ZA200100978B - Muscarinic agonists and antagonists. - Google Patents

Muscarinic agonists and antagonists.

Info

Publication number
ZA200100978B
ZA200100978B ZA200100978A ZA200100978A ZA200100978B ZA 200100978 B ZA200100978 B ZA 200100978B ZA 200100978 A ZA200100978 A ZA 200100978A ZA 200100978 A ZA200100978 A ZA 200100978A ZA 200100978 B ZA200100978 B ZA 200100978B
Authority
ZA
South Africa
Prior art keywords
antagonists
muscarinic agonists
muscarinic
agonists
Prior art date
Application number
ZA200100978A
Other languages
English (en)
Inventor
Gurmit Grewal
Anna Toy-Palmer
Xiong Cai
George Mark Latham
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of ZA200100978B publication Critical patent/ZA200100978B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
ZA200100978A 1998-08-18 2001-02-05 Muscarinic agonists and antagonists. ZA200100978B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9697798P 1998-08-18 1998-08-18

Publications (1)

Publication Number Publication Date
ZA200100978B true ZA200100978B (en) 2002-02-05

Family

ID=22260061

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200100978A ZA200100978B (en) 1998-08-18 2001-02-05 Muscarinic agonists and antagonists.

Country Status (30)

Country Link
US (5) US6093724A (de)
EP (1) EP1112272B1 (de)
JP (1) JP2002523416A (de)
KR (1) KR20010072784A (de)
CN (1) CN1312812A (de)
AR (1) AR020199A1 (de)
AT (1) ATE227724T1 (de)
AU (1) AU750566B2 (de)
BG (1) BG105256A (de)
BR (1) BR9913072A (de)
CA (1) CA2340946A1 (de)
CO (1) CO5130018A1 (de)
DE (1) DE69903961T2 (de)
EE (1) EE200100096A (de)
ES (1) ES2191455T3 (de)
HK (1) HK1038918A1 (de)
HU (1) HUP0103203A3 (de)
ID (1) ID27544A (de)
IL (1) IL141050A0 (de)
IS (1) IS5827A (de)
NO (1) NO20010804L (de)
NZ (1) NZ509762A (de)
PE (1) PE20000988A1 (de)
PL (1) PL346247A1 (de)
RU (1) RU2219179C2 (de)
SK (1) SK1892001A3 (de)
TR (1) TR200100462T2 (de)
WO (1) WO2000011001A1 (de)
YU (1) YU13301A (de)
ZA (1) ZA200100978B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0301442A3 (en) * 2000-10-19 2007-03-28 Pfizer Prod Inc Bridged piperazine derivatives and pharmaceutical compositions containing them
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
WO2002094827A1 (en) * 2001-05-23 2002-11-28 Neurosearch A/S Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20030064979A1 (en) * 2001-06-29 2003-04-03 Hansen Thomas Kruse Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
US6828328B1 (en) * 2002-03-01 2004-12-07 Ucb S.A. Analgesic combination of muscarinic agonists
US7897766B2 (en) * 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US8076350B2 (en) * 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
MX2009010176A (es) * 2007-03-23 2009-10-12 Abbott Lab Derivados de aza-adamantano 4-substituidos y metodos de uso de los mismos.
MX2009010175A (es) 2007-03-23 2009-10-12 Abbott Lab Derivados de acetamida y carboxamida de aza-adamantano y metodos de uso de los mismos.
KR20120044978A (ko) * 2009-06-19 2012-05-08 아보트 러보러터리즈 디아자호모아다만탄 유도체 및 이들의 사용 방법
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
EP3061821B1 (de) 2009-07-22 2019-07-10 Puretech Health LLC Zusammensetzungen zur behandlung von durch muscarinrezeptoraktivierung gelinderten leiden
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2560488B1 (de) 2010-04-23 2015-10-28 Cytokinetics, Inc. Bestimmte aminopyrimidine und aminotriazine, zusammensetzungen daraus und verfahren zu ihrer verwendung
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
US9464078B2 (en) 2010-09-23 2016-10-11 Abbvie Inc. Monohydrate of azaadamantane derivatives
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
AU2018300980A1 (en) 2017-07-12 2020-01-02 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
ES3064093T3 (en) 2017-10-20 2026-04-22 Univ Vanderbilt Antagonists of the muscarinic acetylcholine receptor m4
WO2019126559A1 (en) 2017-12-20 2019-06-27 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
IL281809B (en) 2018-09-28 2022-09-01 Karuna Therapeutics Inc Compositions and methods for the treatment of diseases improved by the activation of muscarinic receptors

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739074A (en) * 1986-01-22 1988-04-19 Pennwalt Corporation Adamantane spiro-pyrrolidine derivatives
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
WO1992011261A1 (en) * 1990-12-21 1992-07-09 Merck Sharp & Dohme Limited 4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
AU702720B2 (en) * 1995-11-02 1999-03-04 Neurosearch A/S Fused tropane-derivatives as neurotransmitter reuptake inhibitors
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US5986100A (en) * 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use
US6057446A (en) * 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds

Also Published As

Publication number Publication date
AU750566B2 (en) 2002-07-25
HK1038918A1 (zh) 2002-04-04
PL346247A1 (en) 2002-01-28
DE69903961T2 (de) 2003-07-03
US6423842B1 (en) 2002-07-23
HUP0103203A3 (en) 2002-10-28
NZ509762A (en) 2002-12-20
ES2191455T3 (es) 2003-09-01
NO20010804L (no) 2001-04-11
CO5130018A1 (es) 2002-02-27
BR9913072A (pt) 2001-05-15
US6251916B1 (en) 2001-06-26
NO20010804D0 (no) 2001-02-16
DE69903961D1 (de) 2002-12-19
BG105256A (en) 2001-11-30
EE200100096A (et) 2002-06-17
SK1892001A3 (en) 2001-11-06
IS5827A (is) 2001-01-26
ID27544A (id) 2001-04-12
JP2002523416A (ja) 2002-07-30
WO2000011001A1 (en) 2000-03-02
YU13301A (sh) 2005-06-10
IL141050A0 (en) 2002-02-10
US20020045617A1 (en) 2002-04-18
CN1312812A (zh) 2001-09-12
AR020199A1 (es) 2002-05-02
AU5775899A (en) 2000-03-14
PE20000988A1 (es) 2000-09-30
US6555550B1 (en) 2003-04-29
EP1112272A1 (de) 2001-07-04
HUP0103203A2 (hu) 2002-01-28
US6093724A (en) 2000-07-25
EP1112272B1 (de) 2002-11-13
TR200100462T2 (tr) 2001-09-21
ATE227724T1 (de) 2002-11-15
CA2340946A1 (en) 2000-03-02
US6323194B1 (en) 2001-11-27
KR20010072784A (ko) 2001-07-31
RU2219179C2 (ru) 2003-12-20

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