YU1402A - Hibridni polipeptidi sa pojačanim farmakokinetičkim osobinama - Google Patents

Hibridni polipeptidi sa pojačanim farmakokinetičkim osobinama

Info

Publication number
YU1402A
YU1402A YU1402A YUP1402A YU1402A YU 1402 A YU1402 A YU 1402A YU 1402 A YU1402 A YU 1402A YU P1402 A YUP1402 A YU P1402A YU 1402 A YU1402 A YU 1402A
Authority
YU
Yugoslavia
Prior art keywords
pharmacokinetic properties
core polypeptide
hybrid polypeptides
peptide sequences
core
Prior art date
Application number
YU1402A
Other languages
English (en)
Inventor
Shawn Barney
Kelly I. Guthrie
Gene Merutka
Mohamed K. Anwer
Dennis M. Lambert
Original Assignee
Trimeris Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trimeris Inc. filed Critical Trimeris Inc.
Publication of YU1402A publication Critical patent/YU1402A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ovaj pronalazak se odnosi na pojacavajuce peptidne sekvence koje originalno poticu iz razlicitih retrovirusnih obuhvatnih (omotanih) (gp41) proteinskih sekvenci koje pojacavaju farmakokineticke osobine bilo kojeg centralnog (osnovnog) polipeptida za koji su vezane. Ovaj pronalazak se bazira na otkricu da hibridni polipeptidi koji obuhvataju pojacavajuce peptidne sekvence vezane za centralni (osnovni) polipeptid imaju pojacane farmakokineticke osobine kao sto je povecan poluzivot. Ovaj pronalazak se dalje odnosi na postupke za pojacavanje farmakokinetickih osobina bilo kojeg centralnog (osnovnog) polipeptida preko vezivanja pojacavajucih peptidnih sekvenci za centralni (osnovni) polipeptid. Centralni (osnovni) polipeptidi koji se trebaju koristiti u praksi ovog pronalaska mogu ukljucivati bilo koji farmakoloski prihvatljiv (podesan) peptid koji se moze primeniti, na primer, kao terapeutski ili profilakticki reagens.
YU1402A 1999-07-09 2000-07-10 Hibridni polipeptidi sa pojačanim farmakokinetičkim osobinama YU1402A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/350,641 US6656906B1 (en) 1998-05-20 1999-07-09 Hybrid polypeptides with enhanced pharmacokinetic properties

Publications (1)

Publication Number Publication Date
YU1402A true YU1402A (sh) 2004-11-25

Family

ID=23377584

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1402A YU1402A (sh) 1999-07-09 2000-07-10 Hibridni polipeptidi sa pojačanim farmakokinetičkim osobinama

Country Status (22)

Country Link
US (2) US6656906B1 (sh)
EP (1) EP1206272A4 (sh)
JP (1) JP2003504344A (sh)
KR (1) KR100755418B1 (sh)
CN (1) CN1254271C (sh)
AR (1) AR024699A1 (sh)
AU (1) AU6082200A (sh)
BR (1) BR0012287A (sh)
CA (1) CA2377677A1 (sh)
CZ (1) CZ200288A3 (sh)
HK (1) HK1045259A1 (sh)
HR (1) HRP20020022A2 (sh)
IL (1) IL147331A0 (sh)
MX (1) MXPA02000012A (sh)
NO (1) NO20020087L (sh)
NZ (1) NZ516550A (sh)
PL (1) PL352685A1 (sh)
RU (1) RU2279883C2 (sh)
TR (1) TR200200766T2 (sh)
TW (1) TWI248364B (sh)
WO (1) WO2001003723A1 (sh)
YU (1) YU1402A (sh)

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Also Published As

Publication number Publication date
HK1045259A1 (zh) 2002-11-22
HRP20020022A2 (en) 2004-02-29
US20030186874A1 (en) 2003-10-02
WO2001003723A9 (en) 2002-07-25
EP1206272A4 (en) 2003-01-02
CZ200288A3 (cs) 2002-06-12
US6656906B1 (en) 2003-12-02
CA2377677A1 (en) 2001-01-18
KR100755418B1 (ko) 2007-09-05
WO2001003723A1 (en) 2001-01-18
TR200200766T2 (tr) 2002-10-21
JP2003504344A (ja) 2003-02-04
CN1373669A (zh) 2002-10-09
AR024699A1 (es) 2002-10-23
RU2279883C2 (ru) 2006-07-20
NO20020087D0 (no) 2002-01-08
PL352685A1 (en) 2003-09-08
MXPA02000012A (es) 2003-07-21
EP1206272A1 (en) 2002-05-22
CN1254271C (zh) 2006-05-03
KR20020029667A (ko) 2002-04-19
IL147331A0 (en) 2002-08-14
US7297784B2 (en) 2007-11-20
TWI248364B (en) 2006-02-01
AU6082200A (en) 2001-01-30
NO20020087L (no) 2002-03-01
NZ516550A (en) 2004-05-28
BR0012287A (pt) 2002-04-02

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