WO2015149098A1 - Dispositif pour prélever et diviser en portions du tissu adipeux - Google Patents

Dispositif pour prélever et diviser en portions du tissu adipeux Download PDF

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Publication number
WO2015149098A1
WO2015149098A1 PCT/AT2015/050079 AT2015050079W WO2015149098A1 WO 2015149098 A1 WO2015149098 A1 WO 2015149098A1 AT 2015050079 W AT2015050079 W AT 2015050079W WO 2015149098 A1 WO2015149098 A1 WO 2015149098A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
portioning
collecting container
hose
fatty tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AT2015/050079
Other languages
German (de)
English (en)
Inventor
Hajnal KIPROV
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Liporegena GmbH
Original Assignee
Liporegena GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ATA50235/2014A external-priority patent/AT514946B1/de
Priority claimed from ATGM50048/2014U external-priority patent/AT14138U1/de
Application filed by Liporegena GmbH filed Critical Liporegena GmbH
Publication of WO2015149098A1 publication Critical patent/WO2015149098A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/60—Containers for suction drainage, adapted to be used with an external suction source
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/89—Suction aspects of liposuction
    • A61M1/892—Suction aspects of liposuction with treatment of the collected fat
    • A61M1/893—Suction aspects of liposuction with treatment of the collected fat with extraction of specific components, e.g. of stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A61M2202/0437—Blood stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/08—Lipoids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/08—Supports for equipment

Definitions

  • the invention relates to a device for removing and Portio ⁇ ning of fatty tissue, with a suction cannula and a thus connected via a hose collecting container, on which
  • Hose a hose pump can be arranged.
  • stem cells which are to be used for a variety of applications to ⁇ future.
  • stem cells can be used for cosmetic purposes, but also to support the treatment of joint diseases or for the therapy of cardiovascular diseases.
  • the extraction of adult stem cells from bone marrow or umbilical cord is stressful and relatively expensive for the patient, so to ⁇ efforts are being made to extract stem cells from adipose tissue.
  • EP 2,380,970 AI describes a method and a device for obtaining stem cells from different types of tissue, for example from adipose tissue.
  • stem cells are used according to EP 2,332,555 A2.
  • the object of the present invention is to provide an abovementioned device for removing and portioning fatty tissue, by means of which at least part of the removed fatty tissue can be used for subsequent reuse, in particular the production of stem cells.
  • the device should be as simple and inexpensive as a disposable product. Additional measures such as the Disposition ⁇ position of a sterile room or clean room are eliminated. Disadvantages of known devices should be avoided or at least reduced.
  • the collecting container is connected via a connecting element with a shut-off device with a liquid container for receiving a fat by gravity in the collecting gravity-absent ⁇ zenden liquid, and the collecting container via further connecting elements with at least one Portionierbenzol ⁇ ter is connected, wherein the suction cannula, the tube, the collecting container, the liquid container, the at least one Portionier actuallyer and the connecting elements fluid-tight with ⁇ each other to a sterile closed system and are arranged in a sterile packaging.
  • the subject device is characterized by a sterile packaged, sterile, CLOSED ⁇ senes system which ensures the sampling and Portionie ⁇ tion of fatty tissue under sterile conditions. Without the need for a sterile room or clean room can thus be done using the device, the portioning desired amounts of fatty tissue and these portions are supplied to the further utilization.
  • the filled fat tissue portions can be used for stem cell production and storage at correspondingly low temperatures.
  • the device can be assembled by relatively simple components, which can be replaced by appropriate prior to packaging
  • Measures such as sterilization, disinfection, pasteurization, heating, chemical applications, or application of gamma rays are sterilized.
  • portioning containers are provided.
  • the amount of Portionier samples and also their size is adjusted according to the respective requirements.
  • a removal set several identically sized Portionier employer, or portioning container with different volumes, can be arranged.
  • the collecting container can be connected via a connecting element with a shut-off device with a surplus container, in which excess container after filling all Portionierbenzol ter excess fatty tissue can be transferred.
  • At least one connecting element is formed by at least one piece of hose and at least one connecting piece, which at least one piece of hose and which ⁇ least one connecting piece fluid-tightly connected to each other, preferably glued or welded.
  • the shut-off devices may be formed by hose clamps or solenoid valves.
  • Hose clamps are suitable for simple ma nually operable removal devices, whereas an automatic or teilautoma tables removal and portioning of the fatty tissue can take place when using solenoid valves.
  • each solenoid valve is preferably connected to a control device, wel che control device further with the hose pump
  • the control device via the control device, an automatic or semi-automatic removal and portioning of the fatty tissue take place by the control device di activation and deactivation of the peristaltic pump and its direction of rotation and the opening and closing of the solenoid valves after egg nem predetermined timing controls. Accordingly, upon removal of the adipose tissue, the peristaltic pump is activated so that carriage of the adipose tissue from the aspiration cannula to the collection container can be accomplished. After completion of the liposuction, a predetermined period of time is waited so that the fluid in the fatty tissue can settle and be transported into the fluid container.
  • the collecting container and / or the liquid container and / or the at least one portioning container and / or the excess container is or are preferably formed by a flexible plastic bag.
  • a flexible plastic bag Such flexible Art ⁇ textile bags, such as those used in blood donations are particularly economical to produce.
  • At least one addition and / or removal opening can be arranged on the collecting container and / or at least on a portioning container.
  • Removal openings which are welded, for example, to the flexible plastic bags, certain substances can be added, or samples are taken for certain investigations.
  • the addition and / or removal opening can be formed by a closable connection, for example a conventional and standardized Luer-Lock connection in medical applications.
  • the addition and / or removal opening can also be formed by a piercing membrane, as is customary in containers for vaccines.
  • At least one suspension opening is arranged on the collecting container and / or on the liquid container and / or on the at least one portioning container and / or on the excess container.
  • the handling can be facilitated by the various containers of the sampling device can be hung on a corresponding bracket.
  • a holding device for releasably securing at least a collecting container and / or the liquid container and / or the at least one portioning container and / or the excess container is provided, the handling in the removal and portioning of the fatty tissue can also be further supported.
  • the holding device can simply be designed with a corresponding number of hooks by means of a linkage connected to a corresponding base. Even more complex embodiments, possibly with electrical and electromechanical components, are also conceivable.
  • the holding device is preferably configured for attachment of the collecting container above the liquid container so that ⁇ can take place a separation of the liquid portion in the adipose tissue and a transportation from the collection container into the liquid container by utilizing the force of gravity.
  • the collection container may, for example, have a capacity of 500ml to 2000ml. For the usual applications, such a volume will suffice for the sump. Of course, however, collecting containers with a larger volume are also conceivable.
  • the at least one portioning container for example, has a capacity of 10ml to 200ml. This volume has proven to be suitable for obtaining stem cells from adipose tissue. If other processing operations are planned, of course, other sizes for the portioning container can be provided.
  • a label is preferably arranged on the collecting container and / or liquid container and / or at least on a portioning container and / or excess container.
  • labels which are preferably attached by gluing to the respective container, a clear Zu ⁇ order to the respective patient is possible.
  • the label may contain the name of the patient or a code representing the patient, for example a barcode.
  • the sterile packaging is preferably tool-less designed to allow rapid removal of the device prior to the removal of fatty tissue.
  • the ste- Rile packaging have a tear tab or tear notch or ⁇ same.
  • FIG. 1 shows a schematic embodiment of a sterile device for removing and portioning fatty tissue in a corresponding packaging
  • FIG. 2 shows a device for removing and portioning fatty tissue according to FIG. 1 when used with optional control
  • FIG. 3 shows a detailed view of two portioning containers of the device for removing and portioning fatty tissue with different shut-off elements
  • FIG. 4 shows a detail view of a portioning container after closure thereof.
  • FIG. 1 shows a schematic embodiment of a sterile device 1 for removing and portioning fatty tissue.
  • the subcutaneous fatty tissue is aspirated.
  • a hose 3 between the suction cannula 2 and a collecting container 4 is a peristaltic pump 5, and peristaltic pump (not shown) which conveys the aspirated adipose tissue of the suction cannula 2 in the collecting container ⁇ .
  • a shut-off device 7 may be arranged.
  • the collecting container 4 is connected via a connecting element 6 and a shut-off device 7 with a liquid ⁇ keits constituteer 8.
  • Peristaltic pump 5 (not shown) in its direction of rotation umgege- returns so that the fatty tissue from the collecting container 4 can be successively conveyed into the portioning container 9.
  • the associated obturator 7 is closed ge ⁇ .
  • the last Portionier matterser was 9 filled with fatty tissue and the associated shutoff WUR closed 7 ⁇ de excess fat tissue can at best be transported in a container About ⁇ shot. 11 This too
  • Surplus container 11 is connected via a corresponding connection ⁇ element 6 and a shut-off device 7 with the collecting container 4.
  • the necessary components of the device 1 for the removal and portioning of fatty tissue namely the suction cannula 2, the tube 3, the collecting container 4, the liquid container 8, the at least one portioning container 9, possibly the excess container 11 and the respective connecting elements 6 and shut-off elements 7 are fluid-tight connected to a sterile, closed system, and placed in a sterile package 10.
  • fatty tissue can be removed and portioned under sterile conditions using the device 1, without the space in which the fatty tissue removal is undertaken being itself sterile or a clean room having to be used.
  • Portionier meanser 9 is adapted to the particular circumstances. For example, in the device 1, three to five, but also more, portioning container 9 may be provided.
  • the connecting elements 6 are gebil ⁇ det in the simplest case by corresponding hose pieces 12 and connectors 13, as explained in more detail with reference to the detail drawing in Figure 3.
  • an addition and / or removal opening 18 may be arranged, taken over the fatty tissue, or certain substances may be added.
  • This addition and / or removal opening 18, which is for example welded to the respective container, can be formed by a closable connection, for example a luer lock connector, or a piercing ⁇ membrane.
  • corresponding suspension openings 19 are arranged on the collecting container 4 and / or on the liquid container 8 and / or on the at least one portioning container 9 and / or on the excess container 11.
  • corresponding labels 21 with corresponding information are arranged on the collecting container 4 and / or liquid container 8 and / or portioning container and / or excess container 11.
  • the labels 21, in particular adhesive labels, may already be arranged on the containers, or prior to the removal of the fatty tissue on the
  • the sterile packaging 10 of all components of the device 1 for removing and portioning the fatty tissue is vorzugswei ⁇ se tool-less apparently by a corresponding tear-open tab or tear notch is included.
  • Fig. 2 shows the device 1 for the removal and portioning of fatty tissue according to Fig. 1 in the application.
  • the components of the device 1 are attached to a corresponding holding device 20, and the peristaltic pump 5 is mounted.
  • the shut-off devices 7 are operated manually after the suction of the fatty tissue and the separation of the liquid content in the fatty tissue in the container 4 in the sosstechniksikeits concerninger 8 and finally after reversal of the hose pump, the portioning of the fat tissue in the portioning 9 and possibly in the excess container 11th performed.
  • the Portionier variouser 9 are sealed fluid-tight and further recovery, such as cooling or stem cell production, fed.
  • solenoid valves may be used as shut-off devices 7 ⁇ to which as well as the peristaltic pump 5 corresponding with a Control device 16 are connected.
  • the control device 16 actuates the peristaltic pump 5 and the corresponding Ab ⁇ locking members 7 according to a predetermined time pattern, so that the removal and portioning of the fatty tissue can be supported.
  • An operating unit for example a computer, can be connected to the control device 16.
  • FIG. 3 shows a detailed view of two portioning containers 9 of the apparatus 1 for removing and portioning fatty tissue.
  • the portioning container 9 are preferably formed by fle ⁇ xible plastic bag 17 and corresponding
  • connection elements 6 to the reservoir 4 can by
  • the shut-off devices 7 can be operated by manually
  • Hose clamps 14 or automatically actuated solenoid valves 15 may be formed.
  • FIG. 4 shows a detailed view on a portio ⁇ nier knowledgeer 9 thereof according to closure.
  • the associated obturator 7 is actuated and then the Portionier variouser 9 sealed fluid-tight, for example by the arrangement ei ⁇ ner weld 22 on the connected to the Portionier matterser 9 piece of hose.
  • the piece of tubing can be separated below the weld 22 and the filled and striglos ⁇ sene Portionier anyer 9 further recovery, for example, stem cell production or cooling, are supplied.
  • the described device 1 for the removal and portioning of fatty tissue is characterized by particular simplicity and cost-effective manufacturability and allows Portionie ⁇ tion of fatty tissue for the further utilization thereof, in particular for the production of adult stem cells from the

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention porte sur un dispositif (1) pour prélever et diviser en portion du tissus adipeux, comprenant une canule d'aspiration (2) et un récipient collecteur (4) relié à la canule par un tuyau (3) auquel une pompe de tuyau (5) peut être reliée. Pour permettre de diviser en portions le tissu adipeux prélevé dans des conditions stériles sans nécessiter de chambre stérile, le récipient collecteur (4) est relié, par l'intermédiaire d'un élément de liaison (6) équipé d'un organe d'arrêt (7), à un récipient de liquide (8) destiné à recevoir un liquide qui s'écoule du tissu adipeux dans le récipient collecteur (4) par gravité, et le récipient collecteur (3) est relié à au moins un récipient de division (9) par l'intermédiaire d'autres éléments de liaison (6). La canule d'aspiration (2), le tuyau (3), le récipient collecteur (4), le récipient de liquide (8), le ou les récipients de division (9), et les éléments de liaison (6) sont reliés les uns aux autres d'une façon étanche aux fluides pour former un système fermé stérile et ils sont enfermés dans un conditionnement stérile (10).
PCT/AT2015/050079 2014-03-31 2015-03-27 Dispositif pour prélever et diviser en portions du tissu adipeux Ceased WO2015149098A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ATA50235/2014 2014-03-31
ATA50235/2014A AT514946B1 (de) 2014-03-31 2014-03-31 Vorrichtung zur Entnahme und Portionierung von Fettgewebe
ATGM50048/2014U AT14138U1 (de) 2014-03-31 2014-03-31 Vorrichtung zur Entnahme und Portionierung von Fettgewebe
ATGM50048/2014 2014-03-31

Publications (1)

Publication Number Publication Date
WO2015149098A1 true WO2015149098A1 (fr) 2015-10-08

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PCT/AT2015/050079 Ceased WO2015149098A1 (fr) 2014-03-31 2015-03-27 Dispositif pour prélever et diviser en portions du tissu adipeux

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WO (1) WO2015149098A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3295974A1 (fr) * 2016-09-20 2018-03-21 Terumo Kabushiki Kaisha Unité de division de préparation médicale et procédé de division de préparation médicale

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006100651A1 (fr) * 2005-03-23 2006-09-28 Biosafe S.A. Systeme integre permettant de recueillir, traiter et transplanter des sous-ensembles de cellules, y compris des cellules souches adultes, pour la medecine regenerative
WO2008121120A1 (fr) * 2007-03-28 2008-10-09 Thermogenesis Corp. Compositions de cellules souches et de cellules progénitrices récupérées à partir de moelle osseuse ou de sang ombilical, système et procédé pour leur préparation
EP2332555A2 (fr) 2004-07-01 2011-06-15 Cytori Therapeutics, Inc. Procédés pour l'utilisation de cellules régénératrices pour promouvoir la cicatrisation de plaies
EP2348103A2 (fr) 2003-09-17 2011-07-27 Cytori Therapeutics, Inc. Procédés d'utilisation de cellules régénératrice dans le traitement de maladies vasculaires périphériques et de troubles connexes
EP2380970A1 (fr) 2003-06-25 2011-10-26 Cytori Therapeutics, Inc. Systèmes et procédé pour séparer et concentrer des cellules régénératrices d'un tissu
WO2012006587A2 (fr) * 2010-07-09 2012-01-12 The Gid Group, Inc. Appareil et procédés relatifs à la collecte et au traitement d'un matériel biologique humain contenant des cellules adipeuses

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2380970A1 (fr) 2003-06-25 2011-10-26 Cytori Therapeutics, Inc. Systèmes et procédé pour séparer et concentrer des cellules régénératrices d'un tissu
EP2348103A2 (fr) 2003-09-17 2011-07-27 Cytori Therapeutics, Inc. Procédés d'utilisation de cellules régénératrice dans le traitement de maladies vasculaires périphériques et de troubles connexes
EP2332555A2 (fr) 2004-07-01 2011-06-15 Cytori Therapeutics, Inc. Procédés pour l'utilisation de cellules régénératrices pour promouvoir la cicatrisation de plaies
WO2006100651A1 (fr) * 2005-03-23 2006-09-28 Biosafe S.A. Systeme integre permettant de recueillir, traiter et transplanter des sous-ensembles de cellules, y compris des cellules souches adultes, pour la medecine regenerative
WO2008121120A1 (fr) * 2007-03-28 2008-10-09 Thermogenesis Corp. Compositions de cellules souches et de cellules progénitrices récupérées à partir de moelle osseuse ou de sang ombilical, système et procédé pour leur préparation
WO2012006587A2 (fr) * 2010-07-09 2012-01-12 The Gid Group, Inc. Appareil et procédés relatifs à la collecte et au traitement d'un matériel biologique humain contenant des cellules adipeuses

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3295974A1 (fr) * 2016-09-20 2018-03-21 Terumo Kabushiki Kaisha Unité de division de préparation médicale et procédé de division de préparation médicale
US20180078454A1 (en) * 2016-09-20 2018-03-22 Terumo Kabushiki Kaisha Medical preparation dividing unit and medical preparation dividing method
JP2018046908A (ja) * 2016-09-20 2018-03-29 テルモ株式会社 医療用製剤分割ユニット及び医療用製剤分割方法
US10751251B2 (en) 2016-09-20 2020-08-25 Terumo Kabushiki Kaisha Medical preparation dividing unit and medical preparation dividing method

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