WO2016205902A3 - Compositions and methods for treating biofilms - Google Patents

Compositions and methods for treating biofilms Download PDF

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Publication number
WO2016205902A3
WO2016205902A3 PCT/BE2016/000028 BE2016000028W WO2016205902A3 WO 2016205902 A3 WO2016205902 A3 WO 2016205902A3 BE 2016000028 W BE2016000028 W BE 2016000028W WO 2016205902 A3 WO2016205902 A3 WO 2016205902A3
Authority
WO
WIPO (PCT)
Prior art keywords
biofilms
composition
compositions
methods
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BE2016/000028
Other languages
French (fr)
Other versions
WO2016205902A2 (en
WO2016205902A8 (en
Inventor
Bruno Cammue
Tanne COOLS
Jan Wouter Drijfhout
Karin Thevissen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Leids Universitair Medisch Centrum LUMC
Original Assignee
Katholieke Universiteit Leuven
Leids Universitair Medisch Centrum LUMC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1511051.3A external-priority patent/GB201511051D0/en
Priority claimed from GBGB1511447.3A external-priority patent/GB201511447D0/en
Application filed by Katholieke Universiteit Leuven, Leids Universitair Medisch Centrum LUMC filed Critical Katholieke Universiteit Leuven
Publication of WO2016205902A2 publication Critical patent/WO2016205902A2/en
Publication of WO2016205902A3 publication Critical patent/WO2016205902A3/en
Publication of WO2016205902A8 publication Critical patent/WO2016205902A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Paints Or Removers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a novel composition for use in inhibiting or treating microbial biofilm formation, said composition comprising a plant defensin or a peptide derivative thereof and an antifungal compound, preferably caspofungin, anidulafungin, micafungin, or amphotericin B. Accordingly, the present invention relates to use of said composition for the inhibition or treatment of biofilms, particularly fungal biofilms, such as Candida biofilms, in a subject or on a surface or other medium susceptible to biofilm formation.
PCT/BE2016/000028 2015-06-23 2016-06-23 Compositions and methods for treating biofilms Ceased WO2016205902A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1511051.3A GB201511051D0 (en) 2015-06-23 2015-06-23 Compositions and methods for treating biofilms
GB1511051.3 2015-06-23
GB1511447.7 2015-06-30
GBGB1511447.3A GB201511447D0 (en) 2015-06-30 2015-06-30 Compositions and methods for treating biofilms

Publications (3)

Publication Number Publication Date
WO2016205902A2 WO2016205902A2 (en) 2016-12-29
WO2016205902A3 true WO2016205902A3 (en) 2017-02-02
WO2016205902A8 WO2016205902A8 (en) 2017-03-30

Family

ID=56851315

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE2016/000028 Ceased WO2016205902A2 (en) 2015-06-23 2016-06-23 Compositions and methods for treating biofilms

Country Status (1)

Country Link
WO (1) WO2016205902A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100018530A1 (en) 2021-07-14 2023-01-14 Clever Bioscience S R L Synergistic antimicrobial compositions containing selected peptides and fatty acids
IT202100018542A1 (en) 2021-07-14 2023-01-14 Clever Bioscience S R L Liposomes containing synergistic antimicrobial combinations based on selected peptides and fatty acids

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BE1013389A3 (en) 2000-04-13 2001-12-04 Atlas Copco Airpower Nv Compressor installation with a dry device.
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US6375722B1 (en) 2000-08-22 2002-04-23 Henderson Engineering Co., Inc. Heat of compression dryer
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US6957403B2 (en) 2001-03-30 2005-10-18 Syntest Technologies, Inc. Computer-aided design system to automate scan synthesis at register-transfer level
US7166149B2 (en) 2004-01-12 2007-01-23 Uop Llc Adsorption process for continuous purification of high value gas feeds
BE1016145A3 (en) 2004-08-02 2006-04-04 Atlas Copco Airpower Nv IMPROVED COMPRESSOR DEVICE.
BE1016149A3 (en) 2004-08-04 2006-04-04 Atlas Copco Airpower Nv METHOD FOR DRYING A GAS AND DEVICE APPLIED THEREOF
BE1016309A3 (en) 2004-11-10 2006-07-04 Atlas Copco Airpower Nv METHOD FOR DRYING COMPRESSED GAS AND APPARATUS APPLIED THEREOF
WO2007079533A1 (en) 2006-01-10 2007-07-19 South Eastern Sydney And Illawarra Area Health Service Method for establishing and proliferating human esc by co-culturing with allogeneic feeder cells in serum-free media
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Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AN M. AERTS ET AL: "The Antifungal Plant Defensin HsAFP1 from Heuchera Sanguinea Induces Apoptosis in Candida Albicans", FRONTIERS IN MICROBIOLOGY, vol. 2, 1 January 2011 (2011-01-01), XP055309602, DOI: 10.3389/fmicb.2011.00047 *
ANA VALENTE ET AL: "Revealing the Properties of Plant Defensins through Dynamics", MOLECULES, vol. 18, no. 9, 13 September 2013 (2013-09-13), pages 11311 - 11326, XP055309768, DOI: 10.3390/molecules180911311 *
KIM VRIENS ET AL: "Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures", PLOS ONE, vol. 10, no. 8, 6 August 2015 (2015-08-06), pages e0132701, XP055309561, DOI: 10.1371/journal.pone.0132701 *
THEVISSEN ET AL: "Therapeutic potential of antifungal plant and insect defensins", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 12, no. 21-22, 1 November 2007 (2007-11-01), pages 966 - 971, XP022338227, ISSN: 1359-6446, DOI: 10.1016/J.DRUDIS.2007.07.016 *
UMA SHANKAR SAGARAM ET AL: "Structure-Activity Determinants in Antifungal Plant Defensins MsDef1 and MtDef4 with Different Modes of Action against Fusarium graminearum", PLOS ONE, vol. 6, no. 4, 1 January 2011 (2011-01-01), pages e18550 - e18550, XP055063980, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0018550 *
VRIENS KIM ET AL: "The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin againstCandida albicansbiofilms", PEPTIDES, vol. 75, 28 November 2015 (2015-11-28), pages 71 - 79, XP029380968, ISSN: 0196-9781, DOI: 10.1016/J.PEPTIDES.2015.11.001 *
YAN JIANG ET AL: "Antimicrobial activities of recombinant mouse Î-defensin 3 and its synergy with antibiotics", JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE, KLUWER ACADEMIC PUBLISHERS, BO, vol. 23, no. 7, 21 April 2012 (2012-04-21), pages 1723 - 1728, XP035076877, ISSN: 1573-4838, DOI: 10.1007/S10856-012-4645-Z *

Also Published As

Publication number Publication date
WO2016205902A2 (en) 2016-12-29
WO2016205902A8 (en) 2017-03-30

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