WO2024256871A3 - Fluorination methods, reagents, fluorinated compositions, and methods of manufacture - Google Patents

Fluorination methods, reagents, fluorinated compositions, and methods of manufacture Download PDF

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Publication number
WO2024256871A3
WO2024256871A3 PCT/IB2024/000319 IB2024000319W WO2024256871A3 WO 2024256871 A3 WO2024256871 A3 WO 2024256871A3 IB 2024000319 W IB2024000319 W IB 2024000319W WO 2024256871 A3 WO2024256871 A3 WO 2024256871A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
reagents
manufacture
fluorination
fluorinated compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2024/000319
Other languages
French (fr)
Other versions
WO2024256871A2 (en
Inventor
Gabriele PUPO
Francesco IBBA
Jamie FERGUSON-LEITCH
Jasraj Singh BABRA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fluorok Ltd
Original Assignee
Fluorok Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluorok Ltd filed Critical Fluorok Ltd
Priority to CN202480052307.8A priority Critical patent/CN121712740A/en
Priority to AU2024305139A priority patent/AU2024305139A1/en
Priority to KR1020267001253A priority patent/KR20260027239A/en
Priority to EP24746793.9A priority patent/EP4727911A2/en
Publication of WO2024256871A2 publication Critical patent/WO2024256871A2/en
Publication of WO2024256871A3 publication Critical patent/WO2024256871A3/en
Priority to IL325229A priority patent/IL325229A/en
Priority to MX2025015028A priority patent/MX2025015028A/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B9/00—General methods of preparing halides
    • C01B9/08—Fluorides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/28—Only halogen atoms, e.g. cyanuric chloride

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Provided herein are compositions and methods of manufacturing compositions useful in producing fluorinated products.
PCT/IB2024/000319 2023-06-15 2024-06-13 Fluorination methods, reagents, fluorinated compositions, and methods of manufacture Ceased WO2024256871A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN202480052307.8A CN121712740A (en) 2023-06-15 2024-06-13 Fluorination methods, reagents, fluorinated compositions and manufacturing methods
AU2024305139A AU2024305139A1 (en) 2023-06-15 2024-06-13 Fluorination methods, reagents, fluorinated compositions, and methods of manufacture
KR1020267001253A KR20260027239A (en) 2023-06-15 2024-06-13 Fluoridation method, reagent, fluoridation composition, and preparation method
EP24746793.9A EP4727911A2 (en) 2023-06-15 2024-06-13 Fluorination methods, reagents, fluorinated compositions, and methods of manufacture
IL325229A IL325229A (en) 2023-06-15 2025-12-09 Fluorination methods, reagents, fluorinated compositions, and methods of manufacture
MX2025015028A MX2025015028A (en) 2023-06-15 2025-12-11 Fluorination methods, reagents, fluorinated compositions, and methods of manufacture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363521147P 2023-06-15 2023-06-15
US63/521,147 2023-06-15

Publications (2)

Publication Number Publication Date
WO2024256871A2 WO2024256871A2 (en) 2024-12-19
WO2024256871A3 true WO2024256871A3 (en) 2025-03-06

Family

ID=91969227

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2024/000319 Ceased WO2024256871A2 (en) 2023-06-15 2024-06-13 Fluorination methods, reagents, fluorinated compositions, and methods of manufacture

Country Status (8)

Country Link
EP (1) EP4727911A2 (en)
KR (1) KR20260027239A (en)
CN (1) CN121712740A (en)
AU (1) AU2024305139A1 (en)
IL (1) IL325229A (en)
MX (1) MX2025015028A (en)
TW (1) TW202506544A (en)
WO (1) WO2024256871A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723603A (en) * 1968-09-28 1973-03-27 Albert Ag Chem Werke Preparation of fluorophosphates
US4174349A (en) * 1978-10-30 1979-11-13 Allied Chemical Corporation Preparation of fluoroorganic compounds with calcium fluoride
US4374108A (en) * 1979-11-22 1983-02-15 Central Glass Company, Limited Process of preparing alkali monofluorophosphate
CN101327923A (en) * 2007-06-19 2008-12-24 云南江磷集团股份有限公司 Preparation of sodium monofluorophosphate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723603A (en) * 1968-09-28 1973-03-27 Albert Ag Chem Werke Preparation of fluorophosphates
US4174349A (en) * 1978-10-30 1979-11-13 Allied Chemical Corporation Preparation of fluoroorganic compounds with calcium fluoride
US4374108A (en) * 1979-11-22 1983-02-15 Central Glass Company, Limited Process of preparing alkali monofluorophosphate
CN101327923A (en) * 2007-06-19 2008-12-24 云南江磷集团股份有限公司 Preparation of sodium monofluorophosphate

Also Published As

Publication number Publication date
AU2024305139A1 (en) 2026-01-15
IL325229A (en) 2026-02-01
EP4727911A2 (en) 2026-04-22
WO2024256871A2 (en) 2024-12-19
KR20260027239A (en) 2026-02-27
CN121712740A (en) 2026-03-20
MX2025015028A (en) 2026-03-02
TW202506544A (en) 2025-02-16

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