WO2019017722A2 - Procédé de production de ginsénoside à partir de racine adventive dérivée de gynostemma pentaphyllum - Google Patents

Procédé de production de ginsénoside à partir de racine adventive dérivée de gynostemma pentaphyllum Download PDF

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Publication number
WO2019017722A2
WO2019017722A2 PCT/KR2018/008204 KR2018008204W WO2019017722A2 WO 2019017722 A2 WO2019017722 A2 WO 2019017722A2 KR 2018008204 W KR2018008204 W KR 2018008204W WO 2019017722 A2 WO2019017722 A2 WO 2019017722A2
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WO
WIPO (PCT)
Prior art keywords
ginsenoside
ginsenosides
callus
roots
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/008204
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English (en)
Korean (ko)
Other versions
WO2019017722A3 (fr
Inventor
김선창
라히미샤디
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Among Co
Intelligent Synthetic Biology Center
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Among Co
Intelligent Synthetic Biology Center
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Publication of WO2019017722A2 publication Critical patent/WO2019017722A2/fr
Publication of WO2019017722A3 publication Critical patent/WO2019017722A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/20—Preparation of steroids containing heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/99—Miscellaneous (1.14.99)
    • C12Y114/99007—Squalene monooxygenase (1.14.99.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01021—Squalene synthase (2.5.1.21), i.e. farnesyl-disphosphate farnesyltransferase

Definitions

  • dammarane saponin namely gypenoside or gynosaponin
  • gypenoside or gynosaponin which is rich in various substances such as cholesterol lowering, immunity enhancement, antitumor, antioxidant, It is known as an active ingredient with biological and clinical effects (Yuin et al. 2004).
  • ginseng Panax ginseng
  • gynosaponin a substance that influences the rate of lowering
  • immunity enhancement antitumor
  • antioxidant antioxidant
  • It is known as an active ingredient with biological and clinical effects Yuin et al. 2004.
  • These biological effects have attracted considerable attention to the ability to replace / supplement ginseng ( Panax ginseng ) (Razmovski-Naumovski et al. 2005).

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

La présente invention concerne un procédé de production d'un ginsénoside à partir d'une racine adventive dérivée de Gynostemma pentaphyllum. Plus particulièrement, la présente invention concerne un procédé de production d'un ginsénoside à partir d'une racine adventive dérivée de Gynostemma pentaphyllum, le procédé comprenant : une étape de formation de la racine adventive à partir de Gynostemma pentaphyllum ; et une étape de séparation du ginsénoside de la racine adventive. Le procédé utilise la racine adventive dérivée de Gynostemma pentaphyllum, qui n'a jusqu'ici pas été utilisée dans la production de ginsénosides, pour produire le ginsénoside, et peut donc être utilement utilisée dans le commerce.
PCT/KR2018/008204 2017-07-21 2018-07-20 Procédé de production de ginsénoside à partir de racine adventive dérivée de gynostemma pentaphyllum Ceased WO2019017722A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0092954 2017-07-21
KR20170092954 2017-07-21

Publications (2)

Publication Number Publication Date
WO2019017722A2 true WO2019017722A2 (fr) 2019-01-24
WO2019017722A3 WO2019017722A3 (fr) 2019-03-28

Family

ID=65015525

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/008204 Ceased WO2019017722A2 (fr) 2017-07-21 2018-07-20 Procédé de production de ginsénoside à partir de racine adventive dérivée de gynostemma pentaphyllum

Country Status (2)

Country Link
KR (1) KR102096348B1 (fr)
WO (1) WO2019017722A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112075341B (zh) * 2020-09-08 2023-04-25 桂林丰润莱生物科技股份有限公司 一种快速培养绞股蓝总皂甙的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3151207B2 (ja) * 1989-03-08 2001-04-03 三井化学株式会社 植物の組織培養方法及びその装置ならびに代謝産物の生産方法
CA2011653A1 (fr) * 1989-03-08 1990-09-08 Hiroshi Deno Methode de culture des tissus vegetaux, appareil utilise a cette fin et methode de production de metabolites
KR101765369B1 (ko) * 2014-09-19 2017-08-08 한국과학기술원 돌외 유래의 신규한 당전이효소 및 이의 용도

Also Published As

Publication number Publication date
KR102096348B1 (ko) 2020-04-03
WO2019017722A3 (fr) 2019-03-28
KR20190010487A (ko) 2019-01-30

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