WO2024253356A1 - Dispositif de surveillance d'état parodontal et son procédé de fonctionnement - Google Patents

Dispositif de surveillance d'état parodontal et son procédé de fonctionnement Download PDF

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Publication number
WO2024253356A1
WO2024253356A1 PCT/KR2024/006721 KR2024006721W WO2024253356A1 WO 2024253356 A1 WO2024253356 A1 WO 2024253356A1 KR 2024006721 W KR2024006721 W KR 2024006721W WO 2024253356 A1 WO2024253356 A1 WO 2024253356A1
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biosensor
user
implant
monitoring device
periodontal
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English (en)
Korean (ko)
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김종은
진간
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University Industry Foundation UIF of Yonsei University
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University Industry Foundation UIF of Yonsei University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4538—Evaluating a particular part of the muscoloskeletal system or a particular medical condition
    • A61B5/4542—Evaluating the mouth, e.g. the jaw
    • A61B5/4552—Evaluating soft tissue within the mouth, e.g. gums or tongue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/412—Detecting or monitoring sepsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors

Definitions

  • the present invention relates to a periodontal condition monitoring device, and more specifically, to a device for monitoring periodontal condition and an operating method thereof.
  • implant placement timing and loading timing varies depending on the doctor's evaluation, but is often determined based on the doctor's clinical judgment rather than objective criteria.
  • the user's biometric information can be acquired to determine the bone recovery status of the periodontal bone, peri-implantitis, or peri-implant mucositis, thereby monitoring the user's condition.
  • the timing of implant placement and loading can be judged based on objective criteria.
  • a device for periodontal condition monitoring can include a biosensor that senses bioinformation of the user by being disposed on at least one of a surface of an implant implanted into an alveolar bone of a user, a surface of a healing abutment placed on the implant, or a surface of a crown placed after removing the healing abutment.
  • the device for periodontal condition monitoring can include at least one processor that obtains a measurement signal including bioinformation of the user from the biosensor. The at least one processor can determine the periodontal condition of the user based on the obtained measurement signal.
  • an operating method of a periodontal condition monitoring device may be provided.
  • the operating method of the periodontal condition monitoring device may include a step of sensing bioinformation of the user through a biosensor disposed on at least one of a surface of an implant implanted into an alveolar bone of the user, a surface of a healing abutment disposed on the implant, and a surface of a crown disposed after removing the healing abutment.
  • the operating method of the periodontal condition monitoring device may include a step of acquiring a measurement signal including the sensed bioinformation.
  • the operating method of the periodontal condition monitoring device may include a step of determining a periodontal condition of the user based on the acquired measurement signal.
  • a computer-readable recording medium recording a computer program for executing a method for implementing the present disclosure may be further provided.
  • the device for periodontal condition monitoring can sense the user's bio-information through a bio-sensor disposed on at least one of the surface of the implant, the surface of the healing abutment disposed on the implant, or the surface of the crown disposed after removing the healing abutment.
  • the device for periodontal condition monitoring can accurately determine the user's periodontal condition, for example, the recovery state of the alveolar bone, peri-implantitis, or peri-implant mucositis, based on the bio-information.
  • the timing of implant placement or loading can be judged based on objective criteria, thereby improving the accuracy and ease of judgment.
  • unintended inflammation or bone loss can be diagnosed and prevented in advance.
  • FIG. 1 is a block diagram illustrating the configuration of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • FIG. 2 is a drawing for explaining the configuration of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • FIG. 3 is a drawing for explaining the configuration of a biosensor according to one embodiment of the present disclosure.
  • FIG. 4 is a drawing for explaining the operation of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • FIG. 5 is a drawing for explaining the operation of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • FIG. 6 is a flowchart for explaining an operation method of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • FIG. 7a is a flowchart for explaining an operation method of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • FIG. 7b is a flowchart for explaining an operation method of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • first, second, etc. are used to distinguish one component from another, and the components are not limited by the aforementioned terms.
  • each step is used for convenience of explanation and do not describe the order of each step. Each step may be performed in a different order than specified unless the context clearly indicates a specific order.
  • FIG. 1 is a block diagram illustrating the configuration of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • FIG. 2 is a drawing for explaining the configuration of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • the periodontal condition monitoring device (100) may include a biosensor (110), a memory (120), and at least one processor (130). However, in some embodiments, the periodontal condition monitoring device (100) may include fewer or more components than the components illustrated in FIGS. 1 and 2.
  • the biosensor (110) can be disposed on at least one of the surface of the implant (300), the surface of a healing abutment (200) disposed on the implant (300), or the surface of a crown disposed on the implant (300).
  • the crown can be disposed by removing the healing abutment disposed on the implant (300).
  • the biosensor (110) can be disposed on a side surface of the surface of the implant (300).
  • the biosensor (110) can be disposed on a side surface of the surface of the healing abutment (200).
  • the biosensor (110) can be disposed on a side surface of the surface of the crown.
  • the biosensor (110) can also be disposed on a lower surface of the surface of the implant (300). Additionally, the biosensor (110) may be placed on the upper surface of the surface of the healing abutment (200). The biosensor (110) may be placed on the upper surface of the surface of the crown.
  • the periodontal condition monitoring device (100) can sense the user's biometric information through the biosensor (110) into which the implant (300), healing abutment (200), or crown is inserted, thereby determining the user's periodontal condition.
  • the types of implants (300), healing abutments (200), and crowns in which the biosensors (110) included in the periodontal condition monitoring device (100) are placed are not limited, and may include implants, healing abutments, and crowns in which a space for placing the biosensors (110) can be secured.
  • the biosensor (110) can sense the user's bioinformation and generate a measurement signal including the sensed bioinformation.
  • the bioinformation can include at least one of the concentration of osteoblasts, the concentration of osteoclasts, the level of a leukocyte expression marker, and the level of a cytokine in the interstitial fluid.
  • the biosensor (110) can also sense other bioinformation of the user for determining the user's periodontal status.
  • At least one processor (130) can obtain a measurement signal including biometric information of a user from a biosensor (110). In one embodiment, at least one processor (130) can determine at least one of whether the user has peri-implantitis or whether the user has peri-implant mucositis based on a level of a leukocyte surface marker included in the measurement signal.
  • At least one processor (130) can determine at least one of whether the user has peri-implantitis or whether the user has peri-implant mucositis based on the level of cytokines in the interstitial fluid included in the measurement signal.
  • At least one processor (130) can determine the recovery status of the user's alveolar bone based on the concentration of osteoblasts and the concentration of osteoclasts included in the measurement signal.
  • sensing the level of a leukocyte surface marker through a biosensor (110) and determining at least one of whether the user has peri-implantitis or peri-implant mucositis through this and sensing the level of a cytokine in interstitial fluid through a biosensor (110) and determining at least one of whether the user has peri-implantitis or peri-implant mucositis through this, will be described later with reference to FIG. 4.
  • the memory (120) can store data supporting various functions of the periodontal condition monitoring device (100).
  • the memory (120) can store a plurality of application programs (or applications) driven by the periodontal condition monitoring device (100), data for the operation of the periodontal condition monitoring device (100), and commands. At least some of these application programs may exist for the basic functions of the periodontal condition monitoring device (100). Meanwhile, the application programs may be stored in the memory, installed in the device, and driven by the processor to perform operations (or functions).
  • the memory (120) may include at least one type of storage medium among a flash memory type, a hard disk type, a Solid State Disk type, an SDD type, a multimedia card micro type, a card type memory (for example, an SD or XD memory, etc.), a random access memory (RAM), a static random access memory (SRAM), a read-only memory (ROM), an electrically erasable programmable read-only memory (EEPROM), a programmable read-only memory (PROM), a magnetic memory, a magnetic disk, and an optical disk.
  • the memory may be a database that is separate from the device but connected by wire or wirelessly.
  • At least one processor (130) may be a general-purpose processor such as a CPU, an AP, a Digital Signal Processor (DSP), or a graphics-only processor such as a GPU or a Vision Processing Unit (VPU). At least one processor (130) controls processing of input data according to predefined operation rules, data, or instructions stored in the memory (120).
  • DSP Digital Signal Processor
  • VPU Vision Processing Unit
  • the memory (120) and at least one processor (130) are illustrated as being implemented as separate configurations, but the memory (120) and at least one processor (130) may be implemented as a single configuration.
  • the periodontal condition monitoring device (100) may further include a communication unit.
  • the communication unit may communicate with a terminal of an administrator who controls management of the periodontal condition monitoring device (100) and whether to provide it to a user, and may communicate with a terminal of a user who uses the service.
  • the communication unit may include one or more modules that connect the periodontal condition monitoring device (100) to one or more networks.
  • the communication unit may include one or more components that enable communication with external devices, and may include, for example, at least one of a broadcast receiving module, a wired communication module, a wireless communication module, a short-range communication module, and a location information module.
  • the wired communication module may include various wired communication modules such as a Local Area Network (LAN) module, a Wide Area Network (WAN) module, or a Value Added Network (VAN) module, as well as various cable communication modules such as a Universal Serial Bus (USB), a High Definition Multimedia Interface (HDMI), a Digital Visual Interface (DVI), RS-232 (recommended standard232), power line communication, or plain old telephone service (POTS).
  • LAN Local Area Network
  • WAN Wide Area Network
  • VAN Value Added Network
  • USB Universal Serial Bus
  • HDMI High Definition Multimedia Interface
  • DVI Digital Visual Interface
  • RS-232 recommended standard232
  • POTS plain old telephone service
  • the wireless communication module may include a wireless communication module that supports various wireless communication methods such as GSM (global System for Mobile Communication), CDMA (Code Division Multiple Access), WCDMA (Wideband Code Division Multiple Access), UMTS (universal mobile telecommunications system), TDMA (Time Division Multiple Access), LTE (Long Term Evolution), 4G, 5G, and 6G, in addition to a WiFi module and a Wireless broadband module.
  • GSM Global System for Mobile Communication
  • CDMA Code Division Multiple Access
  • WCDMA Wideband Code Division Multiple Access
  • UMTS universalal mobile telecommunications system
  • TDMA Time Division Multiple Access
  • LTE Long Term Evolution
  • 4G Long Term Evolution
  • 5G Fifth Generation
  • 6G Wireless broadband module
  • the wireless communication module may include a wireless communication interface including an antenna and a transmitter for transmitting a signal.
  • the wireless communication module may further include a signal conversion module for modulating a digital control signal output from at least one processor (110) through the wireless communication interface into an analog wireless signal under the control of at least one processor (110).
  • the short-range communication module is for short-range communication and can support short-range communication using at least one of Bluetooth, RFID (Radio Frequency Identification), Infrared Data Association (IrDA), UWB (Ultra-Wideband), ZigBee, NFC (Near Field Communication), Wi-Fi (Wireless-Fidelity), Wi-Fi Direct, and Wireless USB (Wireless Universal Serial Bus) technologies.
  • RFID Radio Frequency Identification
  • IrDA Infrared Data Association
  • UWB Ultra-Wideband
  • ZigBee Ultra-Wideband
  • ZigBee Wireless-Fi
  • Wi-Fi Direct Wireless USB (Wireless Universal Serial Bus) technologies.
  • the biosensor (110) may provide a measurement signal generated after sensing the user's biometric information to at least one processor (130) through a communication unit.
  • the at least one processor (130) may provide the user's periodontal status determined based on the acquired measurement signal to an external device or server device through the communication unit.
  • At least one processor (130) may control one or more of the components described above in combination to implement various embodiments according to the present disclosure described in the drawings below on the device.
  • FIG. 2 illustrates three biosensors (110) arranged on a side surface of an implant (300).
  • the present disclosure is not limited thereto, and the periodontal condition monitoring device (100) may include two or fewer biosensors or four or more biosensors arranged on a side surface of an implant (300).
  • the biosensor arranged on a side surface of an implant (300) is referred to as a first biosensor (110).
  • FIG. 2 illustrates one biosensor (110) positioned on the side surface of the healing abutment (200).
  • the periodontal condition monitoring device (100) may include two or more biosensors positioned on the side surface of the healing abutment (200).
  • the biosensor positioned on the side surface of the healing abutment (200) is referred to as a second biosensor (110).
  • the second biosensor (110) may be a biosensor positioned on the side surface of the crown.
  • FIG. 3 is a drawing for explaining the configuration of a biosensor according to one embodiment of the present disclosure.
  • a biosensor may include a substrate (112), a plurality of electrodes (111) spaced apart from each other on the substrate (112), and a conductor (113) electrically connecting the plurality of electrodes (111).
  • the biosensor (110) may include a single electrode.
  • the substrate (112) may be a member that provides a surface on which a plurality of electrodes (111) and a conductor (113) are arranged.
  • the substrate (112) may include a plastic substrate, an insulating film, or a laminated structure including a plurality of insulating layers.
  • the biosensor (110) may include a square shape. At this time, the width and height of the biosensor (110) may each be 1 cm or less. However, the present disclosure is not limited thereto, and the biosensor (110) may also include a shape such as a circle.
  • the color of the biosensor (110) is not limited.
  • the biosensor (110) may have colors that can be expressed by R, G, and B.
  • the plurality of electrodes (111) may be spaced apart from each other on the substrate (112). In one embodiment, the plurality of electrodes (111) may be spaced apart from each other while facing each other. In one embodiment, the plurality of electrodes (111) may include a group IV semiconductor, for example, C, Si, Ge, Sn, etc. The plurality of electrodes (111) may include a group IV compound semiconductor. The plurality of electrodes (111) may include a group VI semiconductor, for example, S, Se, Te, etc. The plurality of electrodes (111) may include a III-V bond semiconductor. In this case, the III-V bond semiconductor can be crystallized with high purity and can include an n-type and a p-type.
  • the plurality of electrodes (111) may include a II-VI bond semiconductor, for example, ZnTe or ZnO. However, the present disclosure is not limited thereto, and the plurality of electrodes (111) may include an I-VII, IV-VI, V-VI semiconductor, II-V semiconductor, I-III-VI2 semiconductor, oxide semiconductor, layered semiconductor, magnetic semiconductor, organic semiconductor, or charge transfer complex.
  • the conductor (113) is disposed on the substrate (112) and can electrically connect a plurality of electrodes (111) that are disposed spaced apart from each other.
  • the conductor (113) is illustrated in a grid shape in FIG. 3, but is not limited thereto.
  • the conductor (113) may include copper, gold, silver, steel, aluminum, brass, or the like.
  • the conductor (113) may include a chemical element, such as mercury or lead, an alloy, such as niobium-titanium, germanium-niobium, niobium nitride, or the like.
  • the conductor (113) may also include ceramics, such as YBCO or magnesium diboride, or the like.
  • the conductor (113) may include a superconducting picotite, such as NaOFeAs, or the like.
  • the conductor (113) may also include an organic superconductor, such as fullerene or carbon nanotube, or the like.
  • the biosensor (110) can sense the user's bioinformation through the intensity of the current flowing through the plurality of electrodes (111) and the conductor (113), etc. In one embodiment, the biosensor (110) can sense the user's bioinformation based on the intensity of the current, etc., which varies according to the bioinformation of the user's alveolar bone or gingiva adjacent to the implant (300), the healing abutment (200), or the crown. At this time, the relationship between the intensity of the current and the bioinformation of the alveolar bone or the bioinformation of the gingiva may be pre-calculated and stored in the memory (120) of the device (100) for periodontal condition monitoring. However, the method by which the biosensor (110) senses the user's bioinformation is not limited thereto.
  • FIG. 4 is a drawing for explaining the operation of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • the same components as those described in FIGS. 1 and 3 are given the same drawing reference numerals, and redundant descriptions are omitted.
  • At least one processor (130) is illustrated as a separate device from the biosensor (110).
  • the present disclosure is not limited thereto, and at least one processor (130) and the biosensor (110) may be configured to be included in one device, for example, a device (100) for periodontal condition monitoring.
  • inflammation may occur around an implant (300) implanted in periodontal bone.
  • peri-implantitis or peri-implant mucositis may occur around the implant (300).
  • a biosensor (110) disposed on the surface of an implant (300), the surface of a healing abutment (300) disposed on the implant (300), or the surface of a crown can sense markers generated by inflammation when peri-implantitis or peri-implant mucositis occurs.
  • the biosensor (110) can sense a level of a leukocyte surface marker.
  • the leukocyte surface marker can include at least one of a user's T lymphocyte surface marker, a B lymphocyte surface marker, a NK cell (Natural Killer cell) surface marker, a neutrophil surface marker, or a monocyte surface marker.
  • the biosensor (110) can sense the above leukocyte surface markers.
  • the biosensor (110) can sense a level of the leukocyte surface marker based on the sensed leukocyte surface markers.
  • the biosensor (110) may generate a measurement signal including bioinformation, including a level of a white blood cell surface marker, and then provide the signal to at least one processor (130).
  • At least one processor (130) can determine at least one of the occurrence of peri-implantitis or the occurrence of peri-implant mucositis based on the acquired measurement signal.
  • At least one processor (130) can determine that at least one of peri-implantitis or peri-implant mucositis has occurred around the implant (300) if the value of the white blood cell surface marker included in the acquired measurement signal is higher than a preset first value.
  • the preset first value may be the value of a leukocyte surface marker measured in a normal state in which peri-implantitis or peri-implant mucositis has not occurred.
  • the biosensor (110) can sense the level of cytokines in the interstitial fluid. In one embodiment, the level of cytokines in the interstitial fluid can be determined based on at least one of the user's Tumor Necrosis Factor-a (TNF-a) or Interleukin-1b (IL-1b). The biosensor (110) can sense at least one of the user's Tumor Necrosis Factor-a or Interleukin-1b. The biosensor (110) can sense the level of cytokines in the interstitial fluid based on at least one of the sensed Tumor Necrosis Factor-a or Interleukin-1b.
  • TNF-a Tumor Necrosis Factor-a
  • IL-1b Interleukin-1b
  • the biosensor (110) can generate a measurement signal including bioinformation including cytokine levels of interstitial fluid and then provide the measurement signal to at least one processor (130).
  • the at least one processor (130) can determine at least one of the occurrence of peri-implantitis or the occurrence of peri-implant mucositis based on the acquired measurement signal.
  • At least one processor (130) may determine that at least one of peri-implantitis or peri-implant mucositis has occurred around the implant (300) if the cytokine level of the interstitial fluid included in the acquired measurement signal is higher than a preset second level.
  • the preset second value may be a cytokine value of interstitial fluid measured in a normal state in which peri-implantitis or peri-implant mucositis has not occurred.
  • peri-implant mucositis in the case of peri-implant mucositis, it may occur in an area relatively adjacent to the healing abutment (200) or crown rather than the implant (300), and in the case of peri-implantitis, it may occur in an area relatively adjacent to the implant (300) rather than the healing abutment (200) or crown.
  • At least one processor (130) can compare the level of the leukocyte surface marker included in the measurement signal acquired from the first biosensor with the level of the leukocyte surface marker included in the measurement signal acquired from the second biosensor to determine the location of the point where inflammation has occurred, and based on this, can determine whether at least one of peri-implantitis or peri-implant mucositis has occurred.
  • At least one processor (130) can compare the level of the cytokine of the interstitial fluid included in the measurement signal acquired from the first biosensor with the level of the cytokine of the interstitial fluid included in the measurement signal acquired from the second biosensor to determine the location of the point where inflammation has occurred, and based on this, can determine whether at least one of peri-implantitis or peri-implant mucositis has occurred.
  • a dentist or the like using a periodontal condition monitoring device (100) can determine in real time that inflammation has occurred in a user receiving dental treatment using an implant (300), postpone the implantation time of the implant (300) or the loading time of an artificial tooth, and provide dental treatment to treat the user's inflammation.
  • the at least one processor (130) may determine that the user's periodontal condition is a healthy state without inflammation. In one embodiment, if the level of a cytokine of the interstitial fluid included in the measurement signal acquired by at least one processor (130) is lower than a preset second level, the at least one processor (130) may determine that the user's periodontal condition is a healthy state without inflammation.
  • a dentist or the like using the periodontal condition monitoring device (100) may determine in real time that inflammation has not occurred in a user receiving dental treatment using an implant (300), and may determine the timing of implantation of the implant (300) or the timing of loading of an artificial tooth.
  • FIG. 5 is a drawing for explaining the operation of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • the same components as those described in FIGS. 1, 3, and 4 are given the same drawing reference numerals, and redundant descriptions are omitted.
  • the recovery status of the alveolar bone adjacent to the implanted implant (300) can be determined.
  • the bone consolidation status of the alveolar bone adjacent to the implanted implant (300) can be determined, and an artificial tooth can be loaded onto the implanted implant (300).
  • a biosensor (110) disposed on the surface of an implant (300), the surface of a healing abutment (200) disposed on the implant (300), or the surface of a crown can sense markers generated during the strengthening process of the alveolar bone.
  • the biosensor (110) can sense the concentration of osteoblasts and the concentration of osteoclasts.
  • the marker of osteoblasts can include at least one of the user's osteocalcin, Bone Morphogenic Protein (BMP), or Bone ALkaline Phosphatase (BALP).
  • BMP Bone Morphogenic Protein
  • BALP Bone ALkaline Phosphatase
  • the marker of osteoclasts can include at least one of Tartrate Resistant Acid Phosphatase (TRAP) or the surface marker of osteoclasts.
  • the biosensor (110) can sense the marker of osteoblasts and the marker of osteoclasts.
  • the biosensor (110) can sense the concentration of osteoblasts and the concentration of osteoclasts based on the sensed marker of osteoblasts and the marker of osteoclasts.
  • the concentration of osteoclasts which ingest and decompose damaged tissue and alveolar bone debris and promote the formation of new alveolar bone tissue, increases. Thereafter, in the later stage of the alveolar bone recovery process, the concentration of osteoblasts, which reconstruct the formation and mineralization of new alveolar bone tissue and bone structure, increases.
  • At least one processor (130) can determine in real time that the recovery state of the alveolar bone adjacent to the implanted implant (300) is in the initial state when the concentration of osteoclasts is higher than the concentration of osteoblasts. Through this, a dentist using the periodontal condition monitoring device (100) can delay the loading time of an artificial tooth of a user receiving dental treatment using an implant (300).
  • At least one processor (130) can determine in real time that the recovery state of the alveolar bone adjacent to the implanted implant (300) is in the late state when the concentration of osteoblasts is higher than the concentration of osteoclasts. Through this, a dentist using a periodontal condition monitoring device (100) can determine the loading time of an artificial tooth of a user receiving dental treatment using an implant (300).
  • the operating method of the periodontal condition monitoring device (100) may include a step (S100) of sensing the user's bio-information through a bio-sensor (110) disposed on at least one of the surface of an implant (300) implanted into the user's alveolar bone, the surface of a healing abutment (200) disposed on the implant (300), or the surface of a crown. At this time, it may also be referred to as measuring the user's bio-information through the bio-sensor (110).
  • the operating method of the periodontal condition monitoring device (100) may include a step (S300) of determining the periodontal condition of the user based on the acquired measurement signal.
  • the periodontal condition of the user may refer to the health condition of the user.
  • the health condition of the user may be determined based on the biometric information included in the acquired measurement signal.
  • Fig. 7a is a flowchart for explaining an operation method of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • steps identical to those described in Fig. 6 are given the same drawing reference numerals, and redundant descriptions are omitted.
  • the operating method of the periodontal condition monitoring device may include, after the step (S200) of obtaining a measurement signal including bioinformation sensed from a biosensor (110), a step (S310) of determining whether periodontal inflammation exists based on at least one of a white blood cell surface marker level or an interstitial fluid cytokine level included in the bioinformation.
  • Fig. 7b is a flowchart for explaining an operation method of a periodontal condition monitoring device according to one embodiment of the present disclosure.
  • steps identical to those described in Fig. 6 are given the same drawing reference numerals, and redundant descriptions are omitted.
  • the operating method of the periodontal condition monitoring device may include, after the step (S200) of obtaining a measurement signal including bio-information sensed from a biosensor (110), a step (S320) of determining the recovery status of alveolar bone based on the concentration of osteoblasts and osteoclasts included in the bio-information.
  • the disclosed embodiments may be implemented in the form of a recording medium storing instructions executable by a computer.
  • the instructions may be stored in the form of program codes, and when executed by a processor, may generate program modules to perform the operations of the disclosed embodiments.
  • the recording medium may be implemented as a computer-readable recording medium.
  • Computer-readable storage media include all types of storage media that store instructions that can be deciphered by a computer. Examples include ROM (Read Only Memory), RAM (Random Access Memory), magnetic tape, magnetic disk, flash memory, and optical data storage devices.
  • ROM Read Only Memory
  • RAM Random Access Memory
  • magnetic tape magnetic tape
  • magnetic disk magnetic disk
  • flash memory optical data storage devices

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Abstract

Un mode de réalisation de la présente divulgation concerne un dispositif de surveillance d'état parodontal et un procédé de fonctionnement du dispositif de surveillance d'état parodontal. Le dispositif de surveillance d'état parodontal peut comprendre : un biocapteur disposé sur une surface d'un implant implanté dans un os alvéolaire d'un utilisateur ; une surface d'un pilier de cicatrisation, ou une surface d'une couronne, disposé sur l'implant et détectant des informations biométriques d'un utilisateur ; et au moins un processeur pour obtenir un signal de mesure comprenant des informations biométriques de l'utilisateur provenant du biocapteur, le ou les processeurs déterminant un état parodontal de l'utilisateur sur la base du signal de mesure obtenu.
PCT/KR2024/006721 2023-06-07 2024-05-17 Dispositif de surveillance d'état parodontal et son procédé de fonctionnement Pending WO2024253356A1 (fr)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0433647A (ja) * 1990-05-30 1992-02-05 Shigeru Saito 人工歯根
JP2015192717A (ja) * 2014-03-31 2015-11-05 アイシン・エィ・ダブリュ株式会社 生体情報取得ユニット
KR20190062180A (ko) * 2017-11-27 2019-06-05 광주과학기술원 센서를 구비한 임플란트 및 이의 동작방법
KR20200008431A (ko) * 2018-07-16 2020-01-28 연세대학교 산학협력단 무선운용 멀티센싱 임플란트 및 이를 포함하는 고위험 노인질환 상시 모니터링 시스템
KR20210022853A (ko) * 2019-08-21 2021-03-04 의료법인사과나무의료재단 치과 진단 시스템

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* Cited by examiner, † Cited by third party
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KR101308942B1 (ko) 2011-07-25 2013-09-24 오스템임플란트 주식회사 Ｒｆｉｄ 태그가 설치된 임플란트

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0433647A (ja) * 1990-05-30 1992-02-05 Shigeru Saito 人工歯根
JP2015192717A (ja) * 2014-03-31 2015-11-05 アイシン・エィ・ダブリュ株式会社 生体情報取得ユニット
KR20190062180A (ko) * 2017-11-27 2019-06-05 광주과학기술원 센서를 구비한 임플란트 및 이의 동작방법
KR20200008431A (ko) * 2018-07-16 2020-01-28 연세대학교 산학협력단 무선운용 멀티센싱 임플란트 및 이를 포함하는 고위험 노인질환 상시 모니터링 시스템
KR20210022853A (ko) * 2019-08-21 2021-03-04 의료법인사과나무의료재단 치과 진단 시스템

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