WO2020071665A3 - 세포의 텔로미어를 신장시키는 조성물 및 그 제조방법 - Google Patents

세포의 텔로미어를 신장시키는 조성물 및 그 제조방법 Download PDF

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WO2020071665A3
WO2020071665A3 PCT/KR2019/012150 KR2019012150W WO2020071665A3 WO 2020071665 A3 WO2020071665 A3 WO 2020071665A3 KR 2019012150 W KR2019012150 W KR 2019012150W WO 2020071665 A3 WO2020071665 A3 WO 2020071665A3
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exosome
composition
extending
cells
telomeres
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WO2020071665A2 (ko
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이용승
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Stemon Inc
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Stemon Inc
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Priority to EP19869268.3A priority Critical patent/EP3862429B1/en
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Priority to JP2021516687A priority patent/JP7320302B2/ja
Priority claimed from KR1020190115381A external-priority patent/KR102228136B1/ko
Publication of WO2020071665A2 publication Critical patent/WO2020071665A2/ko
Publication of WO2020071665A3 publication Critical patent/WO2020071665A3/ko
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Abstract

본 발명은 세포의 텔로미어를 신장시키는 엑소좀, 이를 포함하는 조성물 및 그 제조방법에 관한 것으로서, 보다 상세하게는 TERT, TERF2, DKC1, TERF2IP, RFC1, RAD50, TERF1, PINX1, TNKS1BP1, ACD, NBN, HSPA1L, PARP1, PTGES3, SMG6, BLM, XRCC5, XRCC6, ERCC4, PRKDC, TEP1 및 β-Catenin 중에서 선택된 유전자 하나 이상의 유전자 산물을 포함하는 것을 특징으로 하는, 세포의 텔로미어를 신장시키는 엑소좀, 이를 포함하는 조성물 및 세포에 직간접적으로 물리적 자극을 제공하여 상기 세포로부터 텔로미어를 신장시키는 엑소좀을 유도하는 방법을 개시한다. 이러한 엑소좀을 포함하는 조성물은 기존에 개시된 조성물에 비해 저농도로, 생체에 비침습적인 적용방법으로도 효과를 나타낼 수 있으며, 안전성이 높을 뿐 아니라, 단순히 텔로미어를 신장시키는 데에 그치지 않고, 세포 분열을 유도하고 항노화, 조직재생, 상처치유 및 흉터치유 등의 효과를 가질 수 있다. 또한, 본 발명의 텔로미어를 신장시키는 엑소좀의 제조방법은 기존의 텔로미어 신장용 조성물에 비해 제조가 간단하고, 수율이 높으며, 환경적인 부담이 줄어들 수 있는 효과를 가진다.
PCT/KR2019/012150 2018-10-02 2019-09-19 세포의 텔로미어를 신장시키는 조성물 및 그 제조방법 Ceased WO2020071665A2 (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP19869268.3A EP3862429B1 (en) 2018-10-02 2019-09-19 Composition for extending telomere of cell and preparation method therefor
US17/277,587 US20220073901A1 (en) 2018-10-02 2019-09-19 Composition for extending telomere of cell and preparation method therefor
JP2021516687A JP7320302B2 (ja) 2018-10-02 2019-09-19 細胞のテロメアを伸長させる組成物およびその製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20180117265 2018-10-02
KR10-2018-0117265 2018-10-02
KR1020190115381A KR102228136B1 (ko) 2018-10-02 2019-09-19 세포의 텔로미어를 신장시키는 조성물 및 그 제조방법
KR10-2019-0115381 2019-09-19

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WO2020071665A2 WO2020071665A2 (ko) 2020-04-09
WO2020071665A3 true WO2020071665A3 (ko) 2020-05-22

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PCT/KR2019/012150 Ceased WO2020071665A2 (ko) 2018-10-02 2019-09-19 세포의 텔로미어를 신장시키는 조성물 및 그 제조방법

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US (1) US20220073901A1 (ko)
JP (1) JP7320302B2 (ko)
CN (1) CN110982780A (ko)
WO (1) WO2020071665A2 (ko)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
KR102176845B1 (ko) * 2018-10-02 2020-11-10 주식회사 스템온 유도된 엑소좀을 포함하는 피부 재생 및 상처 치유용 조성물
CN112553152B (zh) * 2020-10-27 2024-09-17 重庆市铂而斐细胞生物技术有限公司 一种快速提高脂肪间充质干细胞外泌体产量的方法
CN116333982A (zh) * 2023-03-23 2023-06-27 深圳市第三人民医院(深圳市肝病研究所) 一种用于皮肤舒敏、抗衰与修复的细胞活性因子制剂组合物及其制备方法与应用
CN120425013A (zh) * 2025-05-13 2025-08-05 温州聚恩辈实业有限公司 一种筛选保护皮肤细胞端粒的活性物的方法

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WO2018057542A1 (en) * 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
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KR101855967B1 (ko) * 2016-03-11 2018-05-10 가톨릭관동대학교산학협력단 물리적 자극에 의한 환경유입을 이용한 세포 리프로그래밍 방법
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WO2020071665A2 (ko) 2020-04-09
JP2022501052A (ja) 2022-01-06
CN110982780A (zh) 2020-04-10
JP7320302B2 (ja) 2023-08-03
US20220073901A1 (en) 2022-03-10

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