YU99092A - Organske soli n,n'-diacetilcistina i postupak za njihovo dobijanje - Google Patents

Organske soli n,n'-diacetilcistina i postupak za njihovo dobijanje

Info

Publication number
YU99092A
YU99092A YU99092A YU99092A YU99092A YU 99092 A YU99092 A YU 99092A YU 99092 A YU99092 A YU 99092A YU 99092 A YU99092 A YU 99092A YU 99092 A YU99092 A YU 99092A
Authority
YU
Yugoslavia
Prior art keywords
diacetylcystine
procedure
production
organic salts
forms
Prior art date
Application number
YU99092A
Other languages
English (en)
Other versions
YU48594B (sh
Inventor
O.M. Anderson
H. Bergstrand
E. Jakupovic
B.G. Joseffson
M. Lindvall
B. Sarnstrand
E. Teneberg
Original Assignee
Aktiebolaget Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aktiebolaget Astra filed Critical Aktiebolaget Astra
Publication of YU99092A publication Critical patent/YU99092A/sh
Publication of YU48594B publication Critical patent/YU48594B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

so organske baze i N,N'-diacetil-cistina u obliku njegovih pojedinačnih izomera t.j. kao D-, L- i mezo- oblici kao i njihovi racemski oblici.
YU99092A 1991-11-29 1992-11-18 Organske soli n-n'-diacetilcistina i postupak njihovog dobijanja YU48594B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine

Publications (2)

Publication Number Publication Date
YU99092A true YU99092A (sh) 1995-12-04
YU48594B YU48594B (sh) 1998-12-23

Family

ID=20384494

Family Applications (1)

Application Number Title Priority Date Filing Date
YU99092A YU48594B (sh) 1991-11-29 1992-11-18 Organske soli n-n'-diacetilcistina i postupak njihovog dobijanja

Country Status (38)

Country Link
US (5) US5385904A (sh)
EP (1) EP0621862B1 (sh)
JP (1) JP3302018B2 (sh)
KR (1) KR100256185B1 (sh)
CN (1) CN1039586C (sh)
AP (1) AP350A (sh)
AT (1) ATE141913T1 (sh)
AU (1) AU657827B2 (sh)
CA (1) CA2123516A1 (sh)
CZ (1) CZ282085B6 (sh)
DE (1) DE69213256T2 (sh)
DK (1) DK0621862T3 (sh)
DZ (1) DZ1637A1 (sh)
EE (1) EE03025B1 (sh)
ES (1) ES2090713T3 (sh)
FI (1) FI942504L (sh)
GR (1) GR3021546T3 (sh)
HK (1) HK62297A (sh)
HR (1) HRP921322B1 (sh)
HU (1) HU215390B (sh)
IL (1) IL103778A (sh)
IS (1) IS1645B (sh)
LV (1) LV11949B (sh)
MA (1) MA22716A1 (sh)
MX (1) MX9206851A (sh)
MY (1) MY110523A (sh)
NO (1) NO301325B1 (sh)
NZ (1) NZ245077A (sh)
PL (2) PL170787B1 (sh)
RU (1) RU2135468C1 (sh)
SE (1) SE9103572D0 (sh)
SG (1) SG73962A1 (sh)
SI (1) SI9200351A (sh)
SK (1) SK281697B6 (sh)
TN (1) TNSN92108A1 (sh)
WO (1) WO1993011104A1 (sh)
YU (1) YU48594B (sh)
ZA (1) ZA928739B (sh)

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US6017959A (en) * 1996-06-18 2000-01-25 Astra Aktiebolag Forms of organic salts of N,N'-diacetylcystine
SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
AR007398A1 (es) * 1996-06-18 1999-10-27 Astrazeneca Ab Proceso para preparar sales inorganicas de n-n'-diacetilcistina
CN1059907C (zh) * 1997-05-23 2000-12-27 中国石油化工集团公司巴陵石化岳阳石油化工总厂 一种含共轭二烯轻聚合物的选择氢化方法
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
SE9800932D0 (sv) 1998-03-20 1998-03-20 Astra Ab New compunds
EP1004302A3 (en) * 1998-10-29 2003-06-04 Ajinomoto Co., Inc. Immunomodulator
SE9900438D0 (sv) * 1999-02-10 1999-02-10 Astra Ab The pharmacological use of certian cystine derivatives
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
NO20003591L (no) * 2000-07-13 2002-01-14 Thia Medica As Fettsyreanaloger for behandling av kreft
SE518784C2 (sv) * 2000-12-27 2002-11-19 Nactilus Ab "N-Acetyl-L-cystein med kompositioner för behandling av neoplasier"
EP1374831A4 (en) * 2001-03-13 2007-07-11 Ajinomoto Kk Cosmetics or external preparations for skin
RU2317299C2 (ru) * 2001-08-10 2008-02-20 Кабусики Кайся Хаясибара Сеибуцу Кагаку Ассоциат, содержащий трегалозу и хлорид кальция, в форме кристаллического моногидрата или безводного кристалла
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DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
CN104436170B (zh) 2004-08-23 2018-02-23 曼金德公司 用于药物输送的二酮哌嗪盐
AU2006290227B2 (en) 2005-09-14 2012-08-02 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
SG10201507036TA (en) 2008-06-13 2015-10-29 Mannkind Corp A dry powder inhaler and system for drug delivery
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
MX2011009512A (es) 2009-03-11 2011-11-29 Mannkind Corp Aparato, sistema y metodo para medir la resistencia de un inhalador.
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
EP2694402B1 (en) 2011-04-01 2017-03-22 MannKind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1200318A1 (en) 2011-10-24 2015-08-07 曼金德公司 Methods and compositions for treating pain
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
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US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
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Also Published As

Publication number Publication date
MY110523A (en) 1998-07-31
FI942504A0 (fi) 1994-05-27
ATE141913T1 (de) 1996-09-15
ZA928739B (en) 1993-06-09
EP0621862B1 (en) 1996-08-28
IS1645B (is) 1997-03-25
LV11949B (en) 1998-07-20
KR100256185B1 (ko) 2000-05-15
MX9206851A (es) 1993-05-01
HU9401473D0 (en) 1994-08-29
NO941968L (no) 1994-05-26
HRP921322B1 (en) 1998-12-31
FI942504A7 (fi) 1994-05-27
WO1993011104A1 (en) 1993-06-10
AU3099692A (en) 1993-06-28
JP3302018B2 (ja) 2002-07-15
ES2090713T3 (es) 1996-10-16
US5693858A (en) 1997-12-02
CZ282085B6 (cs) 1997-05-14
DE69213256D1 (de) 1996-10-02
EE03025B1 (et) 1997-08-15
IL103778A0 (en) 1993-04-04
SE9103572D0 (sv) 1991-11-29
CA2123516A1 (en) 1993-06-10
HK62297A (en) 1997-05-16
FI942504L (fi) 1994-05-27
AU657827B2 (en) 1995-03-23
PL171336B1 (en) 1997-04-30
US5824681A (en) 1998-10-20
AP350A (en) 1994-08-09
LV11949A (lv) 1998-01-20
HUT70851A (en) 1995-11-28
NO941968D0 (no) 1994-05-26
TNSN92108A1 (fr) 1993-06-08
SK63294A3 (en) 1995-02-08
SK281697B6 (sk) 2001-06-11
IS3949A (is) 1993-05-30
CN1039586C (zh) 1998-08-26
HRP921322A2 (en) 1996-10-31
NZ245077A (en) 1995-04-27
SI9200351A (en) 1993-06-30
AP9200448A0 (en) 1993-01-31
PL170787B1 (en) 1997-01-31
US5650538A (en) 1997-07-22
DK0621862T3 (da) 1996-09-16
SG73962A1 (en) 2000-07-18
MA22716A1 (fr) 1993-07-01
CN1073683A (zh) 1993-06-30
RU2135468C1 (ru) 1999-08-27
HU215390B (hu) 1998-12-28
US5804582A (en) 1998-09-08
US5385904A (en) 1995-01-31
DZ1637A1 (fr) 2002-02-17
GR3021546T3 (en) 1997-02-28
YU48594B (sh) 1998-12-23
CZ129794A3 (en) 1995-01-18
JPH07501539A (ja) 1995-02-16
DE69213256T2 (de) 1997-01-23
IL103778A (en) 1997-08-14
EP0621862A1 (en) 1994-11-02
NO301325B1 (no) 1997-10-13

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