WO2013127782A3 - Verwendung von micrornas oder genen als marker zur identifizierung, diagnose und therapie einzelner formen nicht-ischämischer kardiomyopathien oder speichererkrankungen des herzens - Google Patents

Verwendung von micrornas oder genen als marker zur identifizierung, diagnose und therapie einzelner formen nicht-ischämischer kardiomyopathien oder speichererkrankungen des herzens Download PDF

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WO2013127782A3
WO2013127782A3 PCT/EP2013/053800 EP2013053800W WO2013127782A3 WO 2013127782 A3 WO2013127782 A3 WO 2013127782A3 EP 2013053800 W EP2013053800 W EP 2013053800W WO 2013127782 A3 WO2013127782 A3 WO 2013127782A3
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genes
heart
storage diseases
individual forms
markers
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French (fr)
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WO2013127782A2 (de
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Uwe Kühl
Heinz-Peter Schultheiss
Dirk Lassner
Maria ROHDE
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IKDT INSTITUT KARDIALE DIAGNOSTIK und THERAPIE GmbH
Charite Universitaetsmedizin Berlin
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IKDT INSTITUT KARDIALE DIAGNOSTIK und THERAPIE GmbH
Charite Universitaetsmedizin Berlin
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Priority to EP13712154.7A priority patent/EP2820131A2/de
Publication of WO2013127782A2 publication Critical patent/WO2013127782A2/de
Publication of WO2013127782A3 publication Critical patent/WO2013127782A3/de
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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Abstract

Die Erfindung betrifft die Verwendung bestimmter microRNAs und/oder Gene sowohl einzeln als auch in Kombination mehrerer in Form von Profilen als Marker zur Identifizierung einzelner Formen nicht-ischämischer Kardiomyopathien oder Speichererkrankungen des Herzens, und deren Verwendung in diagnostischen Systemen zur Identifizierung einzelner Formen nicht-ischämischer Kardiomyopathien oder Speichererkrankungen des Herzens, das zumindest einen Teil dieser microRNAs und/oder Gene aufweist. Die Erfindung betrifft ferner ein Verfahren zur Identifizierung und Unterscheidung einzelner Formen nicht-ischämischer Kardiomyopathien oder Speichererkrankungen des Herzens unter Verwendung zumindest einzelner dieser microRNAs und/oder Gene. Die Erfindung betrifft außerdem ein Medikament, das mindestens eine Nukleinsäure enthält, die eine Sequenz aufweist, die identisch oder komplementär zu der Sequenz einer dieser microRNAs ist.
PCT/EP2013/053800 2012-02-27 2013-02-26 Verwendung von micrornas oder genen als marker zur identifizierung, diagnose und therapie einzelner formen nicht-ischämischer kardiomyopathien oder speichererkrankungen des herzens Ceased WO2013127782A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE112013001154.9T DE112013001154A5 (de) 2012-02-27 2013-02-26 Verwendung von microRNAs oder Genen als Marker zur Identifizierung, Diagnose und Therapie einzelner Formen nicht-ischämischer Kardiomyopathien oder Speichererkrankungen des Herzens
EP13712154.7A EP2820131A2 (de) 2012-02-27 2013-02-26 Verwendung von micrornas oder genen als marker zur identifizierung, diagnose und therapie einzelner formen nicht-ischämischer kardiomyopathien oder speichererkrankungen des herzens

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012101557A DE102012101557A1 (de) 2012-02-27 2012-02-27 Verwendung von microRNAs oder Genen als Marker zur Identifizierung, Diagnose und Therapie einzelner nicht-ischämischer Kardiomyopathien oder Speichererkrankungen des Herzens
DE102012101557.0 2012-02-27

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WO2013127782A2 WO2013127782A2 (de) 2013-09-06
WO2013127782A3 true WO2013127782A3 (de) 2013-11-21

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PCT/EP2013/053800 Ceased WO2013127782A2 (de) 2012-02-27 2013-02-26 Verwendung von micrornas oder genen als marker zur identifizierung, diagnose und therapie einzelner formen nicht-ischämischer kardiomyopathien oder speichererkrankungen des herzens

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EP (1) EP2820131A2 (de)
DE (2) DE102012101557A1 (de)
WO (1) WO2013127782A2 (de)

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CN104450698A (zh) * 2014-12-11 2015-03-25 中国计量学院 一种蜘蛛线粒体nd4基因全序列扩增引物及鉴定方法
WO2016133395A1 (en) 2015-02-20 2016-08-25 Rijksuniversiteit Groningen Circulating micrornas in patients with acute heart failure
EP4417706A3 (de) * 2015-05-08 2025-02-12 Agency For Science, Technology And Research Verfahren zur diagnose und prognose von chronischer herzinsuffizienz
DE102015216521B3 (de) * 2015-08-28 2017-01-26 Ikdt Institut Kardiale Diagnostik Und Therapie Gmbh Verwendung spezifischer Gene zur diagnostischen Abgrenzung einer eosinophilen Myokarditis von anderen fulminanten entzündlichen Herzmuskelerkrankungen
DE102015216782B3 (de) * 2015-09-02 2017-01-26 Ikdt Institut Kardiale Diagnostik Und Therapie Gmbh Verwendung von im Blutserum oder Blutplasma zirkulierenden microRNAs zur Identifikation biopsiepflichtiger Patienten und als Marker zur Differentialdiagnose einzelner nicht-ischämischer Kardiomyopathien oder Speichererkrankungen des Herzens
WO2017076974A1 (en) * 2015-11-05 2017-05-11 Academisch Medisch Centrum Biomarker for risk stratification in cardiovascular disease
EP3375458A1 (de) * 2017-03-14 2018-09-19 I.C.G.E.B. International Centre for Genetic Engineering and Biotechnology Microrna-hsa-mir-665 für herzhypertrophie
US11225660B2 (en) 2017-10-12 2022-01-18 Emory University Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors
CN108611421B (zh) * 2018-05-15 2021-07-27 唐山市人民医院 检测食管鳞癌标记物microRNA-10b-3p及在试剂盒中的应用
CN112638475B (zh) * 2018-06-28 2024-12-06 英国研究与创新基金会 用于治疗心脏病的microRNA靶向剂
JP2022510488A (ja) * 2018-12-10 2022-01-26 セラ プログノスティックス， インコーポレイテッド 胎盤機能不全のための核酸バイオマーカー
EP3674420A1 (de) * 2018-12-28 2020-07-01 Fundación Para la Investigación del Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana Verfahren zur vorhersage des kardiotoxizitätsrisikos bei krebspatienten, die eine chemotherapeutische mit anthracyclinen erhalten
CN111154870B (zh) * 2019-08-05 2023-06-23 江苏省肿瘤医院 一种鼻咽癌转移诊断和/或预后评估的生物标记
EP4206334A4 (de) * 2020-08-28 2025-01-01 Industry Academic Cooperation Foundation Keimyung University Mikro-rna-biomarker zur vorhersage der arzneimittelreaktion auf antidiabetika und verwendung davon
CN112961912A (zh) * 2020-12-31 2021-06-15 郑州大学第一附属医院 外泌体miRNA作为诊断冠心病的分子标志物及其应用
CN112813158B (zh) * 2021-03-11 2022-12-13 石家庄市人民医院 心肌纤维化疾病辅助诊断相关的miRNA标志物及其应用
CN113846098B (zh) * 2021-09-18 2024-06-25 中国医学科学院基础医学研究所 一种小rna及其在心血管疾病治疗中的用途
CN114081895B (zh) * 2021-11-18 2023-08-04 佳木斯大学 一种用于治疗糖尿病性视网膜病变的miRNA及其应用
CN115418397B (zh) * 2022-04-19 2023-09-19 刘琳 一种用于扩张型心肌病辅助诊断的生物标志物及其应用
CN119082291A (zh) * 2024-09-24 2024-12-06 中国人民解放军总医院第二医学中心 用于诊断评估心肌衰老的miRNA标志物、试剂盒及其应用

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See also references of EP2820131A2 *

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WO2013127782A2 (de) 2013-09-06
DE112013001154A5 (de) 2014-12-11
DE102012101557A1 (de) 2013-08-29
EP2820131A2 (de) 2015-01-07

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