WO2013174752A3 - System aus inhalator und kapsel - Google Patents

System aus inhalator und kapsel Download PDF

Info

Publication number
WO2013174752A3
WO2013174752A3 PCT/EP2013/060272 EP2013060272W WO2013174752A3 WO 2013174752 A3 WO2013174752 A3 WO 2013174752A3 EP 2013060272 W EP2013060272 W EP 2013060272W WO 2013174752 A3 WO2013174752 A3 WO 2013174752A3
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
hole
inhaler
state
exposed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2013/060272
Other languages
English (en)
French (fr)
Other versions
WO2013174752A2 (de
Inventor
Holger Holakovsky
Jessica Frentzel-Beyme
Stephen Terence Dunne
Jens Besseler
Claudius Weiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/059324 external-priority patent/WO2012163704A2/de
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to EP13724241.8A priority Critical patent/EP2852423B1/de
Priority to US14/402,507 priority patent/US10500355B2/en
Priority to JP2015513120A priority patent/JP6365848B2/ja
Priority to PL13724241T priority patent/PL2852423T3/pl
Priority to DK13724241.8T priority patent/DK2852423T3/en
Priority to ES13724241.8T priority patent/ES2683972T3/es
Publication of WO2013174752A2 publication Critical patent/WO2013174752A2/de
Publication of WO2013174752A3 publication Critical patent/WO2013174752A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/26—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts
    • B65D47/28—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts having linear movement
    • B65D47/283—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts having linear movement between tubular parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

System aus einem Inhalator und einer Kapsel (71). Die Kapsel beinhaltet eine vorzugsweise pulverförmige, pharmazeutische Zubereitung, die im Inhalator über mindestens ein Loch (72) aus der Kapsel (71) zur Inhalation austritt. Die Kapsel weist als Kapselelemente eine Kapselkappe (1) und einen Kapselkörper (2) auf, von denen mindestens eins mindestens ein vorgefertigtes Loch aufweist. Das vorgefertigte Loch in der Kapsel ist im Transportzustand des Systems abgedichtet und liegt im Anwendungszustand offen vor. Durch die Betätigung eines Zugmechanismus wird das Loch freigegeben. Zuvor ist das Loch durch eine Kapselaufnahme oder eine Folie verschlossen. In einer Ausführungsform kann die Kapsel in zwei verschiedenen Zuständen z.B. in verschiedenen Einsteckstellungen der Kapselelemente, vorliegen. Im ersten Zustand ist das vorgefertigte Loch geschlossen, im zweiten liegt es frei. Des Weiteren wird ein als Einwegprodukt geeigneter Inhalator gezeigt, der aus Tiefziehteilen bzw. aus Blisterfolie gefertigt wird.
PCT/EP2013/060272 2011-05-27 2013-05-17 System aus inhalator und kapsel Ceased WO2013174752A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP13724241.8A EP2852423B1 (de) 2012-05-21 2013-05-17 System aus inhalator und kapsel
US14/402,507 US10500355B2 (en) 2011-05-27 2013-05-17 System composed of inhaler and capsule
JP2015513120A JP6365848B2 (ja) 2012-05-21 2013-05-17 吸入器及びカプセルで構成されたシステム
PL13724241T PL2852423T3 (pl) 2012-05-21 2013-05-17 System z inhalatora i kapsułki
DK13724241.8T DK2852423T3 (en) 2012-05-21 2013-05-17 System of inhaler and capsule
ES13724241.8T ES2683972T3 (es) 2011-05-27 2013-05-17 Sistema compuesto de inhalador y cápsula

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP2012/059324 2012-05-21
PCT/EP2012/059324 WO2012163704A2 (de) 2011-05-27 2012-05-21 Inhalator und kapsel für einen inhalator

Publications (2)

Publication Number Publication Date
WO2013174752A2 WO2013174752A2 (de) 2013-11-28
WO2013174752A3 true WO2013174752A3 (de) 2014-03-20

Family

ID=48470962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/060272 Ceased WO2013174752A2 (de) 2011-05-27 2013-05-17 System aus inhalator und kapsel

Country Status (1)

Country Link
WO (1) WO2013174752A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109330023A (zh) * 2018-11-26 2019-02-15 楚天飞云制药装备（长沙）有限公司 一种过滤胶囊加工方法及设备
RU2748203C1 (ru) * 2021-01-12 2021-05-20 федеральное государственное бюджетное учреждение "Государственный научно-исследовательский испытательный институт военной медицины" Министерства обороны Российской Федерации (ФГБУ "ГНИИИ ВМ" МО РФ) Ингалятор

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1215560A (fr) * 1957-02-18 1960-04-19 Boîte poudreuse notamment pour poudres pharmaceutiques
FR2032436A2 (de) * 1969-02-27 1970-11-27 Finanz Kompensations Anst
US4076848A (en) * 1976-03-18 1978-02-28 Limur Eleanor De Encapsulated pulverized dehydrated fruit and vegetable product
WO2001072605A1 (en) * 2000-03-27 2001-10-04 Dura Pharmaceuticals, Inc. Containers for individual doses of an inhalable pharmaceutical
US20040131668A1 (en) * 1998-08-05 2004-07-08 Boehringer Ingelheim Pharma Kg Two-part capsule to accept pharmaceutical preparations for powder inhalers
US20040173211A1 (en) * 2003-01-14 2004-09-09 Boehringer Ingelheim International Gmbh Powder inhaler
DE102004040928A1 (de) * 2004-08-24 2006-03-02 Georg Menshen Gmbh & Co. Kg Verschluss für einen Behälter
US20090194105A1 (en) * 2006-04-13 2009-08-06 Jens Besseler Inhaler

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5896855A (en) 1992-12-24 1999-04-27 Rhone-Poulenc Rorer Limited Multi dose inhaler apparatus
DE10258360A1 (de) 2002-12-12 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Kapselkammer zum Aufnehmen einer mit Wirkstoff gefüllten Einwegkapsel
DE10300982A1 (de) 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
ES2310722T3 (es) 2003-03-20 2009-01-16 Galephar M/F Sistema inhalador de polvo seco mejorado.
DE102005001332A1 (de) 2005-01-11 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1215560A (fr) * 1957-02-18 1960-04-19 Boîte poudreuse notamment pour poudres pharmaceutiques
FR2032436A2 (de) * 1969-02-27 1970-11-27 Finanz Kompensations Anst
US4076848A (en) * 1976-03-18 1978-02-28 Limur Eleanor De Encapsulated pulverized dehydrated fruit and vegetable product
US20040131668A1 (en) * 1998-08-05 2004-07-08 Boehringer Ingelheim Pharma Kg Two-part capsule to accept pharmaceutical preparations for powder inhalers
WO2001072605A1 (en) * 2000-03-27 2001-10-04 Dura Pharmaceuticals, Inc. Containers for individual doses of an inhalable pharmaceutical
US20040173211A1 (en) * 2003-01-14 2004-09-09 Boehringer Ingelheim International Gmbh Powder inhaler
DE102004040928A1 (de) * 2004-08-24 2006-03-02 Georg Menshen Gmbh & Co. Kg Verschluss für einen Behälter
US20090194105A1 (en) * 2006-04-13 2009-08-06 Jens Besseler Inhaler

Also Published As

Publication number Publication date
WO2013174752A2 (de) 2013-11-28

Similar Documents

Publication Publication Date Title
WO2009055030A3 (en) Powder conditioning of unit dose drug packages
WO2009008001A3 (en) Inhalation device
BRPI0711985A2 (pt) Dispositivo inalador para a inalação de um medicamento a partir de uma cápsula perfurável
IN2014DN10634A (de)
WO2011161226A3 (en) Novel antibody formulation
HK1197203A1 (en) Low temperature electronic vaporization device and methods
NO20073193L (no) Todelt kapsel omfattende en preliminaer lukning for a romme legemidler for pulverinhalatorer
EA201100487A1 (ru) Ингаляторное устройство и способ раздачи лекарственного средства
WO2007012628A3 (de) Arzneimittelblister
WO2007084587A3 (en) Film lined pouch and method of manufacturing this pouch
AU2010303040A8 (en) Improvements to pressurised metered dose inhalers
WO2014167348A3 (en) Training device
IN2015DN03811A (de)
WO2010127205A3 (en) Fixed dose drug combination formulations
BR112014016985A8 (pt) método de fabricação de corpo de bolsa
NZ708449A (en) Devices and methods for puncturing a capsule to release a powdered medicament therefrom
WO2012047182A3 (en) Single dose dry powder inhalation device
IN2014MN02588A (de)
WO2013104892A8 (en) Application of high dose compounds via inhalation
WO2010039200A3 (en) Dry powder inhalers with endless strips and cooperating piercers and related methods
MX2010005036A (es) Formulaciones de polvo seco que comprenden derivados del acido ascorbico.
MX2007013878A (es) Capsulas para inhaladores.
TR200907917A2 (tr) Kuru toz inhaleri.
BR112013015750A2 (pt) embalagem de saco altamente inerte com segurança para crianças para filmes contendo dose única de princípio ativo.
WO2013174752A3 (de) System aus inhalator und kapsel

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13724241

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2015513120

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 14402507

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2013724241

Country of ref document: EP