. suaveolens
• Example 2 Aqueous extraction of the five species The five plants were dried and crushed. They were macerated in equal parts in distilled water for 3 hours with continuous stirring. Then, the macerate was filtered with Whatman No. 1 filter paper. The resulting filtrate was rotavaporized (B ⁇ CHI Rotavapor R-205), and a dry residue was recovered with a yield of 31.92%.
• Flavonoids cyanidine reaction
• tannins ferrric chloride test
• coumarins ammonia test
• anthraquinones and anfhocyanates potassium hydroxide test
• saponins fluorescence index
• steroidal sapogenins sulfuric acid test
• cardiac glycosides sulfuric acid test
• free quinones sodium hydroxide test
• Mucilages absolute alcohol test
• oses and holosides test with sulfuric acid and thymol
• Macerate contains a number of chemical families such as flavonoids, tannins, mucilages, anthraquinones, coumarins, oses and holosides, generally known by their anti-inflammatory effect (Table 1).
• Example 4 Spectrophotometric determination of flavonoids compounds known by their anti-inflammatory power
• the level of flavonoids was evaluated by spectrophotometry by measuring the absorbance of quercetin in the macerate of the plants studied. The more this species is rich in flavonoids, the higher the optical density of the macerate is important.
• the spectrophotometer is previously calibrated on the absorption wavelength of quercetin (430 nm).
• the syrup made from the plant macerate is rich in flavonoids (16.934 mg quercetin equivalent / g dry extract) ( Figure 1).
• the procedure for evaluating the tannin content consists in carrying out macerations at 10%, repeated 3 times in acetone at 70%; then the macerates were filtered and evaporated under pressure (B ⁇ CHI Rotavapor R-205). Finally, the dry residue is recovered with a yield of 21.68%.
• mice were randomized into control groups and treated and divided into 5 groups of 1 to 9 animals each.
• Group 1 animals were administered with normal saline (0.9% NaCl).
• Groups 2, 3 and 4 animals were administered with the aqueous macerate of the five species studied at doses of 200, 1000 and 5000 mg / kg, bw Animals in group 5 were administered with indomethacin at a dose of 10 mg / kg, pc All treatments were administered orally between 13:00 120 until 14:00 h.
• the macerate administered orally at different doses (0.2, 1 and 5 g / kg, p.c.) has a significant anti-inflammatory / anti-edematous effect (Table 2).
• n 9, *: p ⁇ 0.05 at 6 o'clock.
• Treaty 1 1 11.33 ⁇ 16.16 38.69 ⁇ 0.51 12.43 ⁇ 0.22 3.40 ⁇ 0.01 3.02 ⁇ 0.03

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• Health & Medical Sciences (AREA)
• Natural Medicines & Medicinal Plants (AREA)
• Life Sciences & Earth Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Veterinary Medicine (AREA)
• Public Health (AREA)
• Medicinal Chemistry (AREA)
• Animal Behavior & Ethology (AREA)
• Chemical & Material Sciences (AREA)
• Pharmacology & Pharmacy (AREA)
• Mycology (AREA)
• Medical Informatics (AREA)
• Epidemiology (AREA)
• Microbiology (AREA)
• Engineering & Computer Science (AREA)
• Alternative & Traditional Medicine (AREA)
• Biotechnology (AREA)
• Botany (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Pain & Pain Management (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Rheumatology (AREA)
• Medicines Containing Plant Substances (AREA)
• Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

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Cited By (2)

• 2011
  • 2011-07-15 MA MA34033A patent/MA33970B1/ar unknown
• 2012
  • 2012-06-26 WO PCT/MA2012/000012 patent/WO2013012302A2/fr not_active Ceased

Non-Patent Citations (3)

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