WO2024254218A3 - Non-peptide small molecule fgf14:nav1.6 channel complex protein-protein interaction modulators - Google Patents

Non-peptide small molecule fgf14:nav1.6 channel complex protein-protein interaction modulators Download PDF

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Publication number
WO2024254218A3
WO2024254218A3 PCT/US2024/032668 US2024032668W WO2024254218A3 WO 2024254218 A3 WO2024254218 A3 WO 2024254218A3 US 2024032668 W US2024032668 W US 2024032668W WO 2024254218 A3 WO2024254218 A3 WO 2024254218A3
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WO
WIPO (PCT)
Prior art keywords
protein
fgf14
small molecule
channel complex
peptide small
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/032668
Other languages
French (fr)
Other versions
WO2024254218A2 (en
Inventor
Jia Zhou
Fernanda LAEZZA
Pingyuan WANG
Nolan M. DVORAK
Paul A. WADSWORTH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Priority to EP24819976.2A priority Critical patent/EP4719396A2/en
Publication of WO2024254218A2 publication Critical patent/WO2024254218A2/en
Publication of WO2024254218A3 publication Critical patent/WO2024254218A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to novel small molecule FGF14:NAV1.6 channel complex protein-protein interaction modulators of the general structure according to Formula (I), and the preparation and use thereof:
PCT/US2024/032668 2023-06-05 2024-06-05 Non-peptide small molecule fgf14:nav1.6 channel complex protein-protein interaction modulators Ceased WO2024254218A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP24819976.2A EP4719396A2 (en) 2023-06-05 2024-06-05 Non-peptide small molecule fgf14:nav1.6 channel complex protein-protein interaction modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363506356P 2023-06-05 2023-06-05
US63/506,356 2023-06-05

Publications (2)

Publication Number Publication Date
WO2024254218A2 WO2024254218A2 (en) 2024-12-12
WO2024254218A3 true WO2024254218A3 (en) 2025-04-17

Family

ID=93794700

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/032668 Ceased WO2024254218A2 (en) 2023-06-05 2024-06-05 Non-peptide small molecule fgf14:nav1.6 channel complex protein-protein interaction modulators

Country Status (2)

Country Link
EP (1) EP4719396A2 (en)
WO (1) WO2024254218A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920127A (en) * 1987-02-18 1990-04-24 Beecham Group P.L.C. Substituted indoles and their use as 5-HT3 receptor antagonists
US5444152A (en) * 1990-06-07 1995-08-22 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic peptide derivatives
WO2004099189A1 (en) * 2003-05-09 2004-11-18 F. Hoffmann-La Roche Ag Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists
US20150148349A1 (en) * 2012-06-28 2015-05-28 Novartis Ag Complement pathway modulators and uses thereof
US20190055196A1 (en) * 2015-06-09 2019-02-21 Abbvie Inc. Nuclear receptor modulators

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920127A (en) * 1987-02-18 1990-04-24 Beecham Group P.L.C. Substituted indoles and their use as 5-HT3 receptor antagonists
US5444152A (en) * 1990-06-07 1995-08-22 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic peptide derivatives
WO2004099189A1 (en) * 2003-05-09 2004-11-18 F. Hoffmann-La Roche Ag Methyl indoles and methyl pyrrolopyridines as alph-1 adrenergic agonists
US20150148349A1 (en) * 2012-06-28 2015-05-28 Novartis Ag Complement pathway modulators and uses thereof
US20190055196A1 (en) * 2015-06-09 2019-02-21 Abbvie Inc. Nuclear receptor modulators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE Compound 12 April 2007 (2007-04-12), PUBCHEM: "3-Methylindole-1-carboxamide | C10H10N2O | CID 17913525 - PubChem", XP093305536, Database accession no. 17913525 *

Also Published As

Publication number Publication date
WO2024254218A2 (en) 2024-12-12
EP4719396A2 (en) 2026-04-08

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