WO2017143665A1 - Composition d'alimentation de composé et son application dans la préparation d'additif alimentaire pour animal - Google Patents

Composition d'alimentation de composé et son application dans la préparation d'additif alimentaire pour animal Download PDF

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Publication number
WO2017143665A1
WO2017143665A1 PCT/CN2016/081813 CN2016081813W WO2017143665A1 WO 2017143665 A1 WO2017143665 A1 WO 2017143665A1 CN 2016081813 W CN2016081813 W CN 2016081813W WO 2017143665 A1 WO2017143665 A1 WO 2017143665A1
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WIPO (PCT)
Prior art keywords
feed
animal
acid derivative
benzoate
formula
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Ceased
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PCT/CN2016/081813
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English (en)
Chinese (zh)
Inventor
彭险峰
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Guangzhou Insighter Biotechnology Co Ltd
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Guangzhou Insighter Biotechnology Co Ltd
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Publication of WO2017143665A1 publication Critical patent/WO2017143665A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms

Definitions

  • the invention belongs to the field of animal feed additives, and relates to a compound feed composition containing a butyric acid derivative, a myristic acid derivative and a benzoate and application thereof in preparing an animal feed additive.
  • Animal feed is currently the essential animal-based diet to replace traditional raw produce in animal farming. It is often desirable for animals to consume the least amount of feed in a short period of time for healthy and efficient growth.
  • various functional feed additives are added to the feed during the feed processing process to prepare a functional feed.
  • feed antibiotics, zinc oxide or copper sulfate are commonly used feed additives in the past to improve animal performance and prevent animal diseases.
  • high-dose inorganic zinc or inorganic copper feed additives is toxic to animals and inhibits animal growth; while the abuse of feed antibiotics also leads to microbial resistance, drug residues and drug resistance transmission to human health. Threat.
  • the emergence of these problems has led to restrictions or bans on the use of traditional feed additives in animal farming. Therefore, the development of new safe and efficient feed additives is of great significance to the animal husbandry industry.
  • One of the active ingredients involved in the compound feed composition provided by the present invention is a benzoate.
  • benzoate can prevent or alleviate the symptoms of urinary calculi in ruminants or reduce the acid value of excreta with other ammonium carboxylate salts, and reduce the emission of ammonia in the excretion, but due to the technology in the field It is assumed that benzoic acid will be easily metabolized and degraded by the complex rumen of ruminants, and it is restricted to pigs to control the discharge of excreta gases.
  • the inventors of the present invention found for the first time in the research process that the combination of a carboxylic acid derivative and a benzoate in the breeding of a farm animal has a very significant effect on the control of the diarrhea rate of the animal and the improvement of the production performance, and reaches the common feeding.
  • Levels of feed additives such as antibiotics and high-dose zinc preparations or copper preparations.
  • the carboxylic acid derivative described in the above combined use comprises a butyric acid derivative and a myristic acid derivative.
  • the compound feed composition provided by the present invention contains a butyric acid derivative, a myristic acid derivative, and a benzoate.
  • the butyric acid derivative according to the present invention is butyrate, or the structure thereof is represented by the formula (I), or the structure thereof is as shown in the formula (II):
  • M is selected from H, an alkali metal; and the alkali metal ion includes Na, K, Li, and the like.
  • M is selected from the group consisting of alkaline earth metals, Zn, Fe, Mn, and Cu; and alkaline earth metal ions include Ca, Mg, Be, and the like.
  • the butyrate has a structure as shown in formula (III) or formula (IV):
  • R 1 is selected from C 1-4 straight or branched alkyl
  • the monovalent metal ion butyrate in the above butyrate can be prepared by subjecting butyric acid to a conventional acid-base neutralization reaction with a corresponding base and drying.
  • the divalent metal ion butyrate in the above butyrate is firstly subjected to a conventional neutralization reaction between butyric acid and sodium hydroxide to form sodium butyrate, and then further with a chloride of a divalent metal ion. After the metathesis reaction, it is prepared by separating and drying by precipitation.
  • butyrate can be prepared by rectification of butyric acid with the corresponding C 1-4 linear or branched alkanol or glycerol under esterification conditions.
  • the myristic acid derivative according to the present invention is myristate, or the structure thereof is represented by the formula (V), or the structure thereof is as shown in the formula (VI):
  • M is selected from H, an alkali metal; and the alkali metal ion includes Na, K, Li, and the like.
  • M is selected from the group consisting of alkaline earth metals, Zn, Fe, Mn, and Cu; and alkaline earth metal ions include Ca, Mg, Be, and the like.
  • the myristate has the structure as shown in formula (VII) or formula (VIII):
  • R 5 is selected from C 1-4 straight or branched alkyl
  • the monovalent metal ion myristate in the above myristic acid salt can be prepared by subjecting myristic acid to a conventional acid-base neutralization reaction with my corresponding base and drying.
  • the divalent metal ion myristic acid salt in the above myristic acid salt is first formed by a conventional neutralization reaction between myristic acid and sodium hydroxide to form sodium myristate. It is prepared by metathesis reaction with a chloride of a divalent metal ion, followed by separation and drying by precipitation.
  • the above myristate can be prepared by rectifying the myristic acid with the corresponding C 1-4 linear or branched alkanol or glycerol under esterification conditions.
  • the obtained myristate may exhibit different states of solid and liquid at different temperatures.
  • the benzoate of the present invention is selected from the group consisting of sodium benzoate, potassium benzoate or calcium benzoate, preferably calcium benzoate.
  • the benzoate is an acid-base neutralization reaction of benzoic acid with a corresponding base such as sodium hydroxide, potassium hydroxide or calcium hydroxide, and the reaction solution is concentrated to remove the solvent.
  • the present invention also provides the use of a compound feed composition comprising a butyric acid derivative, a myristic acid derivative and a benzoate in the preparation of a feed additive for animals.
  • the invention proves that the combination of the butyric acid derivative, the myristic acid derivative and the butyric acid derivative in the proper mass ratio to form the forage composition can effectively control various diarrhea of the farmed animal and achieve the most animal performance. optimization.
  • the compound forage composition comprises, in parts by mass, 2-12 parts of a butyric acid derivative, 2-4 parts of a myristic acid derivative, and 20-80 parts of a benzoate.
  • the butyric acid derivatives of the cultured animals were administered separately, and the feed intake of the test animals increased correspondingly with the increase of the dose, and the incidence of diarrhea decreased.
  • the animal benzoate was administered separately, and the diarrhea rate of the cultured animals decreased with the increase of the dose.
  • the animal's production performance improved, but the benzene was dosed at up to 8000 ppm.
  • the diarrhea rate of the animals in the formate test group was almost completely effectively controlled and the animal's production performance did not show the expected improvement effect.
  • the compound forage composition according to the present invention is applied to the breeding of different kinds of farmed animals, and the feed intake of the farmed animals and the production performance of the animals are improved, and the diarrhea rate of the farmed animals is additionally increased. Get well controlled performance in fecal molding and odor control.
  • the compound feed composition of the present invention also contains other trace substances required for other animal nutrition for use in animal breeding.
  • the feed composition further comprises supplementing and balancing nutrients.
  • the feed composition further comprises a health care substance.
  • the feed composition further comprises a physiologically modulating metabolite.
  • the feed composition further comprises an appetite-promoting digestive substance.
  • the feed composition further comprises a processing and preservative-like substance.
  • the feed composition can be a liquid, a solid, a semi-solid, a gel, and the like.
  • the present invention provides a compound forage composition containing a butyric acid derivative, a myristic acid derivative and a benzoate for the preparation of an animal feed additive, in addition to the above-mentioned forage composition, which is also pharmaceutically acceptable.
  • the feed additive can be added to the feed raw material in the feed processing industry according to the demand of the formulated feed to prepare a functional feed for the breeding of the farmed animal.
  • the functional feed on the one hand maintains the health of the animal and on the other hand improves the performance of the animal.
  • the present invention relates to the use of a compound forage composition containing a butyric acid derivative, a myristic acid derivative and a benzoate in the preparation of a diarrhea-resistant feed additive and an animal growth promoter.
  • the use of the animal feed additive for animal breeding has a significant effect in improving feed utilization, improving animal performance, and stimulating animal growth.
  • the animal feed additive can further replace the application of a feed antibiotic animal growth promoter.
  • the animal feed additive can further replace the use of high dose zinc oxide or copper sulfate as an animal growth promoter.
  • the present invention provides a compound forage composition containing a butyric acid derivative, a myristic acid derivative, and a benzoate or an animal feed additive prepared from the composition, which is added to the animal in a separate form. Used in daily rations.
  • the present invention provides a feed composition
  • a feed composition comprising a butyric acid derivative, a myristic acid derivative, and a benzoate or an animal feed additive and feed ingredient, feed additive, prepared from the composition
  • the carrier or diluent is prepared into a feed form such as an additive premixed feed, a concentrated feed, a compound feed, a concentrate feed, etc. in a certain ratio for animal consumption.
  • the feed material according to the present invention refers to a feed material derived from animals, plants, microorganisms or minerals and used for processing feeds but not belonging to feed additives.
  • the feed additive according to the present invention refers to a small amount or a trace amount of substances added during the processing, production and use of feed, including nutritive feed additives and non-nutritive feed additives.
  • the nutritive feed additive refers to a small amount or a trace amount of substances incorporated into the feed for supplementing the nutrients of the feed, including feed grade amino acids, vitamins, mineral trace elements, enzyme preparations, non-protein nitrogen, and the like.
  • Non-nutritive feed additives are small or trace substances that are incorporated into feeds to ensure or improve feed quality and improve feed utilization.
  • the carrier according to the present invention refers to a feedable substance capable of carrying an active ingredient, improving dispersibility, and having good chemical stability and adsorption.
  • the diluent involved in the invention refers to a substance which uniformly distributes the additive raw material in the material and dilutes the high-concentration additive raw material into a low-concentration premix or premix, which can separate the trace components from each other and reduce the active ingredients. Mutual reaction to increase the stability of the active ingredient without affecting the physicochemical properties of the substance.
  • the additive premix feed according to the present invention refers to a feed which is mainly composed of two (types) or two (types) or more nutritive feed additives, and is prepared according to a certain ratio with a carrier or a diluent, including a composite premix feed, and a trace amount. Elemental premix feed, vitamin premix feed.
  • the concentrated feed according to the present invention refers to a feed mainly prepared with a certain proportion of protein, minerals and feed additives.
  • the compound feed according to the present invention refers to a feed prepared by a plurality of feed raw materials and feed additives according to a certain proportion according to the nutritional needs of the farmed animals.
  • the concentrate supplement referred to in the present invention refers to a feed which is prepared by supplementing a plurality of feed materials and feed additives according to a certain ratio in order to supplement the nutrition of the herbivore animal.
  • the compound feed composition provided by the present invention or the feed additive or animal growth promoter prepared therefrom comprises farm animals, poultry and aquaculture animals, and the like, particularly control of diarrhea and dyspepsia in poultry. The effect is more significant.
  • the present invention provides a compound feed composition
  • a compound feed composition comprising a butyric acid derivative, a myristic acid derivative, and a benzoate or an animal feed additive prepared from the composition for use in various growth stages. Breeding of broilers, laying hens, hens, ducks, ducks, geese, turkeys, guinea fowls, pigeons, quails and other artificially reared birds.
  • the present invention provides a compound feed composition containing a butyric acid derivative, a myristic acid derivative, and a benzoate or a feed additive or an animal growth promoter prepared therefrom, and the like. Feeding of livestock such as beef cattle, cows, pigs, raising horses, rabbits, dogs, cats and donkeys in the growing stage.
  • the present invention provides a compound feed composition containing a butyric acid derivative, a myristic acid derivative, and a benzoate or a feed additive or an animal growth promoter prepared therefrom, and the like. Feeding of aquatic animals such as fish, shrimp, clams, crabs or loach in the growing stage.
  • the present invention provides a compound feed composition containing a butyric acid derivative, a myristic acid derivative and a benzoate or an animal feed additive prepared from the composition, which is novel, safe and efficient.
  • Animal feed additives alternative to feed antibiotic animal growth promoters and high doses of zinc oxide or copper sulfate, overcome the drug resistance, drug resistance transmission and other toxic side effects and heavy metals caused by feed antibiotics in animal husbandry
  • the long-term application of the formulation has an impact on animal health and human food safety, and has broad market prospects in animal breeding.
  • the butyric acid derivative, the myristic acid derivative and the benzoate used in the following examples of the present invention are all provided by the research and development center of Guangzhou Instech Biotechnology Co., Ltd., and the sample purity is ⁇ 99%; the Virginiamycin used is used.
  • the preparation is an imported premix, produced by the Belgian production plant of the United States Huibao Co., Ltd.; the colistin sulfate used is produced by Shandong Lukang Pharmaceutical.
  • the compound feed composition of the present invention is prepared as follows:
  • the butyric acid derivative, the myristic acid derivative and the benzoate were uniformly mixed according to the parts by mass of each component to obtain a compound forage composition. It can then be added to animal feed as an animal feed additive.
  • Example 1 Application effect of butyric acid derivatives, myristic acid derivatives and benzoates in weaned pigs
  • Example 2 Effect of compound feed composition on weaned pig feed
  • Example 3 Application effect of compound forage composition in chicken feed.
  • test groups 1800 1 day old fast yellow broilers were randomly divided into 9 test groups, each test group consisted of 4 parallel test groups, each parallel test group was 50, and each group was added as shown in Table 3.
  • a corresponding dose of the additive, wherein the positive control addition was 20 ppm of virginiamycin.
  • they were housed, fed ad libitum and freely drinking water.
  • the test period was 28 days.
  • the average daily gain (ADG), average meat-to-meat ratio (AFCR) and survival rate of the test chickens in each test group were counted within 28 days.
  • ADG average daily gain
  • AFCR average meat-to-meat ratio
  • survival rate of the test chickens in each test group were counted within 28 days.
  • Test results show that different ratios of the compound The improvement of animal performance in feed broiler culture has a significant effect compared with the blank group, calcium myristate group, calcium myristate and calcium butyrate or calcium benzoate. And exceeded the level of the positive control group (Table 3).
  • Example 4 Combined application effect of compound forage composition in grass carp
  • the test fish used was grass carp, which was carried out by the aquatic farm of the Ince Test Site in Guangzhou.
  • the healthy and lively, uniform-sized green carp species were used for formal culture trials after being kept in large cages for 4 weeks.
  • the experimental system was a floating small cage. Both the small cage and the holding cage are placed in a 3500 m 2 pond at the test site. The pond water depth is ⁇ 1.5 m, and the pond water is fully aerated bottom water.
  • 200 fishes that were hungry for 1 day were randomly divided into 5 groups, each group consisted of 4 replicates, and 10 fishes were placed in each replicate. After weighing, they were randomly placed in 16 cages and fed different test feeds. .
  • the test feed was prepared according to the formula.
  • test groups were added with different doses of the compound feed composition containing calcium myristate, calcium butyrate and calcium benzoate in the base material.
  • the test was fed by artificial diet, and the feeding amount was adjusted once a week.
  • the feeding levels (by initial weight) were identical and fed twice a day (7:30 and 15:00).
  • the trial lasted for 8 weeks.
  • the results of the growth promoting test of the compound forage composition on fish are shown in Table 4. The results showed that the test group with different doses of the compound feed composition was superior to the control group in terms of weight gain, feed coefficient and survival rate, and had obvious growth promoting effect.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Fodder In General (AREA)

Abstract

L'invention concerne une composition d'alimentation de composé et son application dans la préparation d'un additif alimentaire pour animal. La composition d'alimentation de composé comprend un dérivé d'acide butyrique, un dérivé d'acide myristique et un benzoate. La composition d'alimentation de composé peut considérablement améliorer la performance de production d'animaux, prévenir et traiter des symptômes de diarrhée chez l'animal, atteignant ou dépassant les résultats d'antibiotiques d'alimentation traditionnels et d'additifs alimentaires à teneur élevée en cuivre ou en zinc.
PCT/CN2016/081813 2016-02-23 2016-05-12 Composition d'alimentation de composé et son application dans la préparation d'additif alimentaire pour animal Ceased WO2017143665A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610098674.9 2016-02-23
CN201610098674.9A CN105724779A (zh) 2016-02-23 2016-02-23 一种复方饲用组合物及其在制备动物饲料添加剂中的应用

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CN115067436A (zh) * 2022-08-22 2022-09-20 山东畜牧兽医职业学院 一种育肥肉鸭养殖专用饲料添加剂的制备方法

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CN108041349A (zh) * 2017-12-26 2018-05-18 重庆医学检验试剂研究所 一种促进水产动物生长的药物组合物及其试剂和方法

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CN104186958A (zh) * 2014-05-23 2014-12-10 广州英赛特生物技术有限公司 肉豆蔻酸铜作为饲料添加剂的应用
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115067436A (zh) * 2022-08-22 2022-09-20 山东畜牧兽医职业学院 一种育肥肉鸭养殖专用饲料添加剂的制备方法
CN115067436B (zh) * 2022-08-22 2022-11-22 山东畜牧兽医职业学院 一种育肥肉鸭养殖专用饲料添加剂的制备方法

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