ZA200209478B - Method for increasing the antioxidative potential of selenium-containing aqueous solutions. - Google Patents

Method for increasing the antioxidative potential of selenium-containing aqueous solutions. Download PDF

Info

Publication number: ZA200209478B
Authority: ZA; South Africa
Prior art keywords: preparation; selenite; food; selenate; containing aqueous
Prior art date: 2000-06-05

Application number

ZA200209478A

Other languages

English (en)

Inventor

Peter Koessler

Norbert Fuchs

Bodo Kuklinski

Raimund Schiefer

Original Assignee

Vis Vitalis Lizenz & Handels

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-05

Filing date

2002-11-21

Publication date

2003-11-21

2002-11-21 Application filed by Vis Vitalis Lizenz & Handels filed Critical Vis Vitalis Lizenz & Handels

2003-11-21 Publication of ZA200209478B publication Critical patent/ZA200209478B/en

Links

BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims description 30
239000007864 aqueous solution Substances 0.000 title claims description 13
230000003078 antioxidant effect Effects 0.000 title claims description 9
238000000034 method Methods 0.000 title claims description 8
229910052711 selenium Inorganic materials 0.000 title description 23
239000011669 selenium Substances 0.000 title description 23
238000002360 preparation method Methods 0.000 claims description 27
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
239000003963 antioxidant agent Substances 0.000 claims description 13
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
239000002253 acid Substances 0.000 claims description 11
229940082569 selenite Drugs 0.000 claims description 11
MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 claims description 11
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
150000007513 acids Chemical class 0.000 claims description 8
201000010099 disease Diseases 0.000 claims description 8
239000000203 mixture Substances 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 6
229940079593 drug Drugs 0.000 claims description 5
239000003814 drug Substances 0.000 claims description 5
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 4
235000013399 edible fruits Nutrition 0.000 claims description 4
239000001630 malic acid Substances 0.000 claims description 4
235000011090 malic acid Nutrition 0.000 claims description 4
208000009889 Herpes Simplex Diseases 0.000 claims description 3
206010019973 Herpes virus infection Diseases 0.000 claims description 3
-1 analgetics Substances 0.000 claims description 3
239000003242 anti bacterial agent Substances 0.000 claims description 3
229940088710 antibiotic agent Drugs 0.000 claims description 3
239000003443 antiviral agent Substances 0.000 claims description 3
208000015181 infectious disease Diseases 0.000 claims description 3
230000003612 virological effect Effects 0.000 claims description 3
230000000202 analgesic effect Effects 0.000 claims description 2
229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
239000002260 anti-inflammatory agent Substances 0.000 claims description 2
230000001857 anti-mycotic effect Effects 0.000 claims description 2
239000002543 antimycotic Substances 0.000 claims description 2
239000006172 buffering agent Substances 0.000 claims description 2
235000015872 dietary supplement Nutrition 0.000 claims description 2
239000000975 dye Substances 0.000 claims description 2
239000000839 emulsion Substances 0.000 claims description 2
239000003381 stabilizer Substances 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 3
229940091258 selenium supplement Drugs 0.000 description 22
235000006708 antioxidants Nutrition 0.000 description 12
229960004150 aciclovir Drugs 0.000 description 9
MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 9
239000000243 solution Substances 0.000 description 9
241001465754 Metazoa Species 0.000 description 8
241000282414 Homo sapiens Species 0.000 description 6
108090000623 proteins and genes Proteins 0.000 description 6
238000002560 therapeutic procedure Methods 0.000 description 6
235000015097 nutrients Nutrition 0.000 description 5
235000018102 proteins Nutrition 0.000 description 5
102000004169 proteins and genes Human genes 0.000 description 5
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 4
230000000694 effects Effects 0.000 description 4
239000000049 pigment Substances 0.000 description 4
229960001471 sodium selenite Drugs 0.000 description 4
239000011781 sodium selenite Substances 0.000 description 4
235000015921 sodium selenite Nutrition 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 3
108090000790 Enzymes Proteins 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
230000009467 reduction Effects 0.000 description 3
230000002829 reductive effect Effects 0.000 description 3
FDKWRPBBCBCIGA-UHFFFAOYSA-N 2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]CC(N)C(O)=O FDKWRPBBCBCIGA-UHFFFAOYSA-N 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
206010039921 Selenium deficiency Diseases 0.000 description 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
239000005864 Sulphur Substances 0.000 description 2
229930003427 Vitamin E Natural products 0.000 description 2
239000002535 acidifier Substances 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
238000000151 deposition Methods 0.000 description 2
230000008021 deposition Effects 0.000 description 2
RVIXKDRPFPUUOO-UHFFFAOYSA-N dimethylselenide Chemical compound C[Se]C RVIXKDRPFPUUOO-UHFFFAOYSA-N 0.000 description 2
239000003925 fat Substances 0.000 description 2
235000019197 fats Nutrition 0.000 description 2
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
235000003969 glutathione Nutrition 0.000 description 2
229960003180 glutathione Drugs 0.000 description 2
230000002503 metabolic effect Effects 0.000 description 2
230000001590 oxidative effect Effects 0.000 description 2
150000002978 peroxides Chemical class 0.000 description 2
230000002265 prevention Effects 0.000 description 2
230000008569 process Effects 0.000 description 2
229940065287 selenium compound Drugs 0.000 description 2
150000003343 selenium compounds Chemical class 0.000 description 2
208000024891 symptom Diseases 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
235000019165 vitamin E Nutrition 0.000 description 2
229940046009 vitamin E Drugs 0.000 description 2
239000011709 vitamin E Substances 0.000 description 2
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
201000004384 Alopecia Diseases 0.000 description 1
241000271566 Aves Species 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
102000016938 Catalase Human genes 0.000 description 1
108010053835 Catalase Proteins 0.000 description 1
208000002177 Cataract Diseases 0.000 description 1
241000207199 Citrus Species 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
208000004898 Herpes Labialis Diseases 0.000 description 1
241000282412 Homo Species 0.000 description 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
208000019926 Keshan disease Diseases 0.000 description 1
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical group CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
239000005913 Maltodextrin Substances 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
206010067152 Oral herpes Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
102000003992 Peroxidases Human genes 0.000 description 1
208000003251 Pruritus Diseases 0.000 description 1
241000282887 Suidae Species 0.000 description 1
102000019197 Superoxide Dismutase Human genes 0.000 description 1
108010012715 Superoxide dismutase Proteins 0.000 description 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
230000009471 action Effects 0.000 description 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
229940124599 anti-inflammatory drug Drugs 0.000 description 1
230000000840 anti-viral effect Effects 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
238000005282 brightening Methods 0.000 description 1
229910052793 cadmium Inorganic materials 0.000 description 1
BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
231100000357 carcinogen Toxicity 0.000 description 1
239000003183 carcinogenic agent Substances 0.000 description 1
210000004027 cell Anatomy 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
230000008859 change Effects 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
210000002808 connective tissue Anatomy 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
230000004069 differentiation Effects 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
229910001882 dioxygen Inorganic materials 0.000 description 1
230000008034 disappearance Effects 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
TUANAMBRHOLYTH-UHFFFAOYSA-L disodium selenite pentahydrate Chemical compound O.O.O.O.O.[Na+].[Na+].[O-][Se]([O-])=O TUANAMBRHOLYTH-UHFFFAOYSA-L 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
230000002255 enzymatic effect Effects 0.000 description 1
235000021112 essential micronutrients Nutrition 0.000 description 1
230000029142 excretion Effects 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
229960004396 famciclovir Drugs 0.000 description 1
GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
210000003746 feather Anatomy 0.000 description 1
239000006052 feed supplement Substances 0.000 description 1
239000003337 fertilizer Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000000989 food dye Substances 0.000 description 1
230000006870 function Effects 0.000 description 1
239000000499 gel Substances 0.000 description 1
230000014509 gene expression Effects 0.000 description 1
235000021472 generally recognized as safe Nutrition 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
230000003676 hair loss Effects 0.000 description 1
210000000003 hoof Anatomy 0.000 description 1
230000003993 interaction Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
230000007803 itching Effects 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
229960004194 lidocaine Drugs 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
229960005015 local anesthetics Drugs 0.000 description 1
229940035034 maltodextrin Drugs 0.000 description 1
239000012528 membrane Substances 0.000 description 1
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
229910052753 mercury Inorganic materials 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
230000035764 nutrition Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
230000008092 positive effect Effects 0.000 description 1
239000004302 potassium sorbate Substances 0.000 description 1
235000010241 potassium sorbate Nutrition 0.000 description 1
229940069338 potassium sorbate Drugs 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000009993 protective function Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000027756 respiratory electron transport chain Effects 0.000 description 1
QYHFIVBSNOWOCQ-UHFFFAOYSA-N selenic acid Chemical class O[Se](O)(=O)=O QYHFIVBSNOWOCQ-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
229960001881 sodium selenate Drugs 0.000 description 1
239000011655 sodium selenate Substances 0.000 description 1
235000018716 sodium selenate Nutrition 0.000 description 1
208000003265 stomatitis Diseases 0.000 description 1
210000004895 subcellular structure Anatomy 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000013589 supplement Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
230000036228 toxication Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
150000004670 unsaturated fatty acids Chemical class 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Epidemiology (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Medicinal Preparation (AREA)

ZA200209478A 2000-06-05 2002-11-21 Method for increasing the antioxidative potential of selenium-containing aqueous solutions. ZA200209478B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0097800A AT412758B (de)	2000-06-05	2000-06-05	Verwendung einer selenithältigen lösung zur behandlung viraler erkrankungen

Publications (1)

Publication Number	Publication Date
ZA200209478B true ZA200209478B (en)	2003-11-21

Family

ID=3683775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200209478A ZA200209478B (en)	2000-06-05	2002-11-21	Method for increasing the antioxidative potential of selenium-containing aqueous solutions.

Country Status (11)

Country	Link
US (1)	US20030180387A1 (da)
EP (1)	EP1286675B8 (da)
AT (1)	AT412758B (da)
AU (2)	AU2001263633B2 (da)
CA (1)	CA2411582C (da)
DE (1)	DE50107692D1 (da)
DK (1)	DK1286675T3 (da)
ES (1)	ES2249441T3 (da)
RU (1)	RU2277915C2 (da)
WO (1)	WO2001093910A2 (da)
ZA (1)	ZA200209478B (da)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT412448B (de) *	2001-02-13	2005-03-25	Vis Vitalis Lizenz & Handels	Verwendung von selenhältigen präparaten
AT412703B (de) *	2001-12-04	2005-06-27	Vis Vitalis Lizenz & Handels	Verwendung von selenithältigen präparaten zur topischen oder bukkalen anwendung
HU227588B1 (hu) *	2004-12-03	2011-09-28	Sinnex Mueszaki Fejlesztoe Es Tanacsado Kft	Többszörösen telítetlen zsírsavak észtereit tartalmazó vírusellenes és immunstimuláns gyógyászati készítmény
RU2329793C1 (ru) *	2007-02-01	2008-07-27	Юрий Михайлович Козлов	Способ лечения и профилактики окислительного стресса у животных
FR2923358A1 (fr) *	2008-11-03	2009-05-15	Olivier Roujansky	Composition alimentaire destinee a renforcer les defenses immunitaires chez des personnes ayant une alimentation desequilibree en acides amines essentiels
FR2934119A1 (fr) *	2009-07-06	2010-01-29	Olivier Claude Alain Roujansky	Composition alimentaire destinee a maintenir en etat de latence les infections herpetiques genitales dues au virus hsv2
AT511159A1 (de)	2011-02-16	2012-09-15	Selo Medical Gmbh	Pharmazeutische zusammensetzungen enthaltend selenit- oder selenathältige verbindungen
US10339933B2 (en)	2016-05-11	2019-07-02	International Business Machines Corporation	Visualization of audio announcements using augmented reality
EP3616693A1 (en)	2018-08-28	2020-03-04	Selo Medical GmbH	Therapy of high-risk human papillomavirus infections
EP3838278A1 (en) *	2019-12-17	2021-06-23	Baxter International Inc	Stabilization of selenite in a nutritional solution by dissolved oxygen
EP3875083A1 (en)	2020-03-03	2021-09-08	Selo Medical GmbH	Composition for use in a treatment of cervical cell abnormalities comprising selenite compound and acid
CN112385761A (zh) *	2020-11-18	2021-02-23	深圳市名之洋生物科技有限公司	富硒水及其制备方法

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US4340590A (en) *	1977-08-02	1982-07-20	Lundy Research Laboratories, Inc.	Method for reducing or inhibiting ecchymosis in skin tissues with inorganic selenium compositions
IT1161213B (it) *	1983-03-08	1987-03-18	Fcn Srl	Composizioni farmaceutiche ad attivita' antineoplastica
US4762726A (en) *	1983-12-30	1988-08-09	Kraft, Inc.	Shelf stable acid food dressings containing fibrous protein complexes
US4668515A (en) *	1984-03-06	1987-05-26	Paul Bankit	Method and compositions for sodium selenite administration
DE3929411A1 (de) *	1988-09-22	1990-03-29	Siegfried Natterer	Pharmazeutische zubereitung sowie verfahren zu ihrer herstellung
DK0630192T3 (da) *	1992-03-11	1996-12-09	Procter & Gamble	Psyllium-drikkeblandingsprodukter indeholdende granuleret base
US5425944A (en) *	1992-10-27	1995-06-20	Harich; Jakob	Antimicrobial grapefruit extract
DE4335441A1 (de) *	1993-10-18	1995-04-20	Hans Dipl Chem Heide	Mittel zur Gesundheitsvorsorge im Herz- Kreislaufsystem beim Menschen
US5512200A (en) *	1994-04-18	1996-04-30	Thomas G. Bongard	Low pH Acidic Compositions
DE4413839C1 (de) *	1994-04-21	1995-10-19	Fritz Koch Pharma Gmbh Dr Med	Kombinationspräparat
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2000
- 2000-06-05 AT AT0097800A patent/AT412758B/de not_active IP Right Cessation
2001
- 2001-05-23 AU AU2001263633A patent/AU2001263633B2/en not_active Ceased
- 2001-05-23 RU RU2002135599/15A patent/RU2277915C2/ru active
- 2001-05-23 EP EP01937841A patent/EP1286675B8/de not_active Expired - Lifetime
- 2001-05-23 CA CA002411582A patent/CA2411582C/en not_active Expired - Lifetime
- 2001-05-23 WO PCT/AT2001/000162 patent/WO2001093910A2/de not_active Ceased
- 2001-05-23 ES ES01937841T patent/ES2249441T3/es not_active Expired - Lifetime
- 2001-05-23 DK DK01937841T patent/DK1286675T3/da active
- 2001-05-23 DE DE50107692T patent/DE50107692D1/de not_active Expired - Lifetime
- 2001-05-23 AU AU6363301A patent/AU6363301A/xx active Pending
- 2001-05-23 US US10/297,533 patent/US20030180387A1/en not_active Abandoned
2002
- 2002-11-21 ZA ZA200209478A patent/ZA200209478B/en unknown

Also Published As

Publication number	Publication date
AT412758B (de)	2005-07-25
EP1286675B8 (de)	2005-12-28
ATA9782000A (de)	2004-12-15
AU6363301A (en)	2001-12-17
CA2411582C (en)	2009-10-27
US20030180387A1 (en)	2003-09-25
DK1286675T3 (da)	2006-03-06
DE50107692D1 (de)	2005-11-17
AU2001263633B2 (en)	2005-11-10
WO2001093910A2 (de)	2001-12-13
CA2411582A1 (en)	2002-12-04
EP1286675B1 (de)	2005-10-12
WO2001093910A3 (de)	2002-11-14
RU2277915C2 (ru)	2006-06-20
EP1286675A2 (de)	2003-03-05
ES2249441T3 (es)	2006-04-01

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