YU35501A - STABILNA FARMACEUTSKA FORMULACIJA KOJA UKLJUČUJE INHIBITOR HMG-CoA REDUKTAZE - Google Patents
STABILNA FARMACEUTSKA FORMULACIJA KOJA UKLJUČUJE INHIBITOR HMG-CoA REDUKTAZEInfo
- Publication number
- YU35501A YU35501A YU35501A YU35501A YU35501A YU 35501 A YU35501 A YU 35501A YU 35501 A YU35501 A YU 35501A YU 35501 A YU35501 A YU 35501A YU 35501 A YU35501 A YU 35501A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pharmaceutical formulation
- hmg
- coa reductase
- reductase inhibitor
- pravastatin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 3
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 3
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 2
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 2
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 abstract 2
- 229960005370 atorvastatin Drugs 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- 239000004615 ingredient Substances 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229960002965 pravastatin Drugs 0.000 abstract 2
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 241000894007 species Species 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 abstract 1
- 241000187643 Amycolatopsis Species 0.000 abstract 1
- 241000228212 Aspergillus Species 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 1
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 241000235395 Mucor Species 0.000 abstract 1
- 241000187654 Nocardia Species 0.000 abstract 1
- 241000228143 Penicillium Species 0.000 abstract 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 1
- AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 229960003765 fluvastatin Drugs 0.000 abstract 1
- 229960004844 lovastatin Drugs 0.000 abstract 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 229950009116 mevastatin Drugs 0.000 abstract 1
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract 1
- BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960002855 simvastatin Drugs 0.000 abstract 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Abstract
Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, i njihovi derivati i analozi poznati su kao inhibitori HMG-CoA reduktaze i koriste se kao antihiperholesterolemijska sredstva. Vecina njih proizvodi se fermentacljom uz koriscenje mikroorganizama razlicitih vrsta identifikovanih kao vrste koje pripadaju rodovima Aspergillus, Monascus, Nocardia, Amycolatopsis, Mucor ili Penicillium, a neki se dobijaju obradjivanjem proizvoda fermentacije uz koriscenje metoda hemijske sinteze ili su proizvodi potpune hemijske sinteze. Gore pomenute aktivne supstance mogu biti destabilisane sredinskim faktorima, njihova degradacija moze takodje biti ubrzana interakcijama sa drugim farmaceutskim sastojcima, kao sto su potporne supstance, povezivaci, lubrikanti, glidansi i dezintegrisuca sredstva, tako da farmaceutski sastojci i postupak za pripremanje farmaceutske formulacije treba da budu precizno odabrani kako bi se izbegle gore pomenute nezeljene interakcije i reakcije. Predmetni pronalazak se odnosi na stabilnu cvrstu farmaceutsku formulaciju za lecenje hiperholesterolemije i hiperlipidemije. Preciznije predmetni pronalazak se odnosi na novu cvrstu stabilnu farmaceutsku formulaciju koja, kao aktivni sastojak, sadrzi jedan od inhibitora HMG-CoA reduktaze, kao sto su atorvastatin, pravastatin, fluvastatin i cerivastatin ili njihove farmaceutski prihvatljive soli.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9800309A SI20109A (sl) | 1998-12-16 | 1998-12-16 | Stabilna farmacevtska formulacija |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU35501A true YU35501A (sh) | 2005-07-19 |
Family
ID=20432372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU35501A YU35501A (sh) | 1998-12-16 | 1999-10-29 | STABILNA FARMACEUTSKA FORMULACIJA KOJA UKLJUČUJE INHIBITOR HMG-CoA REDUKTAZE |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6680341B1 (sh) |
| EP (2) | EP1911445A3 (sh) |
| JP (1) | JP2002532409A (sh) |
| KR (1) | KR100638307B1 (sh) |
| CN (1) | CN1198597C (sh) |
| AT (1) | ATE380020T1 (sh) |
| AU (1) | AU775946B2 (sh) |
| BG (1) | BG105559A (sh) |
| CA (1) | CA2348988C (sh) |
| CZ (1) | CZ302562B6 (sh) |
| DE (1) | DE69937691T2 (sh) |
| ES (1) | ES2299265T3 (sh) |
| HR (1) | HRP20010325A2 (sh) |
| HU (1) | HUP0104258A3 (sh) |
| IL (2) | IL143759A0 (sh) |
| IS (1) | IS5939A (sh) |
| NZ (1) | NZ511260A (sh) |
| PL (1) | PL347686A1 (sh) |
| RU (1) | RU2227019C2 (sh) |
| SI (2) | SI20109A (sh) |
| SK (1) | SK8092001A3 (sh) |
| TR (1) | TR200101235T2 (sh) |
| WO (1) | WO2000035425A1 (sh) |
| YU (1) | YU35501A (sh) |
| ZA (1) | ZA200103802B (sh) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060141036A1 (en) * | 1997-12-12 | 2006-06-29 | Andrx Labs Llc | HMG-CoA reductase inhibitor extended release formulation |
| SI20109A (sl) * | 1998-12-16 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Stabilna farmacevtska formulacija |
| GB0001621D0 (en) | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
| EP1274401B2 (en) | 2000-04-10 | 2014-08-13 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
| USRE44578E1 (en) | 2000-04-10 | 2013-11-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
| US6806290B2 (en) | 2000-06-09 | 2004-10-19 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
| AU4943400A (en) | 2000-06-09 | 2001-12-17 | Lek Tovarna Farmacevtskih | Stabilized pharmaceutically effective composition and pharmaceutical formulationcomprising the same |
| CZ20024015A3 (cs) † | 2000-06-09 | 2003-04-16 | Lek Pharmaceutical D.D. | Stabilní farmaceutický produkt a jeho formulace |
| US20050215636A1 (en) * | 2000-10-05 | 2005-09-29 | Vilmos Keri | Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same |
| SI20848A (sl) * | 2001-03-14 | 2002-10-31 | Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. | Farmacevtska formulacija, ki vsebuje atorvastatin kalcij |
| RU2003131338A (ru) * | 2001-03-27 | 2005-02-10 | Рэнбакси Лабораториз Лимитед (In) | Стабильная фармацевтическая композиция на основе правастатина |
| GB0111077D0 (en) * | 2001-05-04 | 2001-06-27 | Biochemie Gmbh | Organic compounds |
| US7642286B2 (en) * | 2001-06-21 | 2010-01-05 | Andrx Pharmaceuticals, Inc. | Stable pharmaceutical compositions containing pravastatin |
| JP2003055217A (ja) * | 2001-08-10 | 2003-02-26 | Taiyo Yakuhin Kogyo Kk | 医薬組成物 |
| MXPA04006780A (es) * | 2002-01-11 | 2005-06-08 | Athpharma Ltd | Formulaciones farmaceuticas de pravastatina y metodos para usarlas. |
| EP1905431A1 (en) * | 2002-01-11 | 2008-04-02 | Circ Pharma Research and Development Limited | Pravastatin pharmaceutical formulations and methods of their use |
| BR0307720A (pt) * | 2002-02-14 | 2005-01-25 | Ranbaxi Lab Ltd | Formulações de atorvastatina estabilizadas com adições de metal alcalino, método para produzir uma formulação farmacêutica e estabilizar dita formulação |
| CA2385529A1 (en) * | 2002-05-21 | 2003-11-21 | Bernard Charles Sherman | Stable dosage forms comprising atorvastatin calcium |
| US7229644B2 (en) * | 2002-05-23 | 2007-06-12 | Cephalon, Inc. | Pharmaceutical formulations of modafinil |
| SE0202365D0 (sv) * | 2002-08-05 | 2002-08-05 | Pharmacia Ab | New formulation and use thereof |
| EP1551356A2 (en) * | 2002-09-03 | 2005-07-13 | Biovail Laboratories Incorporated | Pravastatin pharmaceutical formulations and methods of their use |
| KR20050088190A (ko) | 2002-12-20 | 2005-09-02 | 화이자 프로덕츠 인코포레이티드 | 콜레스테릴 에스터 전달 단백질 억제제 및 ｈｍｇ-ｃｏａ환원 효소 억제제를 포함하는 투약 형태 |
| US20050271717A1 (en) | 2003-06-12 | 2005-12-08 | Alfred Berchielli | Pharmaceutical compositions of atorvastatin |
| US8163797B2 (en) * | 2003-12-31 | 2012-04-24 | Actavis Elizabeth Llc | Method of treating with stable pravastatin formulation |
| EP1737449A1 (en) * | 2004-03-01 | 2007-01-03 | LEK Pharmaceuticals D.D. | Pharmaceutical composition |
| KR100598326B1 (ko) | 2004-04-10 | 2006-07-10 | 한미약품 주식회사 | ＨＭＧ-ＣｏＡ 환원효소 억제제의 경구투여용 서방형 제제및 이의 제조방법 |
| WO2006008757A2 (en) * | 2004-05-05 | 2006-01-26 | Cadila Healthcare Limited | Stabilized pharmaceutical compositions of pravastatin |
| JP2008509154A (ja) * | 2004-08-06 | 2008-03-27 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | 新規なスタチン薬剤組成物および関連治療方法 |
| US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
| WO2006017692A2 (en) * | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel fenofibrate formulations and related methods of treatment |
| EP1814541A4 (en) * | 2004-11-22 | 2009-10-28 | Dexcel Pharma Technologies Ltd | STABLE ATORVASTATIN FORMULATIONS |
| US20060229277A1 (en) * | 2005-04-08 | 2006-10-12 | Orbus Pharma, Inc. | Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor |
| WO2007016757A1 (en) * | 2005-08-05 | 2007-02-15 | Orbus Pharma Inc. | Stabilized extended release pharmeceutical compositions comprising an hmg-coa reductase inhibitor |
| US20090247603A1 (en) * | 2005-12-23 | 2009-10-01 | Orbus Pharma, Inc. | Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor |
| EP1810667A1 (en) | 2006-01-20 | 2007-07-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising amorphous atorvastatin |
| US20080038332A1 (en) * | 2006-08-10 | 2008-02-14 | Cai Gu Huang | Stable pharmaceutical formulation comprising atorvastatin calcium |
| HU227610B1 (en) * | 2006-09-18 | 2011-09-28 | Richter Gedeon Nyrt | Pharmaceutical compositions containing rosuvastatin potassium |
| WO2008062476A2 (en) * | 2006-10-31 | 2008-05-29 | Glenmark Pharmaceutical Limited | Pharmaceutical composition comprising rosuvastatin or pharmaceutically accepatble salts thereof |
| BG934U1 (bg) * | 2006-12-14 | 2007-11-30 | "Софарма" Ад | Състав за твърда лекарствена форма, съдържащ правастатин |
| US20100196469A1 (en) * | 2007-06-25 | 2010-08-05 | Pharmathen S.A. | Pharmaceutical Formulation containing an HMG-COA Reductase Inhibitor and method for the preparation thereof |
| GB0713707D0 (en) * | 2007-07-13 | 2007-08-22 | Generics Uk Ltd | Stable compositions |
| WO2009024889A2 (en) | 2007-08-21 | 2009-02-26 | Ranbaxy Laboratories Limited | Pharmaceutical composition comprising a hmg-coa reductase inhibitor and ezetimibe |
| DE102007052071A1 (de) | 2007-10-30 | 2009-05-07 | Stada Arzneimittel Ag | Stabilisiertes Atorvastatin |
| JPWO2011049122A1 (ja) * | 2009-10-21 | 2013-03-14 | 第一三共株式会社 | プラバスタチンナトリウム口腔内速崩壊錠及びその製造方法 |
| US8372877B2 (en) * | 2010-04-16 | 2013-02-12 | Cumberland Pharmaceuticals | Stabilized statin formulations |
| KR101248804B1 (ko) * | 2010-05-14 | 2013-03-29 | 한미사이언스 주식회사 | ＨＭＧ-ＣｏＡ 환원효소 억제제 및 이베살탄을 포함하는 이층정 약제학적 복합제제 |
| TR201005326A2 (tr) | 2010-06-30 | 2012-01-23 | B�Lg�� Mahmut | Çoklu dozaj formları. |
| JP5829607B2 (ja) * | 2010-06-30 | 2015-12-09 | 持田製薬株式会社 | ω３脂肪酸の配合製剤 |
| US9107983B2 (en) | 2010-10-27 | 2015-08-18 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising statins |
| US8877221B2 (en) | 2010-10-27 | 2014-11-04 | Warsaw Orthopedic, Inc. | Osteoconductive matrices comprising calcium phosphate particles and statins and methods of using the same |
| EP2698159A4 (en) * | 2011-04-12 | 2014-11-05 | Sawai Seiyaku Kk | PITAVASTATE-CONTAINING PREPARATION AND METHOD OF MANUFACTURING THEREOF |
| WO2012153181A1 (en) * | 2011-05-11 | 2012-11-15 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Pharmaceutical composition comprising pitavastatin or its pharmaceutically acceptable salts |
| US9308190B2 (en) | 2011-06-06 | 2016-04-12 | Warsaw Orthopedic, Inc. | Methods and compositions to enhance bone growth comprising a statin |
| IN2014CN04119A (sh) | 2011-11-15 | 2015-07-10 | Reddys Lab Ltd Dr | |
| KR20140030505A (ko) * | 2012-08-31 | 2014-03-12 | 한미약품 주식회사 | 이베살탄 및 ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 약제학적 캡슐 복합제제 |
| KR101597004B1 (ko) | 2013-07-25 | 2016-02-23 | 씨제이헬스케어 주식회사 | 서방형 메트포르민과 속방형 HMG-CoA 환원효소 억제제를 포함하는 복합제제 |
| EP3184103A1 (en) | 2015-12-21 | 2017-06-28 | Hexal AG | Pharmaceutical composition comprising atorvastatin or a salt thereof |
| CN109044989A (zh) * | 2018-10-09 | 2018-12-21 | 河南师范大学 | 一种阿托伐他汀钙胶囊制剂及其制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US579837A (en) * | 1897-03-30 | Saw-sharpening machine | ||
| MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
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| HU9203780D0 (en) * | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
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| US5298627A (en) * | 1993-03-03 | 1994-03-29 | Warner-Lambert Company | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis |
| US5798375A (en) * | 1995-07-03 | 1998-08-25 | Sankyo Company, Limited | Treatment of arteriosclerosis and xanthoma |
| WO1997023200A1 (en) * | 1995-12-22 | 1997-07-03 | Kowa Company, Ltd. | Pharmaceutical composition stabilized with a basic agent |
| FR2751316B1 (fr) * | 1996-07-19 | 1998-08-28 | Granger Maurice | Appareil distributeur de bandes de papier ouate pour essuie-mains, papier toilette et similaire |
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| US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
| SI20109A (sl) * | 1998-12-16 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Stabilna farmacevtska formulacija |
| AU4943400A (en) * | 2000-06-09 | 2001-12-17 | Lek Tovarna Farmacevtskih | Stabilized pharmaceutically effective composition and pharmaceutical formulationcomprising the same |
| SI21302A (sl) * | 2002-10-11 | 2004-04-30 | LEK farmacevtska dru�ba d.d. | Stabiliziran farmacevtski izdelek z amorfno aktivno učinkovino |
| TW589178B (en) * | 2003-02-21 | 2004-06-01 | China Chemical & Pharmaceutica | A novel industrial process to obtain pravastatin sodium of high purity |
-
1998
- 1998-12-16 SI SI9800309A patent/SI20109A/sl not_active IP Right Cessation
-
1999
- 1999-10-29 KR KR1020017006808A patent/KR100638307B1/ko not_active Expired - Fee Related
- 1999-10-29 SK SK809-2001A patent/SK8092001A3/sk unknown
- 1999-10-29 YU YU35501A patent/YU35501A/sh unknown
- 1999-10-29 TR TR2001/01235T patent/TR200101235T2/xx unknown
- 1999-10-29 ES ES99951034T patent/ES2299265T3/es not_active Expired - Lifetime
- 1999-10-29 NZ NZ511260A patent/NZ511260A/xx unknown
- 1999-10-29 CA CA002348988A patent/CA2348988C/en not_active Expired - Fee Related
- 1999-10-29 WO PCT/IB1999/001749 patent/WO2000035425A1/en not_active Ceased
- 1999-10-29 EP EP07122298A patent/EP1911445A3/en not_active Withdrawn
- 1999-10-29 AT AT99951034T patent/ATE380020T1/de active
- 1999-10-29 CN CNB998144037A patent/CN1198597C/zh not_active Expired - Fee Related
- 1999-10-29 SI SI9931000T patent/SI1148872T1/sl unknown
- 1999-10-29 DE DE69937691T patent/DE69937691T2/de not_active Expired - Lifetime
- 1999-10-29 PL PL99347686A patent/PL347686A1/xx unknown
- 1999-10-29 HR HR20010325A patent/HRP20010325A2/hr not_active Application Discontinuation
- 1999-10-29 CZ CZ20011727A patent/CZ302562B6/cs not_active IP Right Cessation
- 1999-10-29 IL IL14375999A patent/IL143759A0/xx unknown
- 1999-10-29 EP EP99951034A patent/EP1148872B1/en not_active Expired - Lifetime
- 1999-10-29 HU HU0104258A patent/HUP0104258A3/hu unknown
- 1999-10-29 JP JP2000587746A patent/JP2002532409A/ja active Pending
- 1999-10-29 AU AU63608/99A patent/AU775946B2/en not_active Ceased
- 1999-10-29 US US09/600,436 patent/US6680341B1/en not_active Expired - Fee Related
- 1999-10-29 RU RU2001115716/15A patent/RU2227019C2/ru not_active IP Right Cessation
-
2001
- 2001-05-10 ZA ZA200103802A patent/ZA200103802B/en unknown
- 2001-05-15 IS IS5939A patent/IS5939A/is unknown
- 2001-06-04 BG BG105559A patent/BG105559A/xx unknown
- 2001-06-14 IL IL143759A patent/IL143759A/en not_active IP Right Cessation
-
2003
- 2003-09-04 US US10/655,263 patent/US20040072894A1/en not_active Abandoned
-
2008
- 2008-07-11 US US12/172,143 patent/US20090264497A1/en not_active Abandoned
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