ATE349700T1 - Übergangsmetallkomplex-haltige lumineszente proteinfarben - Google Patents
Übergangsmetallkomplex-haltige lumineszente proteinfarbenInfo
- Publication number
- ATE349700T1 ATE349700T1 AT99956756T AT99956756T ATE349700T1 AT E349700 T1 ATE349700 T1 AT E349700T1 AT 99956756 T AT99956756 T AT 99956756T AT 99956756 T AT99956756 T AT 99956756T AT E349700 T1 ATE349700 T1 AT E349700T1
- Authority
- AT
- Austria
- Prior art keywords
- colors
- transition metal
- metal complex
- complex containing
- luminescent protein
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6827—Total protein determination, e.g. albumin in urine
- G01N33/683—Total protein determination, e.g. albumin in urine involving metal ions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Sampling And Sample Adjustment (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Detergent Compositions (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10583998P | 1998-10-27 | 1998-10-27 | |
| US11382898P | 1998-12-23 | 1998-12-23 | |
| US12634699P | 1999-03-26 | 1999-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE349700T1 true ATE349700T1 (de) | 2007-01-15 |
Family
ID=27379984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99956756T ATE349700T1 (de) | 1998-10-27 | 1999-10-27 | Übergangsmetallkomplex-haltige lumineszente proteinfarben |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6316267B1 (de) |
| EP (1) | EP1042676B1 (de) |
| JP (1) | JP2002528723A (de) |
| AT (1) | ATE349700T1 (de) |
| AU (1) | AU744194C (de) |
| CA (1) | CA2314129C (de) |
| DE (1) | DE69934572T2 (de) |
| WO (1) | WO2000025139A1 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329205B1 (en) * | 1999-08-31 | 2001-12-11 | Molecular Probes, Inc. | Detection method using luminescent europium-based protein stains |
| EP1311859B1 (de) * | 2000-08-24 | 2005-10-19 | Bio-Rad Laboratories, Inc. | Trockenpulverzusammensetzung zur proteinmarkierung |
| AU2001296502B2 (en) | 2000-10-02 | 2005-06-09 | Molecular Probes, Inc. | Reagents for labeling biomolecules having aldehyde or ketone moieties |
| JP2004528528A (ja) | 2000-11-20 | 2004-09-16 | インヴィトロジェン コーポレーション | マトリクス中の生体高分子の染色増強用物質 |
| WO2002078906A2 (en) * | 2001-03-29 | 2002-10-10 | Cellect Technologies Corp. | Methods devices and systems for sorting and separating particles |
| EP1406720B1 (de) * | 2001-07-19 | 2013-12-04 | Life Technologies Corporation | Puffer für elektrophorese und verwendung davon |
| US7253003B2 (en) | 2001-10-19 | 2007-08-07 | Wisconsin Alumni Research Foundation | Method for monitoring the environment within a microfluidic device |
| US7112444B2 (en) | 2002-04-24 | 2006-09-26 | Wisconsin Alumni Research Foundation | Method of performing gradient-based assays in a microfluidic device |
| CA2483868A1 (en) * | 2002-05-03 | 2004-05-21 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
| US7445894B2 (en) * | 2002-05-03 | 2008-11-04 | Molecular Probes, Inc. | Compositions and methods for detection and isolation of phosphorylated molecules |
| US20040171034A1 (en) | 2002-05-03 | 2004-09-02 | Brian Agnew | Compositions and methods for detection and isolation of phosphorylated molecules |
| EP1544618B1 (de) * | 2002-07-25 | 2009-03-18 | Ajinomoto Co., Inc. | Proteinanalyseverfahren |
| AU2003258683A1 (en) * | 2002-09-03 | 2004-03-29 | Zeptosens Ag | Analytical platform and detection method with analytes which are to be detected in a sample in the form of immobilized specific binding partners |
| WO2004023143A2 (de) * | 2002-09-03 | 2004-03-18 | Zeptosens Ag | Analytische plattform und nachweisverfahren |
| US7422865B2 (en) * | 2003-01-13 | 2008-09-09 | Agilent Technologies, Inc. | Method of identifying peptides in a proteomic sample |
| KR100601641B1 (ko) * | 2003-08-08 | 2006-07-14 | 삼성전자주식회사 | 비피리딘계 금속 착화합물 및 이를 포함하는 잉크 조성물 |
| KR100561466B1 (ko) * | 2003-08-08 | 2006-03-16 | 삼성전자주식회사 | 자가분산가능한 비피리딘계 금속 착화합물 및 이를 포함한잉크조성물 |
| WO2006083846A2 (en) * | 2005-02-01 | 2006-08-10 | Sigma-Aldrich Co. | Detection of polyamino acids using trimethincyanine dyes |
| US7939613B2 (en) * | 2005-04-22 | 2011-05-10 | The Hong Kong University Of Science And Technology | Fluorescent water-soluble conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same |
| WO2007046882A2 (en) * | 2005-06-06 | 2007-04-26 | University Of Maryland, Baltimore County | Devices and methods for profiling enzyme substrates |
| CN101243315A (zh) * | 2005-06-22 | 2008-08-13 | 粘合剂研究股份有限公司 | 分子印迹聚合物及其在诊断设备中的用途 |
| JP2009524832A (ja) | 2006-01-24 | 2009-07-02 | ライフ テクノロジーズ コーポレーション | 検体を定量するためのデバイスおよび方法 |
| US7947506B2 (en) * | 2006-06-02 | 2011-05-24 | Pierce Biotechnology, Inc. | Protein detection and quantitation using hydroxyquinolone dyes |
| US20080220442A1 (en) * | 2006-12-06 | 2008-09-11 | Proteinics | Difference detection methods using isoelectric focusing chips |
| US9193746B2 (en) * | 2006-12-07 | 2015-11-24 | Biotium, Inc. | Luminescent metal complexes and associated technology |
| DE102007032799B4 (de) | 2007-07-11 | 2018-08-23 | Friedrich-Schiller-Universität Jena | Zuckerhaltige Metallkomplexe und deren Verwendung |
| US8318498B2 (en) * | 2007-10-09 | 2012-11-27 | The Hong Kong Polytechnic University | Luminescent protein staining |
| US20100209943A1 (en) * | 2007-10-10 | 2010-08-19 | David Goldberg | Measurement Of Protease Activity In Post-Mortem Meat Samples |
| WO2009067603A1 (en) * | 2007-11-21 | 2009-05-28 | Bio-Rad Laboratories, Inc. | Photoluminescent metal complexes for protein staining |
| WO2009115649A1 (fr) * | 2008-03-20 | 2009-09-24 | Assistance Publique - Hopitaux De Paris | Procede d'analyse de cellules par cytometrie en flux, utilisation d'un agent antioxydant dans un tel procede et tampon d'incubation comprenant un agent antioxydant |
| US8623324B2 (en) | 2010-07-21 | 2014-01-07 | Aat Bioquest Inc. | Luminescent dyes with a water-soluble intramolecular bridge and their biological conjugates |
| CN102175674A (zh) * | 2011-01-20 | 2011-09-07 | 中南大学 | 一种检测尿液微量清蛋白的方法 |
| ES2911298T3 (es) | 2015-12-16 | 2022-05-18 | Becton Dickinson Co | Colorantes poliméricos en tándem fluorescentes fotoestables que incluyen complejos de metales luminiscentes |
| ES3046711T3 (en) | 2016-04-15 | 2025-12-02 | Beckman Coulter Inc | Photoactive macromolecules and uses thereof |
| MX2019003087A (es) | 2016-09-16 | 2019-08-12 | Cortexyme Inc | Inhibidores cetónicos de gingipain de lisina. |
| US11480503B2 (en) | 2017-03-02 | 2022-10-25 | Seoul National University R&Db Foundation | Method for reducing intracellular non-specific staining caused by metal complex |
| TWI903299B (zh) | 2018-03-08 | 2025-11-01 | 美商英塞特公司 | 作為PI3K-γ抑制劑之胺基吡嗪二醇化合物 |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| US11584825B2 (en) | 2018-12-14 | 2023-02-21 | Beckman Coulter, Inc. | Polymer dye modification and applications |
| CN113666970B (zh) * | 2019-04-30 | 2024-01-12 | 苏州优逸兰迪生物科技有限公司 | 一种钌金属配合物的制备方法 |
| JP2024509725A (ja) | 2021-02-05 | 2024-03-05 | ベックマン コールター， インコーポレイテッド | ポリマー色素－抗体コンジュゲート間の非特異的相互作用を阻止する組成物および方法 |
| WO2023056460A1 (en) | 2021-09-30 | 2023-04-06 | Beckman Coulter, Inc. | Water-soluble tetrahydropyrene based fluorescent polymers |
| WO2023086103A1 (en) | 2021-11-12 | 2023-05-19 | Beckman Coulter, Inc. | Novel formulation for drying of polymer dye conjugated antibodies |
| US20250383357A1 (en) | 2022-07-01 | 2025-12-18 | Beckman Coulter, Inc. | Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives |
| WO2024044327A1 (en) | 2022-08-26 | 2024-02-29 | Beckman Coulter, Inc. | Dhnt monomers and polymer dyes with modified photophysical properties |
| CN120936679A (zh) | 2023-03-17 | 2025-11-11 | 贝克曼库尔特有限公司 | 苯并噻吩并吡咯花菁染料 |
| WO2025064842A1 (en) | 2023-09-21 | 2025-03-27 | Beckman Coulter, Inc. | Dihydrophenanthrene (dhp) bridged dyes for use in flow cytometry |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459356A (en) * | 1982-02-11 | 1984-07-10 | Georgetown University | Radioactive staining of gels to identify proteins |
| US5310687A (en) | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5221605A (en) * | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5316906A (en) | 1991-08-23 | 1994-05-31 | Molecular Probes, Inc. | Enzymatic analysis using substrates that yield fluorescent precipitates |
| DE69219610T2 (de) | 1991-09-16 | 1997-10-02 | Molecular Probes Inc | Dimere unsymmetrische Cyaninfarbstoffe |
| US5321130A (en) | 1992-02-10 | 1994-06-14 | Molecular Probes, Inc. | Unsymmetrical cyanine dyes with a cationic side chain |
| US5410030A (en) | 1993-04-05 | 1995-04-25 | Molecular Probes, Inc. | Dimers of unsymmetrical cyanine dyes containing pyridinium moieties |
| US5534416A (en) | 1993-04-13 | 1996-07-09 | Molecular Probes, Inc. | Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes |
| US5616502A (en) | 1995-05-19 | 1997-04-01 | Molecular Probes, Inc. | Non-specific protein staining using merocyanine dyes |
| AU1055997A (en) | 1995-11-30 | 1997-06-19 | Trustees Of Boston University | Luminescent probes for protein detection |
-
1999
- 1999-10-27 WO PCT/US1999/025349 patent/WO2000025139A1/en not_active Ceased
- 1999-10-27 US US09/429,739 patent/US6316267B1/en not_active Expired - Lifetime
- 1999-10-27 AU AU13293/00A patent/AU744194C/en not_active Ceased
- 1999-10-27 AT AT99956756T patent/ATE349700T1/de active
- 1999-10-27 CA CA002314129A patent/CA2314129C/en not_active Expired - Fee Related
- 1999-10-27 EP EP99956756A patent/EP1042676B1/de not_active Expired - Lifetime
- 1999-10-27 DE DE69934572T patent/DE69934572T2/de not_active Expired - Lifetime
- 1999-10-27 JP JP2000578662A patent/JP2002528723A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE69934572T2 (de) | 2007-04-26 |
| WO2000025139B1 (en) | 2000-07-06 |
| US6316267B1 (en) | 2001-11-13 |
| DE69934572D1 (de) | 2007-02-08 |
| CA2314129C (en) | 2004-06-01 |
| JP2002528723A (ja) | 2002-09-03 |
| EP1042676B1 (de) | 2006-12-27 |
| AU744194C (en) | 2003-05-08 |
| CA2314129A1 (en) | 2000-05-04 |
| WO2000025139A1 (en) | 2000-05-04 |
| EP1042676A1 (de) | 2000-10-11 |
| AU744194B2 (en) | 2002-02-21 |
| AU1329300A (en) | 2000-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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