WO2024231438A2 - Composition topique cosmétique - Google Patents

Composition topique cosmétique Download PDF

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Publication number
WO2024231438A2
WO2024231438A2 PCT/EP2024/062695 EP2024062695W WO2024231438A2 WO 2024231438 A2 WO2024231438 A2 WO 2024231438A2 EP 2024062695 W EP2024062695 W EP 2024062695W WO 2024231438 A2 WO2024231438 A2 WO 2024231438A2
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Prior art keywords
weight
topical composition
water
oil
cosmetic topical
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Ceased
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PCT/EP2024/062695
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English (en)
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WO2024231438A3 (fr
Inventor
Isabel FERNÁNDEZ GARROSA
Jordi GONZÁLEZ PLÁGARO
Maria BORDA BOREU
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Medichem SA
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Medichem SA
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Publication of WO2024231438A3 publication Critical patent/WO2024231438A3/fr
Anticipated expiration legal-status Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Definitions

  • the present invention relates to the field of cosmetics.
  • cosmetic topical compositions in the form of an oil-in-water (O/W) emulsion which are useful for improving the symptoms of atopic dermatitis.
  • O/W oil-in-water
  • Octenidine is the international commonly accepted name (INN) for 1 ,1'-(decane-1 ,10- diyl)bis(N-octylpyridin-4-(1 H)-imine). Octenidine is preferably used in form of its dihydrochloride salt. Octenidine dihydrochloride is a microbiocidal active substance which is mainly used in skin, mucous membrane, and wound antiseptics.
  • Atopic dermatitis is a condition that causes dry, itchy, and inflamed skin that may be localized to a few parts or involve large portions of the body.
  • Atopic dermatitis is a chronic inflammatory skin disease, which is characterized by a strong itching, xeroderma and inflammatory skin lesions. If these symptoms do not cease, can lead into a vicious cycle of severe pruritus and sleep disorders. Continuous scratching may make the skin more vulnerable to infection.
  • Atopic dermatitis is caused by the interaction of different factors such as genetic and environmental conditions. Moreover, it has been seen that an imbalance on the microbiome exists in atopic skin, concretely an overgrowth of Staphylococcus aureus on the skin surface. The overexpression of this bacteria can aggravate the status of the disease.
  • W02007031520A2 relates to a semisolid pharmaceutical composition, such as a gel, an O/W (oil in water) cream, W/O (water in oil) cream, O/W/O cream, W/O/W cream, ambiphilic cream, ointment or a suppository, for the treatment of wounds, atopic dermatitis, infected eczemas, dermatomycoses, vaginal infections, acne, herpes, and/or for controlling multidrug-resistant pathogens comprising from 0.005 to 5% by weight octenidine dihydrochloride and optionally further active ingredients which supplement the activity of octenidine dihydrochloride.
  • a semisolid pharmaceutical composition such as a gel, an O/W (oil in water) cream, W/O (water in oil) cream, O/W/O cream, W/O/W cream, ambiphilic cream, ointment or a suppository, for the treatment of wounds,
  • clotrimazole and other antimycotics with local activity cortisones, tretinoin, benzoyl peroxide, acyclovir, local anaesthetics (e.g. benzocaine, lidocaine, polidocanol inter alia), antibiotics, bufexamac, etc..
  • O/W cream refers to a composition with 0.1 g octenidine dihydrochloride, 4.0 g glycerol monostearate 40-50, 6.0 g cetyl alcohol, 7.5 g medium-chain triglycerides (at least 95% by weight saturated fatty acids with 8 to 10 carbon atoms), 25.5 g white petrolatum, and 7.0 g macrogol 1000 glycerol monostearate.
  • Petrolatum is a mineral hydrocarbon derived from petroleum.
  • WO2015091692A1 relates to a topical pharmaceutical or cosmetic composition
  • a topical pharmaceutical or cosmetic composition comprising (a) 0.01-3.0 wt.% of octenidine dihydrochloride; (b) 1-20 wt.% of at least one petroleum hydrocarbon; (c) 0.5-10 wt.% of at least one C6-C24 fatty acid triglyceride; (d) 1-20 wt.% of at least one C6-C24 fatty alcohol; (e) 1-15 wt% of at least one non-ionic surfactant; (f) 1 to 20 wt. % of at least one polyol; and (g) 30-70 wt.% of water that can be used by patients suffering from atopic dermatitis and/or dry skin to prevent microbial proliferation and to restore the skin barrier function.
  • WO2022122898A1 relates to a cosmetic or pharmaceutical composition, preferably a dermatological composition for reducing the sebum overproduction, comprising or consisting of a synergistic combination of a specific antimicrobial component and an effective amount of 1 ,2-nonanediol and/or 2,3-nonanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols.
  • octenidine hydrochloride and silver citrate are indicated.
  • the composition can also contain one or more lenitive substances, wherein any lenitive substances can be used which are suitable or customary in cosmetic or pharmaceutical applications such as alpha-bisabolol, azulene, guaiazulene, 18-beta-glycyrrhetinic acid, allantoin, Aloe vera juice or gel, extracts of Hamamelis virginiana (witch hazel), Echinacea species, Centella asiatica, chamomile, Arnica monatana, Glycyrrhiza species, algae, seaweed and Calendula officinalis, and vegetable oils such as sweet almond oil, baobab oil, olive oil and panthenol, Laureth-9, Trideceth-9 and 4-t-butylcyclohexanol.
  • any lenitive substances can be used which are suitable or customary in cosmetic or pharmaceutical applications such as alpha-bisabolol, azulene, guaiazulene, 18-beta-gly
  • the inventors have found a new cosmetic topical composition comprising octenidine dihydrochloride, silver citrate solution, Laureth-9, and water useful for improving the skin’s moisture, and the skin’s barrier function, and alleviating atopic symptoms such as itching and redness.
  • a cosmetic topical composition in the form of an oil-in-water (O/W) emulsion comprising:
  • the second aspect of the invention relates to the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion as defined herein above and below, for use in alleviating atopic symptoms such as itching and redness.
  • O/W oil-in-water
  • percentages referred herein are by weight.
  • the term “percentage (%) by weight” refers to the percentage of each ingredient in relation to the total weight of the cosmetic topical composition.
  • the term “percentage (%) by weight” may be denoted as “wt %” herein.
  • the term “part per million” refers to one part per one million parts of the total weight of the cosmetic topical composition.
  • the term “part per million” may be denoted as “ppm” herein.
  • room temperature refers to a temperature of the environment, without heating or cooling, and is generally from 20 °C to 25 °C.
  • any ranges given include both the lower and the upper end-points of the range. Ranges and values given, such as temperatures, times, and the like, should be considered approximate, unless specifically stated.
  • emollient refers to an ingredient that softens, smoothens, and hydrates the skin.
  • emulsifier refers to an ingredient that promotes the formation of intimate mixtures by modifying the interfacial tension between immiscible liquids, as in the mixture of oil and water.
  • humectant refers to an ingredient that holds and retains moisture.
  • thickener refers to an ingredient that increases the viscosity of the cosmetic product.
  • skin conditioning agent refers to an ingredient that is added to the cosmetic product to maintain skin in good condition, for example by reducing flaking and restoring suppleness.
  • metal chelator refers to an ingredient that binds to metal ions.
  • surfactant refers to an ingredient that reduces surface tension and facilitates the formation of emulsions between non-miscible liquids of different polarities.
  • buffer refers to an ingredient that maintains the pH of the cosmetic product.
  • parfum refers to an ingredient that provides a pleasant odor.
  • opacifier refers to an ingredient that is added to the cosmetic product to make it opaque.
  • antistatic refers to an ingredient that reduces or eliminates buildup of static electricity.
  • preservative refers to an ingredient that inhibits microbial growth.
  • solvent refers to an ingredient that helps to dissolve or dilute other cosmetic ingredients.
  • the first aspect of the present invention provides a cosmetic topical composition in the form of an oil-in-water (O/W) emulsion comprising:
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion according to the present invention when applied on the sensitive skin, provides, as shown from the experimental results, a very good cutaneous acceptability and efficacy, preserves, respects, and improves the skin’s moisture and the skin’s barrier function, and alleviates atopic symptoms such as itching and redness.
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion according to the present invention exhibits an adequate chemical and physical stability.
  • oil-in-water (O/W) emulsion refers to a formulation containing an oil phase dispersed in an aqueous phase.
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion according to the present invention comprises octenidine in form of its dihydrochloride salt.
  • Octenidine preferably octenidine dihydrochloride
  • the amount of octenidine used in the cosmetic topical composition of the present invention is from 0.01 to 0.50% by weight, preferably from 0.05 to 0.30% by weight and more preferably about 0.15% by weight, relative to the total weight of the cosmetic topical composition.
  • the concentration of silver ion present in the cosmetic topical composition of the present invention is from 2.20 to 14.20 ppm, preferably from 3.20 to 9.50 ppm, and more preferably about 7.40 ppm of silver ion relative to the total weight of the cosmetic topical composition.
  • the silver ion present in the cosmetic topical composition of the present invention is preferably in form of its salt with citric acid, or a hydrate or solvate thereof. Since citric acid is a trivalent carboxylic acid, silver can form different salts with citric acid such as silver dihydrogen citrate salt (AgCeHyO?), silver monohydrogen citrate salt (Ag2C6H6O?) and silver citrate salt (AgaCeHsO?) or mixtures, hydrates or solvates thereof.
  • the ratio between the different salts of silver ion with citric acid that is present in the cosmetic topical composition of the present invention depends on the pH of the cosmetic topical composition.
  • concentration of the salts of silver ion with citric acid in the cosmetic topical composition is expressed as the equivalent concentration of silver citrate (AgaCeHsO?) salt.
  • the amount of silver citrate used in the cosmetic topical composition of the present invention is from 3.5 to 22.5 ppm, preferably from 5 to 15 ppm, and more preferably about 11.8 ppm of silver citrate relative to the total weight of the cosmetic topical composition.
  • the silver citrate can be used in solid form or alternatively as a silver citrate aqueous solution, such as a stable aqueous mixture of citric acid monohydrate and silver dihydrogen citrate monohydrate.
  • a preferred commercially available silver citrate solution contains a silver ion concentration of 2280 to 2640 ppm corresponding to 0.228 to 0.264% by weight of silver ion, which is a broad-spectrum antimicrobial agent.
  • Laureth-9 also named polidocanol or PEG-9 lauryl alcohol is a polyethylene glycol ether of lauryl alcohol, where the average number of ethylene oxide monomers in the molecule is 9. It relieves itching caused by eczema and dry skin due to its anti-itch properties. It has also emulsifying properties.
  • the amount of Laureth-9 used in the cosmetic topical composition of the present invention is from 0.50 to 3.00% by weight, preferably from 0.70 to 2.00% and more preferably about 1 .00% by weight, relative to the total weight of the cosmetic topical composition.
  • the amount of water used in the cosmetic topical composition of the present invention is from 60.00 to 80.00% by weight, preferably from 65.00% to 75.00% by weight, and more preferably about 70.00% by weight, relative to the total weight of the cosmetic topical composition.
  • the cosmetic topical composition of the present invention may optionally further comprise other well-known cosmetic agents such as emollients, emulsifiers, humectants, thickeners, skin conditioning agents, metal chelators, surfactants, buffers, perfumes, opacifiers, antistatics, preservatives, solvents, and mixtures thereof. Some of the agents may have more than one function in the cosmetic topical composition of the present invention.
  • Non-limiting examples of emollients which can be used in the cosmetic topical composition of the present invention are caprylic/capric triglyceride, coco-caprylate/caprate, tetradecane, dodecane, diethyl succinate, cetearyl alcohol, squalene, bis-diglyceryl polyacyladipate-2, 2-ethylhexyl stearate, cetearyl ethylhexanoate, paraffinum liquidum, dicaprylyl ether, myreth-3 myristate, glyceryl stearate, dimethicone, propylene glycol dicaprylate/dicaprate, sodium polyacrylate, beeswax, caprylyl glycol, oenothera biennis oil, behenyl alcohol, glycine soja seed extract, C12-15 alkyl benzoate, sphingolipids, cetyl palmitate, glyceryl oleate, diethy
  • the emollient used in the cosmetic topical composition of the present invention is selected from the group consisting of caprylic/capric triglyceride, coco-caprylate/caprate, tetradecane, dodecane, diethyl succinate, cetearyl alcohol, squalene, bis-diglyceryl polyacyladipate-2, sodium polyacrylate, and mixtures thereof.
  • Non-limiting examples of emulsifiers which can be used in the cosmetic topical composition of the present invention are polyglyceryl-3-methylglucose distearate, potassium cetyl phosphate, microcrystalline cellulose, cellulose gum, Ceteareth-20, cetearyl glucoside, glyceryl oleate, lanolin, lecithin, PEG-120 methyl glucose dioleate, PEG-20 glyceryl stearate, PEG-40 stearate, PEG-7 hydrogenated castor oil, PEG-7 glyceryl cocoate, polyglyceryl-3 diisostearate, polyglyceryl-3 methylglucose distearate, polyglyceryl-3 polyricinoleate, polyglyceryl-4 caprylate, polysorbate 20, potassium stearate, sodium C12-13 pareth sulfate, sodium stearate, sorbitan laurate, sorbitan oleate, sorbitan stearate, Ste
  • the emulsifier used in the cosmetic topical composition of the present invention is selected from the group consisting of polyglyceryl-3-methylglucose distearate, potassium cetyl phosphate, Laureth-9, microcrystalline cellulose, cellulose gum, and mixtures thereof.
  • Non-limiting examples of humectants which can be used in the cosmetic topical composition of the present invention are glycerin, glycol, lactic acid, PEG-6, saccharide isomerate, sodium lactate, sorbitol, hydroxyethyl urea, propanediol, sodium hyaluronate, and mixtures thereof.
  • the humectant used in the cosmetic topical composition of the present invention is glycerin.
  • Non-limiting examples of thickeners which can be used in the cosmetic topical composition of the present invention are xanthan gum, aluminum starch octenylsuccinate, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, acrylates/Cw-30 alkyl acrylate crosspolymer, sodium polyacrylate, carbomer, 2-ethylhexyl stearate, methoxy PEG-22- dodecyl glycol copolymer, ammonium polyacryloyldimethyl taurate, polyisobutene, and mixtures thereof.
  • the thickener used in the cosmetic topical composition of the present invention is 2-ethylhexyl stearate.
  • Non-limiting examples of skin conditioning agents which can be used in the cosmetic topical composition of the present invention are D-panthenol, alpha-bisabolol, chamomille extract, Sphingomonas ferment extract, ceteraryl ethylhexanoate, butyrospermum parkii butter, avena satiiva leaf, beta-sitosterol, hydroxyethyl urea, oxidized corn oil, tocopherol, alphaglucan oligosaccharide, allantoin, persea gratissima oil, hydrolyzed linseed extract, glycine, 1-2 hexanediol, ethylhexylglycerin, tocopheryl acetate, myristyl myristate, ceramides, laminaria ochroleuca extract.
  • the thickener used in the cosmetic topical composition of the present invention is selected fom the group consistint of D-panthenol, alpha-bisabolol, chamomille extract, Sphingomonas ferment extract, and mixtures thereof.
  • Non-limiting examples of metal chelators which can be used in the cosmetic topical composition of the present invention are disodium EDTA, 2,6-dicarboxypyridine, citric acid, sodium citrate, tetrasodium glutamate diacetate, and mixtures thereof.
  • the metal chelator used in the cosmetic topical composition of the present invention is disodium EDTA.
  • Non limiting examples of surfactants which can be used in the cosmetic topical composition of the present invention are disodium lauryl sulfosuccinate, PEG-100 stearate, polysorbate 20, poloxamer 338, trideceth-6, caprylyl/capryl glucoside, and mixtures thereof.
  • the surfactant used in the cosmetic topical composition of the present invention is trideceth-6.
  • Non limiting examples of buffers which can be used in the cosmetic topical composition of the present invention are sodium hydroxide, triethanolamine, citric acid, ascorbic acid, potassium sorbate, and mixtures therefore.
  • the buffer used in the cosmetic topical composition of the present invention is triethanolamine.
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion of the present invention comprises:
  • Potassium cetyl phosphate is an oil-in-water anionic emulsifier that also works as a surfactant.
  • the amount of potassium cetyl phosphate used in the cosmetic topical composition of the present invention is from 0.50 to 2.50% by weight, preferably from 1 .00 to 2.25% and more preferably about 2.00% by weight.
  • Polyglyceryl-3 methylglucose distearate is a vegetable-based emulsifier.
  • the amount of polyglyceryl-3 methylglucose distearate used in the cosmetic topical composition of the present invention is from 3.00 to 5.00% by weight, preferably from 3.50 to 4.50% and more preferably about 4.00% by weight.
  • Alpha-bisabolol or a-(-)-bisabolol is a natural monocyclic sesquiterpene with skin healing properties that can be used in cosmetic formulations as a skin conditioning agent.
  • the amount of alpha-bisabolol used in the cosmetic topical composition of the present invention is from 0.05 to 0.30% by weight, preferably from 0.10 to 0.25% and more preferably about 0.15% by weight.
  • D-panthenol is derived from vitamin B5 with skin healing properties that can be used in cosmetic formulations as a skin conditioning agent.
  • the amount of D-panthenol used in the cosmetic topical composition of the present invention is from 0.10 to 3.00% by weight, preferably from 0.15 to 1 .00% and more preferably about 0.25% by weight.
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion of the present invention comprises:
  • Caprylic/capric triglyceride is derived from coconut oil and glycerin that can be used in cosmetic formulations as an emollient.
  • the amount of caprylic/capric triglyceride used in the cosmetic topical composition of the present invention is from 6.00 to 8.00% by weight, preferably from 6.50 to 7.50% and more preferably about 7% by weight.
  • Coco-caprylate/caprate is an ester of natural fatty alcohol, caprylic acid and capric acid hat can be used in cosmetic formulations as an emollient.
  • the amount of coco- caprylate/caprate used in the cosmetic topical composition of the present invention is from 2.00 to 6.00% by weight, preferably from 3.00 to 5.00% and more preferably about 4.00% by weight.
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion of the present invention can be in the form of a lotion, cream, gel, spray, and foam, and the like.
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion of the present invention is in the form of a lotion, and more preferably in the form of a body lotion.
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion of the present invention preferably in the form of a lotion, and more preferably in the form of body lotion, can be obtained by any of the process known to a person skilled in the art.
  • the second aspect of the present invention relates to the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion as defined herein above and below, for use for alleviating atopic symptoms such as itching and redness.
  • This aspect may also be formulated as the use of the components of the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion as defined herein above and below for the manufacture of a topical composition for alleviating atopic symptoms such as itching and redness.
  • the present invention also relates to a method for alleviating atopic symptoms such as itching and redness, comprising administering an effective amount for alleviating such atopic symptoms of the components of the cosmetic topical composition as defined herein above and below, in a subject in need thereof, including a human.
  • effective amount for alleviating atopic symptoms such as itching and redness refers to the amount of components that, when administered, is sufficient to prevent development of, or alleviate to some extent, one or more of the symptoms of the condition which is addressed.
  • the particular dose of components of the topical composition administered according to this invention will of course be determined by the particular circumstances surrounding the case, including, the route of administration, the particular symptoms being treated, and the similar considerations.
  • the cosmetic topical composition in the form of an oil-in-water (O/W) emulsion of the present invention can be applied directly to the affected area of the skin of a subject in the usual way and in a usual frequency for cosmetics, such as once or twice daily.
  • O/W oil-in-water
  • An octenidine dihydrochloride body lotion was prepared by the following method based on the ingredients indicated in Table 1.
  • (,) Represents 7.42 ppm of silver ion or 11.76 ppm of silver citrate relative to the total weight of the cosmetic topical composition.
  • aqueous phase ingredients water (65.13% of the total weight of the cosmetic topical composition), PemuPurTM START, D-panthenol, glycerin, potassium cetyl phosphate, disodium EDTA, and octenidine dihydrochloride
  • water 65.13% of the total weight of the cosmetic topical composition
  • PemuPurTM START D-panthenol
  • glycerin glycerin
  • potassium cetyl phosphate sodium EDTA
  • octenidine dihydrochloride octenidine dihydrochloride
  • oil phase ingredients polyglyceryl-3 methylglucose distearate, cetearyl alcohol, caprylic/capric triglyceride, coco-caprylate/caprate, Laureth-9, Vita Silky Fluid®, squalene, bis-diglyceryl polyacyladipate-2, and alpha-bisabolol
  • oil phase ingredients polyglyceryl-3 methylglucose distearate, cetearyl alcohol, caprylic/capric triglyceride, coco-caprylate/caprate, Laureth-9, Vita Silky Fluid®, squalene, bis-diglyceryl polyacyladipate-2, and alpha-bisabolol
  • the content of the container with the oil phase was added over the container with the aqueous phase and after homogenization at 3000 rpm for 3 minutes, the mixture was cooled down below about 40 °C. Then, a mixture of water (5.00% of the total weight of the cosmetic topical composition), silver citrate solution, and triethanolamine 99% was added to the homogenized mixture.
  • Example 1 The efficacy of the composition of Example 1 in improving the skin barrier function in subjects with atopic predisposition and sensitive body skin was assessed with clinical verification. 19 adult subjects with sensitive body skin, atopic predisposition, habitual body itching and skin discomfort (ex. tingling, stiffness, warmth, burning, and redness) used the lotion of Example 1 for 4 weeks. The composition was applied topically to the body under normal conditions of use twice daily.
  • Example 1 is useful for alleviating atopic symptoms such as itching and redness and improves skin barrier function after 4 weeks of use with a very good cutaneous acceptability (in % of the subjects questioned).
  • Example 1 has been found to be chemically and physically stable after subjecting the composition to accelerated stability studies at 40°C for 3 months and after subjecting the composition to stability studies at 25°C for 6 months, and 5°C for 6 months.

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Abstract

La présente invention se rapporte au domaine de la cosmétique. En particulier, l'invention concerne des compositions topiques cosmétiques sous la forme d'une émulsion huile dans eau (H/E) qui sont utiles pour améliorer les symptômes de la dermatite atopique.
PCT/EP2024/062695 2023-05-09 2024-05-08 Composition topique cosmétique Ceased WO2024231438A2 (fr)

Applications Claiming Priority (2)

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EP23382427 2023-05-09
EP23382427.5 2023-05-09

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WO2024231438A2 true WO2024231438A2 (fr) 2024-11-14
WO2024231438A3 WO2024231438A3 (fr) 2025-01-02

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007031520A2 (fr) 2005-09-15 2007-03-22 Air Liquide Sante (International) Utilisation de dichlorhydrate d'octenidine dans des preparations semi-solides
WO2015091692A1 (fr) 2013-12-18 2015-06-25 Almirall, S.A. Compositions cosmétiques ou pharmaceutiques topiques comprenant du dichlorhydrate d'octénidine
WO2022122898A1 (fr) 2020-12-09 2022-06-16 Symrise Ag Compositions comprenant des antimicrobiens et des (bio)-alcanediols pour la protection de la peau

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Publication number Priority date Publication date Assignee Title
WO2022203538A1 (fr) * 2021-03-26 2022-09-29 "Скайлаб Aг" Complexe à quatre composants bio-actif pour réguler la biodiversité de microbiotes de la peau

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007031520A2 (fr) 2005-09-15 2007-03-22 Air Liquide Sante (International) Utilisation de dichlorhydrate d'octenidine dans des preparations semi-solides
WO2015091692A1 (fr) 2013-12-18 2015-06-25 Almirall, S.A. Compositions cosmétiques ou pharmaceutiques topiques comprenant du dichlorhydrate d'octénidine
WO2022122898A1 (fr) 2020-12-09 2022-06-16 Symrise Ag Compositions comprenant des antimicrobiens et des (bio)-alcanediols pour la protection de la peau

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