WO2014147578A3 - Composés antibactériens contre des bactéries résistantes aux médicaments - Google Patents

Composés antibactériens contre des bactéries résistantes aux médicaments Download PDF

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Publication number
WO2014147578A3
WO2014147578A3 PCT/IB2014/059989 IB2014059989W WO2014147578A3 WO 2014147578 A3 WO2014147578 A3 WO 2014147578A3 IB 2014059989 W IB2014059989 W IB 2014059989W WO 2014147578 A3 WO2014147578 A3 WO 2014147578A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug resistant
against drug
antibacterial compounds
resistant bacteria
compounds against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2014/059989
Other languages
English (en)
Other versions
WO2014147578A4 (fr
WO2014147578A2 (fr
Inventor
Rup LAL
Taifo Mahmud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Delhi
Department of Biotechnology of Ministry of Science and Technology India
Oregon State University
Oregon State
Original Assignee
University of Delhi
Department of Biotechnology of Ministry of Science and Technology India
Oregon State University
Oregon State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Delhi, Department of Biotechnology of Ministry of Science and Technology India, Oregon State University, Oregon State filed Critical University of Delhi
Priority to CN201480029144.8A priority Critical patent/CN105228617A/zh
Priority to RU2015144539A priority patent/RU2672064C2/ru
Publication of WO2014147578A2 publication Critical patent/WO2014147578A2/fr
Publication of WO2014147578A3 publication Critical patent/WO2014147578A3/fr
Publication of WO2014147578A4 publication Critical patent/WO2014147578A4/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne la production d'analogues de rifamycine contre des bactéries résistantes aux médicaments. L'invention concerne également des composés antibactériens contre des mycobactéries résistantes aux médicaments. L'invention concerne également une composition pharmaceutique comprenant un composé antibactérien contre des bactéries résistantes aux médicaments, notamment des mycobactéries. L'invention concerne également l'utilisation de composés antibactériens pour le traitement d'une maladie causée par des bactéries, et notamment des mycobactéries.
PCT/IB2014/059989 2013-03-20 2014-03-20 Composés antibactériens contre des bactéries résistantes aux médicaments Ceased WO2014147578A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201480029144.8A CN105228617A (zh) 2013-03-20 2014-03-20 抗耐药性细菌的抗菌化合物
RU2015144539A RU2672064C2 (ru) 2013-03-20 2014-03-20 Антибактериальные соединения против лекарственно-устойчивых бактерий

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN690/DEL/2013 2013-03-20
IN690DE2013 2013-03-20

Publications (3)

Publication Number Publication Date
WO2014147578A2 WO2014147578A2 (fr) 2014-09-25
WO2014147578A3 true WO2014147578A3 (fr) 2015-03-05
WO2014147578A4 WO2014147578A4 (fr) 2015-04-16

Family

ID=50680079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/059989 Ceased WO2014147578A2 (fr) 2013-03-20 2014-03-20 Composés antibactériens contre des bactéries résistantes aux médicaments

Country Status (3)

Country Link
CN (1) CN105228617A (fr)
RU (1) RU2672064C2 (fr)
WO (1) WO2014147578A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119736186A (zh) * 2024-11-27 2025-04-01 云南大学 一株拟无枝酸菌yinm00005及其在制备安莎霉素类化合物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0877087A1 (fr) 1997-05-08 1998-11-11 The Secretary, Department of Biotechnology Vecteurs de clonage pour Amycolatopsis sp. et procédé pour leur préparation
IL149030A0 (en) * 2000-08-09 2002-11-10 Panacea Biotec Ltd Pharmaceutical compositions containing rifampicin, isoniazid or combinations thereof
AU2006326456A1 (en) * 2005-12-14 2007-06-21 Activbiotics Pharma Llc Rifamycin analogs and uses thereof
CN102357249A (zh) * 2011-10-26 2012-02-22 广州赫尔氏药物开发有限公司 能够抑制耐药性结核杆菌的药物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"PROCEEDINGS OF THE NINETY NINTH SESSION OF THE INDIAN SCIENCE CONGRESS Bhubaneswar, 2012 PART II SECTION OF NEW BIOLOGY (Including Biochemistry, Biophysics & Molecular Biology and Biotechnology)", 2012, XP055131525, Retrieved from the Internet <URL:http://www.isc2012.com/pdf/proceedings/new_biology.pdf> [retrieved on 20140724] *
A. NIGAM ET AL: "Modification of Rifamycin Polyketide Backbone Leads to Improved Drug Activity Against Rifampicin-Resistant Mycobacterium tuberculosis", JOURNAL OF BIOLOGICAL CHEMISTRY, 12 June 2014 (2014-06-12), XP055131532, ISSN: 0021-9258, DOI: 10.1074/jbc.M114.572636 *
XU JUN ET AL: "Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699.", MICROBIOLOGY (READING, ENGLAND) AUG 2005, vol. 151, no. Pt 8, August 2005 (2005-08-01), pages 2515 - 2528, XP002727775, ISSN: 1350-0872 *

Also Published As

Publication number Publication date
CN105228617A (zh) 2016-01-06
RU2672064C2 (ru) 2018-11-09
RU2015144539A (ru) 2017-04-20
WO2014147578A4 (fr) 2015-04-16
WO2014147578A2 (fr) 2014-09-25

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