YU12397A - NOVEL PYRIMIDO [1,2-a] INDOLES - Google Patents

NOVEL PYRIMIDO [1,2-a] INDOLES

Info

Publication number: YU12397A
Authority: YU; Yugoslavia
Prior art keywords: indoles; pyrimido; novel pyrimido; drugs; novel
Prior art date: 1996-04-04

Application number

YU12397A

Other languages

English (en)

Serbo-Croatian (sh)

Inventor

Ulrich Dr. Muller

Peter Dr. Eckenberg

Rudi dr. Grutzmann

Hilmar Dr. Bischoff

Dirk Dr. Denzer

Stefan Dr. Wohlfeil

Stefan dr. Lohmer

Ulrich dr. Nielsch

Peter dr. Kolkhof

Original Assignee

Bayer Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-04

Filing date

1997-04-01

Publication date

1999-11-22

1997-04-01 Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft

1999-11-22 Publication of YU12397A publication Critical patent/YU12397A/sr

Links

150000002475 indoles Chemical class 0.000 title 1
239000003814 drug Substances 0.000 abstract 2
229940079593 drug Drugs 0.000 abstract 2
HBBKFNCURJQICW-UHFFFAOYSA-N pyrimido[1,2-a]indole Chemical class C1=CC=NC2=CC3=CC=CC=C3N21 HBBKFNCURJQICW-UHFFFAOYSA-N 0.000 abstract 2
IJXJGQCXFSSHNL-UHFFFAOYSA-N 2-amino-2-phenylethanol Chemical class OCC(N)C1=CC=CC=C1 IJXJGQCXFSSHNL-UHFFFAOYSA-N 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
230000000879 anti-atherosclerotic effect Effects 0.000 abstract 1
WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)

YU12397A 1996-04-04 1997-04-01 NOVEL PYRIMIDO [1,2-a] INDOLES YU12397A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19613550A DE19613550A1 (de)	1996-04-04	1996-04-04	Neue Pyrimido[1,2-a]indole

Publications (1)

Publication Number	Publication Date
YU12397A true YU12397A (en)	1999-11-22

Family

ID=7790502

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU12397A YU12397A (en)	1996-04-04	1997-04-01	NOVEL PYRIMIDO [1,2-a] INDOLES

Country Status (33)

Country	Link
US (1)	US6114341A (sr)
EP (1)	EP0799828A3 (sr)
JP (1)	JPH1059972A (sr)
KR (1)	KR970070008A (sr)
CN (2)	CN1067393C (sr)
AR (1)	AR006497A1 (sr)
AU (1)	AU725786B2 (sr)
BG (1)	BG62934B1 (sr)
BR (1)	BR9701675A (sr)
CA (1)	CA2201434A1 (sr)
CO (1)	CO4520306A1 (sr)
CZ (1)	CZ102297A3 (sr)
DE (1)	DE19613550A1 (sr)
DZ (1)	DZ2201A1 (sr)
EE (1)	EE9700078A (sr)
HN (1)	HN1997000045A (sr)
HR (1)	HRP970154A2 (sr)
HU (1)	HUP9700708A3 (sr)
ID (1)	ID16520A (sr)
IL (3)	IL120590A (sr)
MA (1)	MA24131A1 (sr)
MY (1)	MY126362A (sr)
NO (1)	NO309092B1 (sr)
NZ (1)	NZ314497A (sr)
PE (1)	PE42398A1 (sr)
PL (1)	PL319249A1 (sr)
SG (1)	SG63698A1 (sr)
SK (1)	SK42797A3 (sr)
SV (1)	SV1997000025A (sr)
TN (1)	TNSN97061A1 (sr)
TR (1)	TR199700261A2 (sr)
YU (1)	YU12397A (sr)
ZA (1)	ZA972829B (sr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19826469A1 (de) *	1998-06-13	2000-05-25	Bayer Ag	Verfahren zur Herstellung von 2,4-Dimethylcarbolin und 2,4-Dimethylpyrimido[1,2-a]indol
AU2001244635A1 (en) *	2000-03-30	2001-10-15	Yamanouchi Pharmaceutical Co..Ltd.	Hydrazide derivatives
DE10030375A1 (de) *	2000-06-21	2002-01-03	Bayer Ag	Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
JP4254093B2 (ja) *	2001-10-17	2009-04-15	宇部興産株式会社	５−ハロゲノインドールの製法
DE10349175A1 (de) *	2003-10-22	2005-05-19	Bayer Healthcare Ag	Mittel zur Gewichtsreduktion
KR101494067B1 (ko)	2004-03-05	2015-02-16	더 트러스티스 오브 더 유니버시티 오브 펜실바니아	부작용을 최소화하면서 과지질혈증 및 과콜레스테롤혈증과 연관된 질환 또는 질병의 치료 방법
AU2005230397B2 (en) *	2004-04-09	2010-04-08	Elanco Animal Health Ireland Limited	Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
CA3029306C (en)	2005-05-12	2020-12-29	C.R. Bard Inc.	Removable embolus blood clot filter
EP1890767A2 (en) *	2005-05-27	2008-02-27	Pfizer Products Inc.	Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss
US8062327B2 (en)	2005-08-09	2011-11-22	C. R. Bard, Inc.	Embolus blood clot filter and delivery system
AU2006304689A1 (en) *	2005-10-18	2007-04-26	Aegerion Pharmaceuticals	Compositions for lowering serum cholesterol and/or triglycerides
WO2007133366A2 (en)	2006-05-02	2007-11-22	C. R. Bard, Inc.	Vena cava filter formed from a sheet
JP2010513534A (ja) *	2006-12-21	2010-04-30	エージェリオンファーマシューティカルズ，インコーポレイテッド	Ｍｔｐインヒビターおよびコレステロール吸収インヒビターを含む組み合わせを用いて肥満症を処置する方法
CA3186856A1 (en)	2020-07-29	2022-02-03	Ruth NALLEN	Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA718536B (en) *	1971-01-11	1972-09-27	Wyeth John & Brother Ltd	Heterocyclic compounds
DE2200584A1 (de) *	1971-01-11	1972-07-27	Wyeth John & Brother Ltd	Heterocyclische Verbindungen,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
GB8614246D0 (en) *	1986-06-11	1986-07-16	Wyeth John & Brother Ltd	Substituted pyrimidoindoles
DE4112533A1 (de) *	1991-04-17	1992-10-22	Bayer Ag	Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
DE4200954A1 (de) *	1991-04-26	1992-10-29	Bayer Ag	Heterocyclisch substituierte phenylessigsaeurederivate
DE4309968A1 (de) *	1993-03-26	1994-09-29	Bayer Ag	Phenylglycinamide von heterocyclisch substituierten Phenylessigsäurederivaten
DE4208051A1 (de) *	1992-03-13	1993-09-16	Bayer Ag	Substituierte phenylessigsaeureamide
DE4208052A1 (de) *	1992-03-13	1993-09-16	Bayer Ag	Imidazolyl substituierte phenylessigsaeureamide
US5576342A (en) *	1992-03-13	1996-11-19	Bayer Aktiengesellschaft	Phenylglycinamides of heterocyclically substitued phenylacetic acid derivatives
EP0667867A1 (en) *	1992-11-05	1995-08-23	Smithkline Beecham Plc	Piperidine derivatives as 5-ht4 receptor antagonists
DE4302956A1 (de) *	1993-02-03	1994-08-04	Bayer Ag	Substituierte Imidazo(4,5-b)pyridine und Benzimidazole

1996
- 1996-04-04 DE DE19613550A patent/DE19613550A1/de not_active Withdrawn
1997
- 1997-03-17 HR HR19613550.8A patent/HRP970154A2/xx not_active Application Discontinuation
- 1997-03-24 EP EP97104940A patent/EP0799828A3/de not_active Ceased
- 1997-03-27 NZ NZ314497A patent/NZ314497A/xx unknown
- 1997-03-27 AU AU16603/97A patent/AU725786B2/en not_active Ceased
- 1997-03-31 US US08/829,015 patent/US6114341A/en not_active Expired - Fee Related
- 1997-04-01 CA CA002201434A patent/CA2201434A1/en not_active Abandoned
- 1997-04-01 YU YU12397A patent/YU12397A/sr unknown
- 1997-04-01 SG SG1997001026A patent/SG63698A1/en unknown
- 1997-04-01 MA MA24544A patent/MA24131A1/fr unknown
- 1997-04-02 IL IL12059097A patent/IL120590A/xx not_active IP Right Cessation
- 1997-04-02 BG BG101379A patent/BG62934B1/bg unknown
- 1997-04-02 TR TR97/00261A patent/TR199700261A2/xx unknown
- 1997-04-02 TN TNTNSN97061A patent/TNSN97061A1/fr unknown
- 1997-04-02 ID IDP971112A patent/ID16520A/id unknown
- 1997-04-02 IL IL13164597A patent/IL131645A/xx not_active IP Right Cessation
- 1997-04-02 JP JP9097893A patent/JPH1059972A/ja not_active Withdrawn
- 1997-04-02 PL PL97319249A patent/PL319249A1/xx unknown
- 1997-04-02 DZ DZ970048A patent/DZ2201A1/fr active
- 1997-04-03 AR ARP970101336A patent/AR006497A1/es unknown
- 1997-04-03 EE EE9700078A patent/EE9700078A/xx unknown
- 1997-04-03 CO CO97016906A patent/CO4520306A1/es unknown
- 1997-04-03 KR KR1019970012342A patent/KR970070008A/ko not_active Withdrawn
- 1997-04-03 ZA ZA9702829A patent/ZA972829B/xx unknown
- 1997-04-03 PE PE1997000260A patent/PE42398A1/es not_active Application Discontinuation
- 1997-04-03 NO NO971512A patent/NO309092B1/no not_active IP Right Cessation
- 1997-04-03 MY MYPI97001435A patent/MY126362A/en unknown
- 1997-04-03 CZ CZ971022A patent/CZ102297A3/cs unknown
- 1997-04-03 SK SK427-97A patent/SK42797A3/sk unknown
- 1997-04-04 SV SV1997000025A patent/SV1997000025A/es unknown
- 1997-04-04 HN HN1997000045A patent/HN1997000045A/es unknown
- 1997-04-04 BR BR9701675A patent/BR9701675A/pt active Search and Examination
- 1997-04-04 CN CN97110275A patent/CN1067393C/zh not_active Expired - Fee Related
- 1997-04-04 HU HU9700708A patent/HUP9700708A3/hu unknown
1999
- 1999-08-30 IL IL13164599A patent/IL131645A0/xx unknown
2000
- 2000-09-12 CN CN00127092A patent/CN1312246A/zh active Pending

Also Published As

Publication number	Publication date
KR970070008A (ko)	1997-11-07
TNSN97061A1 (fr)	2005-03-15
SK42797A3 (en)	1997-11-05
NO971512L (no)	1997-10-06
BG101379A (en)	1997-11-28
SG63698A1 (en)	1999-03-30
MY126362A (en)	2006-09-29
EE9700078A (et)	1997-10-15
EP0799828A2 (de)	1997-10-08
BG62934B1 (bg)	2000-11-30
PL319249A1 (en)	1997-10-13
CN1067393C (zh)	2001-06-20
MX9702445A (es)	1997-10-31
IL120590A (en)	2000-02-17
EP0799828A3 (de)	1998-04-08
NZ314497A (en)	1999-10-28
HUP9700708A2 (hu)	1998-10-28
ZA972829B (en)	1997-10-31
HU9700708D0 (en)	1997-05-28
CO4520306A1 (es)	1997-10-15
DZ2201A1 (fr)	2002-12-03
CN1312246A (zh)	2001-09-12
AU1660397A (en)	1997-10-09
NO309092B1 (no)	2000-12-11
PE42398A1 (es)	1998-10-12
BR9701675A (pt)	1998-11-03
CN1176965A (zh)	1998-03-25
HUP9700708A3 (en)	2000-01-28
US6114341A (en)	2000-09-05
AU725786B2 (en)	2000-10-19
HRP970154A2 (en)	1998-04-30
HN1997000045A (es)	1997-06-26
IL131645A (en)	2000-12-06
IL120590A0 (en)	1997-08-14
IL131645A0 (en)	2001-01-28
SV1997000025A (es)	1997-10-23
DE19613550A1 (de)	1997-10-09
TR199700261A2 (xx)	1997-10-21
JPH1059972A (ja)	1998-03-03
CZ102297A3 (en)	1997-10-15
NO971512D0 (no)	1997-04-03
AR006497A1 (es)	1999-08-25
MA24131A1 (fr)	1997-10-01
ID16520A (id)	1997-10-09
CA2201434A1 (en)	1997-10-04

Publication	Publication Date	Title
TR200200785T2 (tr)	2002-09-23	8-Fenil-6,9-dihidro-[1,2,4] triazolo [3,4-i] purin-5-on türevleri
MY109880A (en)	1997-09-30	Substituted biphenylpyridones
ES2045229T3 (es)	1994-01-16	Pirrolidinas 1,3-disubstituidas.
YU12397A (en)	1999-11-22	NOVEL PYRIMIDO [1,2-a] INDOLES
BG103251A (bg)	2000-02-29	Оксадиазоли, методи за получаването им и приложението им като лекарствени средства
ID23374A (id)	2000-04-20	Halogenopirimidin
EA199800946A1 (ru)	1999-06-24	Концентрированный препарат антител
DE69826684D1 (de)	2004-11-04	Kovalent gebundenes n,o-carboxymethylchitosan und seine verwendungen
EE9900481A (et)	2000-06-15	Väikesed molekulid, mida kasutatakse põletikuliste haiguste raviks
WO2001044215A3 (de)	2001-12-06	Fungizide wirkstoffkombinationen
PY950041A (es)	2006-07-03	Compuesto de 1- fenil 3-dimetilamino- propano a procedimientos para su preparacion y a la aplicacion de estas sustancias en farmacologia
TR199902383T2 (xx)	2000-06-21	Yeni pirimidin t�revleri ve bunlar�n haz�rlanmas� i�in proses.
BR9707659A (pt)	1999-04-13	Pirrol(2,3-C) carbarzol-6-onas que potencializam atividade atividade de interferon gama
FI891252A0 (fi)	1989-03-16	1,3,4,5-tetrahydrobenz /c,d/ indol.
ES2133727T3 (es)	1999-09-16	Derivados de acido hidroxamico como inhibidores de metaloproteinasa.
BG101892A (en)	1998-05-29	Sugar-modified cytostatics
RU95101375A (ru)	1996-11-20	Производные n-(3-аминопропил)-n-фенил-5,6,7,8-тетрагидронафталин-2-карбоксамида, их получение и применение в терапии
FI972684L (fi)	1997-06-19	Piperidiinietikkahappojohdannaisia, joita voidaan käyttää fibrinogeeniantagonisteina
TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
ID23424A (id)	2000-04-20	Glikokonjugat dari 20(s)-kamptotesin
ES2124861T3 (es)	1999-02-16	Derivados de aminoacidos y su utilizacion como inhibidores de la encefalinasa.
FI853228A7 (fi)	1986-02-25	Uudet -butyrolaktaamit, niiden farmaseuttisesti aktiiviset koostumukset, menetelmät niiden valmistamiseksi ja niiden käyttö lääkeaineina.
ES2141978T3 (es)	2000-04-01	Retinoides triciclicos, metodos para su produccion y uso.
IT1273790B (it)	1997-07-10	Derivati eterociclici diazotati aventi attivita' aii antagonista
MX9202273A (es)	1993-05-01	Derivados de piridona aminoacido azetidinil substituidos, su preparacion y su aplicacion como medicamentos.