WO2017116188A3 - 양이온성 지질의 선택적 합성 방법 - Google Patents

양이온성 지질의 선택적 합성 방법 Download PDF

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Publication number
WO2017116188A3
WO2017116188A3 PCT/KR2016/015525 KR2016015525W WO2017116188A3 WO 2017116188 A3 WO2017116188 A3 WO 2017116188A3 KR 2016015525 W KR2016015525 W KR 2016015525W WO 2017116188 A3 WO2017116188 A3 WO 2017116188A3
Authority
WO
WIPO (PCT)
Prior art keywords
cationic lipids
selectively synthesizing
synthesizing cationic
selectively
oligoalkyleneamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2016/015525
Other languages
English (en)
French (fr)
Other versions
WO2017116188A2 (ko
Inventor
최성원
남혜영
서민효
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samyang Biopharmaceuticals Corp
Original Assignee
Samyang Biopharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Biopharmaceuticals Corp filed Critical Samyang Biopharmaceuticals Corp
Priority to JP2018534055A priority Critical patent/JP2019501915A/ja
Priority to ES16882140T priority patent/ES2887597T3/es
Priority to US15/781,493 priority patent/US10793516B2/en
Priority to EP16882140.3A priority patent/EP3398932B1/en
Priority to CA3009486A priority patent/CA3009486C/en
Priority to CN201680077505.5A priority patent/CN108473417B/zh
Priority to DK16882140.3T priority patent/DK3398932T3/da
Priority to AU2016382380A priority patent/AU2016382380B2/en
Publication of WO2017116188A2 publication Critical patent/WO2017116188A2/ko
Publication of WO2017116188A3 publication Critical patent/WO2017116188A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)

Abstract

본 발명은 반응조건 변경에 의한 올리고알킬렌아민에 대한 지방산기의 도입률을 조절하여 양이온성 지질을 선택적으로 합성할 수 있는 방법에 관한 것이다.
PCT/KR2016/015525 2015-12-30 2016-12-29 양이온성 지질의 선택적 합성 방법 Ceased WO2017116188A2 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2018534055A JP2019501915A (ja) 2015-12-30 2016-12-29 陽イオン性脂質の選択的合成方法
ES16882140T ES2887597T3 (es) 2015-12-30 2016-12-29 Método para sintetizar selectivamente lípidos catiónicos
US15/781,493 US10793516B2 (en) 2015-12-30 2016-12-29 Method for selectively synthesizing cationic lipids
EP16882140.3A EP3398932B1 (en) 2015-12-30 2016-12-29 Method for selectively synthesizing cationic lipids
CA3009486A CA3009486C (en) 2015-12-30 2016-12-29 Method for selectively synthesizing cationic lipids
CN201680077505.5A CN108473417B (zh) 2015-12-30 2016-12-29 选择性合成阳离子脂质的方法
DK16882140.3T DK3398932T3 (da) 2015-12-30 2016-12-29 Fremgangsmåde til selektiv syntese af kationiske lipider
AU2016382380A AU2016382380B2 (en) 2015-12-30 2016-12-29 Method for selectively synthesizing cationic lipids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2015-0189843 2015-12-30
KR1020150189843A KR101949453B1 (ko) 2015-12-30 2015-12-30 양이온성 지질의 선택적 합성 방법

Publications (2)

Publication Number Publication Date
WO2017116188A2 WO2017116188A2 (ko) 2017-07-06
WO2017116188A3 true WO2017116188A3 (ko) 2017-09-14

Family

ID=59225232

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2016/015525 Ceased WO2017116188A2 (ko) 2015-12-30 2016-12-29 양이온성 지질의 선택적 합성 방법

Country Status (11)

Country Link
US (1) US10793516B2 (ko)
EP (1) EP3398932B1 (ko)
JP (1) JP2019501915A (ko)
KR (1) KR101949453B1 (ko)
CN (1) CN108473417B (ko)
AU (1) AU2016382380B2 (ko)
CA (1) CA3009486C (ko)
DK (1) DK3398932T3 (ko)
ES (1) ES2887597T3 (ko)
PT (1) PT3398932T (ko)
WO (1) WO2017116188A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119998423A (zh) * 2022-11-09 2025-05-13 大金工业株式会社 拨剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040188047A1 (en) * 2003-03-24 2004-09-30 Nof Corporation Paper additive composition and method for producing paper using the same
KR20090088362A (ko) * 2006-10-03 2009-08-19 알닐람 파마슈티칼스 인코포레이티드 지질 함유 조성물
CN104826543A (zh) * 2015-05-21 2015-08-12 北京工商大学 一种含烷基酰胺乙基的季铵盐Gemini表面活性剂的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0699376B2 (ja) * 1990-12-27 1994-12-07 花王株式会社 アミドの製造方法
US5744355A (en) 1994-10-18 1998-04-28 Mayo Foundation For Medical Education And Research cDNA cloning and expression of human liver estrogen sulfotransferase
EP1001680A1 (en) * 1997-07-30 2000-05-24 Monsanto Company Process and compositions promoting biological effectiveness of exogenous chemical substances in plants
US6540808B2 (en) * 2001-04-09 2003-04-01 Mississippi Chemical Corporation Controlled release fertilizers based on self-assembled molecule coatings
PT1771206T (pt) * 2004-05-05 2018-05-16 Silence Therapeutics Gmbh Lípidos, complexos lipídicos e sua utilização
CN102060723B (zh) * 2010-11-23 2013-03-13 湖南师范大学 氨基酸阳离子脂质体纳米颗粒的制备方法
NZ611439A (en) 2010-12-30 2015-05-29 Samyang Biopharmaceuticals Carrier for negatively charged drugs comprising a cationic lipid and a preparation method thereof
US9439856B2 (en) * 2012-04-04 2016-09-13 Samyang Biopharmaceuticals Corporation Method of preparing composition for delivering an anionic drug

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040188047A1 (en) * 2003-03-24 2004-09-30 Nof Corporation Paper additive composition and method for producing paper using the same
KR20090088362A (ko) * 2006-10-03 2009-08-19 알닐람 파마슈티칼스 인코포레이티드 지질 함유 조성물
CN104826543A (zh) * 2015-05-21 2015-08-12 北京工商大学 一种含烷基酰胺乙基的季铵盐Gemini表面活性剂的制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AKINC, A ET AL.: "A Combinatorial Library of Lipid-Like Materials for Delivery of RNAi Therapeutics", NATURE BIOTECHNOLOGY, vol. 26, no. 5, 27 April 2008 (2008-04-27), pages 561 - 569, XP002591574 *
WHITEHEAD, K. A ET AL.: "Synergistic Silencing: Combinations of Lipid-like Materials for Efficacious siRNA Delivery", MOL. THER., vol. 19, no. 9, 12 July 2011 (2011-07-12), pages 1688 - 1694, XP055067340 *

Also Published As

Publication number Publication date
EP3398932A2 (en) 2018-11-07
PT3398932T (pt) 2021-09-06
JP2019501915A (ja) 2019-01-24
EP3398932B1 (en) 2021-08-11
US10793516B2 (en) 2020-10-06
CA3009486C (en) 2020-08-25
AU2016382380B2 (en) 2020-02-06
CN108473417A (zh) 2018-08-31
AU2016382380A1 (en) 2018-07-05
DK3398932T3 (da) 2021-11-01
WO2017116188A2 (ko) 2017-07-06
CA3009486A1 (en) 2017-07-06
KR101949453B1 (ko) 2019-02-18
CN108473417B (zh) 2021-07-02
US20180346410A1 (en) 2018-12-06
KR20170079370A (ko) 2017-07-10
EP3398932A4 (en) 2019-08-07
ES2887597T3 (es) 2021-12-23

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