WO2013174752A3 - Système composé d'un inhalateur et d'une capsule - Google Patents

Système composé d'un inhalateur et d'une capsule Download PDF

Info

Publication number
WO2013174752A3
WO2013174752A3 PCT/EP2013/060272 EP2013060272W WO2013174752A3 WO 2013174752 A3 WO2013174752 A3 WO 2013174752A3 EP 2013060272 W EP2013060272 W EP 2013060272W WO 2013174752 A3 WO2013174752 A3 WO 2013174752A3
Authority
WO
WIPO (PCT)
Prior art keywords
capsule
hole
inhaler
state
exposed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2013/060272
Other languages
German (de)
English (en)
Other versions
WO2013174752A2 (fr
Inventor
Holger Holakovsky
Jessica Frentzel-Beyme
Stephen Terence Dunne
Jens Besseler
Claudius Weiler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2012/059324 external-priority patent/WO2012163704A2/fr
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to EP13724241.8A priority Critical patent/EP2852423B1/fr
Priority to US14/402,507 priority patent/US10500355B2/en
Priority to JP2015513120A priority patent/JP6365848B2/ja
Priority to PL13724241T priority patent/PL2852423T3/pl
Priority to DK13724241.8T priority patent/DK2852423T3/en
Priority to ES13724241.8T priority patent/ES2683972T3/es
Publication of WO2013174752A2 publication Critical patent/WO2013174752A2/fr
Publication of WO2013174752A3 publication Critical patent/WO2013174752A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0043—Non-destructive separation of the package, e.g. peeling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/26—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts
    • B65D47/28—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts having linear movement
    • B65D47/283—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge with slide valves, i.e. valves that open and close a passageway by sliding over a port, e.g. formed with slidable spouts having linear movement between tubular parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un système composé d'un inhalateur et d'une capsule, prévu de préférence pour un usage unique. La capsule contient une préparation pharmaceutique de préférence sous forme de poudre, qui sort de la capsule dans l'inhalateur par au moins un orifice pour être inhalée. Le éléments composant la capsule comprennent un capuchon de capsule et un corps de capsule, dont l'un au moins comporte au moins un orifice préformé. L'orifice préformé de la capsule est fermé de manière étanche lorsque le système est dans un état de transport et est ouvert lorsque le système est dans un état de service. L'orifice est libéré par l'actionnement d'un mécanisme de traction. Avant cela, l'orifice est fermé par un logement de capsule ou par un film. Dans une forme de réalisation, la capsule peut présenter deux états différents, p. ex. dans différentes positions d'insertion des éléments de la capsule. Dans le premier état, l'orifice préformé est fermé, et dans le second état il est ouvert. L'invention concerne également un inhalateur approprié comme produit à usage unique, réalisé à partir d'éléments thermoformés ou d'une feuille à emballage coque.
PCT/EP2013/060272 2011-05-27 2013-05-17 Système composé d'un inhalateur et d'une capsule Ceased WO2013174752A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP13724241.8A EP2852423B1 (fr) 2012-05-21 2013-05-17 Inhalateur et capsule pour inhalateur
US14/402,507 US10500355B2 (en) 2011-05-27 2013-05-17 System composed of inhaler and capsule
JP2015513120A JP6365848B2 (ja) 2012-05-21 2013-05-17 吸入器及びカプセルで構成されたシステム
PL13724241T PL2852423T3 (pl) 2012-05-21 2013-05-17 System z inhalatora i kapsułki
DK13724241.8T DK2852423T3 (en) 2012-05-21 2013-05-17 System of inhaler and capsule
ES13724241.8T ES2683972T3 (es) 2011-05-27 2013-05-17 Sistema compuesto de inhalador y cápsula

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP2012/059324 2012-05-21
PCT/EP2012/059324 WO2012163704A2 (fr) 2011-05-27 2012-05-21 Inhalateur et capsule conçue pour un inhalateur

Publications (2)

Publication Number Publication Date
WO2013174752A2 WO2013174752A2 (fr) 2013-11-28
WO2013174752A3 true WO2013174752A3 (fr) 2014-03-20

Family

ID=48470962

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/060272 Ceased WO2013174752A2 (fr) 2011-05-27 2013-05-17 Système composé d'un inhalateur et d'une capsule

Country Status (1)

Country Link
WO (1) WO2013174752A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109330023A (zh) * 2018-11-26 2019-02-15 楚天飞云制药装备（长沙）有限公司 一种过滤胶囊加工方法及设备
RU2748203C1 (ru) * 2021-01-12 2021-05-20 федеральное государственное бюджетное учреждение "Государственный научно-исследовательский испытательный институт военной медицины" Министерства обороны Российской Федерации (ФГБУ "ГНИИИ ВМ" МО РФ) Ингалятор

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1215560A (fr) * 1957-02-18 1960-04-19 Boîte poudreuse notamment pour poudres pharmaceutiques
FR2032436A2 (fr) * 1969-02-27 1970-11-27 Finanz Kompensations Anst
US4076848A (en) * 1976-03-18 1978-02-28 Limur Eleanor De Encapsulated pulverized dehydrated fruit and vegetable product
WO2001072605A1 (fr) * 2000-03-27 2001-10-04 Dura Pharmaceuticals, Inc. Recipients pour doses individuelles d'un produit pharmaceutique inhalable
US20040131668A1 (en) * 1998-08-05 2004-07-08 Boehringer Ingelheim Pharma Kg Two-part capsule to accept pharmaceutical preparations for powder inhalers
US20040173211A1 (en) * 2003-01-14 2004-09-09 Boehringer Ingelheim International Gmbh Powder inhaler
DE102004040928A1 (de) * 2004-08-24 2006-03-02 Georg Menshen Gmbh & Co. Kg Verschluss für einen Behälter
US20090194105A1 (en) * 2006-04-13 2009-08-06 Jens Besseler Inhaler

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5896855A (en) 1992-12-24 1999-04-27 Rhone-Poulenc Rorer Limited Multi dose inhaler apparatus
DE10258360A1 (de) 2002-12-12 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator mit Kapselkammer zum Aufnehmen einer mit Wirkstoff gefüllten Einwegkapsel
DE10300982A1 (de) 2003-01-14 2004-07-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverinhalator
ES2310722T3 (es) 2003-03-20 2009-01-16 Galephar M/F Sistema inhalador de polvo seco mejorado.
DE102005001332A1 (de) 2005-01-11 2006-07-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1215560A (fr) * 1957-02-18 1960-04-19 Boîte poudreuse notamment pour poudres pharmaceutiques
FR2032436A2 (fr) * 1969-02-27 1970-11-27 Finanz Kompensations Anst
US4076848A (en) * 1976-03-18 1978-02-28 Limur Eleanor De Encapsulated pulverized dehydrated fruit and vegetable product
US20040131668A1 (en) * 1998-08-05 2004-07-08 Boehringer Ingelheim Pharma Kg Two-part capsule to accept pharmaceutical preparations for powder inhalers
WO2001072605A1 (fr) * 2000-03-27 2001-10-04 Dura Pharmaceuticals, Inc. Recipients pour doses individuelles d'un produit pharmaceutique inhalable
US20040173211A1 (en) * 2003-01-14 2004-09-09 Boehringer Ingelheim International Gmbh Powder inhaler
DE102004040928A1 (de) * 2004-08-24 2006-03-02 Georg Menshen Gmbh & Co. Kg Verschluss für einen Behälter
US20090194105A1 (en) * 2006-04-13 2009-08-06 Jens Besseler Inhaler

Also Published As

Publication number Publication date
WO2013174752A2 (fr) 2013-11-28

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