WO2024258932A8 - Microbilles spectralement distinctes utilisant des particules laser - Google Patents

Microbilles spectralement distinctes utilisant des particules laser Download PDF

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Publication number
WO2024258932A8
WO2024258932A8 PCT/US2024/033556 US2024033556W WO2024258932A8 WO 2024258932 A8 WO2024258932 A8 WO 2024258932A8 US 2024033556 W US2024033556 W US 2024033556W WO 2024258932 A8 WO2024258932 A8 WO 2024258932A8
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WO
WIPO (PCT)
Prior art keywords
microbeads
spectrally distinct
laser particles
laser
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2024/033556
Other languages
English (en)
Other versions
WO2024258932A1 (fr
Inventor
Seok-Hyun Yun
Kwon-Hyeon KIM
Nicola Martino
Paul Dannenberg
Sheldon KWOK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Priority to EP24824049.1A priority Critical patent/EP4724788A1/fr
Priority to CN202480039289.XA priority patent/CN121488151A/zh
Publication of WO2024258932A1 publication Critical patent/WO2024258932A1/fr
Publication of WO2024258932A8 publication Critical patent/WO2024258932A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0042—Investigating dispersion of solids
    • G01N2015/0053—Investigating dispersion of solids in liquids, e.g. trouble
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)

Abstract

L'invention concerne un appareil de codes à barres optiques comprenant : une microbille comportant une ou plusieurs particules laser, la microbille étant configurée pour générer un ou plusieurs pics d'émission stimulée excités énergétiquement.
PCT/US2024/033556 2023-06-12 2024-06-12 Microbilles spectralement distinctes utilisant des particules laser Ceased WO2024258932A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP24824049.1A EP4724788A1 (fr) 2023-06-12 2024-06-12 Microbilles spectralement distinctes utilisant des particules laser
CN202480039289.XA CN121488151A (zh) 2023-06-12 2024-06-12 使用激光粒的光谱可区分微珠

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202363507506P 2023-06-12 2023-06-12
US63/507,506 2023-06-12

Publications (2)

Publication Number Publication Date
WO2024258932A1 WO2024258932A1 (fr) 2024-12-19
WO2024258932A8 true WO2024258932A8 (fr) 2025-07-10

Family

ID=93852591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2024/033556 Ceased WO2024258932A1 (fr) 2023-06-12 2024-06-12 Microbilles spectralement distinctes utilisant des particules laser

Country Status (3)

Country Link
EP (1) EP4724788A1 (fr)
CN (1) CN121488151A (fr)
WO (1) WO2024258932A1 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5073497A (en) * 1989-06-30 1991-12-17 Caribbean Microparticles Corporation Microbead reference standard and method of adjusting a flow cytometer to obtain reproducible results using the microbeads
EP2664916B1 (fr) * 2007-04-02 2017-02-08 Acoustic Cytometry Systems, Inc. Procédé de manipulation d'un fluide à l'intérieur d'une cuve à circulation à l'aide d'une focalisation acoustique
JP4389991B2 (ja) * 2007-10-26 2009-12-24 ソニー株式会社 微小粒子の光学的測定方法及び光学的測定装置
CN111786260B (zh) * 2016-06-03 2025-01-24 通用医疗公司 用于微激光器粒子的系统和方法
US20210382061A1 (en) * 2018-10-22 2021-12-09 The General Hospital Corporation Multiplexed single-cell analysis using optically-encoded rna capture particles
EP4100717A1 (fr) * 2020-02-03 2022-12-14 Lase Innovation Inc. Appareil et procédé de cytométrie de flux cyclique utilisant une identification de cellule particularisée
EP4388130A1 (fr) * 2021-08-17 2024-06-26 Lase Innovation Inc. Constructions de codage cellulaire fournissant une identification d'entités cellulaires

Also Published As

Publication number Publication date
EP4724788A1 (fr) 2026-04-15
WO2024258932A1 (fr) 2024-12-19
CN121488151A (zh) 2026-02-06

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