WO2022200380A1 - Procédé de revêtement de particules - Google Patents

Procédé de revêtement de particules Download PDF

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Publication number
WO2022200380A1
WO2022200380A1 PCT/EP2022/057540 EP2022057540W WO2022200380A1 WO 2022200380 A1 WO2022200380 A1 WO 2022200380A1 EP 2022057540 W EP2022057540 W EP 2022057540W WO 2022200380 A1 WO2022200380 A1 WO 2022200380A1
Authority
WO
WIPO (PCT)
Prior art keywords
coating material
particles
stream
passage
fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2022/057540
Other languages
German (de)
English (en)
Inventor
Markus Thommes
Gerhard Schaldach
Anna Katharina PENNEMANN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technische Universitaet Dortmund
Original Assignee
Technische Universitaet Dortmund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technische Universitaet Dortmund filed Critical Technische Universitaet Dortmund
Priority to EP22717757.3A priority Critical patent/EP4313388A1/fr
Publication of WO2022200380A1 publication Critical patent/WO2022200380A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/006—Coating of the granules without description of the process or the device by which the granules are obtained
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/206—Hardening; drying

Definitions

  • the present invention relates to a method for coating particles.
  • the present invention relates in particular to a method with which particles can be provided with a coating in a particularly homogeneous manner.
  • the present invention also relates to a device with which such a method can be carried out.
  • a common method is a coating of active ingredient-containing particles, for example to influence the release rate of an active ingredient in the body.
  • a coating can also be used to determine the release site for an active ingredient during the gastrointestinal passage.
  • the particles are also coated.
  • increasing the abrasion resistance of the particles is often the aim of the coating.
  • Particles are often coated in fluidized bed processes or so-called drum coaters, with both processes applying a liquid to the moving particles via atomizers.
  • the mass applied to each particle can only be spread with a large spread. This leads to a large variation in the layer thickness on the processed particles.
  • Both the layer thickness on a single observed particle and the layer thickness on different particles are subject to a broad distribution. Since both, for example, the Active ingredient release in the case of a pharmaceutical application, as well as abrasion resistance in catalyst particles depend on a uniform and as constant as possible layer thickness of the applied film, a method with which these properties can be adjusted in a targeted manner is desirable.
  • EP 0623 018 Bl relates to a drop-feed process for the manufacture of soft gelatine capsules, the preferably soft or liquid content being encased in soft gelatine which is then solidified in a low-temperature cooling bath containing a chemically inert liquefied gas which does not leave any biologically undesirable or toxic residues on the capsules leaves.
  • WO 2020/037113 A1 describes an approach for generating monodisperse droplets.
  • monodisperse droplets can be effectively obtained by using a plurality of particles to induce jet breakup, which may include: flowing a first fluid in a channel of a microfluidic device into a second fluid under stable ejection conditions to produce a providing a jet of the first fluid in the second fluid, the first fluid being immiscible with the second fluid; and introducing a plurality of particles into the jet of first fluid, thereby causing the jet of first fluid to break up and the encapsulation of the plurality of particles in a plurality of monodisperse droplets of the first fluid in the second fluid to occur.
  • the object of the present invention to provide a measure by which at least one disadvantage of the prior art is at least partially overcome can be. It is in particular an object of the present invention to provide a measure with which particles can be coated with a coating material in a defined and homogeneous manner.
  • the present invention relates to a method for coating particles, comprising the method steps: a) providing particles to be coated; b) providing a coating material, the coating material being in fluid form; c) forming an in particular continuous stream of the coating material; d) introducing the particles into the flow of coating material at a first frequency /1, e) forming drops from the flow of coating material at a second frequency /2, where /2 is equal to or a multiple of f ⁇ such that drops with particles contained therein are formed; and f) solidifying the coating material.
  • Such a method allows significant advantages compared to solutions from the prior art, in particular with regard to a homogeneous coating of particles.
  • the method thus relates to the coating of particles.
  • Such a method can be used, for example, in the production of pharmaceutical products or also in the production of catalyst particles, but without being limited to this.
  • the method comprises the following steps, with the steps preferably taking place in the order mentioned. However, it is not excluded that further method steps are added or that the steps do not follow one another directly, although this is preferred within the meaning of the invention.
  • the particles to be coated are first provided.
  • the particles are not necessarily restricted in terms of type and nature, such as size.
  • it can be advantageous that the particles are stable in the further course of the process and do not melt or go into solution.
  • this can also be influenced, for example, by the choice of the coating material.
  • the particles can be provided in a suitable reservoir from which they can be removed for the further process.
  • Advantageous sizes for the particles, with which the method can subsequently be carried out can be in an exemplary range from >0.2 mm to ⁇ 2 mm, preferably in a range from >0.5 mm to ⁇ 1 mm.
  • the particles may preferably be in a spherical shape, but other shapes are also encompassed by the present invention.
  • a coating material is provided, the coating material being in fluid form.
  • the coating material in its fluid form is not limited. However, it should preferably be ensured that the coating material provided here or with this in fluid
  • the form of existing components does not negatively affect the provided particles, i.e. solve them or enter into a chemical reaction. Because of the aim of producing particles coated with the coating material, it is advantageous if the coating material is present as a solid under standard conditions, ie in particular 22° C. and 1 bar.
  • the presence of the coating material in fluid form can be realized in various ways.
  • the coating material can be present in pure form and can be used in the form of a melt. This can be advantageous since no other substances are introduced into the process, for which it should be ensured that these do not remain in the coating material or negatively affect the particles to be coated.
  • the method is preferably carried out with a two-component system of the particles to be coated and the coating material.
  • the coating material can be a substance or only include one substance. Accordingly, preferably only two material flows can be used, namely a first material flow for the particles to be coated and a second material flow for the coating material. In addition to the aforementioned advantages, this configuration can also allow for a simple construction of apparatus and a cost-effective method.
  • the coating material in process step b) can be present as a solution or as a dispersion.
  • the viscosity of the fluid coating material can be adjusted in a simple and reproducible manner by the selection and/or quantity of a solvent, so that the method is very defined and homogeneous particles and is also very adaptable to the desired coating material.
  • a preferably continuous stream of the coating material is then formed.
  • the fluid coating material is thus set in motion by this method step, so that it flows through a fluid guide provided.
  • the flow rate of the coating material should preferably be constant.
  • the coating material can be provided in fluid form in a reservoir and a suitable fluid pump can generate a corresponding flow of the coating material in the fluid guide.
  • the particles are introduced into the stream of coating material at a first frequency f ⁇ .
  • the particles are thus introduced into the stream of coating material in a defined time sequence and thus at a defined distance from one another with respect to the stream of coating material.
  • this process step can be implemented by discharge units which are known per se and which can introduce the particles into the stream in a definable time sequence.
  • the selected frequency can be dependent in particular on the selected flow rate of the stream of coating material, as is described in more detail below, or on the desired coating thickness.
  • step e) provides for the formation of droplets from the stream of coating material at a second frequency / 2 , where f 2 is equal to or a multiple of f ⁇ , so that droplets containing particles are formed.
  • Drops of the fluid coating material are thus formed, one particle, preferably exactly one particle, being present in each or in a selectable number of drops, depending on the frequency / 2 .
  • the particles are thus enveloped by fluid coating material and separated from other particles, with the coating material being present around the particles in a precisely definable amount and the particles also being homogeneously surrounded by the coating material.
  • the coating material is solidified.
  • the coating material is to be converted from the fluid form to a solid state so as to form particles coated with a solid coating material.
  • this step can be carried out in a selectable manner, with the type of solidification being suitably adapted to the way in which the coating material is brought into a fluid form.
  • this process step can be implemented, for example, by a cooling unit or simply by passive cooling of the coated particles, ie basically by solidification of the melt.
  • this process step can also be carried out as a drying step. Drying steps may be performed using heat, reduced pressure, airflow, or other means to evaporate or evaporate the solvent. Combinations of the aforementioned options are also covered by the present invention.
  • Chemical curing of the coating material is also possible, for example as radiation curing or as free-radical curing, each depending on the specific coating material used.
  • the method described here makes it possible to produce very homogeneously coated particles.
  • the particle coatings are very homogeneous per se, since the particles are homogeneously embedded in a mass of coating material due to the embedding of the particles in drops. If the coating material is solidified in this way, a very homogeneous coating is created, which has a uniform thickness all around.
  • each droplet can have the same size and therefore have the same amount of coating material.
  • the production conditions are the same for all drops, so that the shaped, coated particles are produced very uniformly and thus form a very homogeneous mixture. This can be reinforced by the fact that the coated drops do not mix back, so that adjacent drops do not influence each other.
  • the process is extremely customizable.
  • the thickness of the coating can be easily adjusted by an appropriate choice of the flow rate of the coating material and the frequencies f ⁇ and f i .
  • the amount of coating material from which the corresponding drops can be formed, and thus the thickness of the coating can be adjusted by the drop velocity or the drop formation frequency fi.
  • the flow of the coating material particularly preferably has a constant volume flow.
  • the flow rate of the coating material is uniform, but it can also be ensured that the same amount of coating material always moves along a specific route per unit of time.
  • a particularly reliable adaptability and also a particularly defined and homogeneous coating result can be made possible. This is because the droplets formed from the constant stream of coating material are formed particularly reliably, particularly in this configuration, with the same amount of coating material always being used. Deviations in the amount of coating material in the case of different coated particles can thus be avoided or at least essentially avoided.
  • f ⁇ equals / 2 .
  • the droplet formation occurs in concert with the introduction of the particles into the flow of coating material.
  • the entire coating material provided can be used for coating. Waste can thus be avoided.
  • the quantity that is applied to the particles can be defined by the easily adjustable parameters when setting the corresponding frequencies. This configuration can thus also further improve the homogeneity of the coating.
  • method step e) takes place by introducing periodic disturbances into the stream of coating material.
  • External disruptive influences are to be understood as meaning those which are not generated by the material flows themselves, but rather are generated by a source that is different from the material flows, in particular outside of the material flows, and act on at least one material flow.
  • This configuration allows droplets to be formed from the stream of coating material in a particularly defined manner.
  • the coating result can in turn be particularly homogeneous.
  • external interference makes it possible to adjust the second frequency / 2 in a simple and adaptable manner, so that the coatings can be adapted to different requirements in a very defined manner.
  • Examples of the introduction of external disturbing influences include the introduction of vibrations or also the introduction of sound into the flow of the coating material.
  • this can be realized in particular by a vibration unit acting on a fluid guide for guiding the coating material, with the effect being able to act in particular on a fluid outlet or a tear-off edge for the coating material.
  • a vibration unit acting on a fluid guide for guiding the coating material with the effect being able to act in particular on a fluid outlet or a tear-off edge for the coating material.
  • the vibrations thus introduced into the fluid can bring about effective droplet formation by thread breakup. Then the individual drops can then drip down from a liquid thread after their formation. This in turn is advantageous for the coating formed.
  • a procedure described above can be advantageous in many applications. Examples include, for example, the formation of gloss and color coatings, flavor coatings, protective coatings, release-influencing coatings or active coatings, with the aforementioned examples not being understood to be limiting. Areas of application include but are not limited to the coating of pharmaceutical products and catalysts.
  • active coatings ie coatings with an active substance, can be produced advantageously, since the coatings are very homogeneous and the activity can also be easily adjusted. In the prior art, this was not possible or only possible to a limited extent.
  • a device for coating particles having a fluid guide for guiding a stream of coating material in fluid form and having a filling mechanism for introducing particles to be coated into the stream of coating material at a first frequency / 1 , the device also having a Droplet formation mechanism for forming droplets from the stream of coating material at a second frequency / 2 , where / 2 is equal to or a multiple of f ⁇ , and optionally comprising a solidification unit for solidifying coating material in fluid form.
  • Such a device makes it possible in particular to carry out a method as described in detail above with reference to the coating method. Accordingly, such an apparatus can achieve the advantages as detailed above with respect to the method.
  • the thickness of the Coating of the individual particles per se can be very homogeneous, and different particles can also have a very homogeneous coating with respect to one another.
  • the device comprises a fluid guide for guiding a stream of coating material present in fluid form.
  • the fluid guide can be, for example, a channel that is open at the top, or else it can be closed. It is important that the stream of coating material can be guided in this fluid guide.
  • the fluid guide can be connected to a reservoir for the coating material present in fluid form, from where the latter can be conveyed using a suitable fluid pump, for example, in order to form a continuous stream of the coating material.
  • a constant volume flow of the coating material in the fluid guide can be adjusted by the fluid pump.
  • a filling mechanism is provided for introducing the provided particles to be coated into the flow of coating material at a first frequency f ⁇ .
  • the fluid guide is designed, for example, as a channel that is open at the top, the particles can be introduced into the fluid guide in a simple manner.
  • an opening can be provided at a suitable point of the fluid guide in order to introduce the particles into the stream of coating material.
  • the filling mechanism can be configured as follows, for example.
  • the filling mechanism for introducing particles to be coated into the stream of coating material can have a rotatable disc which at least has a passage and entrainment opening, and wherein a cover element is provided, relative to which the disc is rotatable, the cover element closing the at least one passage and entrainment opening in a entrainment position of the passage and entrainment opening with respect to a rotation and wherein the cover element the at least one passage and entrainment opening releases in a passage position of the passage and entrainment opening with respect to a rotation.
  • a plurality of passage and entrainment openings can be provided, which are arranged in different sectors of a circle, preferably on a circular line.
  • the cover element can form a receiving space for the rotatable disk, the cover element or the rotatable disk forming a collection space for particles to be coated at a passage position of the at least one passage and entrainment opening.
  • the rotatable disc can rotate at a constant speed and thus, whenever the passage and entrainment opening is in a passage position, the particles can pass through and be introduced into the stream of coating material. If an above-described collection space is provided, depending on the size of the particles, one particle can be positioned in a passage and entrainment opening and brought to the passage position by the rotation of the disk.
  • the apparatus further includes a drop formation mechanism for forming drops from the flow of coating material at a second frequency / 2 , where / 2 is equal to or a multiple of f ⁇ .
  • the drop formation mechanism allows successive drops to be formed from the continuous stream of coating material.
  • the droplets are formed by choosing the first and second frequencies accordingly such that each particle is formed into a single droplet. For example, each drop has a particle.
  • this is designed as a vibration unit for introducing vibrations into the flow of the coating material. More precisely, it can be advantageous that the vibration unit acts on a fluid outlet of the fluid guide. This allows droplets to be formed from the stream in a thread breakup in a defined and safe manner at a predefined frequency. In this case, it can be particularly preferred if the drops drip off the thread after they have emerged from the outlet and after they have formed.
  • a sound source can also be provided, which acts on the flow of the coating material by generating pressure fluctuations.
  • the solidification unit can be adapted to the manner in which the coating material has been brought into a fluid form.
  • the solidification unit can be designed as a dryer in order to evaporate or vaporize solvents.
  • the solidification unit can be designed as a cooling unit in order to solidify a melt.
  • the solidification unit can also be a temperature control unit, with which the drops can be cooled and heated. As a result, the solidification unit can be used for different systems and the same device can thus be widely used. If the coating material is in the form of a melt, a solidification unit can be dispensed with, since passive cooling for solidification is also possible.
  • FIG. 1 shows a schematic representation of a device for coating particles according to the present invention
  • FIG. 2 shows a detailed view of a filling mechanism for a device from FIG. 1;
  • FIG. 3 shows a detailed view of droplet formation.
  • a device 10 for coating particles 12 is shown in FIG.
  • the apparatus 10 includes a fluid guide 14 for conducting a stream 16 of fluid coating material 18.
  • the fluid guide 14 may be supplied from a reservoir 20, such as by using a suitable fluid pump 22, which pumps the fluid coating material 18 into the fluid guide 14 pumps.
  • the fluid guide 14 is designed as a channel which is open at the top.
  • a filling mechanism 24 for introducing particles 12 to be coated into the stream 16 of coating material 18 at a first frequency f ⁇ is also shown.
  • the filling mechanism 24 is only shown schematically in FIG. 1, but is shown in greater detail in FIG.
  • FIG. 1 It can thus be seen in FIG. 1 that only two material flows 56, 58 can be used, namely with the first material flow 56 comprising the particles 12 to be coated and the second material flow 58 comprising the coating material 58.
  • the fluid guide 14 then combines the two material flows 56, 58.
  • FIG. 2 shows that the filling mechanism 24 for introducing particles 12 to be coated into the stream 16 of coating material 18 has a rotatable disk 26 which has at least one passage and entrainment opening 28 . It is shown in detail in FIG. 2 that a plurality of passage and entrainment openings 28 is provided, which is arranged in different sectors of a circle and on a circular line, that is to say on the same radius in each case.
  • a cover element 30 is provided, relative to which the rotatable disc 26 can be rotated.
  • the rotatable disk 26 can be arranged in a receiving space 34 of the cover element 30 , the receiving space 34 being formed by a peripheral wall 36 of the cover element 30 .
  • the cover element 30 is designed in such a way that it closes the at least one passage and entrainment opening 28 in an entrainment position of the passage and entrainment opening 28 with respect to a rotation and that the cover element 30 closes the at least one passage and entrainment opening 28 in a passage position of the Passage and entrainment opening 28 releases with respect to a rotation.
  • This is in the design realized in accordance with FIG. 2 in such a way that the cover 30 has an opening 32 in the passage position, through which the particles 12 can be introduced into the flow 16 . If the passage and entrainment opening 28 is not in the passage position but is rotated to a different location, namely to an entrainment position, this is covered by the cover element 30 so that the particles 12 do not enter the flow 16 .
  • the cover element 30 forms a collection space for particles to be coated at a passage position of the passage and entrainment openings 28 of the disc 26, i.e. at a position or in an area through which or through which the passage and entrainment openings 28 rotate 12 trains.
  • the particles 12 get into the passage and entrainment openings 28 and are transported or entrained to the opening 32 by the rotation of the disk 26 and can be inserted into the stream 16 there at a suitable rotational speed at a defined frequency.
  • the collection space can be formed, for example, by the surrounding wall 36, which has a greater thickness than the rotatable disk. If the pane 26 and the cover element 30 are then arranged in a tilted manner, that is to say at an angle of approximately 45° to the horizontal, the particles 12 collect in the lower area, which then serves as a collection space.
  • apparatus 10 is further shown to further include a drop formation mechanism 38 for forming drops 40 from stream 16 of coating material 18 at a second frequency /2, where /2 is equal to or a multiple of f ⁇ .
  • this drop formation mechanism 38 has a vibration unit 42 for introducing vibrations into the flow 16 of the coating material 18 . More precisely, the vibration unit 42 is connected to a fluid outlet 44 or a tear-off edge of the fluid guide 14 and acts on this or on these. For this purpose, in particular, vertically acting vibrations are used, as indicated by the arrow 54 . As a result, the Emergence of the stream 16 from the fluid outlet 44 drops 40 by a filament breakup.
  • a droplet chain of monodisperse droplets 40 is produced, with each droplet 40 enveloping a particle 12 .
  • FIG. 1 also shows that the device has a solidification unit 46 for solidifying coating material 18 present in fluid form.
  • the coating material 18 present in fluid form can be brought into a solid form by this solidification unit 46 .
  • the exact form of the solidification unit 46 is not limited and depends essentially on the way in which the coating material 18 was brought into a fluid form. If the coating material 18 is present as a solution or as a dispersion, the solidification unit 46 can be designed as a drying unit, for example as an IR dryer, for evaporating or evaporating the solvent, as is shown in FIG. If the coating material 18 is in the form of a melt, for example, the solidification unit 46 can be designed as a cooler. Thus, homogeneously coated particles 48 are formed in the solidification unit 46 . These can then be collected. According to FIG. 1, the particles 48 can fall onto a conveyor belt 50 and be transported from there into a storage container 52 and collected there.
  • the method described here or the device 10 described here for coating particles 12 allows uniform surface coatings in an efficient process with a high throughput.
  • the process is continuous and the mass of coating material 18 applied per particle 12 is constant.
  • the throughput depends on the drop formation frequency and is in the range of several 100,000 particles 12 per hour.
  • an example of a method in a device as described above can proceed as follows.
  • the dripping behavior for a filament breakup is well known to the person skilled in the art, in particular for capillary flows.
  • the dripping behavior can be assumed accordingly for any channel flows that may be present.
  • droplet formation can be achieved if the wavelength l is about the vibration or, in principle, the periodic interference at l>2 p rstrahi , where rstrahi is the radius of the free jet. If the frequency of drop formation is known, the thickness of the coating can then be easily determined.
  • hydroxypropylmethylcellulose can be used as the coating material 18, into which particles 12 of microcrystalline cellulose with a diameter of 1 mm are introduced at a frequency f ⁇ of 35 Hz.
  • a wave number ka ⁇ 0.3 to 0.9 can be used for droplet formation , where the wavenumber is defined as 2 p rs trahi /l, where rs trahi is the radius of the free beam and l is the wavelength of the vibration or fundamentally of the periodic disturbances.
  • the volume flow can be 3.5 l/h and the dynamic viscosity of the coating material 18 forming the flow 16 can be h ⁇ 0.008 Pas.

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Abstract

La présente invention concerne un procédé de revêtement de particules (12) comprenant les étapes suivantes : a) fourniture de particules à revêtir (12) ; b) fourniture d'un matériau de revêtement (18), le matériau de revêtement (18) se présentant sous forme fluide ; c) formation d'un flux (16) en particulier continu du matériau de revêtement (18) ; d) introduction des particules (12) dans le flux de matériau de revêtement (18) à une première fréquence ƒ1 ; e) formation de gouttes (40) à partir du flux (16) de matériau de revêtement (18) à une deuxième fréquence ƒ2, ƒ2 étant égale à ou étant un multiple de ƒ1, de sorte que des gouttes (40) contenant des particules (12) sont formées ; et f) solidification du matériau de revêtement (18).
PCT/EP2022/057540 2021-03-23 2022-03-22 Procédé de revêtement de particules Ceased WO2022200380A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP22717757.3A EP4313388A1 (fr) 2021-03-23 2022-03-22 Procédé de revêtement de particules

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102021107251.4A DE102021107251A1 (de) 2021-03-23 2021-03-23 Verfahren zum Beschichten von Partikeln
DE102021107251.4 2021-03-23

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WO2022200380A1 true WO2022200380A1 (fr) 2022-09-29

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DE (1) DE102021107251A1 (fr)
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Citations (4)

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Publication number Priority date Publication date Assignee Title
EP0513603A1 (fr) * 1991-05-14 1992-11-19 Freund Industrial Co., Ltd. Appareil pour produire des capsules sans joint de soudage
EP0623018A1 (fr) 1992-01-17 1994-11-09 Alfatec Pharma Gmbh Procede de fabrication de capsules de gelatine molle selon une methode en goutte.
WO1999006141A1 (fr) * 1997-07-31 1999-02-11 Frank Petrick Procede et dispositif pour enduire et/ou enrober des particules granulaires avec un adhesif durcissable
WO2020037113A1 (fr) 2018-08-17 2020-02-20 The Regents Of The University Of California Formation de gouttelettes déclenchée par des particules monodispersées à partir de jets stables

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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