WO2024254478A3 - Microbials for bacterial inhibition - Google Patents

Microbials for bacterial inhibition Download PDF

Info

Publication number
WO2024254478A3
WO2024254478A3 PCT/US2024/033048 US2024033048W WO2024254478A3 WO 2024254478 A3 WO2024254478 A3 WO 2024254478A3 US 2024033048 W US2024033048 W US 2024033048W WO 2024254478 A3 WO2024254478 A3 WO 2024254478A3
Authority
WO
WIPO (PCT)
Prior art keywords
nrrl
strains
microbials
relates
bacterial inhibition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/033048
Other languages
French (fr)
Other versions
WO2024254478A2 (en
Inventor
Sona SON
Michael R. King
Jessica EDWARD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Discovery Group LLC
Original Assignee
Microbial Discovery Group LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Discovery Group LLC filed Critical Microbial Discovery Group LLC
Priority to CN202480042253.7A priority Critical patent/CN121712518A/en
Priority to EP24820147.7A priority patent/EP4724078A2/en
Publication of WO2024254478A2 publication Critical patent/WO2024254478A2/en
Publication of WO2024254478A3 publication Critical patent/WO2024254478A3/en
Priority to MX2025014302A priority patent/MX2025014302A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Husbandry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physiology (AREA)
  • Fodder In General (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to direct-fed microbials for use in E. coli, Salmonella, and/or Clostridium inhibition in animals. More particularly, the invention relates to isolated Bacillus strains CM256 (NRRL No. B-67706), CM857 (NRRL No. B-67705), CM978 (NRRL No. B-67703), CM1004 (NRRL No. B-67708), and MDG1607 (NRRL No. B-67666), and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use. The invention also relates to the use of isolated Bacillus strains CM256 (NRRL No. B-67706), CM857 (NRRL No. B-67705), CM978 (NRRL No. B-67703), and CM1004 (NRRL No. B-67708), and strains having all of the identifying characteristics of these strains, to treat plants having diseases caused by E. coli, Salmonella, and/or Clostridium.
PCT/US2024/033048 2023-06-08 2024-06-07 Microbials for bacterial inhibition Ceased WO2024254478A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202480042253.7A CN121712518A (en) 2023-06-08 2024-06-07 Microorganisms for bacterial inhibition
EP24820147.7A EP4724078A2 (en) 2023-06-08 2024-06-07 Microbials for bacterial inhibition
MX2025014302A MX2025014302A (en) 2023-06-08 2025-11-28 Microbials for bacterial inhibition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363506993P 2023-06-08 2023-06-08
US63/506,993 2023-06-08

Publications (2)

Publication Number Publication Date
WO2024254478A2 WO2024254478A2 (en) 2024-12-12
WO2024254478A3 true WO2024254478A3 (en) 2025-05-08

Family

ID=93794619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033048 Ceased WO2024254478A2 (en) 2023-06-08 2024-06-07 Microbials for bacterial inhibition

Country Status (4)

Country Link
EP (1) EP4724078A2 (en)
CN (1) CN121712518A (en)
MX (1) MX2025014302A (en)
WO (1) WO2024254478A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100093860A1 (en) * 2006-05-01 2010-04-15 University Gent Hydroxybutyrate and poly-hydroxybutyrate as components of animal feed or feed additives
US20200276279A1 (en) * 2011-02-18 2020-09-03 Dupont Nutrition Biosciences Aps Feed additive composition
US20210236563A1 (en) * 2018-05-01 2021-08-05 Microbial Discovery Group, Llc Microbials for feed

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100093860A1 (en) * 2006-05-01 2010-04-15 University Gent Hydroxybutyrate and poly-hydroxybutyrate as components of animal feed or feed additives
US20200276279A1 (en) * 2011-02-18 2020-09-03 Dupont Nutrition Biosciences Aps Feed additive composition
US20210236563A1 (en) * 2018-05-01 2021-08-05 Microbial Discovery Group, Llc Microbials for feed

Also Published As

Publication number Publication date
CN121712518A (en) 2026-03-20
WO2024254478A2 (en) 2024-12-12
MX2025014302A (en) 2026-01-07
EP4724078A2 (en) 2026-04-15

Similar Documents

Publication Publication Date Title
KR100437497B1 (en) Acid-tolerant Lactobacillus reuteri Probio-16 suppressing the growth of pathogenic microorganisms and rotavirus, and Probiotics containing the same
Svetoch et al. Isolation of Bacillus circulans and Paenibacillus polymyxa strains inhibitory to Campylobacter jejuni and characterization of associated bacteriocins
US6623775B2 (en) Treating or preventing illness growth of Clostridium difficile
Sugita et al. Vibrio sp. strain NM 10, isolated from the intestine of a Japanese coastal fish, has an inhibitory effect against Pasteurella piscicida
Barefoot et al. Identification and purification of a protein that induces production of the Lactobacillus acidophilus bacteriocin lactacin B
WO2001013927A3 (en) Improved topical compositions containing probiotic bacteria, spores, and extracellular products and uses thereof
WO2020074547A8 (en) Lactobacillus crispatus probiotic strains suitable for treating urogenital yeast and bacterial infections
MX2020011464A (en) Microbials for feed.
KR101498272B1 (en) Bacillus subtilis strain isolated from Kimchi, producing antimicrobial substances and having immune activity, and probiotics composition using it
Gao et al. Purification and characteristics of a novel bacteriocin produced by Enterococcus faecalis L11 isolated from Chinese traditional fermented cucumber
Nujthet et al. Biocontrol efficacy of antagonists Trichoderma and Bacillus against post-harvest diseases in mangos
Upadhyay et al. Pseudomonas cepacia causes mycelial deformities and inhibition of conidiation in phytopathogenic fungi
Gholizadeh et al. Study on Bioactive Compounds Produced by Soil Origin Brevibacillus spp.
RU2020132317A (en) USE OF FOOD MICROBIALS IN THE PREVENTION AND/OR TREATMENT OF E. COLI INFECTIONS IN ANIMALS
MX2025014302A (en) Microbials for bacterial inhibition
CA2322371C (en) Antimicrobial agent against acid resistant and heat-resistant bacteria
Upadhyay Growth and bacteriolytic activity of a soil amoeba, Hartmannella glebae
Ceccoli et al. Polyclonal antibodies against O6-methylguanine-DNA methyltransferase in adapted bacteria
KR102445675B1 (en) Novel Bacillus subtilis strain and functionality of fermented ginger using the same
WO2024226571A3 (en) Microbial compositions for inhibiting fusobacterium or trueperella
Jagadeesan et al. Assessment of synthesis machinery of two antimicrobial peptides from Paenibacillus alvei NP75
Sharafi et al. Antibacterial activity of probiotic Lactobacillus plantarum HK01: effect of divalent metal cations and food additives on production efficiency of antibacterial compounds
Venturina et al. Isolation and identification of subtilosin A-producing Bacillus subtilis from mongo sprouts, silage and soil samples in the Philippines
Oladipo Bioprotective potential of bacteriocinogenic Enterococcus gallinarum strains isolated from some Nigerian fermented foods, and of their bacteriocins
Kim et al. Antimicrobial and antioxidant peptide from Bacillus strain CBS73 isolated from Korean Food

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: MX/A/2025/014302

Country of ref document: MX

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112025026421

Country of ref document: BR

WWP Wipo information: published in national office

Ref document number: MX/A/2025/014302

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2024820147

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2024820147

Country of ref document: EP

Effective date: 20260108

ENP Entry into the national phase

Ref document number: 2024820147

Country of ref document: EP

Effective date: 20260108

ENP Entry into the national phase

Ref document number: 2024820147

Country of ref document: EP

Effective date: 20260108

ENP Entry into the national phase

Ref document number: 2024820147

Country of ref document: EP

Effective date: 20260108

ENP Entry into the national phase

Ref document number: 2024820147

Country of ref document: EP

Effective date: 20260108

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24820147

Country of ref document: EP

Kind code of ref document: A2

WWP Wipo information: published in national office

Ref document number: 2024820147

Country of ref document: EP