WO2025016875A1 - Dispositif portatif pour distribution d'une substance pharmaceutique en portions - Google Patents

Dispositif portatif pour distribution d'une substance pharmaceutique en portions Download PDF

Info

Publication number
WO2025016875A1
WO2025016875A1 PCT/EP2024/069704 EP2024069704W WO2025016875A1 WO 2025016875 A1 WO2025016875 A1 WO 2025016875A1 EP 2024069704 W EP2024069704 W EP 2024069704W WO 2025016875 A1 WO2025016875 A1 WO 2025016875A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
holding
hand
held device
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
PCT/EP2024/069704
Other languages
English (en)
Inventor
Alfred Von Schuckmann
Jasraj SINGH
Sanil PRASAD
Santosh BELLARY ROTTI
Vipin VIKKATH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN202480047770.3A priority Critical patent/CN121532226A/zh
Publication of WO2025016875A1 publication Critical patent/WO2025016875A1/fr
Priority to MX2026000763A priority patent/MX2026000763A/es
Anticipated expiration legal-status Critical
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8275—Mechanical
    • A61M2205/8281—Mechanical spring operated

Definitions

  • Hand-held device for dispensing a pharmaceutical substance in portions.
  • the invention relates to a hand-held device for dispensing a pharmaceutical substance in portions, having a housing and a cartridge containing the substance accommodated in the housing, the housing having a mouthpiece and the cartridge being arranged to be movable between a rest position and a dispensing position, further with a pressure part in the housing acting on the cartridge, the pressure part can be displaced between an initial position and a clamping position while building up a force serving to move the cartridge.
  • a holding part that can be moved between a holding position and a release position can also be provided, with the holding part preventing the movement of the cartridge in the holding position.
  • a user For moving the cartridge into the dispensing position, a user has to inhale on the mouthpiece to build up a vacuum.
  • a valve flap can be provided for, which can be moved between a starting position and a pivoted position, wherein it can be in order to move the cartridge into the dispensing position, the valve flap is to be moved from the starting position into the pivoted position by the user inhaling on the mouthpiece.
  • a hand-held device as is particularly described here, is also referred to as an inhaler.
  • the aim is to ensure that the substance is actually inhaled by the user.
  • the hand-held device should only deliver substance to the user, in the dispensing position, when the user has taken the hand-held device with the mouthpiece into his mouth and is inhaling.
  • the holding part In the course of suction, the holding part is removed from a movement path of the cartridge and the cartridge then moves into the dispensing position as a result of the force built up.
  • the valve When moving into the dispensing position, the valve is pressed into the cartridge against the force of a valve spring and a predetermined amount of substance emerges from the cartridge.
  • the substance is usually under pressure and a spraying process occurs.
  • valve flap In a hand-held device known from WO 2020/105 943 Al (US 2021/0 316 092 Al), the valve flap is also the holding part at the same time.
  • WO 2020/105 943 Al US 2021/0 316 092 Al
  • the valve flap is also the holding part at the same time.
  • the invention is concerned with the task of specifying an embodiment which is as safe as possible with regard to the dispensing of substance. Furthermore, the invention is also independently or additionally concerned with the task of ensuring a sufficient force for moving the cartridge into the dispensing position, which is as independent as possible of a specific size of a cartridge.
  • the holding part can be moved between a holding position and a release position, which in the holding position prevents the movement of the cartridge into the dispensing position, that the valve flap in the starting position blocks the movement of the holding part in the holding position and the holding part is moved by the cartridge into the release position when the valve flap moves into the pivoted position, with the force acting on the cartridge in the clamping position being reduced.
  • the valve flap has the task of initially blocking the holding part as long as a user is not inhaling on the mouthpiece in the usual way.
  • the holding part is preferably a part that is separate from the valve flap. Slight movements of the valve flap do not yet lead to the holding part being released.
  • the holding part can be pivoted about a first pivot axis.
  • the holding part is designed as a pivoting part and can be moved between the holding position and the release position, having an advantageous bearing.
  • the holding part has a predetermined first pivoting direction with regard to a move- ment from the holding position into the release position.
  • the holding part can preferably only move in one pivoting direction.
  • the pivoting direction indicates the direction of a movement about the pivoting axis, a direction of rotation of a circular movement.
  • valve flap can be pivoted about a second pivot axis.
  • the valve flap is also a pivoting part.
  • a reset part is provided for resetting the valve flap and/ or the holding part into the starting position or into the holding position.
  • gravity could also be sufficient for resetting in one embodiment.
  • a separate reset part is advantageously provided.
  • the reset part is designed as a reset spring. With the movement of the valve flap from the starting position into the pivoted position and/ or the movement of the holding part from the holding position into the release position, a spring force for resetting can be built up. An automatic reset may result.
  • the reset part has a first spring section which interacts with the housing to reset the reset part.
  • the reset part can also be used to trigger dispensing of substance without prior inhaling at the mouthpiece.
  • the reset part has to be moved as a whole and the first spring section is required to reset the reset part as a whole.
  • the reset part preferably has an auxiliary projection, acting preferably on the valve flap.
  • the reset part has a second spring section which interacts with the valve flap to reset the valve flap. The second spring section preferably ensures that the valve flap automatically moves back from the pivoted position to the initial position.
  • the reset part has a third spring section which interacts with the holding part to reset the holding part.
  • the third spring section preferably ensures that the holding part moves back from the release position into the holding position.
  • the cartridge has a stop part.
  • the cartridge can be seated on the holding part in the clamping position by means of the stop part.
  • the stop part does not have to be an integral part of the cartridge.
  • it can also be part of a counter arranged between the cartridge and the holding part.
  • the fact that the cartridge has a stop part does not necessarily mean that the cartridge acts directly on the stop part, but possibly via a part arranged in between, for example the mentioned counter.
  • the cartridge can also act directly on the stop part.
  • the stop part extends at an angle with respect to a direction of movement of the cartridge.
  • the stop part can exert a force application on the holding part that is inclined with respect to the direction of movement of the cartridge. This can promote the immediate movement of the holding part to the release position when the valve flap moves from the initial position to the pivoted position.
  • the pressure part exerts the force on the cartridge by means of an elastically deformed transmission part.
  • the transmission part is a spring.
  • the transmission part or the spring respectively acts between the pressure part and a support part supported on the cartridge.
  • the transmission part or the spring respectively is preferably not placed directly on the cartridge. In this way, a decoupling from the cartridge with regard to the adjustability of the force can also be achieved in a favorable manner.
  • the force can be adjusted by changing an effective distance between the pressure part and the cartridge.
  • the pressure part can be moved relative to the cartridge anyway, between the initial position and the clamping position, it can also be changed independently or in addition to this mobility in its distance from the cartridge that is relevant for an effect on the cartridge.
  • the pressure part consists of a coupling part and an adjustment part.
  • the coupling part is preferably used for coupling to a part provided for reaching the clamped position. This is more preferably the mouthpiece closure cap, which is moveable from a closed position to an open position and vice versa.
  • the adjustment part is preferably the part of the pressure part that determines the distance on the pressure part side that is relevant for the action on the cartridge.
  • the adjustment part can be displaced relative to the coupling part in order to adjust the force acting in the clamped position.
  • the adjustment part can be screwed into place by means of thread formations formed on the coupling part and the adjustment part. The adjustment part can therefore be further screwed into the coupling part or screwed out of it.
  • the spring is prestressed in the initial position. This enables a safe development of power. Nevertheless, the preload does not have to lead to a load on the cartridge as long as the pressure part is still in the initial position. Relief beyond the given preload is preferably not possible.
  • Fig. 1 a perspective view of the hand-held device
  • Fig. 2 a section through the object according to Figure 1 along the plane II-II, according to a first embodiment
  • FIG. 3 a section according to Figure 2, showing a second embodiment
  • Fig. 4 an exploded view of the second embodiment, concerning the pressure part and the adjustment part
  • Fig. 5 an exploded view of the second embodiment in terms of an assembly with the valve flap and the holding part
  • FIG. 6 an enlarged view of a support part, in a diagonal view from above
  • Fig. 7 an illustration according to FIG. 6, in a view diagonally from below;
  • Fig. 8 a perspective view of an intermediate part
  • Fig. 9 a plan view of the adjustment part
  • Fig. 10 a section through the adjustment part according to FIG. 9 along line X-X;
  • Fig. 11 a section through an assembling unit having the adjustment part, the support part and the intermediate part;
  • FIG. 12 an enlargement of Figure 3 according to XII in Fig. 3;
  • Fig. 13 a section through the object according to Figure 12 along line XIII-XIII;
  • Fig. 14 a partial view of an end portion of the cartridge with stop part being underneath and the holding part and the valve flap;
  • Fig. 15 an exploded view of the parts valve flap, holding part, reset part and receptacle for this;
  • Fig. 16 a plan view of the reset part;
  • Fig. 17 a schematic view of the hand-held device, cut in the area of the adjustment part, with a mouthpiece closure cap being closed;
  • Fig. 18 a representation according to FIG. 17, a relevant distance being changed
  • Fig. 19 a perspective view, showing part of the hand-held device from diagonally below, the mouthpiece closure cap being open;
  • Fig. 20 a section through the object of figure 19, along the plane XX- XX;
  • FIG. 21 an enlargement of XXI in Figure 20
  • Fig. 22 a representation according to FIG. 20, after inhaling by a user, being a theoretical intermediate position
  • FIG. 23 an enlargement of XXIII in Figure 22;
  • Fig. 24 a section along line XXIV-XXIV in Figure 22;
  • FIG. 25 a subsequent representation following FIG. 22;
  • FIG. 26 a subsequent representation of Figure 24 concerning the state according to FIG. 23;
  • FIG. 27 an enlargement of the area XXVII in Figure 25;
  • Fig. 28 a subsequent representation following FIG. 25;
  • FIG. 29 a subsequent representation of Figure 28.
  • FIG. 1 Shown and described, FIG. 1, is a hand-held device 1, which is used for portioned dispensing of preferably sprayable pharmaceutical substance.
  • the substance is contained in a cartridge 2, compare FIGS. 2 and 3.
  • the cartridge 2 has a valve 3 which releases substance by being pressed into the cartridge 2.
  • pushing the valve 3 into the cartridge 2 is achieved by pressing on an opposite end of the cartridge.
  • the valve is accommodated in a valve seat 4, in which a spray nozzle 5 is also formed.
  • the substance is usually under pressure in the cartridge 2, so that the substance is sprayed when it is pressed in. A metered amount of substance is sprayed.
  • the cartridge 2 In order to be able to spray a further quantity, the cartridge 2 must first be relieved again, with the valve 3 moving back into its initial position.
  • the hand-held device 1 also has a housing 6, a mouthpiece 7 and a mouthpiece closure cap 8 .
  • the adjustment part 11 preferably interacts by means of thread formations formed on the coupling part 10 and the adjustment part 11, for example an internal thread 51 and an external thread 50.
  • the coupling part 10 has coupling arms 13.
  • the coupling arms 13 can interact with an eccentric 14 formed on a holding arm 45 of the mouthpiece closure cap 8.
  • the eccentric 14 is preferably accommodated in an oblong hole 46 on preferably each of the coupling armes 13.
  • the force acting between the pressure part 9 and the cartridge 2 is preferably adjustable.
  • the setting can be achieved by changing an effective distance a, compare, for example, FIGS. 2 and 3 as well as 17, between the pressure part 9 and the cartridge 2.
  • the changed distance is shown as a' in Fig. 18.
  • this can be achieved by adjusting the ad- justment part 11 relative to the coupling part 10 using the thread formations mentioned.
  • the smaller distance a' is realized by turning the adjusting part 11 in relation to the coupling part 10 in comparison to FIG. 17.
  • the eccentric 14 can be received in the oblong hole 46 with vertical clearance, which means a free distance b between the eccentric 14 and an associated - lower - edge of the oblong hole 46.
  • Vertical clearance means a free distance b between the eccentric 14 and an associated - lower - edge of the oblong hole 46.
  • “Vertical” is seen here in the direction of movement of the cartridge 2 from the rest position to the starting position. This can mean that when the mouthpiece closure cap 8 is pivoted open, interaction with an edge of the oblong hole 46 only occurs after a larger pivoting angle, so that the force exerted on the cartridge 2 when the mouthpiece closure cap 8 is fully pivoted out is less than it would compared to a maximum possible force due to the displacement of the oblong hole 46.
  • the housing 6 is also preferably formed like a sleeve.
  • the housing 6 and the pressure part 9 are preferably arranged in a nested manner, with the pressure part 9 being on the inside.
  • the housing 6 can be designed in two or more parts.
  • an upper part and a lower part are provided.
  • the lower part essentially comprises the mouthpiece 7, the valve seat 4 and the housing bottoms described below.
  • the two or more parts can be snapped together.
  • Support arms 47 are also formed on the upper housing part.
  • a bearing pin 49 of the mouthpiece closure cap 8 is accommodated in a bearing opening 48 .
  • FIGS. 4 and 5 reference is also be made to FIGS. 4 and 5.
  • valve flap 15 is also provided in the housing 6 of the hand-held device 1 .
  • the valve flap 15 is flow-connected to a suction channel formed by the mouthpiece 7.
  • the valve flap 15 is subjected to negative air pressure.
  • the valve flap 15 is preferably arranged in the housing 6 so that it can pivot. As a result of the application of negative pressure, it can move from an starting position according to FIGS. 2, 3, 14 into a pivoted position according to FIGS 22, 25. It releases a flow path in the manner of a valve, via which further air can flow into the mouthpiece 7 in the course of the suction by the user.
  • a holding part 16 is also provided in the housing 6 of the hand-held device 1.
  • the holding part 16 can be moved between a holding position, as shown in FIGS. 2, 3, and a release position, as shown in FIGS 25, 27, 28.
  • the holding part 16 prevents movement of the cartridge 2 into the dispensing position.
  • the valve flap 15 also blocks the movement of the holding part 16.
  • the holding part 16 can only move when the valve flap 15 moves into the pivoted position. As a result, the blockage of the holding part 16 is released and the cartridge 2 pressing on the holding part 16 moves the holding part 16 into the release position.
  • the holding part 16 can be pivoted about a first pivot axis Al.
  • the holding part 16 can move from the holding position into the release position in a first predetermined pivoting direction R1 about the pivoting axis Al.
  • valve flap 15 can be pivoted about a second pivoting axis A2, preferably also in an identical, second pivoting direction R2, now based on the pivoting axis A2.
  • first and the second pivot axis Al, A2 run approximately parallel to one another.
  • the valve flap 15 and the holding part 16 are preferably arranged next to one another.
  • FIG. 14 Seen in the direction of the mouthpiece 7, they are arranged one behind the other, the holding part 16 being at the front, closer to the mouthpiece 7.
  • valve flap 15 can advantageously only pivot in one direction from the starting position into the pivoted position. The movement from the pivoted position to the starting position or, in relation to the holding part 15, from the release position to the holding position then takes place in the opposite direction.
  • a reset part 17 is provided for resetting the valve flap 15 and the holding part 16 into the starting position or into the holding position.
  • a uniform reset part 17 is provided.
  • the reset part 17 is preferably designed as a reset spring, having parts or extensions or sections with a spring action.
  • the reset part 17 can have a first spring section 18 and/ or a second spring section 19 and/ or a third spring section 20. Regardless of the designation "first” etc. it is also possible for only one or more of the spring sections to be formed.
  • the first spring section 18 interacts with the housing 6, preferably an inner surface of the housing 6, in order to reset the reset part 17 as a whole.
  • This has significance in the context of triggering dispensing of substance without requiring aspiration by a user. Only to this purpose, preferably, the reset part 17 as such is moving.
  • the aim of the hand-held device 1 described here is that a user can only trigger dispensing of substance by inhaling.
  • the reset part 17 can also be used for this purpose (or possibly alone). Such use of the reset part 17 is described in detail further below.
  • the second spring section 19 interacts with the valve flap 15. It makes it possible to move the valve flap 15 back from the pivoted position to the starting position.
  • the valve flap 15 can have a first loading extension 21, compare, for example, FIGS. 15 and 21.
  • the first loading extension 21 has simultaneously moved the second spring section 19 from the position shown in FIG. 24 to the position shown in FIG. 26, building up a restoring force.
  • the second spring section 19 can thereby move the valve flap 15 back into the starting position. This is also illustrated in FIG.16 with respect to the second spring section 19 being shown in complete and dashed lines.
  • the third spring section 20 is used in a comparable manner to reset the holding part 16 from the release position to the holding position.
  • the holding part 16 preferably has, and in the exemplary embodiment, a second loading extension 22, see also Figures 15 and 21.
  • the third spring section 20 is deflected by building up a restoring force.
  • valve flap 15 regularly moves first into the starting position, so that the holding part 16 does not initially reach a blocking position.
  • the holding part 16 can again briefly move the valve flap 15 in the direction of the second pivoting direction R2, as is indicated by the dashed line representation in FIG. 29 and thus reach the blocking position.
  • first 18 or second 19 or third spring section 20, or a combination of the first 18 and the second 19, the second 19 and third 20 or the first 18 and third spring section 20 can also be formed.
  • the second 19 and third spring section 20 can also be fixed directly to the housing 6 or to a common part, which in turn is fixed to the housing 6.
  • a spring force of the first spring section 18 is set stronger than a spring force of the second 19 and the third spring section 20. This makes it possible in particular for the reset part 17 not to move when according to normal use of the handheld device 1, by inhaling on the mouthpiece 7, the valve flap 15 and also the holding part 16 are moved.
  • a spring force of the third spring section 20 is set stronger than a spring force of the second spring section 19.
  • the third spring section 20 loads the holding part 16 into the holding position.
  • This design of the spring forces helps to ensure that even if the valve flap 16 moves slightly due to unintentional external stress, such as a vibration, the holding part 16 does not necessarily move as well.
  • this setting of the spring forces is also important for resetting the valve flap 15 and the holding part 16 into the starting position or the holding position after substance has been dispensed.
  • the spring force of the third spring section 20 is set to be weaker than the force ex- erted by the cartridge 2 when moving from the rest position into the dispensing position. When the cartridge 2 moves into the dispensing position, it can easily overcome the spring force acting on the holding part 16.
  • valve flap 15 has a blocking projection 24.
  • the blocking projection 24 can be favorable with regard to a desired interaction with the holding part 16.
  • the blocking projection 24 in the initial position catches over the holding part 16 located in the holding position.
  • the blocking projection 24 enables the holding part 16 to be held in a form-fitting manner in the holding position.
  • the blocking projection 24 must first be moved completely out of the overhanging position before the holding part 16 can move. With the preferred pivoting movement of the valve flap 15, this can mean a pivoting angle of 5-15° or more.
  • a force resultant KR acting on the holding part 16 in the clamping position see for example Figure 23, of the force exerted on the holding part 16 by the cartridge 2, in the given case by means of the stop part 23, runs in a distance to the first pivot axis Al. In this way, a favorable leverage of the force applied to the holding part 16 by the cartridge 2 or the stop part 23 can be achieved.
  • the force resultant KR runs in a cross section on a first side of the first pivot axis Al, which is opposite a second side of the pivot axis Al towards which the holding part 16 shifts when moving into the release position.
  • the force resultant KR is thus favorable for a force acting on the holding part 16 and pointing in the desired direction of displacement.
  • the holding part 16 has a blocking counter-projection 25 which is overhung by the blocking projection 24 in the holding position. Accordingly, both the holding part 16 and the valve flap 15 preferably have projections which interact for the desired blocking.
  • the holding part 16 has an actuating surface F that runs inclined to a direction of movement of the cartridge 2. This configuration enables the same effect as the stated direction of the force resultant KR. Both measures can be provided individually or in combination.
  • the actuating surface F runs in the shape of a preferably circular arc in a cross section in which the first pivoting axis Al appears in the form of a point.
  • actuating surface F to run at a vertical distance from the first pivoting axis Al.
  • Vertical spacing can correspond to a radial extent of the blocking projection 25 or more. In this way, too, a lever arm with regard to the loading of the holding part 16 by the cartridge 2 is achieved in a favorable manner.
  • the housing 6 has an air-permeable first housing bottom 26.
  • the first housing bot- tom 26 preferably closes off a space at the bottom in which the cartridge 2, optionally a counter 43 and the valve seat 4 are formed or provided for.
  • a counter 43 is provided.
  • the counter 43 is preferably acted upon directly by an underside 44 of the cartridge 2.
  • the stop part 23 is formed on the counter 43, preferably on the underside of the counter 43.
  • a counter with a stop part is shown in the already mentioned WO 2020/105943 Al (US 2021/0316 092 Al)
  • the valve 3 preferably extends, at least in part, through the counter 43.
  • the counter 43 also alternatively or additionally preferably surrounds a region of the valve seat 4.
  • the housing 6 has a second housing bottom 27 formed below the first housing bottom 26.
  • the valve flap 15 is arranged below the first housing bottom 26.
  • the valve flap 15 can be conveniently arranged in a space between the first 26 and the second housing bottom 27.
  • the first housing bottom 26 can also be designed in the manner of a grid, or only with a comparatively narrow air passage opening.
  • the valve flap 15 and/ or the holding part 16 even if they should have been detached from a holder, cannot penetrate the first housing bottom 26 and thus cannot get into the airway to the user.
  • the holding part 16 is arranged below the first housing bottom 26 .
  • valve flap 15 and the holding part 16 are arranged above the second housing bottom 27 .
  • the reset part 17 is arranged below the valve flap 15. In addition, it is preferably arranged above the second housing base 27.
  • the reset part 17 is arranged below the holding part 16.
  • the reset part 17 prefferably has an actuating projection 28.
  • This actuating projection 28 is intended for use without the user actually inhaling, in order to trigger a dispensing process.
  • the actuating projection 28 is barely visible to a user and/ or is hidden.
  • the actuating projection 28 protrudes from the housing 6. As a result, it can be reached and operated comparatively easily in the given case of use.
  • the actuating projection 28 is also covered by the mouthpiece closure cap 8 when the mouthpiece closure cap 8 is closed.
  • the actuating device 28 is also preferably located below the mouthpiece 7, on the front side of the housing 6 that faces the user during use. As a result, it is practically invisible to the user. With normal handling, it is also not touched.
  • the reset part 17 has a supporting projection 29 on which the valve flap 15 rests in the initial position.
  • the adjustment part 11 prefferably has a formation 30 on a side facing away from the cartridge 2 for interaction with a turning tool.
  • the formation 30 can be, for example, a slot for attaching a screwdriver or a polygon for attaching a wrench or an Allen tool (polygon socket).
  • a support part 31 is provided, via which the force is transmitted to the cartridge 2.
  • the support part 31 can interact with the adjustment part 11 in a displaceable manner.
  • the support part 31 is arranged between the cartridge and the spring 12.
  • the support part 31 can be latched to the adjustment part 11.
  • the spring 12 rests on the support part 31.
  • the spring 12 is preferably supported only on the adjustment part 11 and the support part 31.
  • the support part 31 can be moved relative to the adjustment part 11 between a stop position and an adjustment position.
  • the support part 31 moves from the stop position into the adjustment position. It is preferred, see above, that the support part 31 only moves into the adjustment posi- tion in the course of the movement of the pressure part into the clamping position.
  • the portion of the force that increases the preload acts on the cartridge 2 either after the adjustment, before the pressure part 9 is moved into the clamping position, or, preferably, only after the pressure part 9 is moved into the clamping position then as a proportion of the total force acting on cartridge 2.
  • the support part 31 has a stop projection 32 which, in the stop position, bears against a counter-stop 33 of the adjustment part. In this way, the preload can be achieved without a force being necessarily exerted on the cartridge 2 as a result of the preload. Reference is also made to FIG. 11 in this regard.
  • stop projections 32 are provided.
  • three stop projections 32 can be provided. These can be distributed evenly or unevenly over a circumference.
  • several counter-stops 33 can also be provided.
  • the support part 31 is supported on an intermediate part 34 arranged between the support part 31 and the cartridge 2.
  • the intermediate part 34 is secured against rotation on the pressure part 9.
  • the intermediate part 34 can have one or more securing projections 35 which are caught between one or more securing counter-projections 36 of the pressure part 9, in the exemplary embodiment and preferably formed on an inner surface of the coupling part 10. In this way it can be achieved that a rotary movement of the adjustment part 11 does not act on the cartridge 2.
  • the support part 31 faces the intermediate part 34 and has projections 38 , preferably also rib-like, provided for interaction with the ribs 37.
  • projections 38 preferably also rib-like, provided for interaction with the ribs 37.
  • a preferably ratchet-like interaction between the support part 31 and the intermediate part 34 is achieved with the aid of the ribs 37 and projections 38. Since the intermediate part 34 is preferably secured against rotation on the pressure part 9, it can also be achieved in this way, with a connection between the support part 31 and the adjustment part 11, secured against rotation, that an adjustment of the adjustment part 11 is secured. There can be no turning back.
  • a spacer spring 39 acts between the support part 31 and the intermediate part 34.
  • FIG. 8 reference is also made to FIG. 8, for example.
  • a spacer spring 39 is formed onto the intermediate part 34.
  • the one or more spacer springs preferably act on a peripheral overhanging edge 40 of the support part 31.
  • the one or more spacer springs 39 are advantageous with regard to a favorable ratchet-like interaction between the support part 31 and the intermediate part 34.
  • the intermediate part 34 is latched to the support part 31.
  • the snap-in mount can be achieved, for example, by two snap-in feet 41.
  • the support part 31 can be rotated relative to the intermediate part 34.
  • the hand-held device 1 can be used as follows.
  • a user picks up the hand-held device 1 in the closed position according to FIG 1. He then opens the mouthpiece closure cap 8, after which the handheld device 1 is in a configuration according to FIG 18. By pivoting the mouthpiece closure cap 8, the pressure part 9 is shifted from the initial position, which is given in a constellation according to FIG. 1, into the clamping position. A force sufficient for a dispensing process now acts on the cartridge 2.
  • the cartridge 2 has not moved at all or only slightly during the movement of the pressure part 9 into the clamping position. In any case, the cartridge 2 has not moved so much that cartridge 2 is in the dispensing position, so that there is a release of substance. The cartridge 2 cannot yet move into the dispensing position simply because of the opening of the mouthpiece closure cap 8 because it is supported on the holding part 16 by means of the stop part 23.
  • valve flap 15 is moved back into the initial position by the second spring section 19, see FIG 28. Since the cartridge 2, in the exemplary embodiment and preferably the stop part 23, prevents the holding part 16 from moving back into the holding position, the blocking projection 24 reaches under the counter-blocking projection 25, as can also be seen in FIG 28.
  • the user In order to achieve further substance delivery, the user must first close the mouthpiece closure cap 8 again, as indicated in FIG 29.
  • the pressure part 9 is moved back into the initial position. Due to a valve spring (not shown in detail) acting between the valve 3 and the cartridge 2, the cartridge 2 again assumes the position according to FIG. 2 or FIG. 3 with respect to the valve 3.
  • the cartridge 2 moves upwards accordingly and with it the stop part 23 as well.
  • the stop part 23 thus clears the way for the holding part 16 to move into the holding position.
  • the holding part 16 is moved back into the holding position by the third spring section 20.
  • the force acting on the cartridge 2 may have been adjusted, preferably at the factory, by turning the adjustment part 11. This results in a certain degree of relative movement between the pressure part 9, specifically the coupling part 10, and the eccentric 14. In order to be able to absorb this movement, at least to a certain degree, the ob- long hole 46 is designed to be larger in the vertical direction than the corresponding dimensions of the eccentric 14.
  • the actuating projection 28 can be pressed into the housing 6 with regard to the design of the exemplary embodiment in detail.
  • the first loading extension 21 is pressed in by means of an auxiliary pro- jection 42 formed on the reset part, it is moved to such an extent that the valve flap 15 that is moved such that, as a result, the valve flap 15 releases the holding element 16 and the cartridge 2 will correspondingly move into the dispensing position.
  • valve 31 support part

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Coating Apparatus (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif portatif (1) pour distribuer une substance pharmaceutique en portions, avec un boîtier (6) et une cartouche (2), logée dans le boîtier (6) et contenant la substance, le boîtier (6) comportant un embout buccal (7) et la cartouche (2) étant agencée de manière mobile entre une position de repos et une position de distribution, comportant en outre une pièce de pression (9) agencée de manière mobile dans le boîtier (6) pour passer d'une position initiale à une position de serrage afin de créer une force permettant de déplacer la cartouche (2) entre la position de repos et la position de distribution, et comportant un clapet de valve (15) qui peut être déplacé, par un utilisateur inhalant sur l'embout buccal (7), entre une position de départ et une position de pivotement. Afin d'assurer un fonctionnement sûr du dispositif portatif, une partie de maintien (16) est prévue pour pouvoir passer d'une position de maintien à une position de libération, empêchant, dans la position de maintien, le mouvement de la cartouche (2) vers la position de distribution, le clapet (15) en position de départ bloquant le mouvement de la pièce de maintien (16) en position de maintien, la pièce de maintien (16) étant déplacée par la cartouche (2) en position de libération lorsque le clapet (15) passe en position de pivotement, la force agissant sur la cartouche (2) en position de serrage étant ainsi réduite. En outre ou en variante, la force agissant en position de serrage sur la cartouche est réglable.
PCT/EP2024/069704 2023-07-20 2024-07-11 Dispositif portatif pour distribution d'une substance pharmaceutique en portions Pending WO2025016875A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202480047770.3A CN121532226A (zh) 2023-07-20 2024-07-11 用于按份分配药物的手持式装置
MX2026000763A MX2026000763A (es) 2023-07-20 2026-01-19 Dispositivo de mano para dispensar una sustancia farmaceutica en porciones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102023119234.5 2023-07-20
DE102023119234 2023-07-20

Publications (1)

Publication Number Publication Date
WO2025016875A1 true WO2025016875A1 (fr) 2025-01-23

Family

ID=91959310

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2024/069704 Pending WO2025016875A1 (fr) 2023-07-20 2024-07-11 Dispositif portatif pour distribution d'une substance pharmaceutique en portions

Country Status (4)

Country Link
CN (1) CN121532226A (fr)
DE (1) DE102024119932A1 (fr)
MX (1) MX2026000763A (fr)
WO (1) WO2025016875A1 (fr)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085245A1 (fr) * 2000-05-09 2001-11-15 Iep Pharmaceutical Devices Inc. Inhalateur respiratoire a commande pneumatique
US7448342B2 (en) 2004-11-10 2008-11-11 Alfred Von Schuckmann Step-action indexing mechanism
EP2275479A1 (fr) 2003-08-11 2011-01-19 Glaxo Group Limited Aerosol doseur pharmaceutique et procedes associes
US8474447B2 (en) 2007-09-22 2013-07-02 Boehringer Ingelheim International Gmbh Inhaler device
US20160084385A1 (en) 2013-06-04 2016-03-24 Aptar France Sas Metering valve and device for dispensing a fluid product comprising such a valve
WO2017112400A1 (fr) * 2015-12-21 2017-06-29 3M Innovative Properties Company Inhalateurs médicinaux
WO2020015943A1 (fr) * 2018-07-16 2020-01-23 Alfred Von Schuckmann Appareil à main de distribution en portions de substances pulvérisables
WO2020105943A1 (fr) 2018-11-23 2020-05-28 주식회사 케이티앤지 Cigarette et dispositif de génération d'aérosol pour cigarette
US20210008302A1 (en) * 2018-03-07 2021-01-14 Astrazeneca Ab Inhaler

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085245A1 (fr) * 2000-05-09 2001-11-15 Iep Pharmaceutical Devices Inc. Inhalateur respiratoire a commande pneumatique
EP2275479A1 (fr) 2003-08-11 2011-01-19 Glaxo Group Limited Aerosol doseur pharmaceutique et procedes associes
US7448342B2 (en) 2004-11-10 2008-11-11 Alfred Von Schuckmann Step-action indexing mechanism
US7827984B2 (en) 2004-11-10 2010-11-09 Alfred Von Schuckmann Inhaler device
US7984710B2 (en) 2004-11-10 2011-07-26 Alfred Von Schuckmann Inhaler device
US8474447B2 (en) 2007-09-22 2013-07-02 Boehringer Ingelheim International Gmbh Inhaler device
US20160084385A1 (en) 2013-06-04 2016-03-24 Aptar France Sas Metering valve and device for dispensing a fluid product comprising such a valve
WO2017112400A1 (fr) * 2015-12-21 2017-06-29 3M Innovative Properties Company Inhalateurs médicinaux
US20210008302A1 (en) * 2018-03-07 2021-01-14 Astrazeneca Ab Inhaler
WO2020015943A1 (fr) * 2018-07-16 2020-01-23 Alfred Von Schuckmann Appareil à main de distribution en portions de substances pulvérisables
US20210316092A1 (en) 2018-07-16 2021-10-14 Alfred Von Schuckmann Hand-held device for dispensing sprayable substances in a portioned manner
WO2020105943A1 (fr) 2018-11-23 2020-05-28 주식회사 케이티앤지 Cigarette et dispositif de génération d'aérosol pour cigarette

Also Published As

Publication number Publication date
DE102024119932A1 (de) 2025-01-23
MX2026000763A (es) 2026-03-02
CN121532226A (zh) 2026-02-13

Similar Documents

Publication Publication Date Title
US5511540A (en) Inhalation device
CA1236359A (fr) Distributeur de produit pris par inhalation
CN101578118B (zh) 呼吸致动的吸入器致动器
AU767467B2 (en) Inhaler
CN1787879B (zh) 具有封堵器和端帽的流体分配装置
USRE43329E1 (en) One-way actuation release mechanism for a system for applying medicament
US6354290B1 (en) Inhalation apparatus
CA2466446C (fr) Distributeur de liquides, boitier du distributeur, support de stockage destine a etre place dans le distributeur, et arrangement pour le pompage regule d'un liquide d'un reservoirpour liquides
CA2283744C (fr) Dispositif d'inhalation
EP0632734A1 (fr) Distributeur a jet de poudre pour traitements par inhalation de medicament
WO2025016875A1 (fr) Dispositif portatif pour distribution d'une substance pharmaceutique en portions
US20040011822A1 (en) Delivery device
AU2003234748B2 (en) Inhaler
AU2003234746A1 (en) Inhaler
KR20220082021A (ko) 흡입기
EA045032B1 (ru) Ингалятор

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 24745378

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 202617005050

Country of ref document: IN

Ref document number: MX/A/2026/000763

Country of ref document: MX

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112026000786

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: 2024745378

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWP Wipo information: published in national office

Ref document number: MX/A/2026/000763

Country of ref document: MX