WO2020009306A1 - Dispositif et méthode de traitement du cancer par champ électrique utilisant un algorithme d'optimisation - Google Patents

Dispositif et méthode de traitement du cancer par champ électrique utilisant un algorithme d'optimisation Download PDF

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Publication number
WO2020009306A1
WO2020009306A1 PCT/KR2019/002009 KR2019002009W WO2020009306A1 WO 2020009306 A1 WO2020009306 A1 WO 2020009306A1 KR 2019002009 W KR2019002009 W KR 2019002009W WO 2020009306 A1 WO2020009306 A1 WO 2020009306A1
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WO
WIPO (PCT)
Prior art keywords
electric field
tumor
electrodes
cancer treatment
electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2019/002009
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English (en)
Korean (ko)
Inventor
윤명근
성지원
서재현
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea University Research and Business Foundation
Fieldcure Co Ltd
Original Assignee
Korea University Research and Business Foundation
Fieldcure Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020180097291A external-priority patent/KR102104961B1/ko
Application filed by Korea University Research and Business Foundation, Fieldcure Co Ltd filed Critical Korea University Research and Business Foundation
Priority to EP19831280.3A priority Critical patent/EP3819005B1/fr
Priority to US17/257,252 priority patent/US11833351B2/en
Publication of WO2020009306A1 publication Critical patent/WO2020009306A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/08—Arrangements or circuits for monitoring, protecting, controlling or indicating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Definitions

  • the present invention relates to an electric field cancer treatment apparatus and method using an optimization algorithm, and more specifically, to the electric field strength applied to the patient's body tumor prescribed or more, the electric field strength to be delivered to normal tissues to minimize the It relates to an electric field cancer treatment apparatus and method using an optimization algorithm that can optimize the size.
  • Cancer treatment techniques using electromagnetic waves are treated by removing tumors on different principles according to treatment frequency bands.
  • the area around 10 10 MHz is a frequency band where X-rays appear and is treated with the principle of breaking and destroying DNA double helix of cancer cells.
  • the electromagnetic wave near 10 MHz is treated with the principle of generating heat in human tumor and removing it.
  • TFields Tumor Treating Fields
  • TFields is a technology that treats tumors by delaying cell division and kills them. It is a cancer treatment technique that is receiving great attention as it is being treated at 1000 treatment centers around the world.
  • the treatment is performed by selecting the position of the electrode that is capable of delivering the maximum electric field to the tumor and delivering the minimum to the normal tissue, but unnecessarily normal because the same voltage is applied to the electrodes.
  • An electric field can be transmitted to the tissue.
  • the present invention relates to a method and apparatus for treating an electric field by further reducing an electric field unnecessarily transmitted to normal tissue by adjusting not only the position of the electrode but also the voltage applied to each electrode through an optimization algorithm.
  • the electric field cancer treatment apparatus for treating a tumor by applying an electric field to a tumor and normal tissue of the patient using a pair of electrode pads having a plurality of electrodes
  • An image classification unit classifying at least one or more organs in the captured image of each patient for each organ;
  • an electric field optimizer configured to calculate the number and positions of electrodes applied based on the classified tumors and the normal tissues and arrange them on electrode pads having a predetermined size, and determine voltage magnitudes of different magnitudes on the calculated electrodes.
  • the electric field optimizer may calculate the voltage to be applied to the plurality of electrodes in consideration of at least one or more of the type of tumor, the location of the tumor, and the boundary state with normal tissue.
  • the electric field optimizer may calculate the voltage level of the electrode to be applied to the tumor with a prescribed electric field strength or more, and to be delivered to the normal organs at a minimum.
  • the electric field optimizer may set the limit electric field value according to the importance of the long term, so that the electrode may be transmitted below the preset limit electric field value.
  • the electric field optimizer may include an objective function selected using at least one or more of the electric field strength delivered to the tumor or the normal organ, the weight for each normal organ, and the limit electric field value.
  • the pair of electrode pads may be formed with one surface ground of the pair.
  • Electric field cancer treatment method for treating a tumor by applying an electric field to the tumor and normal tissue of the patient using a pair of electrode pads having a plurality of electrodes according to an embodiment of the present invention based on the image image of the patient Calling the image to classify the video image for each organ;
  • the electric field optimizer Through the electric field optimizer, the number and positions of electrodes are arranged on electrode pads of a predetermined size based on the patient's tumor and the boundary state between the tumor and normal tissues, and the magnitude of voltage applied to the plurality of electrodes is calculated to calculate at least one or more treatments.
  • the electric field optimizer may calculate the magnitude of the electrode voltage that can be delivered to the tumor at the same time as the prescription electric field or more.
  • the voltage and frequency applied to the electrodes are each within 0V to 150V, and may be formed with a value between 100 and 300kHz.
  • the magnitude of the voltage applied to the electrode may be determined using at least one of the magnitude of the prescription electric field applied to the tumor, the weight for each organ, and a predetermined limit electric field value.
  • the electric field cancer treatment apparatus and method using the optimization algorithm according to the present invention by adjusting the voltage applied to each electrode by using an optimization algorithm to transmit a different electric field in the body, by applying a different electric field to the tumor and normal tissue, By reducing the size of the electric field delivered to normal tissues relative to the tumor, the risk of treatment side effects can be reduced, thereby increasing the probability of treatment success.
  • FIG. 1 is a conceptual diagram of an electric field cancer treatment apparatus using an optimization algorithm according to an embodiment of the present invention.
  • Figure 2 is a conceptual diagram showing the arrangement of the electric field cancer treatment device electrode according to an embodiment of the present invention.
  • FIG. 3 is a flow chart of the electric field cancer treatment method using an optimization algorithm according to an embodiment of the present invention.
  • 4 and 5 are simulation comparison diagrams comparing the conventional technology with the electric field cancer treatment apparatus using an optimization algorithm according to an embodiment of the present invention.
  • FIG. 1 is a conceptual diagram of an electric field cancer treatment apparatus using an optimization algorithm according to an embodiment of the present invention
  • Figure 2 is a conceptual diagram showing the arrangement of the electric field cancer treatment device electrode according to an embodiment of the present invention.
  • an electric field cancer treatment apparatus using an optimization algorithm is to treat a tumor by applying a voltage to form an electric field in a tumor and normal tissue of a patient.
  • the electrode pad 110, the image classifying unit 120 and the electric field optimizer 130 is configured.
  • the pair of electrode pads 110 includes a plurality of electrodes 111, and the electrodes 111 may be arranged in various ways according to the shape of the electrode pad 110.
  • the electrode 111 has been described as being arranged in a square matrix of 3 ⁇ 3 as shown in FIG. 2 as an example, the number and spacing, etc. can be variously modified through the electric field optimizer 130 to be described later, its shape and arrangement The form is not limited to FIG. 2.
  • the electrode pad 110 is illustrated as having two pairs, the electrode pad 110 may be added or reduced depending on the treatment condition of the patient.
  • the pair of electrode pads 110 may be formed with one surface of the pair as the ground (G).
  • the image classification unit 120 serves to classify at least one or more organs in each image of the captured patient.
  • the image image may be an MRI or CT image. MRI or CT is taken with various organs, including tumors.
  • the image classification unit 120 classifies the plurality of organs photographed by each organ, and determines the separation distance and the positional relationship between the normal tissue and the tumor.
  • the image classifier 120 automatically classifies the organs according to organs or sets a boundary part for each organ according to a user definition, and reconstructs each image into three-dimensional images for each organ to clearly distinguish the positional relationship of each organ.
  • the data may be applied to adjust the size of the pair of electrode pads 110 or the arrangement of the electrodes.
  • the electric field optimizer 130 calculates the number and positions of electrodes applied based on the classified tumor and normal tissue, arranges them on the electrode pad 110 of a predetermined size, and determines voltages of different sizes on the calculated electrodes. do. That is, the electric field optimizer 130 calculates the magnitude of the voltage applied to the electrode in consideration of the classified tumor, normal tissue, and the state of the tumor.
  • the electric field optimizer 130 may calculate the magnitude of the voltage applied to the electrode in consideration of at least one or more of the type of tumor to be treated, the location of the tumor, and the boundary state between the tumor and normal tissue.
  • the electric field optimizer 130 sets the electrode weight as a variable, and separates the electrode to be applied to the voltage and the electrode to be formed of the ground among the plurality of electrodes, the plurality of electrodes can be set differently according to the type of tumor have. For example, in the case of gyomo-sejong, 200kHz, and in the case of lung cancer, it is set to 150kHz to calculate the final electrode weight and voltage of each electrode.
  • the electric field optimizer 130 may include an objective function selected using at least one or more of electric field strength, normal organ weights, and limit electric field values transmitted to a tumor or normal organ.
  • the electric field optimizer 130 may set the limit electric field value according to the importance of the long-term, so that the electrode is delivered to the preset limit electric field value or less.
  • the limit electric field means the range of the electric field is set so that more than the predetermined electric field strength is transmitted to the normal organ.
  • the objective function is to adjust the intensity of the electric field so that the minimum electric field is applied to the main organs of normal tissues when an electric field of more than the prescribed electric field is applied to the tumor.
  • the prescription electric field is the size of the electric field to be delivered over a certain intensity to the total volume of the patient tumor during the treatment of the electric field
  • the limit electric field is the size of the electric field to be delivered below a certain field strength to the total volume of normal organs.
  • the doctor applies the strength of the prescribed electric field to the tumor at 1.5 V / cm, and delivers less than the 0.5 V / cm limit electric field to the total volume in important organs.
  • a treatment plan can be developed.
  • the average electric field strength is the average electric field strength delivered to one organ, and the same electric field is not transmitted to all parts of one organ. Since the electric field strengths are different for each microvolume, the average electric field strength is determined for one organ.
  • the intensity of the electric field can be calculated from the conditions of Equations 2 to 4.
  • Is the electric field strength at point i Is the weight of the j th electrode, Is the strength of the electric field transmitted to point i due to the j th electrode.
  • Equation 2 is calculated based on the strength of the prescription electric field as follows.
  • Equation 3 is to calculate the electric field based on the weight of the importance of the long term and the objective function (f) considering the limit electric field strength of the normal organ.
  • the strength of the marginal electric field is a constant that depends on the importance of the organ.
  • Equation 4 is calculated by considering the weight of each organ and the average electric field strength of the N-th normal organ.
  • the objective function for calculating the electric field acting in the normal organ is not limited to the above equation, and may be used in various ways in consideration of the type and location of the tumor.
  • the present invention is a voltage applied to the electrode is within 0V ⁇ 150V, the frequency is formed to a value between 100 ⁇ 300kHz to calculate the electric field value, is applied to the body in consideration of the location of the tumor and the importance of each organ, etc.
  • the electric field is calculated.
  • the intensity of the electric field calculated through the above-described method is converted into a voltage applied to the electrode.
  • the range of the voltage set as described above may belong to the same range as the conventional treatment device, the present invention, in consideration of the position and the relationship between the tumor and normal organs, and differently set the arrangement and position of the electrode, a plurality of electrodes
  • the therapeutic magnetic field and the general magnetic field of different sizes can be applied to prevent normal tissue from being damaged.
  • FIG. 3 is a flow chart of the electric field cancer treatment method using an optimization algorithm according to an embodiment of the present invention.
  • an electric field cancer treatment method using an optimization algorithm is to treat a tumor by transmitting an electric field to a patient's tumor and normal tissue using a pair of electrode pads having a plurality of electrodes.
  • the number and positions of the electrodes are arranged on the electrode pad having a predetermined size based on the patient's tumor and the boundary state between the tumor and the normal tissue through the electric field optimizer, and the magnitude of the voltage applied to the plurality of electrodes is calculated.
  • the method of arranging the electrodes may be arranged in the form of a square matrix as shown in FIG. 2, but alternatively, asymmetry or spacing may be variously set. However, it is preferable that the pair of electrodes facing each other be formed at the same position with each other.
  • the voltage and frequency applied are set differently between the tumor and normal tissue, the voltage is within 0V ⁇ 150V, the frequency can be formed with a value between 100 ⁇ 300kHz.
  • the treatment is performed by applying the calculated voltages to the plurality of electrodes under optimal conditions of the analyzed treatment plan (S400).
  • 4 and 5 are simulation comparison diagrams comparing the conventional technology with the electric field cancer treatment apparatus using an optimization algorithm according to an embodiment of the present invention.
  • FIG. 4 shows an electric field when a different voltage value is applied to each electrode by applying an electric field distribution and an electric field optimizer which are obtained when the same voltage value is applied to all electrodes in the conventional manner. It shows the distribution (after).
  • Figure 5 shows the electric field distribution (after) when the different voltage values are applied to each electrode by applying the electric field distribution (before) and the optimization algorithm obtained when the same voltage value is applied to all electrodes in the conventional manner.
  • Table 2 shows a quantitative analysis of FIG. 5, and all indicator values after applying the electric field optimizer are reduced. That is, it can be seen that the electric field strength delivered to the normal organ is greatly reduced after applying the electric field optimizer.

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract

La présente invention concerne un dispositif et une méthode de traitement du cancer par champ électrique utilisant un algorithme d'optimisation, le dispositif de traitement de traitement du cancer par champ électrique permettant le traitement d'une tumeur par application de champs électriques à la tumeur et aux tissus normaux d'un patient par utilisation d'au moins une paire de pastilles d'électrode ayant une pluralité d'électrodes. Le dispositif de traitement de traitement du cancer par champ électrique comprend : une unité de classification d'image pour classifier, par organe, au moins un organe dans une image capturée d'un patient ; et une unité d'optimisation de champ électrique pour, sur la base d'une tumeur classifiée et de tissus normaux, calculer le nombre et les positions des électrodes qui sont appliquées et agencer celles-ci sur des pastilles d'électrode ayant une taille prédéterminée, et déterminer des niveaux de tension mutuellement différents pour les électrodes calculées. Selon la présente invention, lorsque des champs électriques appliqués aux électrodes respectives sont ajustés par utilisation d'un algorithme d'optimisation, et que les champs électriques sont transférés à l'intérieur d'un corps humain, des champs électriques mutuellement différents peuvent être appliqués à la tumeur et aux tissus normaux, et ainsi, le niveau du champ électrique transféré aux tissus normaux peut être relativement inférieur au niveau du champ électrique transféré à la tumeur, et, par conséquent, un risque d'effets secondaires de traitement peut être réduit, et ainsi, le taux de réussite de traitement peut être accru.
PCT/KR2019/002009 2018-07-03 2019-02-20 Dispositif et méthode de traitement du cancer par champ électrique utilisant un algorithme d'optimisation Ceased WO2020009306A1 (fr)

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Application Number Priority Date Filing Date Title
EP19831280.3A EP3819005B1 (fr) 2018-07-03 2019-02-20 Dispositif de traitement du cancer par champ électrique utilisant un algorithme d'optimisation
US17/257,252 US11833351B2 (en) 2018-07-03 2019-02-20 Apparatus and method for alternating electric fields therapy using an optimization algorithm

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KR20180077093 2018-07-03
KR10-2018-0077093 2018-07-03
KR10-2018-0097291 2018-08-21
KR1020180097291A KR102104961B1 (ko) 2018-07-03 2018-08-21 최적화 알고리즘을 이용한 전기장 암치료장치

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113171555A (zh) * 2021-04-23 2021-07-27 济南显微智能科技有限公司 一种电场治疗癌症的装置和装置使用方法
CN114099962A (zh) * 2021-12-22 2022-03-01 江苏海莱新创医疗科技有限公司 肿瘤电场治疗系统及其电极片组件
CN114269274A (zh) * 2020-07-16 2022-04-01 株式会社电界 基于吸收能量的电场癌治疗计划系统及方法
CN117204943A (zh) * 2023-11-07 2023-12-12 南京康友医疗科技有限公司 一种射频消融导管的功率控制方法和系统
CN117563139A (zh) * 2024-01-12 2024-02-20 湖南安泰康成生物科技有限公司 一种利用电场抑制肿瘤增殖的设备及处理器
CN117797405A (zh) * 2023-12-29 2024-04-02 应脉医疗科技(上海)有限公司 一种肿瘤治疗场系统及其调控方法

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US20100250209A1 (en) * 2009-03-31 2010-09-30 Pearson Robert M System and method for estimating a treatment region for a medical treatment device
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US20170161454A1 (en) * 2014-07-03 2017-06-08 Bryan Howell Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices
WO2018106843A1 (fr) * 2016-12-06 2018-06-14 The Regents Of The University Of California Stimulation transcutanée multiélectrode optimale à focalité et intensité élevées
KR20180072811A (ko) * 2015-10-28 2018-06-29 지브 봄존 MRI 기반 전도도 측정에 기반한 머리 위 전극 위치의 최적화된 TTField 치료

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Publication number Priority date Publication date Assignee Title
US7146210B2 (en) * 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US20100250209A1 (en) * 2009-03-31 2010-09-30 Pearson Robert M System and method for estimating a treatment region for a medical treatment device
WO2015111091A1 (fr) * 2014-01-21 2015-07-30 新エネルギー産業株式会社 Dispositif médical du type à variation de potentiel électrique
US20170161454A1 (en) * 2014-07-03 2017-06-08 Bryan Howell Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices
KR20180072811A (ko) * 2015-10-28 2018-06-29 지브 봄존 MRI 기반 전도도 측정에 기반한 머리 위 전극 위치의 최적화된 TTField 치료
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114269274A (zh) * 2020-07-16 2022-04-01 株式会社电界 基于吸收能量的电场癌治疗计划系统及方法
CN113171555A (zh) * 2021-04-23 2021-07-27 济南显微智能科技有限公司 一种电场治疗癌症的装置和装置使用方法
CN114099962A (zh) * 2021-12-22 2022-03-01 江苏海莱新创医疗科技有限公司 肿瘤电场治疗系统及其电极片组件
CN117204943A (zh) * 2023-11-07 2023-12-12 南京康友医疗科技有限公司 一种射频消融导管的功率控制方法和系统
CN117204943B (zh) * 2023-11-07 2024-02-09 南京康友医疗科技有限公司 一种射频消融导管的功率控制方法和系统
CN117797405A (zh) * 2023-12-29 2024-04-02 应脉医疗科技(上海)有限公司 一种肿瘤治疗场系统及其调控方法
CN117563139A (zh) * 2024-01-12 2024-02-20 湖南安泰康成生物科技有限公司 一种利用电场抑制肿瘤增殖的设备及处理器
CN117563139B (zh) * 2024-01-12 2024-04-09 湖南安泰康成生物科技有限公司 一种利用电场抑制肿瘤增殖的设备及处理器

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