WO2020144105A1 - Dispositif microfluidique et appareil d'analyse pour un dispositif microfluidique - Google Patents

Dispositif microfluidique et appareil d'analyse pour un dispositif microfluidique Download PDF

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Publication number
WO2020144105A1
WO2020144105A1 PCT/EP2020/050062 EP2020050062W WO2020144105A1 WO 2020144105 A1 WO2020144105 A1 WO 2020144105A1 EP 2020050062 W EP2020050062 W EP 2020050062W WO 2020144105 A1 WO2020144105 A1 WO 2020144105A1
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WO
WIPO (PCT)
Prior art keywords
microfluidic device
cavity
conductor track
movement element
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2020/050062
Other languages
German (de)
English (en)
Inventor
Samir KADIC
Jochen Hoffmann
Christoph FAIGLE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Publication of WO2020144105A1 publication Critical patent/WO2020144105A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—ELECTRIC POWER NETWORKS; CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
    • H02J50/10—Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1816—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using induction heating
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—ELECTRIC POWER NETWORKS; CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
    • H02J50/005—Mechanical details of housing or structure aiming to accommodate the power transfer means, e.g. mechanical integration of coils, antennas or transducers into emitting or receiving devices
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—ELECTRIC POWER NETWORKS; CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
    • H02J50/70—Circuit arrangements or systems for wireless supply or distribution of electric power involving the reduction of electric, magnetic or electromagnetic leakage fields

Definitions

  • the invention is based on a device or a method according to the type of the independent claims.
  • a microfluidic device for example a chip laboratory cartridge, can have a fluidic network with which reagents can be processed.
  • the microfluidic device can be used for energy transfer
  • Current conductors can be arranged to form a three-dimensional
  • Ladder structure can be rolled.
  • DE 102007045946A1 describes such a conductor structure.
  • a conductor track can be arranged in a substrate of a microfluidic device which, when an external component, for example a plunger with a further conductor track, is introduced, can provide the functionality of an electrical coil for non-contact inductive energy transmission to enable.
  • the conductor track can advantageously be arranged in a space-saving manner and can be produced inexpensively.
  • the functionality of the electrical coil for inductive energy transmission is advantageous in terms of degradation-free
  • a microfluidic device is presented.
  • the device has a substrate with at least one cavity and at least one conductor track.
  • a movement element can be inserted into the cavity.
  • the conductor track is arranged on the cavity.
  • the conductor track is shaped to be one
  • the microfluidic device can be, for example, a device for a chip laboratory, also called a lab-on-a-chip system.
  • a chip laboratory can be understood to mean a microfluidic system in which the entire functionality of a macroscopic laboratory can be accommodated on a plastic substrate, for example the size of a credit card, the chip laboratory cartridge, and in which complex biological, diagnostic, chemical or physical processes can be miniaturized.
  • a liquid can be provided or transported on a chip.
  • the microfluidic device can be such a microfluidic cartridge.
  • the substrate can be formed from a polymer, for example polycarbonate or one or a thermoplastic elastomer.
  • the cavity can be a chamber of the cartridge, for example a fluid chamber for storing or processing a fluid in the cartridge. On one side of the cavity on which the
  • the conductor track can be understood to mean, for example, a winding.
  • the winding can, for example, be arranged in the form of a coil or spiral on the cavity.
  • the conductor track can be implemented as printed electronics, for example by means of screen printing of silver or carbon pastes.
  • Movement element can be, for example, a plunger of an analysis device for the microfluidic device. To provide the functionality of an electrical coil when inserting the movement element, this can
  • Movement element for example from a magnetic or
  • magnetizable material for example made of iron.
  • the functionality of an electrical coil can be understood, for example, to mean that a voltage is induced in the conductor track when a magnetic field changes, or vice versa, and a magnetic field is generated when a current flows through the conductor track.
  • the conductor track can be used to provide the
  • the conductor track can have the at least one turn before the movement element is introduced into the cavity or can be obtained by inserting the movement element.
  • the conductor track can be arranged in a spiral around an insertion area for the movement element.
  • the insertion region can have, for example, a section of one side of the cavity.
  • the conductor track can for example on one side of the
  • the cavity can be arranged, or the conductor track can surround a portion of the cavity or two side walls of the cavity, for example in a spiral.
  • This arrangement of the conductor track is advantageously space-saving.
  • the arrangement enables the functionality of the electrical coil to be easily provided by means of the conductor track when the movement element is inserted into the cavity with the conductor track.
  • the conductor track can be formed as an electrical coil according to one embodiment.
  • the conductor track can also be designed as an electrical coil, the inductive
  • the excitation coil can be, for example, another conductor track in the form of a winding around the movement element. If the moving element is inserted into the cavity, this can Movement element represent a core for the conductor track formed as an electrical coil.
  • Excitation coil is thus possible to provide inductive energy transmission through the conductor track as an electrical coil.
  • a contact-free inductive energy transfer between the microfluidic is therefore advantageous
  • the conductor track is formed as an electrical coil
  • microfluidic device have a core element which is arranged within the electrical coil in the cavity.
  • the core element can protrude beyond the electrical coil to form a
  • the core element can be a metal core, for example.
  • the core element can be shaped to protrude into the excitation coil when the movement element is inserted into the cavity.
  • the movement element can be shaped, for example, as a hollow cylinder, and can be shaped to at least partially enclose the core element in the state introduced into the cavity. This advantageously enables the functionality of the electrical coil
  • the substrate can have a shielding element arranged on the cavity.
  • the shielding element can be designed to shield an environment of the cavity from a magnetic field generated by means of the electrical coil.
  • the shielding element can be a metal shell, for example. This advantageously increases
  • Shielding element an electromagnetic compatibility with respect to other components of the microfluidic device or the analyzer for the microfluidic device.
  • the substrate can have an insert element that can be arranged in the cavity.
  • the conductor track can on the
  • Insert element can be arranged.
  • the insert element also called inlay in the following, can for example be shaped to be insertable into the substrate. It is thus advantageously possible to insert the insert element with the Insert the conductor track into a commercially available cartridge as required. This is also advantageous in terms of manufacturing costs.
  • the insert element can also have an upstream substance for processing in the device.
  • the insert element can comprise, for example, a reagent bar in which substances are stored.
  • Under the upstream substance can be used to prepare upstream substances for processing in the device.
  • a liquid reagent can be understood, such as a saline, ethanol-containing or aqueous solution, or a detergent or dry reagent, such as lyophilisate or salt.
  • the inductive energy transfer can thus advantageously be combined with a substance upstream in the microfluidic device.
  • the substrate can also comprise a membrane.
  • the membrane can be arranged on one side of the cavity on which the movement element can be inserted.
  • the membrane can be shaped to seal the cavity on at least the side in a fluid-tight manner.
  • the membrane can be elastic. When the movement element is introduced, the membrane can be deflectable along a direction of movement of the movement element. The fluid-tight sealing of the cavity advantageously enables one
  • the membrane can be formed from an elastic and electrically insulating material.
  • the membrane can be formed from a polymer, for example a thermoplastic elastomer.
  • the membrane can have a layer thickness of 25 to 500 micrometers.
  • the membrane can also be formed from a material that increases a magnetic flux density.
  • the conductor track can be arranged planar on a side of the membrane facing the cavity.
  • windings of the conductor track can extend in a common plane.
  • the conductor track can thus advantageously be arranged in a space-saving manner. If the conductor track is arranged planar on the membrane, the conductor track can for example, be embedded in the membrane. This advantageously protects the conductor track, for example against a damp environment.
  • a further layer for example a further membrane, can be applied to the side of the membrane on which the conductor track is arranged, for example by means of laser welding, in order to cover the conductor track from two sides.
  • the conductor track can be deformable to provide the functionality of the electrical coil by deflecting the membrane.
  • the conductor track can deform. If the conductor track is arranged, for example, in a planar manner on the cavity, the conductor track can be shaped in the form of an electrical coil by the deformation.
  • Movement element can deflect the membrane, whereby material can expand between or in the region of the conductor track.
  • the membrane and the conductor track can thereby be pressed in the direction of movement of the movement element, as a result of which the conductor track deforms to form the electrical coil.
  • the deformation of the coil is not permanent, but is caused by the deflection of the membrane and is by
  • the substrate can have a further conductor track according to one embodiment.
  • the further conductor track can be arranged on the membrane or on a further membrane on the cavity.
  • the further conductor track can, for example, also be planar and can be shaped when the
  • Movement element to be pressed into the conductor track The conductor track and the further conductor track can slip into one another.
  • inductive energy transmission is thus possible without contact.
  • This approach also becomes an analysis device for a microfluidic
  • the microfluidic device has a substrate with at least one cavity into which a movement element can be inserted.
  • the microfluidic device has a conductor track which is arranged on the cavity. The conductor track is shaped to a
  • the analysis device comprises a receiving area for receiving the microfluidic device and a movable platform with the
  • the platform is designed to insert the movement element into the cavity.
  • the microfluidic device can be an embodiment of the above-mentioned device.
  • the microfluidic device can be, for example, a cartridge for a chip laboratory.
  • the analysis device can, for example, be an analysis unit for the microfluidic device.
  • the movement element can be formed from an electrically conductive material or magnetizable material, for example from iron.
  • the movement element can have a diameter of five millimeters to five centimeters.
  • the movement element can be a plunger, for example, which is designed to prepare or bring about a processing of a fluid in the device by insertion into the microfluidic device.
  • the plunger can be shaped to pierce or deflect an element of the microfluidic device, for example the membrane.
  • the movement element can be an adjustment pin for adjusting or correcting a position of the microfluidic device in the receiving area or in the analysis device.
  • the movement element can be a
  • Excitation coil can be arranged as a winding around the movement element on the movement element.
  • the excitation coil can protrude into or be surrounded by the conductor track of the microfluidic device.
  • the excitation coil can also be attached to a section of the
  • Movement element can be arranged, which is not inserted into the cavity during insertion, for example on a portion of the movement element arranged in the platform.
  • the excitation coil is
  • the movement element can be shaped as a hollow cylinder.
  • the movement element can, for example, be designed to comprise a different element when it is introduced into the cavity,
  • the movement element can also be formed from an electrically insulating material, for example from a plastic.
  • Figure 1 is a schematic representation of an analysis device with a microfluidic device according to an embodiment.
  • FIG. 2 shows a schematic illustration of a part of a microfluidic device and an analysis device according to an exemplary embodiment
  • FIG. 3 shows a schematic illustration of a part of a microfluidic device and an analysis device according to an exemplary embodiment
  • FIG. 4 shows a schematic illustration of a part of a microfluidic device and an analysis device according to an exemplary embodiment
  • FIG. 5 shows a schematic illustration of a part of a microfluidic device and an analysis device according to an exemplary embodiment
  • FIG. 6 shows a schematic illustration of part of a microfluidic device according to an exemplary embodiment
  • 7 shows a schematic illustration of a part of a microfluidic device and an analysis device according to an exemplary embodiment
  • Fig. 8 is a schematic representation of an analysis device with a microfluidic device according to an embodiment.
  • FIG. 1 shows a schematic illustration of an analysis device 100 with a microfluidic device 105 according to an exemplary embodiment.
  • the analysis device 100 for the microfluidic device 105 comprises one
  • the platform is designed to introduce the movement element 120 into the microfluidic device 105.
  • the microfluidic device 105 has a substrate 125 with at least one cavity 130.
  • the movement element 120 of the analysis device 100 can be inserted into the cavity 130.
  • the microfluidic device 105 has a conductor track 135.
  • the conductor track 135 is arranged on the cavity 130.
  • the conductor track 135 is designed to provide a functionality of an electrical coil for inductive energy transmission when the movement element 120 is inserted into the cavity 130.
  • the analysis device 100 can be used as a chip laboratory analysis device for a microfluidic cartridge, such as the microfluidic device 105 shown here.
  • the substrate 125 of the microfluidic device 105 is formed from a polymer composite and the microfluidic device 105 contains a fluidic network with which reagents can be processed. If the analysis device 100 is connected to a power supply, for example a power network, electrification of the microfluidic device 105 shown here is by means of Induction possible. This enables contact-free energy transfer from the analysis device 100 to the microfluidic device 105.
  • the microfluidic device 105 has the conductor track 135. The on that
  • Cavity 130 arranged conductor track 135 has at least one winding.
  • the conductor track 135 is optionally shaped to partially enclose the cavity 130.
  • the winding of the conductor track 135 leads around the cavity 130, for example, and thus surrounds the cavity 130
  • the conductor track 135 can, for example, also be arranged planar on one side of the cavity 130, for example on a side of the cavity 130 facing the movement element 120.
  • the conductor track 135 can be formed from a metallic wire, for example from a enamelled copper wire, and has a diameter of for example 0.1 to 0.5
  • the conductor track 135 can advantageously be arranged in the microfluidic device 105 in a space-saving manner.
  • FIG. 2 shows a schematic illustration of a part of a microfluidic device 105 and an analysis device 100 according to one
  • Embodiment As part of the analysis device 100, a section of the platform 115 with the movement element 120 is shown.
  • the section of the microfluidic device 105 shows the cavity 130 in the substrate 125 with the conductor track 135, which according to the exemplary embodiment shown here is arranged as an electrically conductive coil around the cavity 130.
  • the movement element 120 is also introduced into the cavity 130 here.
  • the conductor track 135 is arranged in a spiral around an insertion area for the movement element 120.
  • the winding of the conductor track 135 spirally surrounds the cavity 130.
  • the conductor track 135 thus has a plurality of turns. Movement element 120 points according to that shown here
  • Embodiment an excitation coil 205. If that
  • Movement element 120 with the excitation coil 205 surrounds the conductor track 135 the excitation coil 205.
  • the excitation coil 205 thus lies here as an inner coil within the conductor track 135 formed as an outer coil.
  • the conductor track 135 is thus designed as a further electrical coil.
  • the conductor track 135 is designed to enable inductive energy transmission when the movement element 120 with the excitation coil 205 is inserted into the cavity 130. A contact-free energy transfer between the analysis device 100 and the microfluidic device 105 is thus advantageously possible.
  • the conductor track 135 and the excitation coil 205 are as
  • Induction coils can be used, which slip into one another during mechanical contacting by the introduction of the movement element 120.
  • the movement element 120 is formed from an electrically conductive material, for example as an iron core, in order to amplify a magnetic field during inductive energy transmission.
  • the movement element 120 is, for example, a plunger which is designed to release reagents by introducing them into a reagent chamber of the microfluidic device 105.
  • the arrangement of the excitation coil 205 on the movement element 120 additionally or alternatively makes it possible to electrify the microfluidic device 105 by means of induction.
  • the cavity 130 can also be designed as a microfluidic chamber or as a pre-storage chamber of the microfluidic device 105.
  • the arrangement of the conductor track 135 on an already on the microfluidic is advantageous
  • Device 105 molded chamber or on a chamber that can also be used for other purposes as a cavity 130, which saves space.
  • FIG. 3 shows a schematic illustration of a part of a microfluidic device 105 and an analysis device 100 according to one
  • Embodiment The excerpts of the microfluidic shown here Device 105 with the cavity 130 in the substrate 125 and the conductor track 135 as an electrical coil, and the analysis device 100 with the platform 115 and the movement element 120 correspond or are similar to the exemplary embodiment described with reference to FIG. 2.
  • the excitation coil 205 is arranged on another section of the movement element 120.
  • the movement element 120 has a section embedded in the platform 115, on which the excitation coil 205 is arranged. If the movement element 120 is inserted into the cavity 130, as in the exemplary embodiment shown here, the excitation coil 205 is thus arranged outside the cavity 130 and thus also outside the conductor track 135 as an electrical coil.
  • the movement element 120 is formed from the electrically conductive material, for example the iron core.
  • Excitation coil 205 is advantageously protected from degradation by repeated movement.
  • a core element is also arranged in the cavity 130 within the conductor track 135 as an electrical coil according to one exemplary embodiment.
  • the core element projects beyond the conductor track 135 in order to introduce an excitation magnetic field into the electrical coil.
  • the core element is formed from an electrically conductive material, for example as a metal core.
  • the movement element 120 is shaped as a hollow cylinder according to one embodiment. This protrudes when the movement element 120 is inserted
  • the movement element 120 can then also be made, for example, from an electrically insulating material such as plastic or with a low electrical conductivity.
  • FIG. 4 shows a schematic illustration of a part of a microfluidic device 105 and an analysis device 100 according to one Embodiment.
  • the section of the analysis device 100 shown here comprises the platform 115 and the movement element 120 with the excitation coil 205.
  • Device 105 shows cavity 130 in substrate 125.
  • the microfluidic device 105 also comprises a membrane 405.
  • the membrane 405 is arranged on one side of the cavity 130, on which the movement element 120 can be inserted.
  • the membrane 405 is shaped to seal the cavity 130 on at least the side of the insertion area of the movement element 120 in a fluid-tight manner.
  • the cavity 130 is sealed by means of the
  • Membrane 405 can be used as a fluid chamber or storage chamber of the microfluidic device 105.
  • the membrane 405 is elastic and is designed to respond to mechanical contact with the
  • Movement element 120 to be deflectable.
  • the membrane 405 In the state of the movement element 120 which is introduced here into the cavity 130, the membrane 405 is deflected and projects with the movement element 120 into the conductor track 135 as an electrical coil. To electrify the
  • Microfluidic device 105 by means of induction, it is advantageous if the membrane 405 is formed from a material that is magnetic
  • the membrane 405 is formed from an elastic and electrically insulating material, for example from a thermoplastic elastomer.
  • the membrane 405 has a layer thickness of, for example, 25 to 500 micrometers.
  • the microfluidic device 105 has according to that shown here
  • Embodiment also a be arranged in the cavity 130
  • Insert element 410 The conductor 135 is in this case on the
  • Insert element 410 arranged.
  • the insert element 410 also called inlay, is formed from a polymer, for example from polycarbonate.
  • the insertion element 410 can advantageously be installed in the microfluidic device 105 as required. This advantageously enables one Cost-effective and simple implementation of the arrangement of the conductor track 135 in the microfluidic device 105. Also in the manufacture of the insert element 410, also called inlay, is formed from a polymer, for example from polycarbonate.
  • the insertion element 410 can advantageously be installed in the microfluidic device 105 as required. This advantageously enables one Cost-effective and simple implementation of the arrangement of the conductor track 135 in the microfluidic device 105. Also in the manufacture of the
  • microfluidic device 105 or the insertion element 410 below
  • the insert element 410 also has an upstream substance for processing in the microfluidic device 105.
  • the insert element 410 is shaped, for example, as a reagent bar, in which reagents for processing are stored or stored in the microfluidic device 105.
  • the reagent storage in the microfluidic device 105 in the chamber shown here in the form of the cavity 130 with the insert element 410 can be combined with the transmission of electricity between the microfluidic device 105 and the analysis device 100.
  • microfluidic device 105 according to one embodiment
  • Embodiment a shielding element arranged on the cavity 130.
  • the shielding element is designed to surround the cavity 130 from one created by means of the conductor track 135 as an electrical coil
  • the shielding element can be implemented, for example, as a sheet metal casing which can be arranged on at least one of the inner walls of the cavity 130.
  • the arrangement of the shielding element is advantageous with regard to the electromagnetic compatibility of other components arranged in the microfluidic device 105 or the analysis device 100.
  • FIG. 5 shows a schematic illustration of part of a microfluidic device 105 and an analysis device according to an exemplary embodiment.
  • the microfluidic device 105 corresponds or is similar to the microfluidic device from one of the figures described above and / or the analysis device corresponds or is similar to the analysis device from one of the figures described above.
  • a view of the substrate 125 with the cavity 130 is shown here, around which the conductor track 135 is guided in the form of the winding.
  • the cavity 130 is not designed here as a fluid chamber, but as a cavity 130 for insertion an adjustment pin for correctly positioning the microfluidic device 105 in the analysis device.
  • Movement element 120 with excitation coil 205 is shown as part of the analysis device.
  • the movement element 120 is designed here as an adjustment pin.
  • FIG. 6 shows a schematic illustration of part of a microfluidic device 105 according to an exemplary embodiment.
  • Device 105 corresponds or is similar to the microfluidic device from one of the figures described above. As part of the microfluidic device 105 are here the membrane 405, an insertion area 605 for the
  • Movement element and the conductor track 135 arranged spirally around the insertion region 605 are shown.
  • the insertion area 605 corresponds to at least one diameter of the movement element 120.
  • the conductor track 135 is arranged planar on a side of the membrane 405 facing the cavity.
  • the planar windings of the conductor track 135 extend in a common plane.
  • the conductor track 135 lies here in the form of a coil in one plane.
  • the conductor track 135 is applied to the membrane 405 or embedded in the membrane 405.
  • the membrane 405 can be implemented in two layers, the conductor track 135 being arranged between the two layers of the membrane 405, for example connected by laser welding, in order to cover the electronics of the conductor track 135 from both sides.
  • the elastic material of the membrane 405 has a sealing effect, as a result of which the membrane 405 with the embedded conductor track can also be used in a wet environment, for example if the cavity has the reagent bar for the microfluidic device 105.
  • the conductor track 135 can be implemented as printed electronics, for example by means of screen printing of silver or carbon pastes.
  • the planarly arranged conductor track 135 shown here can optionally be deformed to provide the functionality of the electrical coil, which is described in more detail with reference to the following FIG. 7.
  • FIG. 7 shows a schematic illustration of part of a microfluidic device 105 and an analysis device according to an exemplary embodiment.
  • the part of the microfluidic device 105 shown here is similar or corresponds 6, with the membrane 405 and the planar and spirally arranged conductor track 135.
  • the movement element 120 is shown as part of the analysis device 100.
  • the conductor track 135 can be deformed to provide the functionality of the electrical coil by deflecting the membrane 405.
  • the membrane 405 is deformable by mechanical contact with the movement element 120.
  • the coil-shaped winding of the conductor track 135 becomes deflected along a direction of movement of the membrane
  • the microfluidic device 105 shown here can also be referred to as a device for producing a coil.
  • the membrane 405 is deflected when the movement element, for example in the form of a plunger made of a magnetizable material, onto the insertion area for the
  • Coil turns of the conductor track 135 expand in accordance with the shape and the direction of movement of the movement element 120. In the process, the conductor track 135 deforms, so that it becomes a three-dimensional structure.
  • the deformation of the conductor track 135 is reversible with the elasticity of the membrane 405, and when the movement element 120 is pulled out, the conductor track 135 returns to the flat, planar initial state. This is advantageously space-saving.
  • a complex three-dimensional method is advantageously not required for the planar microfabrication of the conductor track 135.
  • the angle of inclination of the turn of the conductor track 135 is important when deforming to form the electrical coil, so that the conductor track 135 does not experience too great a bend.
  • the microfluidic device 105 has a further conductor track.
  • the further conductor track is arranged on the membrane 405 or on a further membrane on the cavity.
  • the Conductor path 135 and the further conductor path can be arranged such that the further conductor path is pressed into the conductor path 135 when the movement element 120 is inserted.
  • two coils lying one above the other are formed from the conductor track 135 and the further conductor track, which enables contact-free inductive energy transmission.
  • the embodiment of the membrane 405 shown here with the embedded conductor track 135 can also be used to seal the cavity in order to make the cavity usable as a fluid chamber, for example as a reagent storage chamber.
  • FIG. 8 shows a schematic illustration of an analysis device 100 with a microfluidic device 105 according to an exemplary embodiment.
  • the microfluidic device 105 is similar to the exemplary embodiments described with reference to the figures shown above, and comprises the substrate 125 with the cavity 130 and the spiral around the cavity 130
  • the analysis device shown here is similar or corresponds to the analysis device 100 described with reference to the previous figures with the movable platform 115 with the movement element 120.
  • the arrangement of the excitation coil 205 on the movement element 120 corresponds to the embodiment described with reference to FIG. 3, with the arrangement of the excitation coil 205 on a section of the movement element 120 embedded in the platform 115.
  • the platform 115 can be moved here in the direction of the receiving area of the microfluidic device 105.
  • the platform 115 also has, for example, a spindle 805.
  • the spindle 805 is designed to move the platform 115 and thus the movement element 120.
  • the platform 115, the movement element 120 and the microfluidic device 105 are raised until the microfluidic device 105 abuts a ceiling section of the analysis device 100 at the top, as a result of which the
  • Movement element 120 is inserted as far as possible into the cavity 130 of the microfluidic device 105, which is surrounded by the conductor track 135.
  • a consumer 810 can be operated on the microfluidic device 105 via the conductor 135 as an electrical coil by induction.
  • Device 105 optionally includes, as in the exemplary embodiment shown here, electricity-carrying networks and the consumer 810, for example for dielectrophoretic applications.
  • the energy transfer by induction, as here by means of the conductor 135 as an electrical coil and the excitation coil 205 on the movement element 120, is advantageous for a stable one

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Power Engineering (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un dispositif microfluidique (105). Le dispositif microfluidique (105) comporte un substrat (125). Le substrat (125) possède au moins un espace creux (130) dans lequel peut être introduit un élément mobile (120). Le dispositif microfluidique (105) comprend en outre une piste conductrice (135) disposée sur l'espace creux (130). La piste conductrice (135) est façonnée de manière à fournir une fonctionnalité d'une bobine électrique destinée au transfert d'énergie inductive.
PCT/EP2020/050062 2019-01-08 2020-01-03 Dispositif microfluidique et appareil d'analyse pour un dispositif microfluidique Ceased WO2020144105A1 (fr)

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DE102019200109.2A DE102019200109A1 (de) 2019-01-08 2019-01-08 Mikrofluidische Vorrichtung und Analysegerät für eine mikrofluidische Vorrichtung

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DE102020215515A1 (de) 2020-12-09 2022-06-09 Robert Bosch Gesellschaft mit beschränkter Haftung Injektionsstößelpaket für ein Mikrofluidik-Analysesystem sowie Verfahren und Mehrkavitäten-Spritzgießwerkzeug zu seiner Herstellung
WO2022122489A1 (fr) 2020-12-09 2022-06-16 Robert Bosch Gmbh Ensemble de pistons d'injection pour un système d'analyse microfluidique, et procédé et outil de moulage par injection à cavités multiples pour la production de celui-ci
DE102021212515A1 (de) 2021-11-08 2023-05-11 Robert Bosch Gesellschaft mit beschränkter Haftung Injektionsstößelpaket für ein Mikrofluidik-Analysesystem sowie Verfahren und Mehrkavitäten-Spritzgießwerkzeug zu seiner Herstellung
DE102022105562A1 (de) * 2022-03-09 2023-09-14 Plasmion Gmbh System, Verfahren und Trennsäule zur Trennung von Stoffen in einem Stoffgemisch
DE102022207833A1 (de) 2022-07-29 2024-02-01 Robert Bosch Gesellschaft mit beschränkter Haftung Injektionsstößel, Injektionsstößelpaket und Verfahren zu seiner Herstellung, sowie Mikrofluidik-Analysesystem

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DE102007045946A1 (de) 2007-09-25 2009-04-02 Stz Mechatronik Rollflexspule
EP2601517A1 (fr) * 2010-08-06 2013-06-12 DNA Electronics Limited Procédé et appareil pour détecter une propriété d'un fluide
DE102013200350A1 (de) * 2013-01-14 2014-07-17 Robert Bosch Gmbh Mikrofluidische Analysekartusche und Auswerteeinheit

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US5589136A (en) * 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
WO2008009311A1 (fr) * 2006-07-17 2008-01-24 Agilent Technologies, Inc. Régulation de la température d'un échantillon fluidique dans un dispositif fluidique
GB2446204A (en) * 2007-01-12 2008-08-06 Univ Brunel A Microfluidic device

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DE102007045946A1 (de) 2007-09-25 2009-04-02 Stz Mechatronik Rollflexspule
EP2601517A1 (fr) * 2010-08-06 2013-06-12 DNA Electronics Limited Procédé et appareil pour détecter une propriété d'un fluide
DE102013200350A1 (de) * 2013-01-14 2014-07-17 Robert Bosch Gmbh Mikrofluidische Analysekartusche und Auswerteeinheit

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