WO2017141301A1 - Appareil de thérapie par faisceau de particules et procédé de détermination du nombre de balayages d'appareils de thérapie par faisceau de particules - Google Patents

Appareil de thérapie par faisceau de particules et procédé de détermination du nombre de balayages d'appareils de thérapie par faisceau de particules Download PDF

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Publication number
WO2017141301A1
WO2017141301A1 PCT/JP2016/054217 JP2016054217W WO2017141301A1 WO 2017141301 A1 WO2017141301 A1 WO 2017141301A1 JP 2016054217 W JP2016054217 W JP 2016054217W WO 2017141301 A1 WO2017141301 A1 WO 2017141301A1
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WIPO (PCT)
Prior art keywords
dose
particle beam
scans
count value
irradiation
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Ceased
Application number
PCT/JP2016/054217
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English (en)
Japanese (ja)
Inventor
由希子 山田
信彦 伊奈
秀和 近藤
保人 岸井
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Mitsubishi Electric Corp
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Mitsubishi Electric Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Mitsubishi Electric Corp filed Critical Mitsubishi Electric Corp
Priority to PCT/JP2016/054217 priority Critical patent/WO2017141301A1/fr
Priority to JP2017567571A priority patent/JP6494808B2/ja
Priority to CN201680080943.7A priority patent/CN108697904A/zh
Priority to TW105123723A priority patent/TWI604869B/zh
Publication of WO2017141301A1 publication Critical patent/WO2017141301A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present invention relates to a particle beam therapy apparatus for irradiating a particle beam to treat cancer and a method for determining the number of scans of the particle beam therapy apparatus.
  • a method for determining the number of scans of uniform scanning with broad irradiation includes a method of setting a predetermined value or optimizing according to irradiation conditions.
  • Patent Document 1 when 5 GyE is irradiated to the entire irradiation region, all irradiation spots are irradiated with one gate by the particle beam by the first acceleration, and a dose of 3 GyE is given to the irradiation target. It is disclosed to irradiate all irradiation spots again with a particle beam generated by acceleration of 2 to give a dose of 2 GyE to an irradiation target.
  • JP 2014-28310 A (paragraph 0031, FIG. 1)
  • the number of scans is greater in the method of optimization depending on the irradiation conditions, and the flatness of the irradiation field increases as the number of scans increases.
  • it is calculated as the maximum number of times that the spot dose becomes equal to or greater than the minimum dose, but it is necessary to determine from the beam intensity, the movement time between the spots, etc. There was a problem.
  • An object of the present invention is to provide a particle beam therapy system and a method for determining the number of scans of the particle beam therapy system.
  • the particle beam therapy system scans a particle beam with a scanning deflection magnet, measures a dose with a dose monitor, and irradiates the particle beam with an irradiation nozzle that imposes an interlock value on the beam intensity.
  • An irradiation control unit that scans and controls the scanning deflection electromagnet, a treatment planning unit that sets a dose and the number of irradiation spots, the dose, an actually measured dose value, and a count value measured by the dose monitor
  • the number of scans is determined on the basis of the measurement result of the dose calibration that is the ratio of the above, and the total spot count value of the predetermined dose derived from the number of irradiation spots and the interlock value, and the interlock control unit determines the interlock value. Scanning with a predetermined spot count value measured by the dose monitor according to the beam intensity imposed, and irradiating the determined number of scans. Is characterized in that a radiation control calculation unit that.
  • the method of determining the number of scans of the particle beam therapy system includes a dose calibration, a measurement result of dose calibration that is a ratio of an actually measured dose value and a count value measured by a dose monitor, and a predetermined number derived from the number of irradiation spots.
  • the number of scans is determined based on the total spot count value and the interlock value of the doses.
  • the number of scans can be easily determined in a short time by irradiating with the number of times determined by the beam intensity controlled by the interlock value. Can be irradiated.
  • FIG. 1 is a block diagram of the main configuration of the particle beam therapy system according to Embodiment 1 of the present invention
  • FIG. 2 is a bird's-eye view of the schematic configuration of the entire particle beam therapy system.
  • the particle beam therapy system according to Embodiment 1 includes a particle beam generator 10, a particle beam transport unit 20, two particle beam irradiation units 30A and 30B, and the like.
  • FIG. 2 shows a system that typically includes two particle beam irradiation units, there may be more particle beam irradiation units or one particle beam irradiation unit. In FIG. 1, only one particle beam irradiation unit is provided as the particle beam irradiation unit 30 for simplicity.
  • the particle beam transport unit 20 connects the particle beam generator 10 and the particle beam irradiation units 30A and 30B.
  • the particle beam transport unit 20 includes particle beam transport paths 21 and 22 that transport the particle beam generated by the particle beam generation unit 10 to the particle beam irradiation units 30A and 30B, respectively.
  • the particle beam transport unit 20 includes a deflecting electromagnet 50 for changing the direction of the particle beam, and is configured so that the particle beam passes through the vacuum duct.
  • the particle beam irradiation units 30A and 30B are configured to irradiate the target site of the patient with the particle beam PB.
  • the particle beam irradiation units 30A and 30B will be described as the particle beam irradiation unit 30.
  • the particle beam generator 10 includes an injector 11 and an accelerator 12.
  • the injector 11 generates and accelerates particles having a large mass such as a proton beam or a carbon beam.
  • the accelerator 12 accelerates the particles accelerated at the first stage by the injector 11 and emits the particle beam PB.
  • the accelerator 12 is controlled by a signal from the accelerator controller 13 provided in the irradiation controller 80.
  • the accelerator controller 13 supplies an energy control signal to the accelerator 12, sets acceleration energy, sets energy of the particle beam PB emitted from the accelerator 12, and controls time and intensity for emitting the particle beam PB. To do.
  • the particle beam irradiation unit 30 constitutes a treatment room.
  • the particle beam irradiation unit 30 includes an irradiation nozzle 40, a treatment table 32, and the like.
  • the treatment table 32 is used to hold the patient in a supine or sitting position.
  • the irradiation nozzle 40 irradiates the particle beam PB transported to the particle beam irradiation unit 30 toward the irradiation target of the patient on the treatment table 32.
  • FIG. 1 shows a specific configuration of the irradiation nozzle 40 of the particle beam irradiation unit 30 in the first embodiment.
  • the irradiation nozzle 40 shown in FIG. 1 scans the particle beam PB in the horizontal direction, that is, the scanning deflection electromagnets 41a and 41b (41a and 41b) that scan the X and Y planes orthogonal to the particle beam PB irradiation direction. (This may also be referred to as a deflection electromagnet 41.), a scanning deflection electromagnet drive power supply 45 for driving the scanning deflection electromagnet 41, a dose monitor 42 for monitoring the irradiation dose of the particle beam PB, and an energy width of the particle beam PB. It has a ridge filter 43 which is an energy width expanding device.
  • the scanning deflection electromagnet drive power supply 45 is controlled by a signal from the beam scanning controller 16 provided in the irradiation controller 80, and sets the excitation current of the scanning deflection electromagnet 41.
  • the scanning uses a method of scanning the beam irradiation by a method of repeatedly moving and stopping the beam while continuing the irradiation.
  • the dose monitor 42 measures the irradiated dose, and the count value of the measured dose is sent to the irradiation dose controller 14.
  • the irradiation dose controller 14 is provided with an interlock circuit 14a, and the beam intensity is determined in advance by the irradiation dose controller 14 while the particle beam PB moves at a predetermined scanning speed in the spot interval per spot. When the value is exceeded, the beam is cut off, and irradiation is performed with a constant beam intensity at a spot interval per spot.
  • the ridge filter 43 reduces the energy of the particle beam passing therethrough.
  • the thickness of the particle beam passing through the ridge filter 43 varies depending on the location, the particle beam after passing as a whole is the particle before passing through.
  • the energy width is wider than the energy width of the line. Therefore, when the particle beam after passing through the ridge filter 43 is irradiated into the body, for example, the position of the Bragg peak BP, that is, the range of the particle beam is expanded.
  • the irradiation control calculation unit 70 determines the number of scans and the irradiation dose of each irradiation spot based on the administration dose data and the dose calibration measurement result, and outputs the data to the irradiation dose controller 14 of the irradiation control unit 80. To do. Further, the irradiation control calculation unit 70 also determines the energy and spot size of the particle beam that the accelerator 12 should emit and outputs the data to the accelerator controller 13.
  • FIG. 3 shows an image diagram of the irradiation area when the irradiation target is actually irradiated with the particle beam.
  • each circle indicates each irradiation spot, and scanning is performed in the direction of arrow A from the start spot 101 to the end spot 103 (1st Scan).
  • the second irradiation returns to the direction opposite to the scanning direction of the first irradiation, and scans from the start spot 201 to the end spot 203 in the direction of arrow B (2nd). Scan).
  • the scanning is repeated N times (Nth Scan, N is an integer) as many times as necessary to complete all irradiations.
  • FIG. 4 is a flowchart showing the operation of the particle beam therapy system according to the method for determining the number of scans in the first embodiment.
  • the number of scans is determined by the irradiation control calculation unit 70 (step S403).
  • the number of scans N is determined by equation (4).
  • the value of the number of scans N is rounded down to the first decimal place on the safe side. (Equation 4)
  • Number of scans N [Scan] total spot count value [SPC ⁇ Scan] ⁇ allowed minimum spot count value of one spot [SPC] (4)
  • the vibration is caused by the coils used for the scanning deflection electromagnets 41a and 41b.
  • the position monitor delay speed is the time until the beam is accumulated because the beam irradiation position cannot be calculated unless a certain amount of beam is accumulated in the position monitor in order to calculate the irradiation position of the beam by a position monitor (not shown). Therefore, the settling time and the position monitor delay time are times necessary for the beam scanning position control.
  • the irradiation control calculation unit 70 calculates a spot count value that is evenly distributed per scan from the obtained number of scans N and the total spot count value, and obtains it by the beam intensity to which the interlock value is imposed.
  • the particle beam PB is irradiated with the obtained spot count value (step S404).
  • the beam is repeatedly moved and stopped while continuing the irradiation from the start spot 101 to the end spot 103 (see FIG. 3). Note that the spot count value is rounded off to the first decimal place on the safe side so as not to be interlocked.
  • the scanning is repeated N times as many times as necessary (step S405).
  • the second spot 202 at the same position is irradiated with the same spot count, and this scanning is repeated to form the Nth spot N02.
  • this scanning is repeated to form the Nth spot N02.
  • the interlock circuit 14a is provided, and the number of scans is determined based on the interlock value of the beam intensity, so that complicated calculation and measurement are not required to determine the number of scans.
  • the number of scans can be determined by time, and appropriate irradiation can be performed.
  • the irradiation control unit 80 includes the interlock circuit 14a that imposes an interlock value on the beam intensity.
  • the number of scans is determined based on the dose calibration measurement result, which is the ratio of the actually measured dose value and the count value measured by the dose monitor 42, and the total spot count value and interlock value of a predetermined dose derived from the number of irradiation spots.
  • the irradiation controller 80 scans with the predetermined spot count value measured by the dose monitor 42 with the beam intensity controlled by the interlock value and irradiates the determined number of scans.
  • the number of scans can be easily determined in a short time without the need for complicated calculations and measurements, and appropriate irradiation can be performed. .
  • Embodiment 2 the case of irradiating the particle beam PB with the spot count value in which the total spot count value is equally distributed by the number of irradiations N is shown, but in the second embodiment, the case of adjusting the spot count value is shown.
  • FIG. 5 is a diagram showing an irradiation pattern of the particle beam therapy system according to Embodiment 1 and Embodiment 2 of the present invention.
  • 5A shows the irradiation pattern of the first embodiment
  • FIG. 5B shows the irradiation pattern of the second embodiment.
  • the planned dose per spot that is, the total spot count value is 1502 [SPC ⁇ Scan]
  • the number of scans is 3 by the irradiation control calculation unit 70.
  • the spot count value of each scan in which the total spot count value 1502 [SPC ⁇ Scan] is evenly distributed with the number of scans of 3 is rounded down to the first decimal place as the safe side and becomes 500 [SPC].
  • the total dose per spot is 1500 [SPC ⁇ Scan], which deviates from the ideal value.
  • the total spot count value that is, the total dose per spot is the same as the planned dose per spot in the final (third) scan.
  • the adjustment is performed by the irradiation control calculation unit 70. That is, the irradiation control calculation unit 70 causes the irradiation control unit 80 to irradiate with 500 [SPC], which is a spot count value that is uniformly distributed in the first and second scans, and totals in the last (third) scan. It adjusts so that it may irradiate with 502 [SPC] so that it may become the spot count value 1502 [SPC * Scan], and it makes the irradiation control part 80 irradiate.
  • SPC spot count value that is uniformly distributed in the first and second scans, and totals in the last (third) scan.
  • 502 [SPC] so that it may become the spot count value 1502 [SPC * Scan]
  • FIG. 6 is a flowchart showing the operation of the particle beam therapy system according to the method of determining the number of scans in the second embodiment. Steps 601 to 604 are the same as steps 401 to 404 in the first embodiment, and a description thereof will be omitted.
  • the scan is repeated N-1 times as many times as necessary (step S605). For example, in the first spot 102, the same spot count is irradiated to the second spot 202 at the same position, and this scan is repeated for the (N-1) th time. The same spot count is irradiated up to spot (N-1) 02.
  • the irradiation control calculation unit 70 adjusts the spot count value of the final round (Nth) obtained by Equation (6), and the irradiation control unit 80 sets the interlock value.
  • the particle beam PB is irradiated with the given constant beam intensity (step S606).
  • Spot count value [SPC] for the last round total spot count value [SPC ⁇ Scan] ⁇ (N ⁇ 1) spot count value [SPC] ⁇ (N ⁇ 1) to the (N-1) th round (6)
  • the particle beam PB is irradiated with a constant beam intensity, so that the number of scans can be easily determined in a short time. Accuracy can be improved.
  • the spot count value is adjusted in the final scan, but the present invention is not limited to this.
  • the same effect can be obtained by adjusting the spot count value regardless of whether it is the first scan or the middle scan. Further, there may be a plurality of times for adjustment.
  • the irradiation control calculation unit 70 adjusts the spot count value for any one of the scanning times to obtain the total spot count value. Since irradiation is performed, not only can the number of scans be determined in a short time, but also the accuracy of dose irradiation can be improved.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

L'objectif de la présente invention est de déterminer le nombre de balayages dans un appareil de thérapie par faisceau de particules aisément dans un temps court sans nécessiter des préparations telles que des mesures complexes pour déterminer le nombre de balayages. Une unité de commande d'irradiation (80) comprend un circuit de verrouillage (14a) qui impose une valeur de verrouillage à l'intensité de faisceau. Une unité de calcul de commande d'irradiation (70) détermine le nombre de balayages sur la base de la valeur de verrouillage et du taux de comptage de points total d'une dose prédéterminée dérivée d'une dose administration, d'un résultat de mesure d'étalonnage de dose, et du nombre de points d'irradiation, et balaye avec l'intensité de faisceau à laquelle la valeur de verrouillage est imposée par l'unité de commande d'irradiation (80) à un taux de comptage prédéterminé mesuré par un moniteur de dose (42), de manière à irradier le nombre déterminé de balayages.
PCT/JP2016/054217 2016-02-15 2016-02-15 Appareil de thérapie par faisceau de particules et procédé de détermination du nombre de balayages d'appareils de thérapie par faisceau de particules Ceased WO2017141301A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PCT/JP2016/054217 WO2017141301A1 (fr) 2016-02-15 2016-02-15 Appareil de thérapie par faisceau de particules et procédé de détermination du nombre de balayages d'appareils de thérapie par faisceau de particules
JP2017567571A JP6494808B2 (ja) 2016-02-15 2016-02-15 粒子線治療装置
CN201680080943.7A CN108697904A (zh) 2016-02-15 2016-02-15 粒子射线治疗装置及粒子射线治疗装置的扫描次数决定方法
TW105123723A TWI604869B (zh) 2016-02-15 2016-07-27 粒子射線治療裝置及粒子射線治療裝置之掃描次數決定方法

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PCT/JP2016/054217 WO2017141301A1 (fr) 2016-02-15 2016-02-15 Appareil de thérapie par faisceau de particules et procédé de détermination du nombre de balayages d'appareils de thérapie par faisceau de particules

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021049065A1 (fr) * 2019-09-10 2021-03-18 株式会社日立製作所 Appareil de thérapie par faisceau de particules, procédé de commande d'appareil de thérapie par faisceau de particules et programme informatique

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US20100117002A1 (en) * 2008-10-17 2010-05-13 Ad Verwaltungs-Gmbh & Co. Kg Irradiation System and Irradiation Method
US20110297850A1 (en) * 2010-06-07 2011-12-08 Ion Beam Applications Device and method for particle beam delivery
WO2012117538A1 (fr) * 2011-03-02 2012-09-07 三菱電機株式会社 Système d'irradiation par faisceau de particules et procédé de commande pour un système d'irradiation par faisceau de particules

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DE102009033297A1 (de) * 2009-07-15 2011-01-20 Gsi Helmholtzzentrum Für Schwerionenforschung Gmbh Bestrahlung bzw. Bestrahlungsplanung für ein Rescanning-Verfahren mit einem Partikelstrahl
JP6062073B2 (ja) * 2014-01-10 2017-01-18 三菱電機株式会社 粒子線照射装置
US20160030769A1 (en) * 2014-08-01 2016-02-04 Phenix Medical Llc Method and device for fast raster beam scanning in intensity-modulated ion beam therapy

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100117002A1 (en) * 2008-10-17 2010-05-13 Ad Verwaltungs-Gmbh & Co. Kg Irradiation System and Irradiation Method
US20110297850A1 (en) * 2010-06-07 2011-12-08 Ion Beam Applications Device and method for particle beam delivery
WO2012117538A1 (fr) * 2011-03-02 2012-09-07 三菱電機株式会社 Système d'irradiation par faisceau de particules et procédé de commande pour un système d'irradiation par faisceau de particules

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021049065A1 (fr) * 2019-09-10 2021-03-18 株式会社日立製作所 Appareil de thérapie par faisceau de particules, procédé de commande d'appareil de thérapie par faisceau de particules et programme informatique
JP2021040902A (ja) * 2019-09-10 2021-03-18 株式会社日立製作所 粒子線治療装置、粒子線治療装置の制御方法およびコンピュータプログラム
JP7352417B2 (ja) 2019-09-10 2023-09-28 株式会社日立製作所 粒子線治療装置およびコンピュータプログラム

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JPWO2017141301A1 (ja) 2018-03-29
TW201728353A (zh) 2017-08-16
JP6494808B2 (ja) 2019-04-03
TWI604869B (zh) 2017-11-11
CN108697904A (zh) 2018-10-23

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