WO2019059709A3 - Ｈｐ1404 펩타이드로부터 유래한 신규 항균 펩타이드 및 이의 용도 - Google Patents

Ｈｐ1404 펩타이드로부터 유래한 신규 항균 펩타이드 및 이의 용도 Download PDF

Info

Publication number
WO2019059709A3
WO2019059709A3 PCT/KR2018/011241 KR2018011241W WO2019059709A3 WO 2019059709 A3 WO2019059709 A3 WO 2019059709A3 KR 2018011241 W KR2018011241 W KR 2018011241W WO 2019059709 A3 WO2019059709 A3 WO 2019059709A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
amino acid
novel antimicrobial
derived
lysine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/011241
Other languages
English (en)
French (fr)
Other versions
WO2019059709A2 (ko
Inventor
박윤경
김민경
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chosun University Industry Academic Cooperation Foundation
Original Assignee
Chosun University Industry Academic Cooperation Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chosun University Industry Academic Cooperation Foundation filed Critical Chosun University Industry Academic Cooperation Foundation
Priority to US16/648,060 priority Critical patent/US11117931B2/en
Publication of WO2019059709A2 publication Critical patent/WO2019059709A2/ko
Publication of WO2019059709A3 publication Critical patent/WO2019059709A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/08—Amines; Quaternary ammonium compounds containing oxygen or sulfur
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/7295—Antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/195—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Molecular Biology (AREA)
  • Dentistry (AREA)
  • Birds (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Bioinformatics & Cheminformatics (AREA)

Abstract

본 발명은 서열번호 1의 아미노산 서열로 이루어진 Hp1404 펩타이드에서 i) 1번째 및 14번째 아미노산이 결실되고, ii) 4번째 및 8번째 아미노산이 리신(lysine, K)으로 치환되고, iii) 7번째 아미노산이 루신(Leucine, L)으로 치환되고, iv) 9번째 아미노산이 글리신(Glycine, G)이거나 또는 리신(K)으로 치환되고, v) 12번째 아미노산이 세린(Serine, S)이거나 또는 리신(K)으로 치환된 항균 펩타이드 및 이의 용도에 관한 것이다.
PCT/KR2018/011241 2017-09-22 2018-09-21 Ｈｐ1404 펩타이드로부터 유래한 신규 항균 펩타이드 및 이의 용도 Ceased WO2019059709A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US16/648,060 US11117931B2 (en) 2017-09-22 2018-09-21 Antimicrobial peptide derived from Hp1404 peptide and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170122504A KR101998106B1 (ko) 2017-09-22 2017-09-22 Hp1404 펩타이드로부터 유래한 신규 항균 펩타이드 및 이의 용도
KR10-2017-0122504 2017-09-22

Publications (2)

Publication Number Publication Date
WO2019059709A2 WO2019059709A2 (ko) 2019-03-28
WO2019059709A3 true WO2019059709A3 (ko) 2019-06-06

Family

ID=65809924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/011241 Ceased WO2019059709A2 (ko) 2017-09-22 2018-09-21 Ｈｐ1404 펩타이드로부터 유래한 신규 항균 펩타이드 및 이의 용도

Country Status (3)

Country Link
US (1) US11117931B2 (ko)
KR (1) KR101998106B1 (ko)
WO (1) WO2019059709A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102603281B1 (ko) * 2021-01-06 2023-11-16 조선대학교 산학협력단 Hylin a1 펩타이드로부터 유래한 신규 펩타이드 및 이의 용도

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970058720A (ko) * 1996-01-29 1997-08-12 허영섭 향균 및 항진균 활성을 갖는 펩타이드
KR101006321B1 (ko) * 2008-11-14 2011-01-06 서울대학교산학협력단 줄무늬감탕벌 독액으로부터 추출한 항생제 활성을 갖는 펩타이드와 이를 코딩하는 유전자
KR20120051862A (ko) * 2010-11-15 2012-05-23 건국대학교 산학협력단 신규한 항염증 펩타이드 유도체 및 그 용도
KR101440112B1 (ko) * 2012-01-10 2014-09-12 건국대학교 산학협력단 애기뿔소똥구리로부터 분리된 ｃｏｐｒｉｓｉｎ 항생펩타이드의 항균, 항염제로서의 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5294605A (en) * 1990-07-19 1994-03-15 The Scripps Research Institute Amphiphilic peptide compositions and analogues thereof
WO2005019241A2 (en) * 2003-08-18 2005-03-03 E.I. Dupont De Nemours And Company Cationic antimicrobial peptides and compositions thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970058720A (ko) * 1996-01-29 1997-08-12 허영섭 향균 및 항진균 활성을 갖는 펩타이드
KR101006321B1 (ko) * 2008-11-14 2011-01-06 서울대학교산학협력단 줄무늬감탕벌 독액으로부터 추출한 항생제 활성을 갖는 펩타이드와 이를 코딩하는 유전자
KR20120051862A (ko) * 2010-11-15 2012-05-23 건국대학교 산학협력단 신규한 항염증 펩타이드 유도체 및 그 용도
KR101440112B1 (ko) * 2012-01-10 2014-09-12 건국대학교 산학협력단 애기뿔소똥구리로부터 분리된 ｃｏｐｒｉｓｉｎ 항생펩타이드의 항균, 항염제로서의 용도

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LI, Z.: "K1K8: an Hpl404-derived antibacterial peptide", APPL. MICROBIOL. BIOTECHNOL., 8 March 2016 (2016-03-08), pages 5069 - 5077, XP035870442, DOI: doi:10.1007/s00253-016-7395-x *

Also Published As

Publication number Publication date
WO2019059709A2 (ko) 2019-03-28
KR20190033837A (ko) 2019-04-01
US11117931B2 (en) 2021-09-14
US20200216497A1 (en) 2020-07-09
KR101998106B1 (ko) 2019-07-09

Similar Documents

Publication Publication Date Title
EP4442816A3 (en) Mutated glycoprotein of vesicular stomatitis virus
IN2014CN02050A (ko)
PE20120358A1 (es) Mutantes fgf21 y usos de los mismos
MX2011011960A (es) Peptidos penetradores de celulas.
NZ603016A (en) Novel immunotherapy against several tumors including neuronal and brain tumors
MX2020010806A (es) Peptidos anti-inflamatorios y usos de los mismos.
NZ600731A (en) Oxyntomodulin peptide analogue
NZ600690A (en) Fkbp-l and uses thereof
NZ570553A (en) Immunogenic peptide sequences from influenza A and B and uses thereof for vaccines
NZ603811A (en) Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases
EP4374913A3 (en) Novel human serum albumin mutant
WO2010126156A3 (en) Alkaline protease variants
FI3737399T3 (fi) ATF5-peptidivariantit ja niiden käytöt
MY209410A (en) Recombinant protein variants
NZ586074A (en) LCLRP peptides, constructs and uses thereof
WO2007142582A8 (en) Fluorescent proteins and genes encoding them
MY206219A (en) Klk5 inhibitory peptide
SG10201803541TA (en) Biologically active c-terminal arginine-containing peptides
CY1111630T1 (el) Παραγωγα κυτοκινων
WO2010057242A3 (de) Vakzin
WO2019059709A3 (ko) Ｈｐ1404 펩타이드로부터 유래한 신규 항균 펩타이드 및 이의 용도
EA201590431A1 (ru) Пшеница с новыми аллелями rht-b1
WO2019103512A3 (ko) 목적 단백질의 발현 효율을 증진시키기 위한 신규한 펩타이드 및 이를 포함하는 융합 단백질
WO2021062389A3 (en) Peptide for treating cancer
WO2018130212A3 (zh) 胃蛋白抗性改良和催化效率提高的植酸酶YkAPPA突变体

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18858283

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18858283

Country of ref document: EP

Kind code of ref document: A2