WO2024258932A8 - Spectrally distinct microbeads using laser particles - Google Patents

Spectrally distinct microbeads using laser particles Download PDF

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Publication number
WO2024258932A8
WO2024258932A8 PCT/US2024/033556 US2024033556W WO2024258932A8 WO 2024258932 A8 WO2024258932 A8 WO 2024258932A8 US 2024033556 W US2024033556 W US 2024033556W WO 2024258932 A8 WO2024258932 A8 WO 2024258932A8
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WO
WIPO (PCT)
Prior art keywords
microbeads
spectrally distinct
laser particles
laser
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/033556
Other languages
French (fr)
Other versions
WO2024258932A1 (en
Inventor
Seok-Hyun Yun
Kwon-Hyeon KIM
Nicola Martino
Paul Dannenberg
Sheldon KWOK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Priority to EP24824049.1A priority Critical patent/EP4724788A1/en
Priority to CN202480039289.XA priority patent/CN121488151A/en
Publication of WO2024258932A1 publication Critical patent/WO2024258932A1/en
Publication of WO2024258932A8 publication Critical patent/WO2024258932A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0042—Investigating dispersion of solids
    • G01N2015/0053—Investigating dispersion of solids in liquids, e.g. trouble
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)

Abstract

An apparatus for optical barcoding including: a microbead comprising one or more laser particles, the microbead being configured to generate one or more stimulated emission peaks hen energetically excited.
PCT/US2024/033556 2023-06-12 2024-06-12 Spectrally distinct microbeads using laser particles Ceased WO2024258932A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP24824049.1A EP4724788A1 (en) 2023-06-12 2024-06-12 Spectrally distinct microbeads using laser particles
CN202480039289.XA CN121488151A (en) 2023-06-12 2024-06-12 Microspheres can be distinguished using the spectral properties of laser-guided particles.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363507506P 2023-06-12 2023-06-12
US63/507,506 2023-06-12

Publications (2)

Publication Number Publication Date
WO2024258932A1 WO2024258932A1 (en) 2024-12-19
WO2024258932A8 true WO2024258932A8 (en) 2025-07-10

Family

ID=93852591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033556 Ceased WO2024258932A1 (en) 2023-06-12 2024-06-12 Spectrally distinct microbeads using laser particles

Country Status (3)

Country Link
EP (1) EP4724788A1 (en)
CN (1) CN121488151A (en)
WO (1) WO2024258932A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073497A (en) * 1989-06-30 1991-12-17 Caribbean Microparticles Corporation Microbead reference standard and method of adjusting a flow cytometer to obtain reproducible results using the microbeads
EP2664916B1 (en) * 2007-04-02 2017-02-08 Acoustic Cytometry Systems, Inc. Method for manipulating a fluid medium within a flow cell using acoustic focusing
JP4389991B2 (en) * 2007-10-26 2009-12-24 ソニー株式会社 Method and apparatus for optical measurement of fine particles
CN111786260B (en) * 2016-06-03 2025-01-24 通用医疗公司 Systems and methods for microlaser particles
US20210382061A1 (en) * 2018-10-22 2021-12-09 The General Hospital Corporation Multiplexed single-cell analysis using optically-encoded rna capture particles
EP4100717A1 (en) * 2020-02-03 2022-12-14 Lase Innovation Inc. Apparatus and method for cyclic flow cytometry using particularized cell identification
EP4388130A1 (en) * 2021-08-17 2024-06-26 Lase Innovation Inc. Cellular coding constructs providing identification of cellular entities

Also Published As

Publication number Publication date
EP4724788A1 (en) 2026-04-15
WO2024258932A1 (en) 2024-12-19
CN121488151A (en) 2026-02-06

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