WO2013115897A3 - Détection de pathogènes utilisant une fluorescence augmentée par le métal - Google Patents

Détection de pathogènes utilisant une fluorescence augmentée par le métal Download PDF

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Publication number
WO2013115897A3
WO2013115897A3 PCT/US2012/065655 US2012065655W WO2013115897A3 WO 2013115897 A3 WO2013115897 A3 WO 2013115897A3 US 2012065655 W US2012065655 W US 2012065655W WO 2013115897 A3 WO2013115897 A3 WO 2013115897A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligands
pathogen
peptide
silver particles
enhanced fluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2012/065655
Other languages
English (en)
Other versions
WO2013115897A2 (fr
WO2013115897A9 (fr
Inventor
Melanie TOMCZAK
David C. LIPTAK
Melinda A. OSTENDORF
Clint B. SMITH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UES Inc
Original Assignee
UES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UES Inc filed Critical UES Inc
Priority to EP12852456.8A priority Critical patent/EP2780709A2/fr
Publication of WO2013115897A2 publication Critical patent/WO2013115897A2/fr
Publication of WO2013115897A9 publication Critical patent/WO2013115897A9/fr
Publication of WO2013115897A3 publication Critical patent/WO2013115897A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

L'invention concerne des capteurs de pathogènes, des systèmes destinés à la détection de pathogènes, des ligands peptidiques et des procédés destinés à la détection de pathogènes. Les capteurs de pathogènes incluent des particules d'argent fixées à des substrats optiquement transparents, un peptide de capture ou des ligands de type glycane immobilisé(s), fixé(s) aux particules d'argent et un peptide ou des ligands de type glycane de marquage libre(s) comportant des fluorophores. La liaison des ligands de capture immobilisés et des ligands de marquage libres au pathogène positionne le fluorophore à une distance suffisante des particules d'argent pour initier la fluorescence augmentée par le métal.
PCT/US2012/065655 2011-11-16 2012-11-16 Détection de pathogènes utilisant une fluorescence augmentée par le métal Ceased WO2013115897A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP12852456.8A EP2780709A2 (fr) 2011-11-16 2012-11-16 Détection de pathogènes utilisant une fluorescence augmentée par le métal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161560501P 2011-11-16 2011-11-16
US61/560,501 2011-11-16

Publications (3)

Publication Number Publication Date
WO2013115897A2 WO2013115897A2 (fr) 2013-08-08
WO2013115897A9 WO2013115897A9 (fr) 2013-09-26
WO2013115897A3 true WO2013115897A3 (fr) 2013-11-28

Family

ID=48483182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/065655 Ceased WO2013115897A2 (fr) 2011-11-16 2012-11-16 Détection de pathogènes utilisant une fluorescence augmentée par le métal

Country Status (2)

Country Link
EP (1) EP2780709A2 (fr)
WO (1) WO2013115897A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106442479B (zh) * 2016-08-30 2019-10-22 华南师范大学 纸基双极性电极电化学发光分子开关系统用于快速灵敏基因检测致病菌的方法
GB202019024D0 (en) * 2020-12-02 2021-01-13 Paraytec Ltd Diagnostic testing
US20250215042A1 (en) * 2022-04-01 2025-07-03 Genevant Sciences Gmbh Mannose-targeted compositions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036419A1 (fr) * 1998-12-15 2000-06-22 Exiqon A/S Couplage de glucides derives du lipopolysaccharide a des surfaces solides
WO2007084141A2 (fr) * 2005-01-24 2007-07-26 Sri International Chelates de lanthanide stimules en surface
EP2248912A1 (fr) * 2002-11-26 2010-11-10 University of Maryland Biotechnology Dosage biologique grande sensibilité permettant de détecter des pathogènes par fluorescence ameliorée par métal
US20120238035A1 (en) * 2011-03-18 2012-09-20 Geddes Chris D Multicolor microwave-accelerated metal-enhanced fluorescence (m-mamef)

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000036419A1 (fr) * 1998-12-15 2000-06-22 Exiqon A/S Couplage de glucides derives du lipopolysaccharide a des surfaces solides
EP2248912A1 (fr) * 2002-11-26 2010-11-10 University of Maryland Biotechnology Dosage biologique grande sensibilité permettant de détecter des pathogènes par fluorescence ameliorée par métal
WO2007084141A2 (fr) * 2005-01-24 2007-07-26 Sri International Chelates de lanthanide stimules en surface
US20120238035A1 (en) * 2011-03-18 2012-09-20 Geddes Chris D Multicolor microwave-accelerated metal-enhanced fluorescence (m-mamef)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE Geneseq [online] 21 October 2004 (2004-10-21), "GW182 peptide 106 for epitope mapping.", XP002703971, retrieved from EBI accession no. GSP:ADQ81249 Database accession no. ADQ81249 *
DISNEY M D ET AL: "Detection of bacteria with carbohydrate-functionalized fluorescent polymers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ACS PUBLICATIONS, US, vol. 126, no. 41, 25 September 2004 (2004-09-25), pages 13343 - 13346, XP002366145, ISSN: 0002-7863, DOI: 10.1021/JA047936I *
DUANE M. HATCH ET AL: "Biotinylated Bi- and Tetra-antennary Glycoconjugates for Escherichia coli Detection", CHEMBIOCHEM, vol. 9, no. 15, 13 October 2008 (2008-10-13), pages 2433 - 2442, XP055081635, ISSN: 1439-4227, DOI: 10.1002/cbic.200800188 *

Also Published As

Publication number Publication date
WO2013115897A2 (fr) 2013-08-08
WO2013115897A9 (fr) 2013-09-26
EP2780709A2 (fr) 2014-09-24

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