YU215678A - Process for obtaining 3-(2-hydroxy-4-(subst.)phenyl)-azacycloalkanes - Google Patents

Process for obtaining 3-(2-hydroxy-4-(subst.)phenyl)-azacycloalkanes

Info

Publication number
YU215678A
YU215678A YU02156/78A YU215678A YU215678A YU 215678 A YU215678 A YU 215678A YU 02156/78 A YU02156/78 A YU 02156/78A YU 215678 A YU215678 A YU 215678A YU 215678 A YU215678 A YU 215678A
Authority
YU
Yugoslavia
Prior art keywords
azacycloalkanes
subst
hydroxy
phenyl
obtaining
Prior art date
Application number
YU02156/78A
Other languages
English (en)
Inventor
Melvin, Jr
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of YU215678A publication Critical patent/YU215678A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
YU02156/78A 1977-09-13 1978-09-12 Process for obtaining 3-(2-hydroxy-4-(subst.)phenyl)-azacycloalkanes YU215678A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/832,869 US4147872A (en) 1977-09-13 1977-09-13 3-[2-Hydroxy-4-(substituted)-phenyl]azacycloalkanes and derivatives thereof as analgesic agents and intermediates therefor

Publications (1)

Publication Number Publication Date
YU215678A true YU215678A (en) 1983-06-30

Family

ID=25262819

Family Applications (1)

Application Number Title Priority Date Filing Date
YU02156/78A YU215678A (en) 1977-09-13 1978-09-12 Process for obtaining 3-(2-hydroxy-4-(subst.)phenyl)-azacycloalkanes

Country Status (23)

Country Link
US (1) US4147872A (da)
JP (5) JPS5935397B2 (da)
AR (2) AR222019A1 (da)
AT (1) AT368753B (da)
AU (1) AU507953B1 (da)
BE (1) BE870403A (da)
CA (1) CA1113463A (da)
CH (1) CH638187A5 (da)
DE (1) DE2839883A1 (da)
DK (1) DK401078A (da)
ES (2) ES473287A1 (da)
FI (1) FI66173C (da)
FR (4) FR2401913A1 (da)
GB (1) GB2004548B (da)
IE (1) IE47717B1 (da)
IL (1) IL55555A (da)
IT (1) IT1099026B (da)
LU (1) LU80219A1 (da)
NL (1) NL7809272A (da)
PH (1) PH15372A (da)
PT (1) PT68542A (da)
SE (2) SE7809606L (da)
YU (1) YU215678A (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
FI792076A7 (fi) * 1978-07-05 1981-01-01 Ciba Geigy Ag Menetelmä uusien fenyylipiperidiinijohdannaisten valmistamiseksi.
US4312876A (en) * 1979-02-23 1982-01-26 Hoechst-Roussel Pharmaceuticals Incorporated Antidepressive and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
US4302590A (en) * 1979-02-23 1981-11-24 Hoechst-Roussel Pharmaceuticals, Inc. Intermediates for the preparation of 4-aryloxy-3-phenylpiperidines
US4216218A (en) * 1979-02-23 1980-08-05 American Hoechst Corporation Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
ZA821888B (en) * 1981-04-01 1983-02-23 Haessle Ab Novel phenyl-piperidines
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4529732A (en) * 1983-03-14 1985-07-16 Pfizer Inc. 2-[2-Hydroxy-4-(substituted)phenyl]piperidines
FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2004017920A2 (en) * 2002-08-23 2004-03-04 University Of Connecticut Novel biphenyl and biphenyl-like cannabinoids
DE102004036349A1 (de) * 2004-07-27 2006-03-23 Grünenthal GmbH Substituierte 3-Phenylpiperidin-Derivate
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質(rap)結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CA2900309A1 (fr) 2013-02-14 2014-08-21 Galderma Research & Development Procede de synthese de 4-piperidin-4-yl-benzene-1,3-diol et de ses sels et nouveau compose 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate de tert-butyle

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2310761A1 (fr) * 1975-05-16 1976-12-10 Roussel Uclaf Nouveaux derives de la phenyl-piperidine et leurs sels, procede de preparation et application a titre de medicaments

Also Published As

Publication number Publication date
ES480151A1 (es) 1980-04-01
ATA658078A (de) 1982-03-15
IL55555A0 (en) 1978-12-17
FR2401913A1 (fr) 1979-03-30
JPS5935397B2 (ja) 1984-08-28
PH15372A (en) 1982-12-10
AU507953B1 (en) 1980-03-06
FR2401913B1 (da) 1983-01-21
AR220567A1 (es) 1980-11-14
FR2412529A1 (fr) 1979-07-20
CH638187A5 (fr) 1983-09-15
JPS5463086A (en) 1979-05-21
IL55555A (en) 1982-08-31
JPS5640155B2 (da) 1981-09-18
JPS5538365A (en) 1980-03-17
IE781837L (en) 1979-03-13
FR2412531A1 (fr) 1979-07-20
FR2412530B1 (da) 1982-11-12
IT1099026B (it) 1985-09-18
FI782793A7 (fi) 1979-03-14
NL7809272A (nl) 1979-03-15
JPS5492973A (en) 1979-07-23
BE870403A (fr) 1979-03-12
IE47717B1 (en) 1984-05-30
AR222019A1 (es) 1981-04-15
IT7827557A0 (it) 1978-09-12
PT68542A (en) 1978-10-01
FR2412530A1 (fr) 1979-07-20
US4147872A (en) 1979-04-03
AT368753B (de) 1982-11-10
SE8305422L (sv) 1983-10-03
LU80219A1 (fr) 1980-04-21
FR2412531B1 (da) 1983-01-14
JPS5495577A (en) 1979-07-28
DE2839883A1 (de) 1979-03-15
JPS5538366A (en) 1980-03-17
GB2004548A (en) 1979-04-04
CA1113463A (en) 1981-12-01
FI66173B (fi) 1984-05-31
SE7809606L (sv) 1979-03-14
DK401078A (da) 1979-03-14
GB2004548B (en) 1982-03-24
FR2412529B1 (da) 1983-01-14
FI66173C (fi) 1984-09-10
SE8305422D0 (sv) 1983-10-03
ES473287A1 (es) 1980-03-01

Similar Documents

Publication Publication Date Title
YU41121B (en) Process for obtaining 1-phenyl-2-azolyl-4,4-dmethyl-1-pentene-3-ole
PT67988A (en) Process for preparing polyene compounds.
YU61480A (en) Process for obtaining 3-(1-imidazolylalkyl)-indoles
AU512051B2 (en) Process for preparing 1, 4: , 6-dianhydro-d-glucitol-2-nitrate
AU4152178A (en) 1,9-dihydroxyoctahydrophenanthrenes
AU507953B1 (en) 3-(2-Hydroxy-4-(substituted)phenyl) Azacycloalkane Derivatives
YU210878A (en) Process for obtaining new fungicidal 2,2-dichlorocyanovinyl compounds
YU71279A (en) Process for obtaining a,10a-cis-hexahydrodiabenzo(b,d)pyran-9-one
YU287779A (en) Process for obtaining 7-oxo-4-thia-1-aca-bicyclo(3.2.0)heptane derivatives
NZ192392A (en) 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones
YU215478A (en) Process for obtaining 3-(2-hydroxy-4-(subst.)phenyl)-cycloalkanol derivatives
YU39804B (en) Process for obtaining new gona-4,9(10)-dienes
YU41015B (en) Process for obtainig 2-formqequinoxaline -1,4-dioxyde cyanoacetylhydrazone
YU78679A (en) Process for obtaining 1,3-dibenzoyloxy-17 alpha-ethinyl-7 alpha-methyl-1,3,5(10)-estratriene-17 beta-ol
YU43762B (en) Process for obtaining 3-(5-or 3-sub.-5- or 3-isoxazolyl)-1-allyl or alkyl-4-subst.-5-subst. or nonsubst. 2-imidazolidinones
YU221882A (en) Process for obtaining 4a, 9b-transhexahydro-gamma-carboline compounds
YU262579A (en) New process for obtaining 6-piperidino-2,4-diamino-pyrimidine-3-oxide
YU54178A (en) Process for obtaining 2,1,3-thiadiazine-4-one-2,2-dioxide deerivatives
JPS5436210A (en) Continuous process for preparing aldehyde
YU40698B (en) Process for preparing 2-(2,2,2-trihaloethy)-4-halocyclobutane-l-ones
YU226081A (en) Process for obtaining 2-hydroxy-4-(subst.)phenyl-cycloalkanes
YU225981A (en) Process for obtaining pharmaceutically active 4-(2-hydroxy-4-(subst.)phenyl)naphthalene-2-one
GB1549506A (en) Process for the preparation of 2-(1-p-chlorophenyl-1-phenylacetyl)-indane-1,3-dione
PT67927A (en) Process for preparing d-homosteroids.
YU202779A (en) Process for obtaining 1,2,3-thiadiazole-5-yl-carbamide