WO2014201536A1 - Dosimètre de rayonnement ionisant - Google Patents

Dosimètre de rayonnement ionisant Download PDF

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Publication number
WO2014201536A1
WO2014201536A1 PCT/BR2014/000234 BR2014000234W WO2014201536A1 WO 2014201536 A1 WO2014201536 A1 WO 2014201536A1 BR 2014000234 W BR2014000234 W BR 2014000234W WO 2014201536 A1 WO2014201536 A1 WO 2014201536A1
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WIPO (PCT)
Prior art keywords
ionizing radiation
dosimeter
radiation
dose
polymer
Prior art date
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Ceased
Application number
PCT/BR2014/000234
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English (en)
Portuguese (pt)
Inventor
Carlos Frederico DE OLIVEIRA GRAEFF
Erika SOARES BRONZE UHLE
David MOREIRA FERNANDES
Maria Vitória RUSSO
Ilaria Fratoddi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade Estadual Paulista Julio de Mesquita Filho UNESP
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Universidade Estadual Paulista Julio de Mesquita Filho UNESP
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Publication of WO2014201536A1 publication Critical patent/WO2014201536A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
    • G01T1/02—Dosimeters
    • G01T1/04—Chemical dosimeters

Definitions

  • the present invention describes an ionizing radiation dosimeter. More specifically, it comprises a system for measuring ionizing radiation doses composed of a solution of conjugated organometallic polymers that have their fluorescence altered when irradiated due to the formation of new emitting centers and structural changes in the polymer chain.
  • the perception of radiation occurs through the result of the interaction of radiation with a sensitive medium, in this case a detector.
  • dosimeters are those in which the interaction of radiation induces physical or chemical changes in the material, and is subsequently quantified through a certain measurement or observation process.
  • High-energy gamma-ray radiation detection and dosimetry are crucial in many areas of human activity, from energy, national security, construction and public health [Knoll, G. F. Radiation Detection and Measurement, Wiley, Hoboken, N. J., 2010].
  • ZnCdTe can be operated at room temperature, but it is challenging to obtain large and perfect crystals [Persyk, DE; Schardt, MA; Moi, TE; Ritter, KA; Muehllehner, G., IEEE Trans. Nucl. Sci., 1980, 27: 168].
  • Nal Scintillator (T1) is a good detector at room temperature, but its energy resolution is limited [Owens, AJ Synchrotron Radiat., 2006, 13: 143].
  • Germanium crystals offer high energy resolution but require low operating temperatures in liquid nitrogen [Berninger, WH, IEEE Trans. Nucl. Sci., 1974, 21: 374].
  • Conjugated polymers have been suggested as radiation detecting materials based on their optical and electrical properties [(Friend, RH et al. 1999 Nature 397121-8), (Mcquade, DT, Pullen, AE; Swager, TM 2000 Chem. Rev. 1002537 -74) and (Krebs, FC Sol. Energy Mater. Sol. Celi. 2009, 93, 394)].
  • Conjugated polymers are organic semiconductors, and semiconductor behavior is therefore associated with ⁇ molecular orbitals located along the polymeric chain.
  • Semiconductor polymers are part of a new class of materials that combine the electronic and optical properties of semiconductors with the mechanical properties and processing advantages of polymers. These conjugated organic polymers can be both electrical and semiconductor insulators.
  • conjugated polymers were primarily studied to detect radiation from charged particles such as electrons [Campbell, IH; Crone, BK Adv. Mater., 2006, 18: 77], protons [Lee, KW; Mo, KH; Jang, JW; Lee, CEJ Korean Phys. Sound. 2005; 47: 130] and particles [Beckerle, R; Strobele, H. Nucl. Instrum. Methods Phys. Res. 2000; 449: 302].
  • conjugated polymer films and pellets for X-ray and ⁇ -ray detection was limited by several factors, the main one being the high-dose radiation response (> 1 kGy) [(S Graham, SC et al Synth Met. 1997; 84: 903) and (Atreya, M. et al. Polym. Degrad. Stabil. 1999; 65: 287)].
  • thermoplastic dosimeter that uses a dye for detecting ionizing radiation, said dye that changes color upon impinging ionizing radiation.
  • US4306154 describes an ionization chamber type dosimeter in almost all thermoplastic material except the electrometer and contacts.
  • US 4489240 describes a real-time measurement dosimeter made of a radiochromic dye solution within a plastic tube that is sensitive to ionizing radiation.
  • US4668714 describes a moldable dosimeter containing a rubber and crystalline alanine powder.
  • alanine crystals an amino acid
  • ESR spin electronic resonance
  • US4853548 describes a radiation dosimeter made with a known amount of an aromatic endoperoxide in an organic matrix containing high atomic number atoms. When exposed to ionizing radiation, aromatic endoperoxide decomposes, producing a fluorescent compound. Once irradiated, the device is fluorometrically detected by controlled light exposure and the dosimeter is then discarded.
  • US5099132 describes a dosimeter comprising a support having a polymer containing halogen atoms or a polymer containing acetic acid functional groups and a color pH indicator. With irradiation, polymer acids are released and the dose is determined by changing the indicator color, allowing to measure doses from 0.1 to 1 Mrad (1 to 10 kGy).
  • US5451792 describes a gamma radiation detector made of a polyester film substrate in which a circular region is filled with an ionizing radiation sensitive layer made of 1-bromoadamantane and a dye, and coated with another layer so that the polymer is only the support.
  • US6646273 describes a radiation dosimeter using polymer irradiation in the presence of halogen compounds that release acids that react with indicators when irradiated.
  • the document BRPI0600986 describes a radiation dosimeter consisting of a solution of conjugated polymers that has its color change when irradiated due to the decrease of its effective conjugation.
  • the dosimeter consists of a container containing solution-conjugated polymers so that when irradiated, the polymer reacts with the solvent by modifying its color. This change can be measured visually or with the aid of a spectrophotometer, and color variation and / or change in optical properties (UV-Vis) is associated with the amount of irradiation dose, said dosimeter useful only for doses greater than 1 Gy.
  • Polymer solutions are much more sensitive to ionizing radiation than polymers in the form of powders or films, so polymer solutions can be applied to medical dosimetry and other industry areas such as radiation dose determination in radiotherapy and diagnosis and sterilization processes.
  • Halogenated organic solvents and toluene revealed that UV-Vis and fluorescence spectra are affected by structural changes occurring in the polymer chain. The irradiation interacts with halogenated solvent, causing its radiolysis, generating radicals in the solution. The radicals formed add to the polymer chains forming new emitting centers.
  • the state of the art describes dosimeters that use polymers as a matrix or as a reagent material for radiation indicators, without reference to the use of polymers as radiation indicators in ranges below 1 Gy, using the ratio measurement method. between two emission bands observed in the fluorescence spectrum, based on the increase of the emission band by 420 nm with increase of the radiation dose.
  • An ionizing radiation dosimeter potentially useful in medical dosimetry, low dose personal dosimetry and in the food industry with the determination of doses in the irradiation of food and blood is characteristic of the invention.
  • an ionizing radiation dosimeter that can be used in two operating ranges, below 1 Gy with application in personal dosimetry, and in the range of 1-50 Gy with application in therapeutic dosimetry, sterilization of food and blood.
  • An ionizing radiation dosimeter is characteristic of the invention. It is made up of an easy-to-handle conjugated organometallic polymer solution that does not require sophisticated equipment to measure radiation doses. A spectrophotometer or a fluorimeter may be used.
  • An ionizing radiation dosimeter that measures the radiation dose by the ratio of the relative amplitude of the emission band altered by the presence of a new emitter center formed after irradiation, that is, uses the result of two bands measured thereon, is characteristic of the invention. conditions, giving independence as to the sensitivity of the equipment, and not depending on factors that may vary over time, such as the absolute intensity of the band.
  • Figure 1A shows UV-Vis absorption spectra of solutions at a concentration of 0.0250 mg / ml irradiated at doses below 1 Gy.
  • Figure 1B shows UV-Vis absorption spectra of solutions at a concentration of 0.0250 mg / ml irradiated at doses of 1-90 Gy.
  • Figure 2A shows photoluminescence spectra of solutions at a concentration of 0.0250 mg / ml irradiated at doses below 1 Gy.
  • Figure 2B shows photoluminescence spectra of solutions at a concentration of 0.0250 mg / ml irradiated at doses of 1-90 Gy.
  • Figure 3A graphs the dose dependence x fluorescence intensity amplitude ratio for doses below 1 Gy.
  • Figure 3B presents the dose dependence x fluorescence intensity plot for doses in the range 1-90 Gy.
  • Figure 3C presents the graph of the dependence of the maximum absorption peak displacement x irradiation dose in the range of 1-90 Gy for concentrations i) 0.0500 mg / ml (C1), ii) 0.0375 mg / ml ( C2), iii) 0.0250 mg / ml (C3) and iv) 0.01125 mg / ml (C4).
  • the ionizing radiation dosimeter provides an ionizing radiation measuring device that quantifies the radiation dose, said dosimeter comprising a sealed support that stores a poly [1,10-bis (ethynyl) organic metallic polymer formulation. -4,4'-biphenyl (bis (tributylphosphine)) Pt- (ll)] (Pt-DEBP) dissolved in halogenated organic solvent, in this case chloroform over a broad concentration range, another solvent which may be used may be used. radicals in the reaction medium under the action of ionizing radiation.
  • chloroform Upon interaction of radiation, chloroform absorbs gamma rays, forming chlorine radicals in solution. Chlorine radicals add to the triple bonds of the polymer chain, generating new emitting centers that alter the photoluminescence spectra.
  • UV-Vis and photoluminescence spectra may be taken directly into the tube if the dimensions and constituent material of the tube do not interfere with the measurements, or an aliquot of the solution may be collected for analysis.
  • UV-Vis absorption and photoemission spectra change.
  • the absorption band shifts to shorter wavelengths.
  • photoluminescence the main emission line of non-irradiated material peaking at 398 nm is replaced by a new emission line at 420 nm which increases its emission intensity with the irradiation dose, evidencing a new method of dose determination. of ionizing radiation.
  • the ratio of the relative amplitude of the initial emission band at 398 nm and altered emission band (420 nm) is calculated by the presence of a new emitting center formed after irradiation.
  • the conjugated organometallic polymer used was prepared in the liquid phase by dissolving in the organic solvent.
  • chloroform (CHCl 3) at different concentrations i) 0.0500 mg / mL (C1), ii) 0.0375 mg / mL (C2), iii) 0.0250 mg / mL (C3) and iv) 0.01125 mg / ml (C4), and placed in 4 ml glass containers with silicone sealed screw cap.
  • the samples were irradiated with different doses of gamma radiation (doses below 1 Gy and between 1-90 Gy) at room temperature using a 1.25 MeV energy cobaltherapy unit.
  • Pt-DEBP solutions of 0.0250 mg / mL concentration in chloroform were prepared and analyzed.
  • a new band at 425 nm can be seen as a function of the formation of new emitting centers, the intensity of which increases with increasing irradiation dose.
  • the dosimeter object of the present invention has a linearity dose x fluorescence amplitude ratio, which can be used as a low dose dosimeter applied in personal dosimetry.
  • the dosimeter presents dose linearity for both analysis, absorption and fluorescence, and can be used for dosimetry in both measurement processes.
  • the analysis of absorption and photoluminescence spectra for the studied dose ranges shows us that the device can be used as an ionizing radiation dosimeter in two ranges.
  • a linear dose x fluorescence amplitude ratio can be observed and can be used as a low dose dosimeter applied in personal dosimetry.
  • the system presents dose linearity for both analysis, absorption and fluorescence, and can be used for dosimetry in both measurement processes.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Molecular Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of Radiation (AREA)

Abstract

L'invention concerne un dosimètre de rayonnement ionisant comprenant un support fermé hermétiquement permettant de stocker une formulation de polymère organique métallique poly[1,10-bis(éthynyl)-4,4'-biphényl (bis(tributylphosphine))Pt-(ll)] (Pt-DEBP) dissous dans un solvant organique halogéné en différentes concentrations, la mesure de la dose de rayonnement ionisant étant calculée au moyen du rapport de l'amplitude relative de la bande d'émission modifiée par la présence d'un nouveau centre émetteur formé après irradiation.
PCT/BR2014/000234 2013-06-21 2014-06-18 Dosimètre de rayonnement ionisant Ceased WO2014201536A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRBR1020130157082 2013-06-21
BR102013015708A BR102013015708A2 (pt) 2013-06-21 2013-06-21 dosímetro de radiação ionizante

Publications (1)

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WO2014201536A1 true WO2014201536A1 (fr) 2014-12-24

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BR (1) BR102013015708A2 (fr)
WO (1) WO2014201536A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5099132A (en) * 1986-12-04 1992-03-24 Sumitomo Electric Industries, Ltd. Dosimeter
US5451792A (en) * 1993-03-31 1995-09-19 Hartwell Dosimeters Limited Gamma radiation detection
US6646273B2 (en) * 2001-01-04 2003-11-11 Sunband Sun exposure and radiation dosimeter
BRPI0600986A (pt) * 2006-03-20 2007-11-27 Univ Sao Paulo dosìmetro de radiação ionizante e método de utilização

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5099132A (en) * 1986-12-04 1992-03-24 Sumitomo Electric Industries, Ltd. Dosimeter
US5451792A (en) * 1993-03-31 1995-09-19 Hartwell Dosimeters Limited Gamma radiation detection
US6646273B2 (en) * 2001-01-04 2003-11-11 Sunband Sun exposure and radiation dosimeter
BRPI0600986A (pt) * 2006-03-20 2007-11-27 Univ Sao Paulo dosìmetro de radiação ionizante e método de utilização

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BATAGIN-NETO, A ET AL.: "Optical Behavior of Conjugated Pt- Containing Polymetallaynes Exposed to Gamma-Ray - Radiation Doses", J. PHYS. CHEM. B, vol. 115, no. 25, 9 June 2011 (2011-06-09), pages 8047 - 8053 *
FRATODDI, I ET AL.: "Structural Changes of Conjugated Pt- Containing Polymetallaynes Exposed to Gamma Ray Radiation Doses", J. PHYS. CHEM. A, vol. 116, no. 34, 17 August 2012 (2012-08-17), pages 8768 - 8774 *

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