WO2015015102A3 - Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Download PDF

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Publication number
WO2015015102A3
WO2015015102A3 PCT/FR2014/051944 FR2014051944W WO2015015102A3 WO 2015015102 A3 WO2015015102 A3 WO 2015015102A3 FR 2014051944 W FR2014051944 W FR 2014051944W WO 2015015102 A3 WO2015015102 A3 WO 2015015102A3
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WO
WIPO (PCT)
Prior art keywords
agomelatine
contain
pharmaceutical compositions
sulphonic acids
preparing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2014/051944
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English (en)
Other versions
WO2015015102A2 (fr
Inventor
Hanbin Shan
Yuhui SHEN
Ying Luo
Philippe Letellier
Michael Lynch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Pharmaceutical Industry
Les Laboratoires Servier SAS
Original Assignee
Shanghai Institute of Pharmaceutical Industry
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2013/080337 external-priority patent/WO2015013865A1/fr
Priority claimed from FR1360124A external-priority patent/FR3012142B1/fr
Priority to JP2016530580A priority Critical patent/JP6595990B2/ja
Priority to UAA201601715A priority patent/UA116811C2/uk
Priority to HK16111309.5A priority patent/HK1223088A1/zh
Priority to MEP-2020-125A priority patent/ME03741B/fr
Priority to EA201600142A priority patent/EA031237B1/ru
Priority to SG11201600006RA priority patent/SG11201600006RA/en
Priority to RU2016106958A priority patent/RU2673080C2/ru
Priority to US14/907,670 priority patent/US9573891B2/en
Priority to ES14758162T priority patent/ES2792248T3/es
Priority to AU2014298304A priority patent/AU2014298304B2/en
Priority to CA2919601A priority patent/CA2919601C/fr
Priority to RS20200720A priority patent/RS60440B1/sr
Priority to SI201431601T priority patent/SI3027588T1/sl
Priority to EP14758162.3A priority patent/EP3027588B1/fr
Priority to PL14758162T priority patent/PL3027588T3/pl
Application filed by Shanghai Institute of Pharmaceutical Industry, Les Laboratoires Servier SAS filed Critical Shanghai Institute of Pharmaceutical Industry
Priority to KR1020167004732A priority patent/KR20160035599A/ko
Priority to HRP20200927TT priority patent/HRP20200927T1/hr
Priority to HK16106760.7A priority patent/HK1218745B/xx
Priority to DK14758162.3T priority patent/DK3027588T3/da
Priority to CN201480042633.7A priority patent/CN105473547B/zh
Priority to MX2016001219A priority patent/MX369303B/es
Priority to LTEP14758162.3T priority patent/LT3027588T/lt
Priority to NZ716151A priority patent/NZ716151A/en
Publication of WO2015015102A2 publication Critical patent/WO2015015102A2/fr
Publication of WO2015015102A3 publication Critical patent/WO2015015102A3/fr
Priority to ZA2016/00448A priority patent/ZA201600448B/en
Anticipated expiration legal-status Critical
Priority to CY20201100565T priority patent/CY1123214T1/el
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
    • C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
    • C07C309/35—Naphthalene sulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
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  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nouveaux complexes d'agomélatine et d'acides sulfoniques de formule (I). Médicaments.
PCT/FR2014/051944 2013-07-29 2014-07-28 Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Ceased WO2015015102A2 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
KR1020167004732A KR20160035599A (ko) 2013-07-29 2014-07-28 아고멜라틴 및 설폰산의 신규한 복합체, 이를 제조하기 위한 방법 및 이를 함유하는 약학적 조성물
NZ716151A NZ716151A (en) 2013-07-29 2014-07-28 Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them
PL14758162T PL3027588T3 (pl) 2013-07-29 2014-07-28 Kompleksy agomelatyny i kwasów sulfonowych, sposób ich wytwarzania i kompozycje farmaceutyczne je zawierające
HK16111309.5A HK1223088A1 (zh) 2013-07-29 2014-07-28 阿戈美拉汀和磺酸的新复合物、其制备方法和包含其的药物组合物
MEP-2020-125A ME03741B (fr) 2013-07-29 2014-07-28 Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA201600142A EA031237B1 (ru) 2013-07-29 2014-07-28 Новые комплексы агомелатина и сульфокислот, способ их получения и фармацевтические композиции, которые их содержат
SG11201600006RA SG11201600006RA (en) 2013-07-29 2014-07-28 Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them
RU2016106958A RU2673080C2 (ru) 2013-07-29 2014-07-28 Новые комплексы агомелатина и сульфокислот, способ их получения и фармацевтические композиции, которые их содержат
US14/907,670 US9573891B2 (en) 2013-07-29 2014-07-28 Complexes of agomelatine and sulphonic acids, a process for their preparation and pharmaceutical compositions containing them
ES14758162T ES2792248T3 (es) 2013-07-29 2014-07-28 Complejos de agomelatina y ácidos sulfónicos, procedimiento de su preparación y composiciones farmacéuticas que los contienen
AU2014298304A AU2014298304B2 (en) 2013-07-29 2014-07-28 Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them
CA2919601A CA2919601C (fr) 2013-07-29 2014-07-28 Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
RS20200720A RS60440B1 (sr) 2013-07-29 2014-07-28 Kompleksi agomelatina i sulfonskih kiselina, postupak za njihovo dobijanje i farmaceutske kompozicije koje ih sadrže
SI201431601T SI3027588T1 (sl) 2013-07-29 2014-07-28 Kompleksi agomelatina in sulfonskih kislin, postopek za pripravo le-teh in farmacevtskih sestavkov, ki jih vsebujejo
EP14758162.3A EP3027588B1 (fr) 2013-07-29 2014-07-28 Complexes d'agomélatine et d'acides sulfoniques, procédé de leur préparation et compositions pharmaceutiques qui les contiennent
JP2016530580A JP6595990B2 (ja) 2013-07-29 2014-07-28 アゴメラチンとスルホン酸との新規な複合体、これらの製造方法及びこれらを含有する医薬組成物
CN201480042633.7A CN105473547B (zh) 2013-07-29 2014-07-28 阿戈美拉汀和磺酸的新复合物、其制备方法和包含其的药物组合物
LTEP14758162.3T LT3027588T (lt) 2013-07-29 2014-07-28 Agomelatino ir sulfonrūgščių kompleksai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos
HRP20200927TT HRP20200927T1 (hr) 2013-07-29 2014-07-28 Kompleksi agomelatina i sulfonskih kiselina, postupak njihove proizvodnje i proizvodnje farmaceutskih pripravaka koji ih sadržavaju
HK16106760.7A HK1218745B (en) 2013-07-29 2014-07-28 Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them
DK14758162.3T DK3027588T3 (da) 2013-07-29 2014-07-28 Komplekser af agomelatin og sulfonsyre, fremgangsmåde til deres fremstilling og lægemiddelsammensætninger som indeholder dem
UAA201601715A UA116811C2 (uk) 2013-07-29 2014-07-28 Комплекси агомелатину та сульфонових кислот, спосіб їх одержання та фармацевтичні композиції, що їх містять
MX2016001219A MX369303B (es) 2013-07-29 2014-07-28 Nuevos complejos de agomelatina y de acidos sulfonicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
ZA2016/00448A ZA201600448B (en) 2013-07-29 2016-01-20 Novel complexes of agomelatine and sulphonic acids, method for preparing same and the pharmaceutical compositions that contain them
CY20201100565T CY1123214T1 (el) 2013-07-29 2020-06-19 Συμπλοκα αγομελατινης και σουλφονικα οξεα, μεθοδος παρασκευης αυτων και φαρμακευτικες συνθεσεις που περιεχουν αυτα

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/CN2013/080337 WO2015013865A1 (fr) 2013-07-29 2013-07-29 Complexes d'acides sulfoniques et d'agomélatine et leur préparation
CNPCT/CN2013/080337 2013-07-29
FR1360124 2013-10-17
FR1360124A FR3012142B1 (fr) 2013-10-17 2013-10-17 Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
WO2015015102A2 WO2015015102A2 (fr) 2015-02-05
WO2015015102A3 true WO2015015102A3 (fr) 2015-12-03

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PCT/FR2014/051944 Ceased WO2015015102A2 (fr) 2013-07-29 2014-07-28 Nouveaux complexes d'agomelatine et d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (26)

Country Link
US (1) US9573891B2 (fr)
EP (1) EP3027588B1 (fr)
JP (1) JP6595990B2 (fr)
CN (1) CN105473547B (fr)
AU (1) AU2014298304B2 (fr)
CA (1) CA2919601C (fr)
CY (1) CY1123214T1 (fr)
DK (1) DK3027588T3 (fr)
EA (1) EA031237B1 (fr)
ES (1) ES2792248T3 (fr)
HK (1) HK1223088A1 (fr)
HR (1) HRP20200927T1 (fr)
HU (1) HUE049928T2 (fr)
LT (1) LT3027588T (fr)
ME (1) ME03741B (fr)
MX (1) MX369303B (fr)
NZ (1) NZ716151A (fr)
PL (1) PL3027588T3 (fr)
PT (1) PT3027588T (fr)
RS (1) RS60440B1 (fr)
RU (1) RU2673080C2 (fr)
SG (1) SG11201600006RA (fr)
SI (1) SI3027588T1 (fr)
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AU2014298304B2 (en) 2018-07-26
HRP20200927T1 (hr) 2020-09-18
MX369303B (es) 2019-11-05
RS60440B1 (sr) 2020-07-31
CA2919601C (fr) 2018-02-27
EP3027588B1 (fr) 2020-04-01
NZ716151A (en) 2020-06-26
SG11201600006RA (en) 2016-02-26
CN105473547A (zh) 2016-04-06
ES2792248T3 (es) 2020-11-10
EA201600142A1 (ru) 2016-11-30
SI3027588T1 (sl) 2020-08-31
RU2016106958A3 (fr) 2018-05-18
CY1123214T1 (el) 2021-12-31
LT3027588T (lt) 2020-07-10
UA116811C2 (uk) 2018-05-10
PL3027588T3 (pl) 2020-11-02
CA2919601A1 (fr) 2015-02-05
PT3027588T (pt) 2020-06-02
HK1218745A1 (zh) 2017-03-10
US20160159735A1 (en) 2016-06-09
DK3027588T3 (da) 2020-07-06
HK1223088A1 (zh) 2017-07-21
JP2016525566A (ja) 2016-08-25
ZA201600448B (en) 2017-04-26
ME03741B (fr) 2021-04-20
EA031237B1 (ru) 2018-12-28
EP3027588A2 (fr) 2016-06-08
RU2673080C2 (ru) 2018-11-22
US9573891B2 (en) 2017-02-21
WO2015015102A2 (fr) 2015-02-05
JP6595990B2 (ja) 2019-10-23
MX2016001219A (es) 2016-05-26
AU2014298304A1 (en) 2016-02-04
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