ZA200005196B - Oxidized Thymosin Beta 4. - Google Patents

Oxidized Thymosin Beta 4. Download PDF

Info

Publication number: ZA200005196B
Authority: ZA; South Africa
Prior art keywords: thymosin; oxidised; salt; active variant; pharmaceutical formulation
Prior art date: 1998-03-28

Application number

ZA200005196A

Other languages

English (en)

Inventor

Robert Duncan Stevenson

Anthony John Lawrence

John Young

Darryl John Cecil Pappin

Original Assignee

Univ Glasgow

Imp Cancer Res Technology

Robert Duncan Stevenson

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-28

Filing date

2000-09-27

Publication date

2002-01-02

2000-09-27 Application filed by Univ Glasgow, Imp Cancer Res Technology, Robert Duncan Stevenson filed Critical Univ Glasgow

2002-01-02 Publication of ZA200005196B publication Critical patent/ZA200005196B/en

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Classifications

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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57581—Thymosin; Related peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Genetics & Genomics (AREA)
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Medicinal Chemistry (AREA)
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Animal Behavior & Ethology (AREA)
Public Health (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Biophysics (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
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Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
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ZA200005196A 1998-03-28 2000-09-27 Oxidized Thymosin Beta 4. ZA200005196B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9806632.7A GB9806632D0 (en)	1998-03-28	1998-03-28	Peptide factor

Publications (1)

Publication Number	Publication Date
ZA200005196B true ZA200005196B (en)	2002-01-02

Family

ID=10829414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200005196A ZA200005196B (en)	1998-03-28	2000-09-27	Oxidized Thymosin Beta 4.

Country Status (15)

Country	Link
US (3)	US6602519B1 (fr)
EP (1)	EP1094833B1 (fr)
JP (1)	JP2002509893A (fr)
KR (1)	KR20010074461A (fr)
CN (2)	CN1644586A (fr)
AT (1)	ATE232396T1 (fr)
AU (1)	AU766493B2 (fr)
CA (1)	CA2325984A1 (fr)
DE (1)	DE69905368T2 (fr)
ES (1)	ES2192839T3 (fr)
GB (1)	GB9806632D0 (fr)
IL (1)	IL138665A0 (fr)
NZ (1)	NZ507642A (fr)
WO (1)	WO1999049883A2 (fr)
ZA (1)	ZA200005196B (fr)

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GB9806632D0 (en) *	1998-03-28	1998-05-27	Stevenson Robert	Peptide factor
US20070015698A1 (en) *	1998-07-30	2007-01-18	United States Of America As Represented By The Secretary Of Health	Treatment of skin, and wound repair, with thymosin beta 4
AU766826B2 (en) *	1998-07-30	2003-10-23	Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The	Thymosin beta4 promotes wound repair
US20070191275A1 (en) *	1998-07-30	2007-08-16	Regenerx Biopharmaceuticals, Inc.	Method of treating, preventing, inhibiting or reducing damage to cardiac tissue with thymosin beta 4 fragments
US20060100156A1 (en) *	2004-10-01	2006-05-11	Regenerx Biopharmaceuticals, Inc.	Cell nucleus-entering compositions
US20040067227A1 (en) *	2001-11-02	2004-04-08	Goldstein Allan L.	Inhibition or reversal of skin aging by actin-sequestering peptides
EP1994941A3 (fr) *	2000-10-20	2012-07-25	Hamburger Stiftung zur Förderung von Wissenschaft und Kultur	Médicament contenant au moins une protéine oxydée
PT1335743E (pt)	2000-11-02	2010-03-29	Regenerx Biopharmaceuticals	Inibição ou reversão do envelhecimento da pele por meio de péptidos sequestrando actina
AU2002255736B2 (en) *	2001-03-15	2006-08-31	Regenerx, Biopharmaceuticals, Inc.	Methods of treating disorders of the eye and surrounding tissue with thymosin beta4 (Tbeta4), analogues, isoforms and other derivatives
WO2003020215A2 (fr)	2001-08-29	2003-03-13	Regenerx Biopharmaceuticals, Inc.	Procedes de guerison ou de prevention de l'inflammation, de la deterioration ou d'autres modifications intervenant avant, pendant ou immediatement apres un evenement myocardique par thymosine beta 4, ses analogues, isoformes ou autres derives
AU2008201749B2 (en) *	2002-02-06	2010-05-13	Regenerx Biopharmaceuticals, Inc.	Treatment of Infections and Other Disorders
AU2003296875B2 (en) *	2002-02-06	2008-01-24	Regenerx Biopharmaceuticals, Inc.	Treatment of infections and other disorders
AU2003223601A1 (en) *	2002-04-12	2003-10-27	King's College London	ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN Beta 4
US6821524B2 (en) *	2002-06-03	2004-11-23	Jan Marini Skin Research, Inc.	Cosmetic skin care compositions
US20060263360A1 (en) *	2003-03-31	2006-11-23	Regenerx Biopharmaceuticals, Inc.	Compositions and methods for delivering thymosin beta 4, analogues, isoforms and other derivatives
WO2005027958A1 (fr) *	2003-09-19	2005-03-31	Imperial College Innovations Ltd	Thymosine-beta-sulphoxyde comme immunodepresseur actif
EP1706136A4 (fr) *	2003-12-22	2009-09-16	Regenerx Biopharmaceuticals	Procede de traitement ou de prevention des reponses biologiques ou immunologiques a un agent reactif chimique, biologique ou toxique
WO2005087805A1 (fr) *	2004-03-05	2005-09-22	Regenerx Biopharmaceuticals, Inc.	Traitement ou prevention de formation de matrice extracellulaire
EP1835927A4 (fr) *	2005-01-14	2008-06-18	Regenerx Biopharmaceuticals	Peptides thymosine beta modifies
JP2008543877A (ja)	2005-06-17	2008-12-04	リジェナークス・バイオファーマスーティカルズ・インコーポレイテッド	Ｌｋｋｔｅｔおよび／またはｌｋｋｔｎｔ組成物および組織の悪化、傷害または損傷を処置または予防するための方法
EP1913013A2 (fr) *	2005-07-19	2008-04-23	Grannus Biosciences	Thymosine beta4 oxydee tronquee et derives de celle-ci
ES2288118B1 (es) *	2006-05-10	2008-11-01	Bcn Peptides, S.A.	Procedimiento para sintetizar timosinas.
CN101297965B (zh) *	2008-06-16	2011-01-05	浙江省中医药研究院	胸腺肽β4在制备防治支气管哮喘药物中的应用
US20100247693A1 (en) *	2009-03-24	2010-09-30	Marini Jan L	Cosmetic formulation to treat rosacea telangiectasia
US8580742B2 (en)	2010-03-05	2013-11-12	N.V. Perricone Llc	Topical glutathione formulations for menopausal skin
US20110160144A1 (en) *	2009-12-28	2011-06-30	Perricone Nicholas V	Topical Acyl Glutathione Formulations
US8609604B2 (en)	2009-12-28	2013-12-17	N.V. Perricone Llc	Methods of improving the appearance of aging skin
JP5847418B2 (ja)	2011-03-30	2016-01-20	富士フイルム株式会社	細胞接着性タンパク質
US9808654B2 (en)	2013-02-11	2017-11-07	Jan Marini Skin Research	Post procedure skin care gel and methods of use thereof
CN110215513B (zh) *	2018-11-15	2022-02-22	北京诺思兰德生物技术股份有限公司	经修饰的胸腺素β4在治疗放射性肠炎方面的用途

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US3998798A (en) *	1972-12-22	1976-12-21	The Trustees Of The University Of Pennsylvania	Monellin, a sweet polypeptide derived from fruit of dioscoreophyllum cumminsii
US4297276A (en) *	1979-03-23	1981-10-27	Hoffman-La Roche Inc.	Thymosin beta 3 and beta 4
US4389343A (en)	1981-12-24	1983-06-21	Hoffmann-La Roche Inc.	Immunopotentiating peptides from thymus
US4388234A (en)	1981-12-28	1983-06-14	Hoffmann-La Roche Inc.	Peptide isolation
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US5593964A (en) *	1993-10-07	1997-01-14	The George Washington University Medical Center	Method of treating septic shock by preventing actin polymerization
US5578570A (en) *	1993-10-07	1996-11-26	The George Washington University Medical Center	Method of treating septic shock using thymosin β4
US5468729A (en) *	1993-10-26	1995-11-21	Alpha 1 Biomedicals	Method for treatment of autoimmune hepatitis
GB9806632D0 (en) *	1998-03-28	1998-05-27	Stevenson Robert	Peptide factor

1998
- 1998-03-28 GB GBGB9806632.7A patent/GB9806632D0/en not_active Ceased
1999
- 1999-03-29 CN CNA2004100879091A patent/CN1644586A/zh active Pending
- 1999-03-29 ES ES99913428T patent/ES2192839T3/es not_active Expired - Lifetime
- 1999-03-29 AU AU31553/99A patent/AU766493B2/en not_active Ceased
- 1999-03-29 US US09/647,117 patent/US6602519B1/en not_active Expired - Fee Related
- 1999-03-29 IL IL13866599A patent/IL138665A0/xx not_active IP Right Cessation
- 1999-03-29 EP EP99913428A patent/EP1094833B1/fr not_active Expired - Lifetime
- 1999-03-29 CN CNB998059579A patent/CN1178695C/zh not_active Expired - Fee Related
- 1999-03-29 CA CA002325984A patent/CA2325984A1/fr not_active Abandoned
- 1999-03-29 NZ NZ507642A patent/NZ507642A/en unknown
- 1999-03-29 WO PCT/GB1999/000833 patent/WO1999049883A2/fr not_active Ceased
- 1999-03-29 JP JP2000540846A patent/JP2002509893A/ja active Pending
- 1999-03-29 KR KR1020007010794A patent/KR20010074461A/ko not_active Withdrawn
- 1999-03-29 DE DE69905368T patent/DE69905368T2/de not_active Expired - Fee Related
- 1999-03-29 AT AT99913428T patent/ATE232396T1/de not_active IP Right Cessation
2000
- 2000-09-27 ZA ZA200005196A patent/ZA200005196B/en unknown
2003
- 2003-01-09 US US10/339,271 patent/US20040213772A1/en not_active Abandoned
2006
- 2006-06-14 US US11/452,738 patent/US20060229234A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69905368D1 (en)	2003-03-20
US20040213772A1 (en)	2004-10-28
DE69905368T2 (de)	2003-12-18
ATE232396T1 (de)	2003-02-15
IL138665A0 (en)	2001-10-31
WO1999049883A3 (fr)	2001-02-22
WO1999049883A2 (fr)	1999-10-07
EP1094833A2 (fr)	2001-05-02
CN1644586A (zh)	2005-07-27
AU766493B2 (en)	2003-10-16
EP1094833B1 (fr)	2003-02-12
ES2192839T3 (es)	2003-10-16
CA2325984A1 (fr)	1999-10-07
CN1308543A (zh)	2001-08-15
CN1178695C (zh)	2004-12-08
US20060229234A1 (en)	2006-10-12
JP2002509893A (ja)	2002-04-02
AU3155399A (en)	1999-10-18
KR20010074461A (ko)	2001-08-04
GB9806632D0 (en)	1998-05-27
NZ507642A (en)	2003-10-31
US6602519B1 (en)	2003-08-05

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